Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP

REFERENCES

• Ahmad, F., and B. J. Goldstein. 1997. Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. J. Biol. Chem. 272:448–457.
   PubMed Web of Science ®Google Scholar
• Andersen, J. N., O. H. Mortensen, G. H. Peters, P. G. Drake, L. F. Iversen, O. H. Olsen, P. G. Jansen, H. S. Andersen, N. K. Tonks, and N. P. Moller. 2001. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol. Cell. Biol. 21:7117–7136.
   PubMed Web of Science ®Google Scholar
• Bevan, P. 2001. Insulin signalling. J. Cell Sci. 114:1429–1430.
   PubMed Web of Science ®Google Scholar
• Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820.
   PubMed Web of Science ®Google Scholar
• Bruning, J. C., D. Gautam, D. J. Burks, J. Gillette, M. Schubert, P. C. Orban, R. Klein, W. Krone, D. Muller-Wieland, and C. R. Kahn. 2000. Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122–2125.
   PubMed Web of Science ®Google Scholar
• Buckley, D. A., A. Cheng, P. A. Kiely, M. L. Tremblay, and R. O'Connor. 2002. Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol. Cell. Biol. 22:1998–2010.
   PubMed Web of Science ®Google Scholar
• Cheng, A., G. S. Bal, B. P. Kennedy, and M. L. Tremblay. 2001. Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B. J. Biol. Chem. 276:25848–25855.
   PubMedGoogle Scholar
• Drake, P. G., and B. I. Posner. 1998. Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action. Mol. Cell. Biochem. 182:79–89.
   PubMed Web of Science ®Google Scholar
• Dube, N., A. Cheng, and M. L. Tremblay. 2004. The role of protein tyrosine phosphatase 1B in Ras signaling. Proc. Natl. Acad. Sci. USA 101:1834–1839.
   PubMedGoogle Scholar
• Dykxhoorn, D. M., C. D. Novina, and P. A. Sharp. 2003. Killing the messenger: short RNAs that silence gene expression. Nat. Rev. Mol. Cell Biol. 4:457–467.
   PubMed Web of Science ®Google Scholar
• Eck, M. J., S. Dhe-Paganon, T. Trub, R. T. Nolte, and S. E. Shoelson. 1996. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell 85:695–705.
   PubMed Web of Science ®Google Scholar
• Elchebly, M., P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, A. L. Loy, D. Normandin, A. Cheng, J. Himms-Hagen, C. C. Chan, C. Ramachandran, M. J. Gresser, M. L. Tremblay, and B. P. Kennedy. 1999. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544–1548.
   PubMed Web of Science ®Google Scholar
• Faria, T. N., V. A. Blakesley, H. Kato, B. Stannard, D. LeRoith, and C. T. Roberts, Jr. 1994. Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J. Biol. Chem. 269:13922–13928.
   PubMedGoogle Scholar
• Flint, A. J., T. Tiganis, D. Barford, and N. K. Tonks. 1997. Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl. Acad. Sci. USA 94:1680–1685.
   PubMed Web of Science ®Google Scholar
• Frangioni, J. V., P. H. Beahm, V. Shifrin, C. A. Jost, and B. G. Neel. 1992. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68:545–560.
   PubMed Web of Science ®Google Scholar
• Galic, S., M. Klingler-Hoffmann, M. T. Fodero-Tavoletti, M. A. Puryer, T. C. Meng, N. K. Tonks, and T. Tiganis. 2003. Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol. Cell. Biol. 23:2096–2108.
   PubMed Web of Science ®Google Scholar
• Gambhir, K. K., J. A. Archer, and C. J. Bradley. 1978. Characteristics of human erythrocyte insulin receptors. Diabetes 27:701–708.
   PubMed Web of Science ®Google Scholar
• Goldstein, B. J. 2002. Protein-tyrosine phosphatases: emerging targets for therapeutic intervention in type 2 diabetes and related states of insulin resistance. J. Clin. Endocrinol. Metab. 87:2474–2480.
