Prss16 Is Not Required for T-Cell Development

REFERENCES

• Anderson, G., and E. J. Jenkinson. 2001. Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1:31–40.
   PubMedGoogle Scholar
• Anderson, G., J. J. Owen, N. C. Moore, and E. J. Jenkinson. 1994. Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro. J. Exp. Med. 179:2027–2031.
   PubMedGoogle Scholar
• Arnold, P. Y., N. L. La Gruta, T. Miller, K. M. Vignali, P. S. Adams, D. L. Woodland, and D. A. Vignali. 2002. The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues. J. Immunol. 169:739–749.
   PubMedGoogle Scholar
• Baldwin, K. K., B. P. Trenchak, J. D. Altman, and M. M. Davis. 1999. Negative selection of T cells occurs throughout thymic development. J. Immunol. 163:689–698.
   PubMed Web of Science ®Google Scholar
• Barton, G. M., and A. Y. Rudensky. 1999. Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283:67–70.
   PubMedGoogle Scholar
• Berg, L. J., B. Fazekas de St. Groth, A. M. Pullen, and M. M. Davis. 1989. Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection. Nature 340:559–562.
   PubMedGoogle Scholar
• Bowlus, C. L., J. Ahn, T. Chu, and J. R. Gruen. 1999. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cell. Immunol. 196:80–86.
   PubMedGoogle Scholar
• Carson, R. T., K. M. Vignali, D. L. Woodland, and D. A. Vignali. 1997. T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage. Immunity 7:387–399.
   PubMed Web of Science ®Google Scholar
• Cheunsuk, S., R. Sparks, J. K. Noveroske, T. Hsu, M. J. Justice, M. E. Gershwin, J. R. Gruen, and C. L. Bowlus. 2002. Expression, genomic structure and mapping of the thymus specific protease Prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility. J. Autoimmun. 18:311–316.
   PubMedGoogle Scholar
• Farr, A. G., D. J. Eisenhardt, and S. K. Anderson. 1986. Isolation of murine thymic epithelium and an improved method for its propagation in vitro. Anat. Rec. 216:85–94.
   PubMedGoogle Scholar
• Fink, P. J., and M. J. Bevan. 1978. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148:766–775.
   PubMedGoogle Scholar
• Fukui, Y., T. Ishimoto, M. Utsuyama, T. Gyotoku, T. Koga, K. Nakao, K. Hirokawa, M. Katsuki, and T. Sasazuki. 1997. Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 6:401–410.
   PubMed Web of Science ®Google Scholar
• Gapin, L., Y. Fukui, J. Kanellopoulos, T. Sano, A. Casrouge, V. Malier, E. Beaudoing, D. Gautheret, J. M. Claverie, T. Sasazuki, and P. Kourilsky. 1998. Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex. J. Exp. Med. 187:1871–1883.
   PubMed Web of Science ®Google Scholar
• Godfrey, D. I., S. J. Kinder, P. Silvera, and A. G. Baxter. 1997. Flow cytometric study of T cell development in NOD mice reveals a deficiency in αβTCR+CDR−CD8− thymocytes. J. Autoimmun. 10:279–285.
   PubMed Web of Science ®Google Scholar
• Hammond, K. J., D. G. Pellicci, L. D. Poulton, O. V. Naidenko, A. A. Scalzo, A. G. Baxter, and D. I. Godfrey. 2001. CD1d-restricted NKT cells: an interstrain comparison. J. Immunol. 167:1164–1173.
   PubMed Web of Science ®Google Scholar
• Hogquist, K. A., A. J. Tomlinson, W. C. Kieper, M. A. McGargill, M. C. Hart, S. Naylor, and S. C. Jameson. 1997. Identification of a naturally occurring ligand for thymic positive selection. Immunity 6:389–399.
   PubMedGoogle Scholar
• Honey, K., K. Benlagha, C. Beers, K. Forbush, L. Teyton, M. J. Kleijmeer, A. Y. Rudensky, and A. Bendelac. 2002. Thymocyte expression of cathepsin L is essential for NKT cell development. Nat. Immunol. 3:1069–1074.
