41
Views
177
CrossRef citations to date
0
Altmetric
Signal Transduction

IQGAP1 Is a Scaffold for Mitogen-Activated Protein Kinase Signaling

, &
Pages 7940-7952 | Received 22 Dec 2004, Accepted 21 Jun 2005, Published online: 27 Mar 2023

REFERENCES

  • Belanger, L. F., S. Roy, M. Tremblay, B. Brott, A. M. Steff, W. Mourad, P. Hugo, R. Erikson, and J. Charron. 2003. Mek2 is dispensable for mouse growth and development. Mol. Cell. Biol. 23:4778–4787.
  • Blagoev, B., I. Kratchmarova, S. E. Ong, M. Nielsen, L. J. Foster, and M. Mann. 2003. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat. Biotechnol. 21:315–318.
  • Briggs, M. W., Z. Li, and D. B. Sacks. 2002. IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J. Biol. Chem. 277:7453–7465.
  • Briggs, M. W., and D. B. Sacks. 2003. IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett. 542:7–11.
  • Briggs, M. W., and D. B. Sacks. 2003. IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep. 4:571–574.
  • Cacace, A. M., N. R. Michaud, M. Therrien, K. Mathes, T. Copeland, G. M. Rubin, and D. K. Morrison. 1999. Identification of constitutive and Ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Mol. Cell. Biol. 19:229–240.
  • Castro-Obregon, S., R. V. Rao, G. del Rio, S. F. Chen, K. S. Poksay, S. Rabizadeh, S. Vesce, X. K. Zhang, R. A. Swanson, and D. E. Bredesen. 2004. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J. Biol. Chem. 279:17543–17553.
  • Chang, L., and M. Karin. 2001. Mammalian MAP kinase signalling cascades. Nature 410:37–40.
  • Chen, Z., T. B. Gibson, F. Robinson, L. Silvestro, G. Pearson, B. Xu, A. Wright, C. Vanderbilt, and M. H. Cobb. 2001. MAP kinases. Chem. Rev. 101:2449–2476.
  • Erickson, J. W., R. A. Cerione, and M. J. Hart. 1997. Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase. J. Biol. Chem. 272:24443–24447.
  • Fukata, M., S. Kuroda, K. Fujii, T. Nakamura, I. Shoji, Y. Matsuura, K. Okawa, A. Iwamatsu, A. Kikuchi, and K. Kaibuchi. 1997. Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J. Biol. Chem. 272:29579–29583.
  • Fukata, M., T. Watanabe, J. Noritake, M. Nakagawa, M. Yamaga, S. Kuroda, Y. Matsuura, A. Iwamatsu, F. Perez, and K. Kaibuchi. 2002. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109:873–885.
  • Giroux, S., M. Tremblay, D. Bernard, J. F. Cardin-Girard, S. Aubry, L. Larouche, S. Rousseau, J. Huot, J. Landry, L. Jeannotte, and J. Charron. 1999. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9:369–372.
  • Gustin, M. C., J. Albertyn, M. Alexander, and K. Davenport. 1998. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62:1264–1300.
  • Hancock, J. F. 2003. Ras proteins: different signals from different locations. Nat. Rev. Mol. Cell. Biol. 4:373–384.
  • Hart, M. J., M. G. Callow, B. Souza, and P. Polakis. 1996. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 15:2997–3005.
  • Ho, Y. D., J. L. Joyal, Z. Li, and D. B. Sacks. 1999. IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J. Biol. Chem. 274:464–470.
  • Hunter, T. 2000. Signaling-2000 and beyond. Cell 100:113–127.
  • Jaffe, A. B., P. Aspenstrom, and A. Hall. 2004. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol. Cell. Biol. 24:1736–1746.
  • Joyal, J. L., R. S. Annan, Y. D. Ho, M. E. Huddleston, S. A. Carr, M. J. Hart, and D. B. Sacks. 1997. Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry. J. Biol. Chem. 272:15419–15425.
  • Katata, T., K. Irie, A. Fukuhara, T. Kawakatsu, A. Yamada, K. Shimizu, and Y. Takai. 2003. Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 22:2097–2109.
  • Kim, S. H., S. K. Lee, and K. Y. Choi. 1998. Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway. Mol. Cell 8:130–137.
  • Kolch, W. 2000. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351:289–305.
  • Kortenjann, M., and P. E. Shaw. 1995. Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts. Oncogene 11:2105–2112.
  • Kuroda, S., M. Fukata, M. Nakagawa, K. Fujii, T. Nakamura, T. Ookubo, I. Izawa, T. Nagase, N. Nomura, H. Tani, I. Shoji, Y. Matsuura, S. Yonehara, and K. Kaibuchi. 1998. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281:832–835.
