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Signal Transduction

Inhibiting Myosin Light Chain Kinase Induces Apoptosis In Vitro and In Vivo

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Pages 6259-6266 | Received 06 Feb 2004, Accepted 13 Apr 2005, Published online: 27 Mar 2023

REFERENCES

  • Adelstein, R. S. 1983. Regulation of contractile proteins by phosphorylation. J. Clin. Investig. 72:1863–1866.
  • Bain, J., H. McLauchlan, M. Elliott, and P. Cohen. 2003. The specificities of protein kinase inhibitors: an update. Biochem. J. 371:199–204.
  • Berglund, J. J., M. Riegler, Y. Zolotarevsky, E. Wenzl, and J. R. Turner. 2001. Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G1487–G1493.
  • Brancolini, C., M. Benedetti, and C. Schneider. 1995. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO J. 14:5179–5190.
  • Burridge, K. 1999. Crosstalk between Rac and Rho. Science 283:2028–2029.
  • Cai, S., L. Pestic-Dragovich, M. E. O'Donnell, N. Wang, D. Ingber, E. Elson, and P. de Lanerolle. 1998. Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Am. J. Physiol. 275:C1349–C1356.
  • Chen, L., X. Xin, A. D. Eckhart, N. Yang, and J. E. Faber. 1995. Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ. J. Biol. Chem. 270:30980–30988.
  • Chew, T. L., R. A. Masaracchia, Z. M. Goeckeler, and R. B. Wysolmerski. 1998. Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J. Muscle Res. Cell Motil. 19:839–854.
  • Chrzanowska-Wodnicka, M., and K. Burridge. 1996. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133:1403–1415.
  • de Lanerolle, P., R. S. Adelstein, J. R. Feramisco, and K. Burridge. 1981. Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells. Proc. Natl. Acad. Sci. USA 78:4738–4742.
  • de Lanerolle, P., and R. J. Paul. 1991. Myosin phosphorylation/dephosphorylation and regulation of airway smooth muscle contractility. Am. J. Physiol. 261:L1–L14.
  • Elson, E. L. 1988. Cellular mechanics as an indicator of cytoskeletal structure and function. Annu. Rev. Biophys. Biophys. Chem. 17:397–430.
  • Fishkind, D. J., L.-G. Cao, and Y.-L. Wang. 1991. Microinjection of the catalytic fragment of myosin light chain kinase into dividing cells: effects on mitosis and cytokinesis. J. Cell Biol. 114:967–975.
  • Frisch, S. M., and H. Francis. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124:619–626.
  • Gandhi, S., D. D. Lorimer, and P. de Lanerolle. 1997. Expression of a mutant myosin light chain that cannot be phosphorylated increases paracellular permeability. Am. J. Physiol. 272:F214–F221.
  • Garcia, J. G., A. D. Verin, M. Herenyiova, and D. English. 1998. Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration. J. Appl. Physiol. 84:1817–1821.
  • Harvey, K. J., J. F. Blomquist, and D. S. Ucker. 1998. Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2, caspase, and cyclin-dependent kinase activities. Mol. Cell. Biol. 18:2912–2922.
  • Harvey, K. J., D. Lukovic, and D. S. Ucker. 2000. Caspase-dependent Cdk activity is a requisite effector of apoptotic death events. J. Cell Biol. 148:59–72.
  • Hecht, G., L. Pestic, G. Nikcevic, A. Koutsouris, J. Tripuraneni, D. D. Lorimer, G. Nowak, V. Guerriero, Jr., E. L. Elson, and P. de Lanerolle. 1996. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am. J. Physiol. 271:C1678–C1684.
  • Hengartner, M. O. 2000. The biochemistry of apoptosis. Nature 407:770–776.
  • Ingber, D. E., D. Prusty, Z. Sun, H. Batensky, and N. Wang. 1995. Cell shape, cytoskeletal mechanics and cell cycle control in angiogenesis. J. Biochem. 28:13828–13834.
  • Jacks, T., and R. A. Weinberg. 2002. Taking the study of cancer cell survival to a new dimension. Cell 111:923–925.
  • Jin, Y., S. J. Atkinson, J. A. Marrs, and P. J. Gallagher. 2001. Myosin II light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1. J. Biol. Chem. 276:30342–30349.