   PubMed Web of Science ®Google Scholar
• Goldstein, B. J., F. Ahmad, W. Ding, P. M. Li, and W. R. Zhang. 1998. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182:91–99.
   PubMed Web of Science ®Google Scholar
• Goldstein, B. J., A. Bittner-Kowalczyk, M. F. White, and M. Harbeck. 2000. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J. Biol. Chem. 275:4283–4289.
   PubMed Web of Science ®Google Scholar
• Gottschalk, W. K., R. Lammers, and A. Ullrich. 1992. The carboxy terminal 110 amino acid portion of the insulin receptor is important for insulin signalling to pyruvate dehydrogenase. Biochem. Biophys. Res. Commun. 189:906–911.
   PubMedGoogle Scholar
• Gum, R. J., L. L. Gaede, S. L. Koterski, M. Heindel, J. E. Clampit, B. A. Zinker, J. M. Trevillyan, R. G. Ulrich, M. R. Jirousek, and C. M. Rondinone. 2003. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52:21–28.
   PubMed Web of Science ®Google Scholar
• Haj, F. G., B. Markova, L. D. Klaman, F. D. Bohmer, and B. G. Neel. 2003. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J. Biol. Chem. 278:739–744.
   PubMed Web of Science ®Google Scholar
• Hashimoto, N., E. P. Feener, W. R. Zhang, and B. J. Goldstein. 1992. Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J. Biol. Chem. 267:13811–13814.
   PubMed Web of Science ®Google Scholar
• Ibarra-Sanchez, M., P. D. Simoncic, F. R. Nestel, P. Duplay, W. S. Lapp, and M. L. Tremblay. 2000. The T-cell protein tyrosine phosphatase. Semin. Immunol. 12:379–386.
   PubMed Web of Science ®Google Scholar
• Ibarra-Sanchez, M. J., J. Wagner, M. T. Ong, C. Lampron, and M. L. Tremblay. 2001. Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-κB activation. Oncogene 20:4728–4739.
   PubMedGoogle Scholar
• Iversen, L. F., K. B. Moller, A. K. Pedersen, G. H. Peters, A. S. Petersen, H. S. Andersen, S. Branner, S. B. Mortensen, and N. P. Moller. 2002. Structure determination of T cell protein tyrosine phosphatase. J. Biol. Chem. 20:20.
   Google Scholar
• Jiang, Z. Y., Y. W. Lin, A. Clemont, E. P. Feener, K. D. Hein, M. Igarashi, T. Yamauchi, M. F. White, and G. L. King. 1999. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Investig. 104:447–457.
   PubMed Web of Science ®Google Scholar
• Johnson, T. O., J. Ermolieff, and M. R. Jirousek. 2002. Protein tyrosine phosphatase 1B inhibitors for diabetes. Nat. Rev. Drug. Discov. 1:696–709.
   PubMed Web of Science ®Google Scholar
• Klaman, L. D., O. Boss, O. D. Peroni, J. K. Kim, J. L. Martino, J. M. Zabolotny, N. Moghal, M. Lubkin, Y. B. Kim, A. H. Sharpe, A. Stricker-Krongrad, G. I. Shulman, B. G. Neel, and B. B. Kahn. 2000. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 20:5479–5489.
   PubMed Web of Science ®Google Scholar
• Kohanski, R. A. 1993. Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites. Biochemistry 32:5773–5780.
   PubMed Web of Science ®Google Scholar
• Kuboki, K., Z. Y. Jiang, N. Takahara, S. W. Ha, M. Igarashi, T. Yamauchi, E. P. Feener, T. P. Herbert, C. J. Rhodes, and G. L. King. 2000. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 101:676–681.
   PubMed Web of Science ®Google Scholar
• Kulas, D. T., B. J. Goldstein, and R. A. Mooney. 1996. The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases. J. Biol. Chem. 271:748–754.
