33
Views
40
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Lack of the Central Nervous System- and Neural Crest-Expressed Forkhead Gene Foxs1 Affects Motor Function and Body Weight

, , , , &
Pages 5616-5625 | Received 21 Dec 2004, Accepted 31 Mar 2005, Published online: 27 Mar 2023

REFERENCES

  • Accili, D., and K. C. Arden. 2004. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421–426.
  • Ang, S. L., and J. Rossant. 1994. HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78:561–574.
  • Bergquist, F., H. N. Shahabi, and H. Nissbrandt. 2003. Somatodendritic dopamine release in rat substantia nigra influences motor performance on the accelerating rod. Brain Res. 973:81–91.
  • Bernardis, L. L. 1975. The dorsomedial hypothalamic nucleus in autonomic and neuroendocrine homeostasis. Can. J. Neurol. Sci. 2:45–60.
  • Bernardis, L. L., and L. L. Bellinger. 1991. Brown (BAT) and white (WAT) adipose tissue in high-fat junk food (HFJF) and chow-fed rats with dorsomedial hypothalamic lesions (DMNL rats). Behav. Brain Res. 43:191–195.
  • Blomqvist, S. R., H. Vidarsson, S. Fitzgerald, B. R. Johansson, A. Ollerstam, R. Brown, A. E. Persson, G. G. Bergstrom, and S. Enerback. 2004. Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J. Clin. Investig. 113:1560–1570.
  • Cao, W. H., W. Fan, and S. F. Morrison. 2004. Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus. Neuroscience 126:229–240.
  • Carlsson, P., and M. Mahlapuu. 2002. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250:1–23.
  • Carter, R. J., L. A. Lione, T. Humby, L. Mangiarini, A. Mahal, G. P. Bates, S. B. Dunnett, and A. J. Morton. 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci. 19:3248–3257.
  • Cederberg, A., R. Betz, S. Lagercrantz, C. Larsson, M. Hulander, P. Carlsson, and S. Enerback. 1997. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. Genomics 44:344–346.
  • Cederberg, A., L. M. Gronning, B. Ahren, K. Tasken, P. Carlsson, and S. Enerback. 2001. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106:563–573.
  • Chaplan, S. R., F. W. Bach, J. W. Pogrel, J. M. Chung, and T. L. Yaksh. 1994. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods 53:55–63.
  • Chen, X., M. J. Rubock, and M. Whitman. 1996. A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383:691–696. (Erratum, 384:648.)
  • Chen, X., E. Weisberg, V. Fridmacher, M. Watanabe, G. Naco, and M. Whitman. 1997. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389:85–89.
  • Clifton-Bligh, R. J., J. M. Wentworth, P. Heinz, M. S. Crisp, R. John, J. H. Lazarus, M. Ludgate, and V. K. Chatterjee. 1998. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia. Nat. Genet. 19:399–401.
  • Couly, G., P. Coltey, A. Eichmann, and N. M. Le Douarin. 1995. The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels. Mech. Dev. 53:97–112.
  • Couly, G. F., P. M. Coltey, and N. M. Le Douarin. 1992. The developmental fate of the cephalic mesoderm in quail-chick chimeras. Development 114:1–15.
  • Crisponi, L., M. Deiana, A. Loi, F. Chiappe, M. Uda, P. Amati, L. Bisceglia, L. Zelante, R. Nagaraja, S. Porcu, M. S. Ristaldi, R. Marzella, M. Rocchi, M. Nicolino, A. Lienhardt-Roussie, A. Nivelon, A. Verloes, D. Schlessinger, P. Gasparini, D. Bonneau, A. Cao, and G. Pilia. 2001. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat. Genet. 27:159–166.
  • Crowley, C., S. D. Spencer, M. C. Nishimura, K. S. Chen, S. Pitts-Meek, M. P. Armanini, L. H. Ling, S. B. MacMahon, D. L. Shelton, A. D. Levinson, et al. 1994. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001–1011.
  • D'Amico-Martel, A., and D. M. Noden. 1983. Contributions of placodal and neural crest cells to avian cranial peripheral ganglia. Am. J. Anat. 166:445–468.
  • Enerback, S., B. G. Ohlsson, L. Samuelsson, and G. Bjursell. 1992. Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis. Mol. Cell. Biol. 12:4622–4633.
  • Ernfors, P., K. F. Lee, J. Kucera, and R. Jaenisch. 1994. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503–512.
  • Etchevers, H. C., C. Vincent, N. M. Le Douarin, and G. F. Couly. 2001. The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development 128:1059–1068.
  • Farinas, I., K. R. Jones, C. Backus, X. Y. Wang, and L. F. Reichardt. 1994. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369:658–661.
  • Gerlai, R., P. Pisacane, and S. Erickson. 2000. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav. Brain Res. 109:219–227.
  • Hulander, M., A. E. Kiernan, S. R. Blomqvist, P. Carlsson, E. J. Samuelsson, B. R. Johansson, K. P. Steel, and S. Enerback. 2003. Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development 130:2013–2025.
  • Hulander, M., W. Wurst, P. Carlsson, and S. Enerback. 1998. The winged helix transcription factor Fkh10 is required for normal development of the inner ear. Nat. Genet. 20:374–376.
  • Iida, K., H. Koseki, H. Kakinuma, N. Kato, Y. Mizutani-Koseki, H. Ohuchi, H. Yoshioka, S. Noji, K. Kawamura, Y. Kataoka, F. Ueno, M. Taniguchi, N. Yoshida, T. Sugiyama, and N. Miura. 1997. Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124:4627–4638.
