Nucleocytoplasmic Transport: Integrating mRNA Production and Turnover with Export through the Nuclear Pore

REFERENCES

• Babu, J. R., Jeganathan K. B., Baker D. J., Wu X., Kang-Decker N., and van Deursen J. M.. 2003. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J. Cell Biol. 160:341–353.
   PubMed Web of Science ®Google Scholar
• Bachi, A., Braun I. C., Rodrigues J. P., Pante N., Ribbeck K., von Kobbe C., Kutay U., Wilm M., Gorlich D., Carmo-Fonseca M., and Izaurralde E.. 2000. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA 6:136–158.
   PubMed Web of Science ®Google Scholar
• Ball, J. R., Dimaano C., and Ullman K. S.. 2004. The RNA binding domain within the nucleoporin Nup153 associates preferentially with single-stranded RNA. RNA 10:19–27.
   PubMedGoogle Scholar
• Bangs, P., Burke B., Powers C., Craig R., Purohit A., and Doxsey S.. 1998. Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export. J. Cell Biol. 143:1801–1812.
   PubMedGoogle Scholar
• Bastos, R., Lin A., Enarson M., and Burke B.. 1996. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J. Cell Biol. 134:1141–1156.
   PubMed Web of Science ®Google Scholar
• Bednenko, J., Cingolani G., and Gerace L.. 2003. Nucleocytoplasmic transport: navigating the channel. Traffic 4:127–135.
   PubMed Web of Science ®Google Scholar
• Blevins, M. B., Smith A. M., Phillips E. M., and Powers M. A.. 2003. Complex formation among the RNA export proteins Nup98, Rae1/Gle2, and TAP. J. Biol. Chem. 278:20979–20988.
   PubMed Web of Science ®Google Scholar
• Bray, M., Prasad S., Dubay J. W., Hunter E., Jeang K. T., Rekosh D., and Hammarskjold M. L.. 1994. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA 91:1256–1260.
   PubMed Web of Science ®Google Scholar
• Chavez, S., Beilharz T., Rondon A. G., Erdjument-Bromage H., Tempst P., Svejstrup J. Q., Lithgow T., and Aguilera A.. 2000. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19:5824–5834.
   PubMed Web of Science ®Google Scholar
• Clouse, K. N., Luo M. J., Zhou Z., and Reed R.. 2001. A Ran-independent pathway for export of spliced mRNA. Nat. Cell Biol. 3:97–99.
   PubMed Web of Science ®Google Scholar
• Daigle, N., Beaudouin J., Hartnell L., Imreh G., Hallberg E., Lippincott-Schwartz J., and Ellenberg J.. 2001. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J. Cell Biol. 154:71–84.
   PubMed Web of Science ®Google Scholar
• Daneholt, B. 2001. Assembly and transport of a premessenger RNP particle. Proc. Natl. Acad. Sci. USA 98:7012–7017.
   PubMed Web of Science ®Google Scholar
• Del Priore, V., Snay C. A., Bahr A., and Cole C. N.. 1996. The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export. Mol. Biol. Cell 7:1601–1621.
   PubMedGoogle Scholar
• Dimaano, C., Ball J. R., Prunuske A. J., and Ullman K. S.. 2001. RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. J. Biol. Chem. 276:45349–45357.
   PubMedGoogle Scholar
• Dreyfuss, G., Kim V. N., and Kataoka N.. 2002. Messenger-RNA-binding proteins and the messages they carry. Nat. Rev. Mol. Cell Biol. 3:195–205.
   PubMed Web of Science ®Google Scholar
• Estruch, F., and Cole C. N.. 2003. An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol. Biol. Cell 14:1664–1676.
   PubMedGoogle Scholar
• Fabre, E., Boelens W. C., Wimmer C., Mattaj I. W., and Hurt E. C.. 1994. Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78:275–289.
   PubMed Web of Science ®Google Scholar
• Fahrenkrog, B., and Aebi U.. 2003. The nuclear pore complex: nucleocytoplasmic transport and beyond. Nat. Rev. Mol. Cell Biol. 4:757–766.
