9
Views
42
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Critical Prosurvival Roles for C/EBPβ and Insulin-Like Growth Factor I in Macrophage Tumor Cells

, &
Pages 3238-3250 | Received 17 Sep 2003, Accepted 12 Jan 2004, Published online: 27 Mar 2023

REFERENCES

  • Akira, S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., Nakajima T., Hirano T., and Kishimoto T.. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897–1906.
  • Alessi, D. R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., and Hemmings B. A.. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541–6551.
  • Andrews, D. W., Resnicoff M., Flanders A. E., Kenyon L., Curtis M., Merli G., Baserga R., Iliakis G., and Aiken R. D.. 2001. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. J. Clin. Oncol. 19:2189–2200.
  • Baker, J., Liu J. P., Robertson E. J., and Efstratiadis A.. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73–82.
  • Baserga, R. 1995. The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res. 55:249–252.
  • Blasi, E., Mathieson B. J., Varesio L., Cleveland J. L., Borchert P. A., and Rapp U. R.. 1985. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 318:667–670.
  • Blasi, E., Radzioch D., Merletti L., and Varesio L.. 1989. Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer Biochem. Biophys. 10:303–317.
  • Blasi, E., Radzioch D., and Varesio L.. 1988. Inhibition of retroviral mRNA expression in the murine macrophage cell line GG2EE by biologic response modifiers. J. Immunol. 141:2153–2157.
  • Blasi, E., Varesio L., and Wiltrout R. H.. 1988. Tumor formation by a murine macrophage cell line immortalized in vitro by v-raf and v-myc oncogenes. Cancer Immunol. Immunother. 27:109–113.
  • Bouchard, C., Staller P., and Eilers M.. 1998. Control of cell proliferation by Myc. Trends Cell Biol. 8:202–206.
  • Buck, M., Poli V., Hunter T., and Chojkier M.. 2001. C/EBPβ phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol. Cell 8:807–816.
  • Buck, M., Poli V., van der Geer P., Chojkier M., and Hunter T.. 1999. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol. Cell 4:1087–1092.
  • Bundy, L. M., and Sealy L.. 2003. CCAAT/enhancer binding protein beta (C/EBPβ)-2 transforms normal mammary epithelial cells and induces epithelial to mesenchymal transition in culture. Oncogene 22:869–883.
  • Cheng, L., Du C., Murray D., Tong X., Zhang Y. A., Chen B. P., and Hawley R. G.. 1997. A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells. Gene Ther. 4:1013–1022.
  • Cox, G. W., Mathieson B. J., Gandino L., Blasi E., Radzioch D., and Varesio L.. 1989. Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver. J. Natl. Cancer Inst. 81:1492–1496.
  • Descombes, P., Chojkier M., Lichtsteiner S., Falvey E., and Schibler U.. 1990. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4:1541–1551.
  • Descombes, P., and Schibler U.. 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569–579.
  • Dveksler, G. S., Basile A. A., and Dieffenbach C. W.. 1992. Analysis of gene expression: use of oligonucleotide primers for glyceraldehyde-3-phosphate dehydrogenase. PCR Methods Appl. 1:283–285.
  • Evan, G., Harrington E., Fanidi A., Land H., Amati B., and Bennett M.. 1994. Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos. Trans. R. Soc. London B 345:269–275.
  • Evan, G. I., and Vousden K. H.. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411:342–348.
  • Furstenberger, G., and Senn H. J.. 2002. Insulin-like growth factors and cancer. Lancet Oncol. 3:298–302.
  • Graf, T., von Weizsaecker F., Grieser S., Coll J., Stehelin D., Patschinsky T., Bister K., Bechade C., Calothy G., and Leutz A.. 1986. v-mil induces autocrine growth and enhanced tumorigenicity in v-myc-transformed avian macrophages. Cell 45:357–364.
  • Greenbaum, L. E., Li W., Cressman D. E., Peng Y., Ciliberto G., Poli V., and Taub R.. 1998. CCAAT enhancer-binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J. Clin. Investig. 102:996–1007.
  • Hawley, R. G., Lieu F. H., Fong A. Z., and Hawley T. S.. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1:136–138.
  • Hu, H. M., Baer M., Williams S. C., Johnson P. F., and Schwartz R. C.. 1998. Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1. J. Immunol. 160:2334–2342.
