Glucocorticoid Receptor (GR)-Associated SMRT Binding to C/EBPβ TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression

REFERENCES

• Alonzi, T., D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert, and V. Poli. 2001. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation in the liver. Mol. Cell. Biol. 21:1621–1632.
   PubMed Web of Science ®Google Scholar
• Bolton, M. G., A. Munoz, L. P. Jacobson, J. D. Groopman, Y. Y. Maxuitenko, B. D. Roebuck, and T. W. Kensler. 1993. Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis. Cancer Res. 53:3499–3504.
   PubMed Web of Science ®Google Scholar
• Dowell, P., J. E. Ishmael, D. Avram, V. J. Peterson, D. J. Nevrivy, and M. Leid. 1999. Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. J. Biol. Chem. 274:15901–15907.
   PubMedGoogle Scholar
• Eggert, M., C. C. Mows, D. Tripier, R. Arnold, J. Michel, J. Nickel, S. Schmidt, M. Beato, and R. Renkawitz. 1995. A fraction enriched in a novel glucocorticoid receptor-interacting protein stimulates receptor-dependent transcription in vitro. J. Biol. Chem. 270:30755–30759.
   PubMedGoogle Scholar
• Falkner, K. C., J. A. Pinaire, G. H. Xiao, T. E. Geoghegan, and R. A. Prough. 2001. Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. Mol. Pharmacol. 60:611–619.
   PubMed Web of Science ®Google Scholar
• Falkner, K. C., T. H. Rushmore, M. W. Linder, and R. A. Prough. 1998. Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. Mol. Pharmacol. 53:1016–1026.
   PubMed Web of Science ®Google Scholar
• Fischle, W., F. Dequiedt, M. J. Hendzel, M. G. Guenther, M. A. Lazar, W. Voelter, and E. Verdin. 2002. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol. Cell 9:45–57.
   PubMed Web of Science ®Google Scholar
• Gotoh, T., S. Chowdhury, M. Takiguchi, and M. Mori. 1997. The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPβ. J. Biol. Chem. 272:3694–3698.
   PubMedGoogle Scholar
• Guenther, M. G., O. Barak, and M. A. Lazar. 2001. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol. Cell. Biol. 21:6091–6101.
   PubMed Web of Science ®Google Scholar
• Guo, S., S. B. Cichy, He, X., Q. Yang, M. Ragland, A. K. Ghosh, P. F. Johnson, and T. G. Unterman. 2001. Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPβ). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPβ. J. Biol. Chem. 276:8516–8523.
   PubMedGoogle Scholar
• Horlein, A. J., A. M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C. K. Glass, and M. G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 37:397–404.
   Google Scholar
• Jover, R., R. Bort, M. J. Gomez-Lechon, and J. V. Castell. 2002. Down-regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factor involved. FASEB J. 16:1799–1801.
   PubMed Web of Science ®Google Scholar
• Kang, K. W., I. J. Cho, C. H. Lee, and S. G. Kim. 2003. Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein β activation in the induction of glutathione S-transferase by oltipraz. J. Natl. Cancer Inst. 95:53–66.
   PubMed Web of Science ®Google Scholar
• Kang, K. W., S. J. Lee, J. W. Park, and S. G. Kim. 2002. Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol. Pharmacol. 62:1001–1010.
   PubMed Web of Science ®Google Scholar
• Kang, K. W., M. K. Cho, C. H. Lee, and S. G. Kim. 2001. Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated GSTA2 induction in H4IIE cells. Mol. Pharmacol. 59:1147–1156.
   PubMed Web of Science ®Google Scholar
• Kang, K. W., J. H. Ryu, and S. G. Kim. 2001. Activation of phosphatidylinositol 3-kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells. Toxicol. Lett. 121:191–197.
   PubMedGoogle Scholar
• Kang, K. W., J. H. Ryu, and S. G. Kim. 2000. The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated GSTA2 induction by decreased glutathione in H4IIE hepatoma cells. Mol. Pharmacol. 58:1017–1025.
   PubMed Web of Science ®Google Scholar
• Katoh, Y., K. Itoh, E. Yoshida, M. Miyagishi, A. Fukamizu, and M. Yamamoto. 2001. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6:857–868.
   PubMed Web of Science ®Google Scholar
• Kensler, T. W. 1997. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect. 105(S4):965–970.
   PubMedGoogle Scholar
• Kurihara, I., H. Shibata, T. Suzuki, T. Ando, S. Kobayashi, M. Hayashi, I. Saito, and T. Saruta. 2002. Expression and regulation of nuclear receptor coactivators in glucocorticoid action. Mol. Cell. Endocrinol. 189:181–189.