  • Kaufmann, S. H., and M. O. Hengartner. 2001. Programmed cell death: alive and well into the new millennium. Trends Cell Biol. 11:526–534.
  • Klemke, R. L., S. Cai, A. L. Giannini, P. J. Gallagher, P. de Lanerolle, and D. A. Cheresh. 1997. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137:481 492.
  • Kothakota, S., T. Azuma, C. Reinhard, A. Klippel, J. Tang, T. J. McGarry, M. W. Kirschner, K. Koths, D. J. Kwiatkowski, and L. T. Williams. 1997. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294–298.
  • Krarup, T., L. D. Jakobsen, B. S. Jensen, and E. K. Hoffmann. 1998. Na+-K+-2Cl− cotransport in Ehrlich cells: regulation by protein phosphatases and kinases. Am. J. Physiol. 275:C239–C250.
  • Mills, J. C., N. L. Stone, J. Erhardt, and R. N. Pittman. 1998. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J. Cell Biol. 140:627–636.
  • Nakanishi, S., K. Yamada, K. Iwahashi, K. Kuroda, and H. Kase. 1990. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol. 37:482–488.
  • Obara, K., A. Takai, J. C. Ruegg, and P. de Lanerolle. 1989. Okadaic acid, a phosphatase inhibitor, produces a Ca2+ and calmodulin-independent contraction of lamb tracheal smooth muscle. Pfluger's Arch. 414:134–138.
  • Petrache, I., K. Birukov, A. L. Zaiman, M. T. Crow, H. Deng, R. Wadgaonkar, L. H. Romer, and J. G. N. Garcia. 2003. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB J. 17:407–416.
  • Petrache, I., M. T. Crow, M. Neussm, and J. G. Garcia. 2003. Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochem. Biophys. Res. Commun. 306:244–249.
  • Sanders, L. C., F. Matsumura, G. M. Bokoch, and P. de Lanerolle. 1999. Inhibition of myosin light chain kinase by p21-activated kinase. Science 283:2083–2085.
  • Satterwhite, L. L., M. J. Lohka, K. L. Wilson, T. Y. Scherson, L. J. Cisek, J. L. Corden, and T. D. Pollard. 1992. Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesis. J. Cell Biol. 118:595–605.
  • Schoenwaelder, S. M., and K. Burridge. 1999. Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11:274–286.
  • Sebbagh, M., C. Renvoize, J. Hamelin, N. Riche, J. Bertoglio, and J. Breard. 2001. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat. Cell Biol. 3:346–352.
  • Somlyo, A. P., and A. V. Somlyo. 1994. Signal transduction and regulation in smooth muscle. Nature 372:231–236.
  • Straight, A. F., A. Cheung, J. Limouze, I. Chen, N. J. Westwood, J. R. Sellers, and T. J. Mitchison. 2003. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299:1743–1747.
  • Trybus, K. M. 1996. Myosin regulation and assembly, p. 37–46. In M. Barany (ed.), Biochemistry of muscle contraction. Academic Press, San Diego, Calif.
  • Ucker, D. S. 1997. Death and dying in the immune system. Adv. Pharmacol. 41:179–218.
  • Verin, A. D., A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J. G. Garcia. 2001. Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am. J. Physiol. 281:L565–L574.
  • Weaver, V. M., S. Lelievre, J. N. Lakins, M. A. Chrenek, J. C. Jones, F. Giancotti, Z. Werb, and M. J. Bissell. 2002. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205–216.
  • Wilson, A. K., G. Gorgas, W. D. Claypool, and P. de Lanerolle. 1991. An increase or a decrease in myosin II phosphorylation inhibits macrophage motility. J. Cell Biol. 114:277–283.
  • Wilson, A. K., R. S. Pollenz, R. L. Chisholm, and P. de Lanerolle. 1992. The role of myosin I and II in cell motility. Cancer Metastasis Rev. 11:79–91.
  • Wilson, A. K., A. Takai, J. C. Ruegg, and P. de Lanerolle. 1991. Okadaic acid, a phosphatase inhibitor, decreases macrophage motility. Am. J. Physiol. 260:L105–L112.
  • Wysolmerski, R. B., and D. Lagunoff. 1991. Regulation of permeabilized endothelial cell retraction by myosin phosphorylation. Am. J. Physiol. 261:C32–C40.
  • Yamakita, Y., S. Yamashiro, and F. Matusmura. 1994. In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells. J. Cell Biol. 124:129–137.

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