   PubMedGoogle Scholar
• Kasai, M., E. Kominami, and T. Mizuochi. 1998. The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway. Eur. J. Immunol. 28:1867–1876.
   PubMedGoogle Scholar
• Kisielow, P., H. S. Teh, H. Bluthmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730–733.
   PubMed Web of Science ®Google Scholar
• Lie, B. A., L. M. Sollid, H. Ascher, J. Ek, H. E. Akselsen, K. S. Rønningen, E. Thorsby, and D. E. Undlien. 1999. A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease. Tissue Antigens 54:162–168.
   PubMed Web of Science ®Google Scholar
• Lie, B. A., J. A. Todd, F. Pociot, J. Nerup, H. E. Akselsen, G. Joner, K. Dahl-Jørgensen, K. S. Rønningen, E. Thorsby, and D. E. Undlien. 1999. The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. Am. J. Hum. Genet. 64:793–800.
   PubMedGoogle Scholar
• Mizuochi, T., M. Kasai, T. Kokuho, T. Kakiuchi, and K. Hirokawa. 1992. Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells. J. Exp. Med. 175:1601–1605.
   PubMedGoogle Scholar
• Nakagawa, T., W. Roth, P. Wong, A. Nelson, A. Farr, J. Deussing, J. A. Villadangos, H. Ploegh, C. Peters, and A. Y. Rudensky. 1998. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 280:450–453.
   PubMed Web of Science ®Google Scholar
• Oukka, M., P. Andre, P. Turmel, N. Besnard, V. Angevin, L. Karlsson, P. L. Trans, D. Charron, B. Bihain, K. Kosmatopoulos, and V. Lotteau. 1997. Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines. Eur. J. Immunol. 27:855–859.
   PubMed Web of Science ®Google Scholar
• Robinson, J. H., and A. A. Delvig. 2002. Diversity in MHC class II antigen presentation. Immunology 105:252–262.
   PubMedGoogle Scholar
• Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101:455–458.
   PubMed Web of Science ®Google Scholar
• Sant'Angelo, D. B., E. Robinson, C. A. Janeway, Jr., and L. K. Denzin. 2002. Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor. Eur. J. Immunol. 32:2510–2520.
   PubMed Web of Science ®Google Scholar
• Sant'Angelo, D. B., P. G. Waterbury, B. E. Cohen, W. D. Martin, L. Van Kaer, A. C. Hayday, and C. A. Janeway, Jr. 1997. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity 7:517–524.
   PubMed Web of Science ®Google Scholar
• Shi, G. P., R. A. Bryant, R. Riese, S. Verhelst, C. Driessen, Z. Li, D. Bromme, H. L. Ploegh, and H. A. Chapman. 2000. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J. Exp. Med. 191:1177–1186.
   PubMed Web of Science ®Google Scholar
• Tolosa, E., W. Li, Y. Yasuda, W. Wienhold, L. K. Denzin, A. Lautwein, C. Driessen, P. Schnorrer, E. Weber, S. Stevanovic, R. Kurek, A. Melms, and D. Bromme. 2003. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J. Clin. Investig. 112:517–526.
   PubMed Web of Science ®Google Scholar
• Tourne, S., T. Miyazaki, A. Oxenius, L. Klein, T. Fehr, B. Kyewski, C. Benoist, and D. Mathis. 1997. Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice. Immunity 7:187–195.
   PubMedGoogle Scholar
• Villadangos, J. A., R. A. Bryant, J. Deussing, C. Driessen, A. M. Lennon-Dumenil, R. J. Riese, W. Roth, P. Saftig, G. P. Shi, H. A. Chapman, C. Peters, and H. L. Ploegh. 1999. Proteases involved in MHC class II antigen presentation. Immunol. Rev. 172:109–120.
   PubMed Web of Science ®Google Scholar
• Wu, A. J., H. Hua, S. H. Munson, and H. O. McDevitt. 2002. Tumor necrosis factor-α regulation of CD+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA 99:12287–12292.
   PubMed Web of Science ®Google Scholar