Genetic Deletion of Murine SPRY Domain-Containing SOCS Box Protein 2 (SSB-2) Results in Very Mild Thrombocytopenia

REFERENCES

• Alexander, W. S., and C. G. Begley. 1998. Thrombopoietin in vitro and in vivo. Cytokines Cell Mol. Ther. 4:25–34.
   PubMedGoogle Scholar
• Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403–410.
   PubMed Web of Science ®Google Scholar
• Berger, G., D. W. Hartwell, and D. D. Wagner. 1998. P-selectin and platelet clearance. Blood 92:4446–4452.
   PubMed Web of Science ®Google Scholar
• Bonadio, W. A., H. H. Hennes, J. Machi, and E. Madagame. 1989. Efficacy of measuring BUN in assessing children with dehydration due to gastroenteritis. Ann. Emerg. Med. 18:755–757.
   PubMedGoogle Scholar
• Chang, M., Y. Suen, G. Meng, J. S. Buzby, J. Bussel, V. Shen, C. van de Ven, and M. S. Cairo. 1996. Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood 88:3354–3362.
   PubMed Web of Science ®Google Scholar
• Croker, B. A., D. L. Krebs, J. G. Zhang, S. Wormald, T. A. Willson, E. G. Stanley, L. Robb, C. J. Greenhalgh, I. Forster, B. E. Clausen, N. A. Nicola, D. Metcalf, D. J. Hilton, A. W. Roberts, and W. S. Alexander. 2003. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4:540–545.
   PubMed Web of Science ®Google Scholar
• Croker, B. A., D. Metcalf, L. Robb, W. Wei, S. Mifsud, L. DiRago, L. A. Cluse, K. D. Sutherland, L. Hartley, E. Williams, J. G. Zhang, D. J. Hilton, N. A. Nicola, W. S. Alexander, and A. W. Roberts. 2004. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20:153–165.
   PubMed Web of Science ®Google Scholar
• Duarte, C. G., and H. G. Preuss. 1993. Assessment of renal function: glomerular and tubular. Clin. Lab. Med. 13:33–52.
   PubMedGoogle Scholar
• Elefanty, A. G., C. G. Begley, D. Metcalf, L. Barnett, F. Kontgen, and L. Robb. 1998. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ “knock-in” strategy. Proc. Natl. Acad. Sci. USA 95:11897–11902.
   PubMedGoogle Scholar
• Hilton, D. J., R. T. Richardson, W. S. Alexander, E. M. Viney, T. A. Willson, N. S. Sprigg, R. Starr, S. E. Nicholson, D. Metcalf, and N. A. Nicola. 1998. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95:114–119.
   PubMed Web of Science ®Google Scholar
• Jackson, C. W., L. K. Brown, B. C. Somerville, S. A. Lyles, and A. T. Look. 1984. Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood 63:768–778.
   PubMed Web of Science ®Google Scholar
• Kile, B. T., D. Metcalf, S. Mifsud, L. DiRago, N. A. Nicola, D. J. Hilton, and W. S. Alexander. 2001. Functional analysis of Asb-1 using genetic modification in mice. Mol. Cell. Biol. 21:6189–6197.
   PubMed Web of Science ®Google Scholar
• Kimura, S., A. W. Roberts, D. Metcalf, and W. S. Alexander. 1998. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. USA 95:1195–1200.
   PubMed Web of Science ®Google Scholar
• Krebs, D. L., R. T. Uren, D. Metcalf, S. Rakar, J. G. Zhang, R. Starr, D. P. De Souza, K. Hanzinikolas, J. Eyles, L. M. Connolly, R. J. Simpson, N. A. Nicola, S. E. Nicholson, M. Baca, D. J. Hilton, and W. S. Alexander. 2002. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol. Cell. Biol. 22:4567–4578.
   PubMed Web of Science ®Google Scholar
• Kuter, D. J. 1996. The physiology of platelet production. Stem Cells 14(Suppl. 1):88–101.
   PubMedGoogle Scholar
• Kuter, D. J., and R. D. Rosenberg. 1995. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720–2730.
   PubMed Web of Science ®Google Scholar
• Liu, J. J., J. Y. Wang, C. Zhang, A. Nilsson, and R. D. Duan. 2002. Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats. Med. Sci. Monit. 8:BR56–BR60.