   PubMed Web of Science ®Google Scholar
• Fahrenkrog, B., Maco B., Fager A. M., Koser J., Sauder U., Ullman K. S., and Aebi U.. 2002. Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex. J. Struct. Biol. 140:254–267.
   PubMed Web of Science ®Google Scholar
• Fleckner, J., Zhang M., Valcarcel J., and Green M. R.. 1997. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 11:1864–1872.
   PubMed Web of Science ®Google Scholar
• Fribourg, S., and Conti E.. 2003. Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15. EMBO Rep. 4:699–703.
   PubMedGoogle Scholar
• Fried, H., and Kutay U.. 2003. Nucleocytoplasmic transport: taking an inventory. Cell. Mol. Life Sci. 60:1659–1688.
   PubMed Web of Science ®Google Scholar
• Frosst, P., Guan T., Subauste C., Hahn K., and Gerace L.. 2002. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J. Cell Biol. 156:617–630.
   PubMed Web of Science ®Google Scholar
• Gatfield, D., and Izaurralde E.. 2002. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J. Cell Biol. 159:579–588.
   PubMed Web of Science ®Google Scholar
• Gatfield, D., Le Hir H., Schmitt C., Braun I. C., Kocher T., Wilm M., and Izaurralde E.. 2001. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr. Biol. 11:1716–1721.
   PubMedGoogle Scholar
• Gorsch, L. C., Dockendorff T. C., and Cole C. N.. 1995. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. J. Cell Biol. 129:939–955.
   PubMedGoogle Scholar
• Green, D. M., Johnson C. P., Hagan H., and Corbett A. H.. 2003. The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export. Proc. Natl. Acad. Sci. USA 100:1010–1015.
   PubMedGoogle Scholar
• Green, D. M., Marfatia K. A., Crafton E. B., Zhang X., Cheng X., and Corbett A. H.. 2002. Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J. Biol. Chem. 277:7752–7760.
   PubMedGoogle Scholar
• Griffis, E. R., Altan N., Lippincott-Schwartz J., and Powers M. A.. 2002. Nup98 is a mobile nucleoporin with transcription-dependent dynamics. Mol. Biol. Cell 13:1282–1297.
   PubMed Web of Science ®Google Scholar
• Griffis, E. R., Craige B., Dimaano C., Ullman K. S., and Powers M. A.. Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription dependent mobility. Mol. Biol. Cell, in press.
   Google Scholar
• Griffis, E. R., Xu S., and Powers M. A.. 2003. Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes. Mol. Biol. Cell 14:600–610.
   PubMed Web of Science ®Google Scholar
• Gruter, P., Tabernero C., von Kobbe C., Schmitt C., Saavedra C., Bachi A., Wilm M., Felber B. K., and Izaurralde E.. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1:649–659.
   PubMed Web of Science ®Google Scholar
• Guzik, B. W., Levesque L., Prasad S., Bor Y. C., Black B. E., Paschal B. M., Rekosh D., and Hammarskjold M. L.. 2001. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. Mol. Cell. Biol. 21:2545–2554.
   PubMed Web of Science ®Google Scholar
• Hase, M. E., and Cordes V. C.. 2003. Direct interaction with nup153 mediates binding of tpr to the periphery of the nuclear pore complex. Mol. Biol. Cell 14:1923–1940.
   PubMed Web of Science ®Google Scholar
• Herold, A., Klymenko T., and Izaurralde E.. 2001. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA 7:1768–1780.
   PubMed Web of Science ®Google Scholar
• Herold, A., Teixeira L., and Izaurralde E.. 2003. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J. 22:2472–2483.
   PubMed Web of Science ®Google Scholar
• Hieronymus, H., and Silver P. A.. 2003. Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat. Genet. 33:155–161.
   PubMed Web of Science ®Google Scholar
• Hodge, C. A., Colot H. V., Stafford P., and Cole C. N.. 1999. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. EMBO J. 18:5778–5788.
   PubMedGoogle Scholar
• Huang, Y., Gattoni R., Stevenin J., and Steitz J. A.. 2003. SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. Mol. Cell 11:837–843.