  • Kagan, B. L., Henke R. T., Cabal-Manzano R., Stoica G. E., Nguyen Q., Wellstein A., and Riegel A. T.. 2003. Complex regulation of the fibroblast growth factor-binding protein in MDA-MB-468 breast cancer cells by CCAAT/enhancer-binding protein beta. Cancer Res. 63:1696–1705.
  • Kelley, T. W., Graham M. M., Doseff A. I., Pomerantz R. W., Lau S. M., Ostrowski M. C., Franke T. F., and Marsh C. B.. 1999. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J. Biol. Chem. 274:26393–26398.
  • Kowenz-Leutz, E., Twamley G., Ansieau S., and Leutz A.. 1994. Novel mechanism of C/EBP β (NF-M) transcriptional control: activation through derepression. Genes Dev. 8:2781–2791.
  • Kulik, G., Klippel A., and Weber M. J.. 1997. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595–1606.
  • Lamb, J., Ramaswamy S., Ford H. L., Contreras B., Martinez R. V., Kittrell F. S., Zahnow C. A., Patterson N., Golub T. R., and Ewen M. E.. 2003. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114:323–334.
  • Lee, A. W., and States D. J.. 2000. Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors. Mol. Cell. Biol. 20:6779–6798.
  • LeRoith, D., Baserga R., Helman L., and Roberts C. T., Jr. 1995. Insulin-like growth factors and cancer. Ann. Intern. Med. 122:54–59.
  • LeRoith, D., and Roberts C. T., Jr. 2003. The insulin-like growth factor system and cancer. Cancer Lett. 195:127–137.
  • Liu, H., Perlman H., Pagliari L. J., and Pope R. M.. 2001. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation. J. Exp. Med. 194:113–126.
  • Liu, J. L., Grinberg A., Westphal H., Sauer B., Accili D., Karas M., and LeRoith D.. 1998. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol. Endocrinol. 12:1452–1462.
  • Liu, J. P., Baker J., Perkins A. S., Robertson E. J., and Efstratiadis A.. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (IGF1r). Cell 75:59–72.
  • McCarthy, T. L., Thomas M. J., Centrella M., and Rotwein P.. 1995. Regulation of insulin-like growth factor I transcription by cyclic adenosine 3′,5′-monophosphate (cAMP) in fetal rat bone cells through an element within exon 1: protein kinase A-dependent control without a consensus AMP response element. Endocrinology 136:3901–3908.
  • McCubrey, J. A., Steelman L. S., Hoyle P. E., Blalock W. L., Weinstein-Oppenheimer C., Franklin R. A., Cherwinski H., Bosch E., and McMahon M.. 1998. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 12:1903–1929.
  • McCubrey, J. A., Steelman L. S., Moye P. W., Hoyle P. E., Weinstein-Oppenheimer C., Chang F., Pearce M., White M. K., Franklin R., and Blalock W. L.. 2000. Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells. Adv. Enzyme Regul. 40:305–337.
  • Metz, T., Graf T., and Leutz A.. 1991. Activation of cMGF expression is a critical step in avian myeloid leukemogenesis. EMBO J. 10:837–844.
  • Morrione, A., DeAngelis T., and Baserga R.. 1995. Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J. Virol. 69:5300–5303.
  • Moschos, S. J., and Mantzoros C. S.. 2002. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology 63:317–332.
  • Nakajima, T., Kinoshita S., Sasagawa T., Sasaki K., Naruto M., Kishimoto T., and Akira S.. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207–2211.
  • Neumann, C., and Sorg C.. 1980. Sequential expression of functions during macrophage differentiation in murine bone marrow liquid cultures. Eur. J. Immunol. 10:834–840.
  • Okuda, K., Matulonis U., Salgia R., Kanakura Y., Druker B., and Griffin J. D.. 1994. Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1. Exp. Hematol. 22:1111–1117.
  • Parrizas, M., Saltiel A. R., and LeRoith D.. 1997. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272:154–161.
  • Pelengaris, S., Rudolph B., and Littlewood T.. 2000. Action of Myc in vivo—proliferation and apoptosis. Curr. Opin. Genet. Dev. 10:100–105.
  • Rask, K., Thorn M., Ponten F., Kraaz W., Sundfeldt K., Hedin L., and Enerback S.. 2000. Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBβ) and C/EBζ (CHOP) correlate with invasiveness of human colorectal cancer. Int. J. Cancer 86:337–343.