   PubMedGoogle Scholar
• Matsumura, I., and Y. Kanakura. 2002. Molecular control of megakaryopoiesis and thrombopoiesis. Int. J. Hematol. 75:473–483.
   PubMedGoogle Scholar
• Metcalf, D., N. A. Nicola, and D. P. Gearing. 1990. Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood 76:50–56.
   PubMed Web of Science ®Google Scholar
• Neben, T. Y., J. Loebelenz, L. Hayes, K. McCarthy, J. Stoudemire, R. Schaub, and S. J. Goldman. 1993. Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Blood 81:901–908.
   PubMed Web of Science ®Google Scholar
• Nicholson, S. E., D. De Souza, L. J. Fabri, J. Corbin, T. A. Willson, J. G. Zhang, A. Silva, M. Asimakis, A. Farley, A. D. Nash, D. Metcalf, D. J. Hilton, N. A. Nicola, and M. Baca. 2000. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97:6493–6498.
   PubMed Web of Science ®Google Scholar
• Ogilvy, S., A. G. Elefanty, J. Visvader, M. L. Bath, A. W. Harris, and J. M. Adams. 1998. Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment. Blood 91:419–430.
   PubMed Web of Science ®Google Scholar
• Ponting, C., J. Schultz, and P. Bork. 1997. SPRY domains in ryanodine receptors (Ca2+-release channels). Trends Biochem. Sci. 22:193–194.
   PubMed Web of Science ®Google Scholar
• Raz, E. 2000. The function and regulation of Vasa-like genes in germ-cell development. Genome Biol. 1:REVIEWS1017.
   PubMedGoogle Scholar
• Roberts, A. W., L. Robb, S. Rakar, L. Hartley, L. Cluse, N. A. Nicola, D. Metcalf, D. J. Hilton, and W. S. Alexander. 2001. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA 98:9324–9329.
   PubMed Web of Science ®Google Scholar
• Schultz, J., F. Milpetz, P. Bork, and C. P. Ponting. 1998. SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. USA 95:5857–5864.
   PubMed Web of Science ®Google Scholar
• Starr, R., D. Metcalf, A. G. Elefanty, M. Brysha, T. A. Willson, N. A. Nicola, D. J. Hilton, and W. S. Alexander. 1998. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. USA 95:14395–14399.
   PubMed Web of Science ®Google Scholar
• Strasser, A., A. W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T-cell death and perturbs thymic self-censorship. Cell 67:889–899.
   PubMed Web of Science ®Google Scholar
• Styhler, S., A. Nakamura, and P. Lasko. 2002. Vasa localization requires the SPRY-domain and SOCS-box containing protein, Gustavus. Dev. Cell 3:865–876.
   PubMedGoogle Scholar
• Tanaka, S. S., Y. Toyooka, R. Akasu, Y. Katoh-Fukui, Y. Nakahara, R. Suzuki, M. Yokoyama, and T. Noce. 2000. The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev. 14:841–853.
   PubMed Web of Science ®Google Scholar
• Wang, D., Z. Li, E. M. Messing, and G. Wu. 2002. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J. Biol. Chem. 277:36216–36222.
   PubMedGoogle Scholar
• Yao, S., S. L. Masters, J. G. Zhang, K. R. Palmer, J. J. Babon, N. A. Nicola, S. E. Nicholson, and R. S. Norton. 2005. Backbone 1H, 13C, and 15N assignments of the 25-kDa SPRY domain-containing SOCS box protein 2 (SSB-2). J. Biomolec. NMR 31:69–70.
   PubMedGoogle Scholar
• Yoshimura, A., T. Ohkubo, T. Kiguchi, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, T. Hara, and A. Miyajima. 1995. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816–2826.
   PubMed Web of Science ®Google Scholar
• Zhang, J. G., A. Farley, S. E. Nicholson, T. A. Willson, L. M. Zugaro, R. J. Simpson, R. L. Moritz, D. Cary, R. Richardson, G. Hausmann, B. J. Kile, S. B. Kent, W. S. Alexander, D. Metcalf, D. J. Hilton, N. A. Nicola, and M. Baca. 1999. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96:2071–2076.
   PubMed Web of Science ®Google Scholar