   PubMed Web of Science ®Google Scholar
• Iborra, F. J., Jackson D. A., and Cook P. R.. 2000. The path of RNA through nuclear pores: apparent entry from the sides into specialized pores. J. Cell Sci. 113:291–302.
   PubMed Web of Science ®Google Scholar
• Izaurralde, E., Jarmolowski A., Beisel C., Mattaj I. W., Dreyfuss G., and Fischer U.. 1997. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137:27–35.
   PubMedGoogle Scholar
• Jensen, T. H., Boulay J., Rosbash M., and Libri D.. 2001. The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr. Biol. 11:1711–1715.
   PubMed Web of Science ®Google Scholar
• Jensen, T. H., Dower K., Libri D., and Rosbash M.. 2003. Early formation of mRNP: license for export or quality control? Mol. Cell 11:1129–1138.
   PubMed Web of Science ®Google Scholar
• Katahira, J., Strasser K., Podtelejnikov A., Mann M., Jung J. U., and Hurt E.. 1999. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18:2593–2609.
   PubMed Web of Science ®Google Scholar
• Kataoka, N., Diem M. D., Kim V. N., Yong J., and Dreyfuss G.. 2001. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J. 20:6424–6433.
   PubMedGoogle Scholar
• Kataoka, N., Yong J., Kim V. N., Velazquez F., Perkinson R. A., Wang F., and Dreyfuss G.. 2000. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol. Cell 6:673–682.
   PubMedGoogle Scholar
• Kendirgi, F., Barry D. M., Griffis E. R., Powers M. A., and Wente S. R.. 2003. An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J. Cell Biol. 160:1029–1040.
   PubMed Web of Science ®Google Scholar
• Kiesler, E., Miralles F., and Visa N.. 2002. HEL/UAP56 binds cotranscriptionally to the Balbiani ring pre-mRNA in an intron-independent manner and accompanies the BR mRNP to the nuclear pore. Curr. Biol. 12:859–862.
   PubMedGoogle Scholar
• Kiseleva, E., Goldberg M. W., Allen T. D., and Akey C. W.. 1998. Active nuclear pore complexes in Chironomus: visualization of transporter configurations related to mRNP export. J. Cell Sci. 111:223–236.
   PubMed Web of Science ®Google Scholar
• Kosova, B., Pante N., Rollenhagen C., Podtelejnikov A., Mann M., Aebi U., and Hurt E.. 2000. Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p. J. Biol. Chem. 275:343–350.
   PubMedGoogle Scholar
• Kraemer, D., and Blobel G.. 1997. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. Proc. Natl. Acad. Sci. USA 94:9119–9124.
   PubMedGoogle Scholar
• Lee, M. S., Henry M., and Silver P. A.. 1996. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes Dev. 10:1233–1246.
   PubMed Web of Science ®Google Scholar
• Le Hir, H., Izaurralde E., Maquat L. E., and Moore M. J.. 2000. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19:6860–6869.
   PubMed Web of Science ®Google Scholar
• Lei, E. P., Krebber H., and Silver P. A.. 2001. Messenger RNAs are recruited for nuclear export during transcription. Genes Dev. 15:1771–1782.
   PubMed Web of Science ®Google Scholar
• Lei, E. P., and Silver P. A.. 2002. Intron status and 3′-end formation control cotranscriptional export of mRNA. Genes Dev. 16:2761–2766.
   PubMed Web of Science ®Google Scholar
• Longman, D., Johnstone I. L., and Caceres J. F.. 2003. The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA 9:881–891.
   PubMed Web of Science ®Google Scholar
• Lu, S., and Cullen B. R.. 2003. Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. RNA 9:618–630.
   PubMed Web of Science ®Google Scholar
• Luo, M. J., and Reed R.. 1999. Splicing is required for rapid and efficient mRNA export in metazoans. Proc. Natl. Acad. Sci. USA 96:14937–14942.
