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Signal Transduction

Gadd45a Expression Induces Bim Dissociation from the Cytoskeleton and Translocation to Mitochondria

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Pages 4488-4500 | Received 04 Sep 2004, Accepted 17 Mar 2005, Published online: 27 Mar 2023

REFERENCES

  • Adams, J. M., and S. Cory. 2001. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26:61–66.
  • Antonsson, B., and J. C. Martinou. 2000. The Bcl-2 protein family. Exp. Cell Res. 256:50–57.
  • Carrier, F., M. L. Smith, I. Bae, K. E. Kilpatrick, T. J. Lansing, C. Y. Chen, M. Engelstein, S. H. Friend, W. D. Henner, T. M. Gilmer, et al. 1994. Characterization of human Gadd45, a p53-regulated protein. J. Biol. Chem. 269:32672–32677.
  • Edmonds, B. T., J. Wyckoff, Y. G. Yeung, Y. Wang, E. R. Stanley, J. Jones, J. Segall, and J. Condeelis. 1996. Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. J. Cell Science 109:2705–2714.
  • Fan, W., S. Jin, T. Tong, H. Zhao, F. Fan, M. J. Antinore, B. Rajasekaran, M. Wu, and Q. Zhan. 2002. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. J. Biol. Chem. 277:8061–8067.
  • Fornace, A. J., Jr., I. Alamo, Jr., and M. C. Hollander. 1988. DNA damage-inducible transcripts in mammalian cells. Proc. Natl. Acad. Sci. USA 85:8800–8804.
  • Harkin, D. P., J. M. Bean, D. Miklos, Y. H. Song, V. B. Truong, C. Englert, F. C. Christians, L. W. Ellisen, S. Maheswaran, J. D. Oliner, and D. A. Haber. 1999. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97:575–586.
  • Hildesheim, J., D. V. Bulavin, M. R. Anver, W. G. Alvord, M. C. Hollander, L. Vardanian, and A. J. Fornace, Jr. 2002. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res. 62:7305–7315.
  • Hollander, M. C., M. S. Sheikh, D. V. Bulavin, K. Lundgren, L. Augeri-Henmueller, R. Shehee, T. A. Molinaro, K. E. Kim, E. Tolosa, J. D. Ashwell, M. P. Rosenberg, Q. Zhan, P. M. Fernandez-Salguero, W. F. Morgan, C. X. Deng, and A. J. Fornace, Jr. 1999. Genomic instability in Gadd45a-deficient mice. Nat. Genet. 23:176–184.
  • Jin, S., M. J. Antinore, F. D. Lung, X. Dong, H. Zhao, F. Fan, A. B. Colchagie, P. Blanck, P. P. Roller, A. J. Fornace, Jr., and Q. Zhan. 2000. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J. Biol. Chem. 275:16602–16608.
  • Jin, S., T. Tong, W. Fan, F. Fan, M. J. Antinore, X. Zhu, L. Mazzacurati, X. Li, K. L. Petrik, B. Rajasekaran, M. Wu, and Q. Zhan. 2002. GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity. Oncogene 21:8696–8704.
  • Jin, S., H. Zhao, F. Fan, P. Blanck, W. Fan, A. B. Colchagie, A. J. Fornace, Jr., and Q. Zhan. 2000. BRCA1 activation of the GADD45 promoter. Oncogene 19:4050–4057.
  • Kastan, M. B., Q. Zhan, W. S. el-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587–597.
  • Lei, K., and R. J. Davis. 2003. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl. Acad. Sci. USA 100:2432–2437.
  • Moore, R. C., and R. J. Cyr. 2000. Association between elongation factor-1alpha and microtubules in vivo is domain dependent and conditional. Cell Motil. Cytoskeleton 45:279–292.
  • Moore, R. C., N. A. Durso, and R. J. Cyr. 1998. Elongation factor-1alpha stabilizes microtubules in a calcium/calmodulin-dependent manner. Cell Motil. Cytoskeleton 41:168–180.
  • O'Connor, L., D. C. Huang, L. A. O'Reilly, and A. Strasser. 2000. Apoptosis and cell division. Curr. Opin. Cell Biol. 12:257–263.