   PubMed Web of Science ®Google Scholar
• Kulas, D. T., W. R. Zhang, B. J. Goldstein, R. W. Furlanetto, and R. A. Mooney. 1995. Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR. J. Biol. Chem. 270:2435–2438.
   PubMed Web of Science ®Google Scholar
• Lam, M. H., B. J. Michell, M. T. Fodero-Tavoletti, B. E. Kemp, N. K. Tonks, and T. Tiganis. 2001. Cellular stress regulates the nucleocytoplasmic distribution of the protein tyrosine phosphatase TCPTP. J. Biol. Chem. 276:37700–37707.
   PubMedGoogle Scholar
• Mahadev, K., H. Motoshima, X. Wu, J. M. Ruddy, R. S. Arnold, G. Cheng, J. D. Lambeth, and B. J. Goldstein. 2004. The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol. Cell. Biol. 24:1844–1854.
   PubMed Web of Science ®Google Scholar
• Mahadev, K., A. Zilbering, L. Zhu, and B. J. Goldstein. 2001. Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J. Biol. Chem. 276:21938–21942.
   PubMed Web of Science ®Google Scholar
• Meng, T. C., D. A. Buckley, S. Galic, T. Tiganis, and N. K. Tonks. 2004. Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J. Biol. Chem. 279:37716–37725.
   PubMed Web of Science ®Google Scholar
• Nef, S., S. Verma-Kurvari, J. Merenmies, J. D. Vassalli, A. Efstratiadis, D. Accili, and L. F. Parada. 2003. Testis determination requires insulin receptor family function in mice. Nature 426:291–295.
   PubMed Web of Science ®Google Scholar
• Persson, C., C. Savenhed, A. Bourdeau, M. L. Tremblay, B. Markova, F. D. Bohmer, F. G. Haj, B. G. Neel, A. Elson, C. H. Heldin, L. Ronnstrand, A. Ostman, and C. Hellberg. 2004. Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 24:2190–2201.
   PubMed Web of Science ®Google Scholar
• Ramachandran, C., R. Aebersold, N. K. Tonks, and D. A. Pot. 1992. Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases. Biochemistry 31:4232–4238.
   PubMedGoogle Scholar
• Robinson, T. J., J. A. Archer, K. K. Gambhir, V. W. Hollis, Jr., L. Carter, C. Bradley, and C. J. Bradley. 1979. Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans. Characteristics of human erythrocyte insulin receptors. Science 205:200–202.
   PubMed Web of Science ®Google Scholar
• Rondinone, C. M., J. M. Trevillyan, J. Clampit, R. J. Gum, C. Berg, P. Kroeger, L. Frost, B. A. Zinker, R. Reilly, R. Ulrich, M. Butler, B. P. Monia, M. R. Jirousek, and J. F. Waring. 2002. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes 51:2405–2411.
   PubMed Web of Science ®Google Scholar
• Salmeen, A., J. N. Andersen, M. P. Myers, N. K. Tonks, and D. Barford. 2000. Molecular basis for recognition and dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol. Cell 6:1401–1412.
   PubMed Web of Science ®Google Scholar
• Saltiel, A. R., and C. R. Kahn. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799–806.
   PubMed Web of Science ®Google Scholar
• Schubert, M., D. Gautam, D. Surjo, K. Ueki, S. Baudler, D. Schubert, T. Kondo, J. Alber, N. Galldiks, E. Kustermann, S. Arndt, A. H. Jacobs, W. Krone, C. R. Kahn, and J. C. Bruning. 2004. Role for neuronal insulin resistance in neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 101:3100–3105.
   PubMed Web of Science ®Google Scholar
• Shimizu, S., H. Maegawa, K. Egawa, K. Shi, M. Bryer-Ash, and A. Kashiwagi. 2002. Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes. Endocrinology 143:4563–4569.
   PubMedGoogle Scholar
• Simoncic, P. D., A. Lee-Loy, D. L. Barber, M. L. Tremblay, and C. J. McGlade. 2002. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12:446–453.