   PubMed Web of Science ®Google Scholar
• Luo, M. L., Zhou Z., Magni K., Christoforides C., Rappsilber J., Mann M., and Reed R.. 2001. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413:644–647.
   PubMed Web of Science ®Google Scholar
• McGarvey, T., Rosonina E., McCracken S., Li Q., Arnaout R., Mientjes E., Nickerson J. A., Awrey D., Greenblatt J., Grosveld G., and Blencowe B. J.. 2000. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. J. Cell Biol. 150:309–320.
   PubMed Web of Science ®Google Scholar
• Murphy, R., Watkins J. L., and Wente S. R.. 1996. GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function. Mol. Biol. Cell 7:1921–1937.
   PubMedGoogle Scholar
• Murphy, R., and Wente S. R.. 1996. An RNA-export mediator with an essential nuclear export signal. Nature 383:357–360.
   PubMed Web of Science ®Google Scholar
• Noble, S. M., and Guthrie C.. 1996. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143:67–80.
   PubMed Web of Science ®Google Scholar
• Nott, A., Meislin S. H., and Moore M. J.. 2003. A quantitative analysis of intron effects on mammalian gene expression. RNA 9:607–617.
   PubMed Web of Science ®Google Scholar
• Ohno, M., Segref A., Kuersten S., and Mattaj I. W.. 2002. Identity elements used in export of mRNAs. Mol. Cell 9:659–671.
   PubMedGoogle Scholar
• Powers, M. A., Forbes D. J., Dahlberg J. E., and Lund E.. 1997. The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways. J. Cell Biol. 136:241–250.
   PubMed Web of Science ®Google Scholar
• Rayala, H. J., Kendirgi F., Barry D. M., Majerus P. A., and Wente S. R.. 2003. The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155. Mol. Cell Proteomics 3:145–155.
   PubMedGoogle Scholar
• Reed, R. 2003. Coupling transcription, splicing and mRNA export. Curr. Opin. Cell Biol. 15:326–331.
   PubMedGoogle Scholar
• Rodrigues, J. P., Rode M., Gatfield D., Blencowe B. J., Carmo-Fonseca M., and Izaurralde E.. 2001. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc. Natl. Acad. Sci. USA 98:1030–1035.
   PubMed Web of Science ®Google Scholar
• Rout, M. P., Aitchison J. D., Magnasco M. O., and Chait B. T.. 2003. Virtual gating and nuclear transport: the hole picture. Trends Cell Biol. 13:622–628.
   PubMedGoogle Scholar
• Santos-Rosa, H., Moreno H., Simos G., Segref A., Fahrenkrog B., Pante N., and Hurt E.. 1998. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol. Cell. Biol. 18:6826–6838.
   PubMed Web of Science ®Google Scholar
• Schmitt, C., von Kobbe C., Bachi A., Pante N., Rodrigues J. P., Boscheron C., Rigaut G., Wilm M., Seraphin B., Carmo-Fonseca M., and Izaurralde E.. 1999. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. EMBO J. 18:4332–4347.
   PubMedGoogle Scholar
• Segref, A., Sharma K., Doye V., Hellwig A., Huber J., Luhrmann R., and Hurt E.. 1997. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J. 16:3256–3271.
   PubMed Web of Science ®Google Scholar
• Shamsher, M. K., Ploski J., and Radu A.. 2002. Karyopherin β2B participates in mRNA export from the nucleus. Proc. Natl. Acad. Sci. USA 99:14195–14199.
   PubMedGoogle Scholar
• Shibata, S., Matsuoka Y., and Yoneda Y.. 2002. Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells. Genes Cells 7:421–434.
   PubMed Web of Science ®Google Scholar
• Stoffler, D., Feja B., Fahrenkrog B., Walz J., Typke D., and Aebi U.. 2003. Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport. J. Mol. Biol. 328:119–130.
   PubMed Web of Science ®Google Scholar
• Strasser, K., Bassler J., and Hurt E.. 2000. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. J. Cell Biol. 150:695–706.
   PubMed Web of Science ®Google Scholar
• Strasser, K., and Hurt E.. 2001. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature 413:648–652.
