Epidermal Growth Factor Receptor Stimulation Activates the RNA Binding Protein CUG-BP1 and Increases Expression of C/EBPβ-LIP in Mammary Epithelial Cells

REFERENCES

• Alaoui-Jamali, M. A., D. J. Song, N. Benlimame, L. Yen, X. Deng, M. Hernandez-Perez, and T. Wang. 2003. Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors. Cancer Res. 63:3764–3774.
   PubMed Web of Science ®Google Scholar
• Badley, J. E., Bishop G. A., St John T., and Frelinger J. A.. 1988. A simple, rapid method for the purification of poly A+ RNA. BioTechniques 6:114–116.
   PubMed Web of Science ®Google Scholar
• Baer, M., and Johnson P. F.. 2000. Generation of truncated C/EBPβ isoforms by in vitro proteolysis. J. Biol. Chem. 275:26582–26590.
   PubMed Web of Science ®Google Scholar
• Bundy, L. M., and Sealy L.. 2003. CCAAT/enhancer binding protein beta (C/EBPβ)-2 transforms normal mammary epithelial cells and induces epithelial to mesenchymal transition in culture. Oncogene 22:869–883.
   PubMedGoogle Scholar
• Calkhoven, C. F., Muller C., and Leutz A.. 2000. Translational control of C/EBPα and C/EBPβ isoform expression. Genes Dev. 14:1920–1932.
   PubMed Web of Science ®Google Scholar
• Descombes, P., and Schibler U.. 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569–579.
   PubMed Web of Science ®Google Scholar
• Dux, A., and Muhlbock O.. 1969. Mouse mammary carcinoma induced by pituitary isografts in mammary fat pads. Proc. Soc. Exp. Biol. Med. 130:355–359.
   PubMedGoogle Scholar
• Ethier, S. P., Moorthy R., and Dilts C. A.. 1991. Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells. Cell Growth Differ. 2:593–602.
   PubMedGoogle Scholar
• Gray, N. K., and Wickens M.. 1998. Control of translation initiation in animals. Annu. Rev. Cell Dev. Biol. 14:399–458.
   PubMed Web of Science ®Google Scholar
• Hsu, W., and Chen-Kiang S.. 1993. Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells. Mol. Cell. Biol. 13:2515–2523.
   PubMed Web of Science ®Google Scholar
• Kowenz-Leutz, E., and A. Leutz. 1999. A C/EBPβ isoform recruits the SWI/SNF complex to activate myeloid genes. Mol. Cell 4:735–743.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229–241.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1991. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:887–903.
   PubMed Web of Science ®Google Scholar
• Lai, C. C., Chiu T. H., Rosenberg H. C., and Huang W. H.. 1993. Improved proteinase K digestion for the rapid isolation of mRNA from mammalian tissues. BioTechniques 15:620–626.
   PubMedGoogle Scholar
• Lamb, J., Ramaswamy S., Ford H. L., Contreras B., Martinez R. V., Kittrell F. S., Zahnow C. A., Patterson N., Golub T. R., and Ewen M. E.. 2003. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114:323–334.
   PubMed Web of Science ®Google Scholar
• Li, S., and Rosen J. M.. 1994. Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region. Mol. Endocrinol. 8:1328–1335.
   PubMedGoogle Scholar
• Lincoln, A. J., Monczak Y., Williams S. C., and Johnson P. F.. 1998. Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames. J. Biol. Chem. 273:9552–9560.
   PubMedGoogle Scholar
• Milde-Langosch, K., T. Loning, and A. M. Bamberger. 2003. Expression of the CCAAT/enhancer-binding proteins C/EBPα, C/EBPβ and C/EBPδ in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Res. Treat. 79:175–185.
   Google Scholar
• Morris, D. R., and Geballe A. P.. 2000. Upstream open reading frames as regulators of mRNA translation. Mol. Cell. Biol. 20:8635–8642.
   PubMed Web of Science ®Google Scholar
• Moyer, J. D., Barbacci E. G., Iwata K. K., Arnold L., Boman B., Cunningham A., DiOrio C., Doty J., Morin M. J., Moyer M. P., Neveu M., Pollack V. A., Pustilnik L. R., Reynolds M. M., Sloan D., Theleman A., and Miller P.. 1997. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57:4838–4848.
   PubMed Web of Science ®Google Scholar
• Nakajima, T., Kinoshita S., Sasagawa T., Sasaki K., Naruto M., Kishimoto T., and Akira S.. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207–2211.
   PubMed Web of Science ®Google Scholar
• Rajasekhar, V. K., Viale A., Socci N. D., Wiedmann M., Hu X., and Holland E. C.. 2003. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell 12:889–901.