   PubMed Web of Science ®Google Scholar
• Tartare, S., I. Mothe, A. Kowalski-Chauvel, J. P. Breittmayer, R. Ballotti, and E. Van Obberghen. 1994. Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor. J. Biol. Chem. 269:11449–11455.
   PubMed Web of Science ®Google Scholar
• Tatar, M., A. Bartke, and A. Antebi. 2003. The endocrine regulation of aging by insulin-like signals. Science 299:1346–1351.
   PubMed Web of Science ®Google Scholar
• Tavare, J. M., R. M. O'Brien, K. Siddle, and R. M. Denton. 1988. Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping. Biochem. J. 253:783–788.
   PubMedGoogle Scholar
• ten Hoeve, J., M. J. Ibarra-Sanchez, Y. Fu, W. Zhu, M. Tremblay, M. David, and K. Shuai. 2002. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 22:5662–5668.
   PubMed Web of Science ®Google Scholar
• Tiganis, T. 2002. Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor. IUBMB Life 53:3–14.
   PubMedGoogle Scholar
• Tiganis, T., A. M. Bennett, K. S. Ravichandran, and N. K. Tonks. 1998. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 18:1622–1634.
   PubMed Web of Science ®Google Scholar
• Tonks, N. K. 2003. PTP1B: from the sidelines to the front lines. FEBS Lett. 546:140–148.
   PubMed Web of Science ®Google Scholar
• Tonks, N. K., and B. G. Neel. 2001. Combinatorial control of the specificity of protein tyrosine phosphatases. Curr. Opin. Cell Biol. 13:182–195.
   PubMed Web of Science ®Google Scholar
• White, M. F. 1997. The insulin signalling system and the IRS proteins. Diabetologia 2(Suppl. 40):S2–S17.
   Google Scholar
• White, M. F. 1998. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182:3–11.
   PubMed Web of Science ®Google Scholar
• You-Ten, K. E., E. S. Muise, A. Itie, E. Michaliszyn, J. Wagner, S. Jothy, W. S. Lapp, and M. L. Tremblay. 1997. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J. Exp. Med. 186:683–693.
   PubMed Web of Science ®Google Scholar
• Zabolotny, J. M., K. K. Bence-Hanulec, A. Stricker-Krongrad, F. Haj, Y. Wang, Y. Minokoshi, Y. B. Kim, J. K. Elmquist, L. A. Tartaglia, B. B. Kahn, and B. G. Neel. 2002. PTP1B regulates leptin signal transduction in vivo. Dev. Cell. 2:489–495.
   PubMed Web of Science ®Google Scholar
• Zabolotny, J. M., Y. B. Kim, O. D. Peroni, J. K. Kim, M. A. Pani, O. Boss, L. D. Klaman, S. Kamatkar, G. I. Shulman, B. B. Kahn, and B. G. Neel. 2001. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc. Natl. Acad. Sci. USA 98:5187–5192.
   PubMed Web of Science ®Google Scholar
• Zhang, W. R., P. M. Li, M. A. Oswald, and B. J. Goldstein. 1996. Modulation of insulin signal transduction by ectopic overexpression of the receptor-type protein-tyrosine phosphatase LAR. Mol. Endocrinol. 10:575–584.
   PubMed Web of Science ®Google Scholar
• Zinker, B. A., C. M. Rondinone, J. M. Trevillyan, R. J. Gum, J. E. Clampit, J. F. Waring, N. Xie, D. Wilcox, P. Jacobson, L. Frost, P. E. Kroeger, R. M. Reilly, S. Koterski, T. J. Opgenorth, R. G. Ulrich, S. Crosby, M. Butler, S. F. Murray, R. A. McKay, S. Bhanot, B. P. Monia, and M. R. Jirousek. 2002. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc. Natl. Acad. Sci. USA 99:11357–11362.
   PubMed Web of Science ®Google Scholar