Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells

REFERENCES

• Alarcon-Vargas, D., and Z. Ronai. 2004. c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J. Biol. Chem. 279:5008–5016.
   PubMedGoogle Scholar
• Alfonso-De Matte, M. Y., H. Yang, M. S. Evans, J. Q. Cheng, and P. A. Kruk. 2002. Telomerase is regulated by c-Jun NH2-terminal kinase in ovarian surface epithelial cells. Cancer Res. 62:4575–4578.
   PubMed Web of Science ®Google Scholar
• Ameyar, M., M. Wisniewska, and J. B. Weitzman. 2003. A role for AP-1 in apoptosis: the case for and against. Biochimie 85:747–752.
   PubMed Web of Science ®Google Scholar
• Arias, J., A. S. Alberts, P. Brindle, F. X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminy. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226–229.
   PubMed Web of Science ®Google Scholar
• Autexier, C., R. Pruzan, W. D. Funk, and C. W. Greider. 1996. Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J. 15:5928–5935.
   PubMed Web of Science ®Google Scholar
• Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349–352.
   PubMed Web of Science ®Google Scholar
• Bushel, P., J. H. Kim, W. Chang, J. J. Catino, H. E. Ruley, and C. C. Kumar. 1995. Two serum response elements mediate transcriptional repression of human smooth muscle alpha-actin promoter in ras-transformed cells. Oncogene 10:1361–1370.
   PubMed Web of Science ®Google Scholar
• Cong, Y. S., J. Wen, and S. Bacchetti. 1999. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 8:137–142.
   PubMed Web of Science ®Google Scholar
• Counter, C. M., J. Gupta, C. B. Harley, B. Leber, and S. Bacchetti. 1995. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 85:2315–2320.
   PubMed Web of Science ®Google Scholar
• Devereux, T. R., I. Horikawa, C. H. Anna, L. A. Annab, C. A. Afshari, and J. C. Barrett. 1999. DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res. 59:6087–6090.
   PubMed Web of Science ®Google Scholar
• Feng, J., W. D. Funk, S. S. Wang, S. L. Weinrich, A. A. Avilion, C. P. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, et al. 1995. The RNA component of human telomerase. Science 269:1236–1241.
   PubMed Web of Science ®Google Scholar
• Greenberg, R. A., R. C. Allsopp, L. Chin, G. B. Morin, and R. A. DePinho. 1998. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16:1723–1730.
   PubMedGoogle Scholar
• Harle-Bachor, C., and P. Boukamp. 1996. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. USA 93:6476–6481.
   PubMed Web of Science ®Google Scholar
• Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458–460.
   PubMed Web of Science ®Google Scholar
• Hirai, S., B. Bourachot, and M. Yaniv. 1990. Both Jun and Fos contribute to transcription activation by the heterodimer. Oncogene 5:39–46.
   PubMedGoogle Scholar
• Hiyama, K., Y. Hirai, S. Kyoizumi, M. Akiyama, E. Hiyama, M. A. Piatyszek, J. W. Shay, S. Ishioka, and M. Yamakido. 1995. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 155:3711–3715.
   PubMed Web of Science ®Google Scholar
• Horikawa, I., P. L. Cable, C. Afshari, and J. C. Barrett. 1999. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res. 59:826–830.
   PubMed Web of Science ®Google Scholar
• Iavarone, C., A. Catania, M. J. Marinissen, R. Visconti, M. Acunzo, C. Tarantino, M. S. Carlomagno, C. B. Bruni, J. S. Gutkind, and M. Chiariello. 2003. The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J. Biol. Chem. 278:50024–50030.
   PubMedGoogle Scholar
• Ito, H., S. Kyo, T. Kanaya, M. Takakura, M. Inoue, and M. Namiki. 1998. Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer. Clin. Cancer Res. 4:1603–1608.
   PubMed Web of Science ®Google Scholar
• Kanaya, T., S. Kyo, M. Takakura, H. Ito, M. Namiki, and M. Inoue. 1998. hTERT is a critical determinant of telomerase activity in renal-cell carcinoma. Int. J. Cancer 78:539–543.
   PubMedGoogle Scholar
• Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015.
   PubMed Web of Science ®Google Scholar
• Kugoh, H., K. Shigenami, K. Funaki, J. C. Barrett, and M. Oshimura. 2003. Human chromosome 5 carries a putative telomerase repressor gene. Genes Chromosomes Cancer 36:37–47.
   PubMedGoogle Scholar
• Kyo, S., and M. Inoue. 2002. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy. Oncogene 21:688–697.