   PubMed Web of Science ®Google Scholar
• Strasser, K., and Hurt E.. 2000. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19:410–420.
   PubMed Web of Science ®Google Scholar
• Strasser, K., Masuda S., Mason P., Pfannstiel J., Oppizzi M., Rodriguez-Navarro S., Rondon A. G., Aguilera A., Struhl K., Reed R., and Hurt E.. 2002. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417:304–308.
   PubMed Web of Science ®Google Scholar
• Stutz, F., Bachi A., Doerks T., Braun I. C., Seraphin B., Wilm M., Bork P., and Izaurralde E.. 2000. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6:638–650.
   PubMed Web of Science ®Google Scholar
• Stutz, F., and Izaurralde E.. 2003. The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol. 13:319–327.
   PubMed Web of Science ®Google Scholar
• Suntharalingam, M., and Wente S. R.. 2003. Peering through the pore. Nuclear pore complex structure, assembly, and function. Dev. Cell 4:775–789.
   PubMed Web of Science ®Google Scholar
• Tan, W., Zolotukhin A. S., Bear J., Patenaude D. J., and Felber B. K.. 2000. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. RNA 6:1762–1772.
   PubMedGoogle Scholar
• Thomsen, R., Libri D., Boulay J., Rosbash M., and Jensen T. H.. 2003. Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. RNA 9:1049–1057.
   PubMed Web of Science ®Google Scholar
• Ullman, K. S. 2002. RNA export: searching for mRNA identity. Curr. Biol. 12:R461–R463.
   PubMedGoogle Scholar
• Ullman, K. S., Shah S., Powers M. A., and Forbes D. J.. 1999. The nucleoporin nup153 plays a critical role in multiple types of nuclear export. Mol. Biol. Cell 10:649–664.
   PubMed Web of Science ®Google Scholar
• van Deursen, J., Boer J., Kasper L., and Grosveld G.. 1996. G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. EMBO J. 15:5574–5583.
   PubMed Web of Science ®Google Scholar
• Vasu, S., Shah S., Orjalo A., Park M., Fischer W. H., and Forbes D. J.. 2001. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J. Cell Biol. 155:339–354.
   PubMedGoogle Scholar
• Walther, T. C., Alves A., Pickersgill H., Loiodice I., Hetzer M., Galy V., Hulsmann B. B., Kocher T., Wilm M., Allen T., Mattaj I. W., and Doye V.. 2003. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113:195–206.
   PubMed Web of Science ®Google Scholar
• Watkins, J. L., Murphy R., Emtage J. L., and Wente S. R.. 1998. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc. Natl. Acad. Sci. USA 95:6779–6784.
   PubMed Web of Science ®Google Scholar
• Weis, K. 2003. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112:441–451.
   PubMed Web of Science ®Google Scholar
• Wiegand, H. L., Coburn G. A., Zeng Y., Kang Y., Bogerd H. P., and Cullen B. R.. 2002. Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol. Cell. Biol. 22:245–256.
   PubMed Web of Science ®Google Scholar
• Wiegand, H. L., Lu S., and Cullen B. R.. 2003. Exon junction complexes mediate the enhancing effect of splicing on mRNA expression. Proc. Natl. Acad. Sci. USA 100:11327–11332.
   PubMed Web of Science ®Google Scholar
• Zenklusen, D., Vinciguerra P., Wyss J. C., and Stutz F.. 2002. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol. Cell. Biol. 22:8241–8253.
   PubMed Web of Science ®Google Scholar
• Zhao, J., Jin S. B., Bjorkroth B., Wieslander L., and Daneholt B.. 2002. The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm. EMBO J. 21:1177–1187.
   PubMedGoogle Scholar
• Zhou, Z., Luo M. J., Straesser K., Katahira J., Hurt E., and Reed R.. 2000. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407:401–405.
   PubMedGoogle Scholar
• Zimowska, G., and Paddy M. R.. 2002. Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure. Exp. Cell Res. 276:223–232.
   PubMed Web of Science ®Google Scholar