Membrane Insertion by Anthrax Protective Antigen in Cultured Cells

REFERENCES

• Abrami, L., M. Lindsay, R. G. Parton, S. H. Leppla, and F. G. van der Goot. 2004. Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J. Cell Biol. 166:645–651.
   PubMedGoogle Scholar
• Abrami, L., S. Liu, P. Cosson, S. H. Leppla, and F. G. Van Der Goot. 2003. Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J. Cell Biol. 160:321–328.
   PubMed Web of Science ®Google Scholar
• Beauregard, K. E., R. J. Collier, and J. A. Swanson. 2000. Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization. Cell Microbiol. 2:251–258.
   PubMedGoogle Scholar
• Benson, E. L., P. D. Huynh, A. Finkelstein, and R. J. Collier. 1998. Identification of residues lining the anthrax protective antigen channel. Biochemistry 37:3941–3948.
   PubMedGoogle Scholar
• Blaustein, R. O., T. M. Koehler, R. J. Collier, and A. Finkelstein. 1989. Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers. Proc. Natl. Acad. Sci. USA 86:2209–2213.
   PubMed Web of Science ®Google Scholar
• Boll, W., M. Ehrlich, R. J. Collier, and T. Kirchhausen. 2004. Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur. J. Cell Biol. 83:281–288.
   PubMedGoogle Scholar
• Bradley, K. A., J. Mogridge, M. Mourez, R. J. Collier, and J. A. Young. 2001. Identification of the cellular receptor for anthrax toxin. Nature 414:225–229.
   PubMed Web of Science ®Google Scholar
• Collier, R. J., and J. A. Young. 2003. Anthrax toxin. Annu. Rev. Cell Dev. Biol. 19:45–70.
   PubMed Web of Science ®Google Scholar
• Duesbery, N. S., C. P. Webb, S. H. Leppla, V. M. Gordon, K. R. Klimpel, T. D. Copeland, N. G. Ahn, M. K. Oskarsson, K. Fukasawa, K. D. Paull, and G. F. Vande Woude. 1998. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280:734–737.
   PubMed Web of Science ®Google Scholar
• Friedlander, A. M. 1986. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261:7123–7126.
   PubMed Web of Science ®Google Scholar
• Gordon, V. M., S. H. Leppla, and E. L. Hewlett. 1988. Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect. Immun. 56:1066–1069.
   PubMed Web of Science ®Google Scholar
• Leppla, S. H. 2000. Anthrax toxin, p. 445–472. In K. Aktories and I. Just (ed.), Bacterial protein toxins. Springer, Berlin, Germany.
   Google Scholar
• Leppla, S. H. 1982. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc. Natl. Acad. Sci. USA 79:3162–3166.
   PubMed Web of Science ®Google Scholar
• Melton, J. A., M. W. Parker, J. Rossjohn, J. T. Buckley, and R. K. Tweten. 2004. The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J. Biol. Chem. 279:14315–14322.
   PubMedGoogle Scholar
• Milne, J. C., S. R. Blanke, P. C. Hanna, and R. J. Collier. 1995. Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol. Microbiol. 15:661–666.
   PubMed Web of Science ®Google Scholar
• Milne, J. C., and R. J. Collier. 1993. pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol. Microbiol. 10:647–653.
   PubMed Web of Science ®Google Scholar
• Milne, J. C., D. Furlong, P. C. Hanna, J. S. Wall, and R. J. Collier. 1994. Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J. Biol. Chem. 269:20607–20612.
   PubMed Web of Science ®Google Scholar
• Mogridge, J., K. Cunningham, and R. J. Collier. 2002. Stoichiometry of anthrax toxin complexes. Biochemistry 41:1079–1082.
   PubMed Web of Science ®Google Scholar
• Mogridge, J., K. Cunningham, D. B. Lacy, M. Mourez, and R. J. Collier. 2002. The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc. Natl. Acad. Sci. USA 99:7045–7048.
   PubMed Web of Science ®Google Scholar
• Molloy, S. S., P. A. Bresnahan, S. H. Leppla, K. R. Klimpel, and G. Thomas. 1992. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J. Biol. Chem. 267:16396–16402.
   PubMed Web of Science ®Google Scholar
• Mourez, M., M. Yan, D. B. Lacy, L. Dillon, L. Bentsen, A. Marpoe, C. Maurin, E. Hotze, D. Wigelsworth, R. A. Pimental, J. D. Ballard, R. J. Collier, and R. K. Tweten. 2003. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc. Natl. Acad. Sci. USA 100:13803–13808.
   PubMed Web of Science ®Google Scholar
• Petosa, C., R. J. Collier, K. R. Klimpel, S. H. Leppla, and R. C. Liddington. 1997. Crystal structure of the anthrax toxin protective antigen. Nature 385:833–838.
   PubMed Web of Science ®Google Scholar
• Ramachandran, R., A. P. Heuck, R. K. Tweten, and A. E. Johnson. 2002. Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat. Struct. Biol. 9:823–827.
   PubMedGoogle Scholar
• Scobie, H. M., G. J. Rainey, K. A. Bradley, and J. A. Young. 2003. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc. Natl. Acad. Sci. USA 100:5170–5174.
   PubMed Web of Science ®Google Scholar
• Sellman, B. R., M. Mourez, and R. J. Collier. 2001. Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science 292:695–697.
   PubMed Web of Science ®Google Scholar
• Sellman, B. R., S. Nassi, and R. J. Collier. 2001. Point mutations in anthrax protective antigen that block translocation. J. Biol. Chem. 276:8371–8376.
   PubMed Web of Science ®Google Scholar
• Song, L., M. R. Hobaugh, C. Shustak, S. Cheley, H. Bayley, and J. E. Gouaux. 1996. Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science 274:1859–1866.
   PubMed Web of Science ®Google Scholar
• Udenfriend, S. 1962. Fluorescence assay in biology and medicine. Academic Press, New York, N.Y.
   Google Scholar
• Ulmer, T. S., S. Soelaiman, S. Li, C. B. Klee, W. J. Tang, and A. Bax. 2003. Calcium dependence of the interaction between calmodulin and anthrax edema factor. J. Biol. Chem. 278:29261–29266.
   PubMedGoogle Scholar
• Vitale, G., R. Pellizzari, C. Recchi, G. Napolitani, M. Mock, and C. Montecucco. 1998. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem. Biophys. Res. Commun. 248:706–711.
   PubMed Web of Science ®Google Scholar
• Wigelsworth, D. J., B. A. Krantz, K. A. Christensen, D. B. Lacy, S. J. Juris, and R. J. Collier. 2004. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J. Biol. Chem. 279:23349–23356.
   PubMed Web of Science ®Google Scholar
• Zhang, L., O. Gjoerup, and T. M. Roberts. 2004. The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc. Natl. Acad. Sci. USA 101:10296–10301.
   PubMed Web of Science ®Google Scholar
• Zhang, S., A. Finkelstein, and R. J. Collier. 2004. Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc. Natl. Acad. Sci. USA 101:16756–16761.
   PubMed Web of Science ®Google Scholar
• Zhang, S., E. Udho, Z. Wu, R. J. Collier, and A. Finkelstein. 2004. Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys. J. 87:3842–3849.
   PubMed Web of Science ®Google Scholar