  • Resnicoff, M., Coppola D., Sell C., Rubin R., Ferrone S., and Baserga R.. 1994. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res. 54:4848–4850.
  • Resnicoff, M., Sell C., Rubini M., Coppola D., Ambrose D., Baserga R., and Rubin R.. 1994. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res. 54:2218–2222.
  • Robinson, G. W., Johnson P. F., Hennighausen L., and Sterneck E.. 1998. The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev. 12:1907–1916.
  • Seagroves, T. N., Krnacik S., Raught B., Gay J., Burgess-Beusse B., Darlington G. J., and Rosen J. M.. 1998. C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 12:1917–1928.
  • Sell, C., Dumenil G., Deveaud C., Miura M., Coppola D., DeAngelis T., Rubin R., Efstratiadis A., and Baserga R.. 1994. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14:3604–3612.
  • Sell, C., Rubini M., Rubin R., Liu J. P., Efstratiadis A., and Baserga R.. 1993. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. USA 90:11217–11221.
  • Sterneck, E., Blattner C., Graf T., and Leutz A.. 1992. Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases. Mol. Cell. Biol. 12:1728–1735.
  • Sterneck, E., Muller C., Katz S., and Leutz A.. 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor. EMBO J. 11:115–126.
  • Sterneck, E., Tessarollo L., and Johnson P. F.. 1997. An essential role for C/EBPβ in female reproduction. Genes Dev. 11:2153–2162.
  • Sundfeldt, K., Ivarsson K., Carlsson M., Enerback S., Janson P. O., Brannstrom M., and Hedin L.. 1999. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPβ during epithelial tumour progression. Br. J. Cancer 79:1240–1248.
  • Talapatra, S., and Thompson C. B.. 2001. Growth factor signaling in cell survival: implications for cancer treatment. J. Pharmacol. Exp. Ther. 298:873–878.
  • Tanaka, T., Akira S., Yoshida K., Umemoto M., Yoneda Y., Shirafuji N., Fujiwara H., Suematsu S., Yoshida N., and Kishimoto T.. 1995. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353–361.
  • Thomas, M. J., Umayahara Y., Shu H., Centrella M., Rotwein P., and McCarthy T. L.. 1996. Identification of the cAMP response element that controls transcriptional activation of the insulin-like growth factor-I gene by prostaglandin E2 in osteoblasts. J. Biol. Chem. 271:21835–21841.
  • Trojan, J., Blossey B. K., Johnson T. R., Rudin S. D., Tykocinski M., and Ilan J.. 1992. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 89:4874–4878.
  • Tushinski, R. J., Oliver I. T., Guilbert L. J., Tynan P. W., Warner J. R., and Stanley E. R.. 1982. Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28:71–81.
  • Umayahara, Y., Billiard J., Ji C., Centrella M., McCarthy T. L., and Rotwein P.. 1999. CCAAT/enhancer-binding protein delta is a critical regulator of insulin-like growth factor-I gene transcription in osteoblasts. J. Biol. Chem. 274:10609–10617.
  • Umayahara, Y., Ji C., Centrella M., Rotwein P., and McCarthy T. L.. 1997. CCAAT/enhancer-binding protein delta activates insulin-like growth factor-I gene transcription in osteoblasts. Identification of a novel cyclic AMP signaling pathway in bone. J. Biol. Chem. 272:31793–31800.
  • Valentinis, B., and Baserga R.. 2001. IGF-I receptor signalling in transformation and differentiation. Mol. Pathol. 54:133–137.
  • Williams, S. C., Cantwell C. A., and Johnson P. F.. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553–1567.
  • Yee, D. 2001. Are the insulin-like growth factors relevant to cancer? Growth Horm. IGF Res. 11:339–345.
  • Zahnow, C. A. 2002. CCAAT/enhancer binding proteins in normal mammary development and breast cancer. Breast Cancer Res. 4:113–121.
  • Zhu, S., Oh H.-S., Shim M., Sterneck E., Johnson P. F., and Smart R. C.. 1999. C/EBPβ modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression. Mol. Cell. Biol. 19:7181–7190.
  • Zhu, S., Yoon K., Sterneck E., Johnson P. F., and Smart R. C.. 2002. CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc. Natl. Acad. Sci. USA 99:207–212.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.