  • Levchenko, A., J. Bruck, and P. W. Sternberg. 2000. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA 97:5818–5823.
  • Lewis, T. S., P. S. Shapiro, and N. G. Ahn. 1998. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:49–139.
  • Li, W., M. Han, and K. L. Guan. 2000. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 14:895–900.
  • Li, Z., S. H. Kim, J. M. Higgins, M. B. Brenner, and D. B. Sacks. 1999. IQGAP1 and calmodulin modulate E-cadherin function. J. Biol. Chem. 274:37885–37892.
  • Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966–970.
  • Mataraza, J. M., M. W. Briggs, Z. Li, A. Entwistle, A. J. Ridley, and D. B. Sacks. 2003. IQGAP1 promotes cell motility and invasion. J. Biol. Chem. 278:41237–41245.
  • Mateer, S. C., A. E. McDaniel, V. Nicolas, G. M. Habermacher, M. J. Lin, D. A. Cromer, M. E. King, and G. S. Bloom. 2002. The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J. Biol. Chem. 277:12324–12333.
  • Mbele, G. O., J. C. Deloulme, B. J. Gentil, C. Delphin, M. Ferro, J. Garin, M. Takahashi, and J. Baudier. 2002. The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. J. Biol. Chem. 277:49998–50007.
  • McCallum, S. J., W. J. Wu, and R. A. Cerione. 1996. Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. J. Biol. Chem. 271:21732–21737.
  • Meighan-Mantha, R. L., A. Wellstein, and A. T. Riegel. 1997. Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of HL-60 cells. Exp. Cell Res. 234:321–328.
  • Morrison, D. K., and R. J. Davis. 2003. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19:91–118.
  • Nguyen, A., W. R. Burack, J. L. Stock, R. Kortum, O. V. Chaika, M. Afkarian, W. J. Muller, K. M. Murphy, D. K. Morrison, R. E. Lewis, J. McNeish, and A. S. Shaw. 2002. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 22:3035–3045.
  • Park, S. H., A. Zarrinpar, and W. A. Lim. 2003. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299:1061–1064.
  • Robbins, D. J., E. Zhen, H. Owaki, C. A. Vanderbilt, D. Ebert, T. D. Geppert, and M. H. Cobb. 1993. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J. Biol. Chem. 268:5097–5106.
  • Roy, M., Z. Li, and D. B. Sacks. 2004. IQGAP1 binds ERK2 and modulates its activity. J. Biol. Chem. 279:17329–17337.
  • Ruiz-Velasco, R., C. C. Lanning, and C. L. Williams. 2002. The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin. J. Biol. Chem. 277:33081–33091.
  • Schaeffer, H. J., A. D. Catling, S. T. Eblen, L. S. Collier, A. Krauss, and M. J. Weber. 1998. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281:1668–1671.
  • Sokol, S. Y., Z. Li, and D. B. Sacks. 2001. The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J. Biol. Chem. 276:48425–48430.
  • Swart-Mataraza, J. M., Z. Li, and D. B. Sacks. 2002. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J. Biol. Chem. 277:24753–24763.
  • Torii, S., M. Kusakabe, T. Yamamoto, M. Maekawa, and E. Nishida. 2004. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7:33–44.
  • Ussar, S., and T. Voss. 2004. MEK1 and MEK2, different regulators of the G1/S transition. J. Biol. Chem. 279:43861–43869.
  • Vasilescu, J., X. Guo, and J. Kast. 2004. Identification of protein-protein interactions using in vivo cross-linking and mass spectrometry. Proteomics 4:3845–3854.
  • Vomastek, T., H. J. Schaeffer, A. Tarcsafalvi, M. E. Smolkin, E. A. Bissonette, and M. J. Weber. 2004. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc. Natl. Acad. Sci. USA 101:6981–6986.
  • Watanabe, T., S. Wang, J. Noritake, K. Sato, M. Fukata, M. Takefuji, M. Nakagawa, N. Izumi, T. Akiyama, and K. Kaibuchi. 2004. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev. Cell 7:871–883.
  • Xu, B., J. L. Wilsbacher, T. Collisson, and M. H. Cobb. 1999. The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J. Biol. Chem. 274:34029–34035.
  • Yeung, K., T. Seitz, S. Li, P. Janosch, B. McFerran, C. Kaiser, F. Fee, K. D. Katsanakis, D. W. Rose, H. Mischak, J. M. Sedivy, and W. Kolch. 1999. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401:173–177.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.