ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation

REFERENCES

• Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499–511.
   PubMed Web of Science ®Google Scholar
• Buckley, A. F., C. T. Kuo, and J. M. Leiden. 2001. Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nat. Immunol. 2:698–704.
   PubMed Web of Science ®Google Scholar
• Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313–316.
   PubMed Web of Science ®Google Scholar
• Ghosh, P., T. H. Tan, N. R. Rice, A. Sica, and H. A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA 90:1696–1700.
   PubMedGoogle Scholar
• Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14:1693–1711.
   PubMed Web of Science ®Google Scholar
• Hernandez-Hoyos, G., M. K. Anderson, C. Wang, E. V. Rothenberg, and J. Alberola-Ila. 2003. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19:83–94.
   PubMed Web of Science ®Google Scholar
• Himes, S. R., L. S. Coles, R. Reeves, and M. F. Shannon. 1996. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity 5:479–489.
   PubMed Web of Science ®Google Scholar
• Hoyos, B., D. W. Ballard, E. Bohnlein, M. Siekevitz, and W. C. Greene. 1989. Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression. Science 244:457–460.
   PubMed Web of Science ®Google Scholar
• Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333–342.
   PubMed Web of Science ®Google Scholar
• Karin, M., and A. Lin. 2002. NF-κB at the crossroads of life and death. Nat. Immunol. 3:221–227.
   PubMed Web of Science ®Google Scholar
• Kuo, C. T., M. L. Veselits, and J. M. Leiden. 1997. LKLF: a transcriptional regulator of single-positive T cell quiescence and survival. Science 277:1986–1990.
   PubMed Web of Science ®Google Scholar
• Lai, J. H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T. H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260–4271.
   PubMed Web of Science ®Google Scholar
• Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2:725–734.
   PubMed Web of Science ®Google Scholar
• Lin, L., M. S. Spoor, A. J. Gerth, S. L. Brody, and S. L. Peng. 2004. Modulation of Th1 activation and inflammation by the NF-κB repressor Foxj1. Science 303:1017–1020.
   PubMed Web of Science ®Google Scholar
• Maggirwar, S. B., E. W. Harhaj, and S. C. Sun. 1997. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol. Cell. Biol. 17:2605–2614.
   PubMed Web of Science ®Google Scholar
• McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319–1327.
   PubMedGoogle Scholar
• Miaw, S. C., A. Choi, E. Yu, H. Kishikawa, and I. C. Ho. 2000. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 12:323–333.
   PubMedGoogle Scholar
• Miaw, S. C., B. Y. Kang, I. A. White, and I. C. Ho. 2004. A repressor of GATA-mediated negative feedback mechanism of T cell activation. J. Immunol. 172:170–177.
   PubMedGoogle Scholar
• Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145–173.
   PubMed Web of Science ®Google Scholar
• Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258–5267.
   PubMed Web of Science ®Google Scholar
• Novak, T. J., P. M. White, and E. V. Rothenberg. 1990. Regulatory anatomy of the murine interleukin-2 gene. Nucleic Acids Res. 18:4523–4533.
   PubMed Web of Science ®Google Scholar
• Omori, M., M. Yamashita, M. Inami, M. Ukai-Tadenuma, M. Kimura, Y. Nigo, H. Hosokawa, A. Hasegawa, M. Taniguchi, and T. Nakayama. 2003. CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity 19:281–294.
   PubMedGoogle Scholar
• Ouyang, W., M. Lohning, Z. Gao, M. Assenmacher, S. Ranganath, A. Radbruch, and K. M. Murphy. 2000. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12:27–37.
   PubMed Web of Science ®Google Scholar
• Pai, S. Y., M. L. Truitt, and I. C. Ho. 2004. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 101:1993–1998.
   PubMedGoogle Scholar
• Pai, S. Y., M. L. Truitt, C. N. Ting, J. M. Leiden, L. H. Glimcher, and I. C. Ho. 2003. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19:863–875.
   PubMed Web of Science ®Google Scholar
• Plevy, S. E., J. H. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin-12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572–4588.
   PubMed Web of Science ®Google Scholar
• Ranger, A. M., M. Oukka, J. Rengarajan, and L. H. Glimcher. 1998. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 9:627–635.
   PubMedGoogle Scholar
• Rao, A., C. Luo, and P. G. Hogan. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:707–747.
   PubMed Web of Science ®Google Scholar
• Rothenberg, E. V., and S. B. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93:9358–9365.
   PubMed Web of Science ®Google Scholar
• Shapiro, V. S., K. E. Truitt, J. B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol. Cell. Biol. 17:4051–4058.
   PubMed Web of Science ®Google Scholar
• Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655–669.
   PubMed Web of Science ®Google Scholar
• Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295:338–342.
   PubMed Web of Science ®Google Scholar
• Tang, C. J., C. K. Chuang, H. M. Hu, and T. K. Tang. 2001. The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. J. Biol. Chem. 276:19631–19639.
   PubMedGoogle Scholar
• Zhang, D. H., L. Cohn, P. Ray, K. Bottomly, and A. Ray. 1997. Transcription factor gata-3 is differentially expressed murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272:21597–21603.
   PubMed Web of Science ®Google Scholar
• Zheng, W. P., and R. A. Flavell. 1997. The transcription factor Gata-3 is necessary and sufficient for Th2 cytokine gene expression in Cd4 T cells. Cell 89:587–596.
   PubMed Web of Science ®Google Scholar