   PubMed Web of Science ®Google Scholar
• Laherty, C. D., W. M. Yang, J. M. Sun, J. R. Davie, E. Seto, and R. N. Eisenman. 1997. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell 89:349–356.
   PubMed Web of Science ®Google Scholar
• Li, H., C. Leo, D. J. Schroen, and J. D. Chen. 1997. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol. Endocrinol. 11:2025–2037.
   PubMedGoogle Scholar
• Ma, H., H. Hong, S. M. Huang, R. A. Irvine, P. Webb, P. J. Kushner, G. A. Coetzee, and M. R. Stallcup. 1999. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. Mol. Cell. Biol. 19:6164–6173.
   PubMedGoogle Scholar
• Matsuno, F., S. Chowdhury, T. Gotoh, K. Iwase, H. Matsuzaki, K. Takatsuki, M. Mori, and M. Takiguchi. 1996. Induction of the C/EBPβ gene by dexamethasone and glucagon in primary-cultured rat hepatocytes. J. Biochem. (Tokyo) 119:524–532.
   PubMed Web of Science ®Google Scholar
• Mink, S., B. Haenig, and K. H. Klempnauer. 1997. Interaction and functional collaboration of p300 and C/EBPβ. Mol. Cell. Biol. 17:6609–6617.
   PubMed Web of Science ®Google Scholar
• Nam, S. Y., C. K. Cho, and S. G. Kim. 1998. Correlation of increased mortality with the suppression of radiation-inducible microsomal epoxide hydrolase and glutathione S-transferase gene expression by dexamethasone: effects on vitamin C and E-induced radioprotection. Biochem. Pharmacol. 56:1295–1304.
   PubMedGoogle Scholar
• Nancy, V., R. M. Wolthuis, M. F. De Tand, I. Janoueix-Lerosey, J. L. Bos, and J. De Gunzburg. 1999. Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2. J. Biol. Chem. 274:8737–8745.
   PubMedGoogle Scholar
• Park, E. Y., I. J. Cho, and S. G. Kim. 2004. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. Cancer Res. 64:3701–3713.
   PubMed Web of Science ®Google Scholar
• Park, I. N., I. J. Cho, and S. G. Kim. 2004. Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. Mol. Pharmacol. 65:1475–1484.
   PubMedGoogle Scholar
• Pearce, D., and K. R. Yamamoto. 1993. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259:1161–1165.
   PubMedGoogle Scholar
• Ramos-Gomez, M., P. M. Dolan, K. Itoh, M. Yamamoto, and T. W. Kensler. 2003. Interactive effects of Nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24:461–467.
   PubMed Web of Science ®Google Scholar
• Rushing, S. R., and M. S. Denison. 2002. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch. Biochem. Biophys. 403:189–201.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., K. Harshman, I. Kemler, U. Malipiero, W. Schaffner, and A. Fontana. 1990. Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins. Nucleic Acids Res. 18:5495–5503.
   PubMedGoogle Scholar
• Seo, J. B., M. J. Noh, E. J. Yoo, S. Y. Park, J. Park, I. K. Lee, S. D. Park, and J. B. Kim. 2003. Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-α. Mol. Endocrinol. 17:1522–1533.
   PubMedGoogle Scholar
• Szapary, D., Y. Huang, and S. S. Simons, Jr. 1999. Opposing effects of corepressor and coactivators in determining the dose-response curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor-regulated gene expression. Mol. Endocrinol. 13:2108–2121.
   PubMedGoogle Scholar
• Thimmulappa, R. K., K. H. Mai, S. Srisuma, T. W. Kensler, M. Yamamoto, and S. Biswal. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62:5196–5203.
   PubMed Web of Science ®Google Scholar
• Wong, C. W., and M. L. Privalsky. 1998. Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol. Cell. Biol. 18:5500–5510.
   PubMedGoogle Scholar
• Xiao, G. H., J. A. Pinaire, A. D. Rodrigues, and R. A. Prough. 1995. Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes. Drug Metab. Dispos. 23:642–650.
   PubMed Web of Science ®Google Scholar
• Yeh, W. C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168–181.
   PubMed Web of Science ®Google Scholar
• Yoon, H. G., D. W. Chan, Z. Q. Huang, Li, J., J. D. Fondell, J. Qin, and J. Wong. 2003. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 22:1336–1346.
   PubMed Web of Science ®Google Scholar