   PubMed Web of Science ®Google Scholar
• Rask, K., Thorn M., Ponten F., Kraaz W., Sundfeldt K., Hedin L., and Enerback S.. 2000. Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBβ) and C/EBζ (CHOP) correlate with invasiveness of human colorectal cancer. Int. J. Cancer 86:337–343.
   PubMedGoogle Scholar
• Raught, B., Gingras A. C., James A., Medina D., Sonenberg N., and Rosen J. M.. 1996. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2α are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res. 56:4382–4386.
   PubMedGoogle Scholar
• Raught, B., Liao W. S., and Rosen J. M.. 1995. Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression. Mol. Endocrinol. 9:1223–1232.
   PubMedGoogle Scholar
• Roberts, R., Timchenko N. A., Miller J. W., Reddy S., Caskey C. T., Swanson M. S., and Timchenko L. T.. 1997. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc. Natl. Acad. Sci. USA 94:13221–13226.
   PubMed Web of Science ®Google Scholar
• Rose-Hellekant, T. A., K. Gilchrist, and E. P. Sandgren. 2002. Strain background alters mammary gland lesion phenotype in transforming growth factor-alpha transgenic mice. Am. J. Pathol. 161:1439–1447.
   PubMedGoogle Scholar
• Sandgren, E. P., Schroeder J. A., Qui T. H., Palmiter R. D., Brinster R. L., and Lee D. C.. 1995. Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res. 55:3915–3927.
   PubMed Web of Science ®Google Scholar
• Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell 103:211–225.
   PubMed Web of Science ®Google Scholar
• Soule, H. D., Maloney T. M., Wolman S. R., Peterson W. D., Jr., Brenz R., McGrath C. M., Russo J., Pauley R. J., Jones R. F., and Brooks S. C.. 1990. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50:6075–6086.
   PubMed Web of Science ®Google Scholar
• Sundfeldt, K., Ivarsson K., Carlsson M., Enerback S., Janson P. O., Brannstrom M., and Hedin L.. 1999. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPβ during epithelial tumour progression. Br. J. Cancer 79:1240–1248.
   PubMedGoogle Scholar
• Timchenko, L. T., Iakova P., Welm A. L., Cai Z. J., and Timchenko N. A.. 2002. Calreticulin interacts with C/EBPα and C/EBPβ mRNAs and represses translation of C/EBP proteins. Mol. Cell. Biol. 22:7242–7257.
   PubMedGoogle Scholar
• Timchenko, L. T., Miller J. W., Timchenko N. A., DeVore D. R., Datar K. V., Lin L., Roberts R., Caskey C. T., and Swanson M. S.. 1996. Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res. 24:4407–4414.
   PubMed Web of Science ®Google Scholar
• Timchenko, L. T., Timchenko N. A., Caskey C. T., and Roberts R.. 1996. Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. Hum. Mol. Genet. 5:115–121.
   PubMedGoogle Scholar
• Timchenko, N. A., Cai Z. J., Welm A. L., Reddy S., Ashizawa T., and Timchenko L. T.. 2001. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J. Biol. Chem. 276:7820–7826.
   PubMed Web of Science ®Google Scholar
• Timchenko, N. A., Welm A. L., Lu X., and Timchenko L. T.. 1999. CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms. Nucleic Acids Res. 27:4517–4525.
   PubMed Web of Science ®Google Scholar
• van't Veer, L. J., H. Dai, M. J. van de Vijver, Y. D. He, A. A. Hart, M. Mao, H. L. Peterse, K. van der Kooy, M. J. Marton, A. T. Witteveen, G. J. Schreiber, R. M. Kerkhoven, C. Roberts, P. S. Linsley, R. Bernards, and S. H. Friend. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530–536.
   PubMed Web of Science ®Google Scholar
• Welm, A. L., Mackey S. L., Timchenko L. T., Darlington G. J., and Timchenko N. A.. 2000. Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA. J. Biol. Chem. 275:27406–27413.
   PubMed Web of Science ®Google Scholar
• Welm, A. L., Timchenko N. A., and Darlington G. J.. 1999. C/EBPα regulates generation of C/EBPβ isoforms through activation of specific proteolytic cleavage. Mol. Cell. Biol. 19:1695–1704.
   PubMed Web of Science ®Google Scholar
• Xiong, W., Hsieh C. C., Kurtz A. J., Rabek J. P., and Papaconstantinou J.. 2001. Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites. Nucleic Acids Res. 29:3087–3098.
   PubMedGoogle Scholar
• Zahnow, C. A., Cardiff R. D., Laucirica R., Medina D., and Rosen J. M.. 2001. A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation. Cancer Res. 61:261–269.
   PubMed Web of Science ®Google Scholar
• Zahnow, C. A., Younes P., Laucirica R., and Rosen J. M.. 1997. Overexpression of C/EBPβ-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. J. Natl. Cancer Inst. 89:1887–1891.
   PubMed Web of Science ®Google Scholar