  • O'Reilly, L. A., L. Cullen, J. Visvader, G. J. Lindeman, C. Print, M. L. Bath, D. C. Huang, and A. Strasser. 2000. The proapoptotic BH3-only protein Bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am. J. Pathol. 157:449–461.
  • Putcha, G. V., K. L. Moulder, J. P. Golden, P. Bouillet, J. A. Adams, A. Strasser, and E. M. Johnson. 2001. Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 29:615–628.
  • Puthalakath, H., D. C. Huang, L. A. O'Reilly, S. M. King, and A. Strasser. 1999. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Molecular Cell 3:287–296.
  • Roucou, X., B. Antonsson, and J. C. Martinou. 2001. Involvement of mitochondria in apoptosis. Cardiol. Clin. 19:45–55.
  • Shaulian, E., and M. Karin. 1999. Stress-induced JNK activation is independent of Gadd45 induction. J. Biol. Chem. 274:29595–29598.
  • Shiina, N., Y. Gotoh, N. Kubomura, A. Iwamatsu, and E. Nishida. 1994. Microtubule severing by elongation factor 1α. Science 266:282–285.
  • Strasser, A., L. O'Connor, and V. M. Dixit. 2000. Apoptosis signaling. Annu. Rev. Biochem. 69:217–245.
  • Takekawa, M., and H. Saito. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521–530.
  • Talapatra, S., J. D. Wagner, and C. B. Thompson. 2002. Elongation factor-1 alpha is a selective regulator of growth factor withdrawal and ER stress-induced apoptosis. Cell Death Differ. 9:856–861.
  • Tatsuka, M., H. Mitsui, M. Wada, A. Nagata, H. Nojima, and H. Okayama. 1992. Elongation factor-1α gene determines susceptibility to transformation. Nature 359:333–336.
  • Thangaraju, M., S. H. Kaufmann, and F. J. Couch. 2000. BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines. J. Biol. Chem. 275:33487–33496.
  • Vaux, D. L., and A. Strasser. 1996. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93:2239–2244.
  • Wang, X. 2001. The expanding role of mitochondria in apoptosis. Genes Dev. 15:2922–2933.
  • Wang, X., M. Gorospe, and N. J. Holbrook. 1999. gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress. J. Biol. Chem. 274:29599–29602.
  • Wang, X. W., Q. Zhan, J. D. Coursen, M. A. Khan, H. U. Kontny, L. Yu, M. C. Hollander, P. M. O'Connor, A. J. Fornace, Jr., and C. C. Harris. 1999. GADD45 induction of a G2/M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA 96:3706–3711.
  • Zhan, Q., M. J. Antinore, X. W. Wang, F. Carrier, M. L. Smith, C. C. Harris, and A. J. Fornace, Jr. 1999. Association with Cdc2 and inhibition of Cdc2/cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18:2892–2900.
  • Zhan, Q., I. Bae, M. B. Kastan, and A. J. Fornace, Jr. 1994. The p53-dependent gamma-ray response of GADD45. Cancer Res. 54:2755–2760.
  • Zhan, Q., S. Fan, M. L. Smith, I. Bae, K. Yu, I. Alamo, Jr., P. M. O'Connor, and A. J. Fornace, Jr. 1996. Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation. DNA Cell Biol. 15:805–815.
  • Zhan, Q., S. Jin, B. Ng, J. Plisket, S. Shangary, A. Rathi, K. D. Brown, and R. Baskaran. 2002. Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene 21:5335–5345.
  • Zhan, Q., K. A. Lord, I. Alamo, Jr., M. C. Hollander, F. Carrier, D. Ron, K. W. Kohn, B. Hoffman, D. A. Liebermann, and A. J. Fornace, Jr. 1994. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell. Biol. 14:2361–2371.

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