  • Ji, R. R., Q. Zhang, P. Y. Law, H. H. Low, R. Elde, and T. Hokfelt. 1995. Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J. Neurosci. 15:8156–8166.
  • Kaestner, K. H. 2000. The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. Trends Endocrinol. Metab. 11:281–285.
  • Kaestner, K. H., W. Knochel, and D. E. Martinez. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14:142–146.
  • Kaestner, K. H., K. H. Lee, J. Schlondorff, H. Hiemisch, A. P. Monaghan, and G. Schutz. 1993. Six members of the mouse forkhead gene family are developmentally regulated. Proc. Natl. Acad. Sci. USA 90:7628–7631.
  • Kaufmann, E., and W. Knochel. 1996. Five years on the wings of fork head. Mech. Dev. 57:3–20.
  • Klein, R., I. Silos-Santiago, R. J. Smeyne, S. A. Lira, R. Brambilla, S. Bryant, L. Zhang, W. D. Snider, and M. Barbacid. 1994. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368:249–251.
  • Kopecky, J., G. Clarke, S. Enerback, B. Spiegelman, and L. P. Kozak. 1995. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Investig. 96:2914–2923.
  • Korn, J., B. Christ, and H. Kurz. 2002. Neuroectodermal origin of brain pericytes and vascular smooth muscle cells. J. Comp. Neurol. 442:78–88.
  • Kotchabhakdi, N., and F. Walberg. 1978. Cerebellar afferent projections from the vestibular nuclei in the cat: an experimental study with the method of retrograde axonal transport of horseradish peroxidase. Exp. Brain Res. 31:591–604.
  • Labosky, P. A., G. E. Winnier, T. L. Jetton, L. Hargett, A. K. Ryan, M. G. Rosenfeld, A. F. Parlow, and B. L. Hogan. 1997. The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development 124:1263–1274.
  • Landgren, H., and P. Carlsson. 2004. FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome. Dev. Dyn. 231:396–401.
  • Laurie, D. J., P. H. Seeburg, and W. Wisden. 1992. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12:1063–1076.
  • Le Douarin, N. M., and M. A. Teillet. 1974. Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique. Dev. Biol. 41:162–184.
  • Lehmann, O. J., N. D. Ebenezer, T. Jordan, M. Fox, L. Ocaka, A. Payne, B. P. Leroy, B. J. Clark, R. A. Hitchings, S. Povey, P. T. Khaw, and S. S. Bhattacharya. 2000. Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma. Am. J. Hum. Genet. 67:1129–1135.
  • Lin, J. C., L. Cai, and C. L. Cepko. 2001. The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain. J. Neurosci. 21:159–168.
  • Nakae, J., W. H. Biggs III, T. Kitamura, W. K. Cavenee, C. V. Wright, K. C. Arden, and D. Accili. 2002. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32:245–253.
  • Newlands, S. D., J. T. Vrabec, I. M. Purcell, C. M. Stewart, B. E. Zimmerman, and A. A. Perachio. 2003. Central projections of the saccular and utricular nerves in macaques. J. Comp. Neurol. 466:31–47.
  • Noden, D. M. 1993. Spatial integration among cells forming the cranial peripheral nervous system. J. Neurobiol. 24:248–261.
  • Ogg, S., S. Paradis, S. Gottlieb, G. I. Patterson, L. Lee, H. A. Tissenbaum, and G. Ruvkun. 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994–999.
  • Parysek, L. M., and R. D. Goldman. 1988. Distribution of a novel 57 kDa intermediate filament (IF) protein in the nervous system. J. Neurosci. 8:555–563.
  • Rubinstein, M., T. J. Phillips, J. R. Bunzow, T. L. Falzone, G. Dziewczapolski, G. Zhang, Y. Fang, J. L. Larson, J. A. McDougall, J. A. Chester, C. Saez, T. A. Pugsley, O. Gershanik, M. J. Low, and D. K. Grandy. 1997. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90:991–1001.
  • Smeyne, R. J., R. Klein, A. Schnapp, L. K. Long, S. Bryant, A. Lewin, S. A. Lira, and M. Barbacid. 1994. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368:246–249.
  • Steel, K. P., D. R. Davidson, and I. J. Jackson. 1992. TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 115:1111–1119.
  • Tybulewicz, V. L., C. E. Crawford, P. K. Jackson, R. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153–1163.
  • Weeber, E. J., M. Levy, M. J. Sampson, K. Anflous, D. L. Armstrong, S. E. Brown, J. D. Sweatt, and W. J. Craigen. 2002. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J. Biol. Chem. 277:18891–18897.
  • Weigel, D., and H. Jackle. 1990. The fork head domain: a novel DNA binding motif of eukaryotic transcription factors. Cell 63:455–456.
  • Weigel, D., G. Jurgens, F. Kuttner, E. Seifert, and H. Jackle. 1989. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 57:645–658.
  • Winnier, G. E., L. Hargett, and B. L. Hogan. 1997. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11:926–940.
  • Wolfrum, C., D. Q. Shih, S. Kuwajima, A. W. Norris, C. R. Kahn, and M. Stoffel. 2003. Role of Foxa-2 in adipocyte metabolism and differentiation. J. Clin. Investig. 112:345–356.
  • Yildirim-Toruner, C., K. Subramanian, L. El Manjra, E. Chen, S. Goldstein, and E. Vitale. 2004. A novel frameshift mutation of FOXC2 gene in a family with hereditary lymphedema-distichiasis syndrome associated with renal disease and diabetes mellitus. Am. J. Med. Genet. 131:281–285.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.