   PubMed Web of Science ®Google Scholar
• Kyo, S., T. Kanaya, M. Takakura, M. Tanaka, and M. Inoue. 1999. Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues. Int. J. Cancer 80:60–63.
   PubMed Web of Science ®Google Scholar
• Kyo, S., M. Takakura, T. Kohama, and M. Inoue. 1997. Telomerase activity in human endometrium. Cancer Res. 57:610–614.
   PubMed Web of Science ®Google Scholar
• Kyo, S., M. Takakura, T. Taira, T. Kanaya, H. Itoh, M. Yutsudo, H. Ariga, and M. Inoue. 2000. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 28:669–677.
   PubMedGoogle Scholar
• Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408.
   PubMed Web of Science ®Google Scholar
• Meyerson, M., C. M. Counter, E. N. Eaton, L. W. Ellisen, P. Steiner, S. D. Caddle, L. Ziaugra, R. L. Beijersbergen, M. J. Davidoff, Q. Liu, S. Bacchetti, D. A. Haber, and R. A. Weinberg. 1997. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785–795.
   PubMed Web of Science ®Google Scholar
• Nakamura, T. M., G. B. Morin, K. B. Chapman, S. L. Weinrich, W. H. Andrews, J. Lingner, C. B. Harley, and T. R. Cech. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955–959.
   PubMed Web of Science ®Google Scholar
• Nakayama, J., H. Tahara, E. Tahara, M. Saito, K. Ito, H. Nakamura, T. Nakanishi, E. Tahara, T. Ide, and F. Ishikawa. 1998. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat. Genet. 18:65–68.
   PubMed Web of Science ®Google Scholar
• Nishimoto, A., N. Miura, I. Horikawa, H. Kugoh, Y. Murakami, S. Hirohashi, H. Kawasaki, A. F. Gazdar, J. W. Shay, J. C. Barrett, and M. Oshimura. 2001. Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene 20:828–835.
   PubMedGoogle Scholar
• Nozawa, K., K. Maehara, and K. Isobe. 2001. Mechanism for the reduction of telomerase expression during muscle cell differentiation. J. Biol. Chem. 276:22016–22023.
   PubMedGoogle Scholar
• Ohno, J., Y. Horio, Y. Sekido, Y. Hasegawa, M. Takahashi, J. Nishizawa, H. Saito, F. Ishikawa, and K. Shimokata. 2001. Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development. Carcinogenesis 22:751–756.
   PubMedGoogle Scholar
• Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
   PubMed Web of Science ®Google Scholar
• Schreiber, M., A. Kolbus, F. Piu, A. Szabowski, U. Mohle-Steinlein, J. Tian, M. Karin, P. Angel, and E. F. Wagner. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607–619.
   PubMed Web of Science ®Google Scholar
• Shaulian, E., and M. Karin. 2002. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4:E131–E136.
   PubMed Web of Science ®Google Scholar
• Shay, J. W., and S. Bacchetti. 1997. A survey of telomerase activity in human cancer. Eur. J. Cancer 33:787–791.
   PubMed Web of Science ®Google Scholar
• Takakura, M., S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo, and M. Inoue. 1999. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59:551–557.
   PubMed Web of Science ®Google Scholar
• Takakura, M., S. Kyo, T. Kanaya, M. Tanaka, and M. Inoue. 1998. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res. 58:1558–1561.
   PubMed Web of Science ®Google Scholar
• Takakura, M., S. Kyo, Y. Sowa, Z. Wang, N. Yatabe, Y. Maida, M. Tanaka, and M. Inoue. 2001. Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res. 29:3006–3011.
   PubMed Web of Science ®Google Scholar
• Tanaka, H., M. Shimizu, I. Horikawa, H. Kugoh, J. Yokota, J. C. Barrett, and M. Oshimura. 1998. Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region. Genes Chromosomes Cancer 23:123–133.
   PubMedGoogle Scholar
• Vaziri, H., W. Dragowska, R. C. Allsopp, T. E. Thomas, C. B. Harley, and P. M. Lansdorp. 1994. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 91:9857–9860.
   PubMed Web of Science ®Google Scholar
• Yasumoto, S., C. Kunimura, K. Kikuchi, H. Tahara, H. Ohji, H. Yamamoto, T. Ide, and T. Utakoji. 1996. Telomerase activity in normal human epithelial cells. Oncogene 13:433–439.
   PubMed Web of Science ®Google Scholar
• Yi, X., J. W. Shay, and W. E. Wright. 2001. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res. 29:4818–4825.
   PubMed Web of Science ®Google Scholar