REFERENCES
- Atwal, J. K., B. Massie, F. D. Miller, and D. R. Kaplan. 2000. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and PI3-kinase. Neuron 27:265–277.
- Bar-Sagi, D., and J. R. Feramisco. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42:841–848.
- Bernards, A., and J. Settleman. 2004. GAP control: regulating the regulators of small GTPases. Trends Cell Biol. 14:377–385.
- Bos, J. L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49:4682–4689.
- Bos, J. L., K. de Bruyn, J. Enserink, B. Kuiperij, S. Rangarajan, H. Rehmann, J. Riedl, J. de Rooij, F. van Mansfeld, and F. Zwartkruis. 2003. The role of Rap1 in integrin-mediated cell adhesion. Biochem. Soc. Trans. 31:83–86.
- Campbell, S. L., R. Khosravi-Far, K. L. Rossman, G. J. Clark, and C. J. Der. 1998. Increasing complexity of Ras signaling. Oncogene 17:1395–1413.
- Chan, A. M., T. Miki, K. A. Meyers, and S. A. Aaronson. 1994. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. Proc. Natl. Acad. Sci. USA 91:7558–7562.
- Chao, M. V. 2003. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4:299–309.
- Chen, X. Q., I. Tan, T. Leung, and L. Lim. 1999. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells. J. Biol. Chem. 274:19901–19905.
- Chin, P. C., L. Liu, B. E. Morrison, A. Siddiq, R. R. Ratan, T. Bottiglieri, and S. R. D'Mello. 2004. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J. Neurochem. 90:595–608.
- Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841–852.
- Cuenda, A., and D. R. Alessi. 2000. Use of kinase inhibitors to dissect signaling pathways. Methods Mol. Biol. 99:161–175.
- Daniels, R. H., P. S. Hall, and G. M. Bokoch. 1998. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J. 17:754–764.
- Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494–498.
- Elbashir, S. M., J. Harborth, K. Weber, and T. Tuschl. 2002. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26:199–213.
- Elbashir, S. M., W. Lendeckel, and T. Tuschl. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:188–200.
- Fukuda, M., Y. Gotoh, T. Tachibana, K. Dell, S. Hattori, Y. Yoneda, and E. Nishida. 1995. Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene 11:239–244.
- Gibbs, J. B. 1995. Determination of guanine nucleotides bound to Ras in mammalian cells. Methods Enzymol. 255:118–125.
- Goi, T., G. Rusanescu, T. Urano, and L. A. Feig. 1999. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol. Cell. Biol. 19:1731–1741.
- Greene, L. A., and A. S. Tischler. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73:2424–2428.
- He, T. C., S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, and B. Vogelstein. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95:2509–2514.
- Hindley, A., and W. Kolch. 2002. Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J. Cell Sci. 115:1575–1581.
- Huang, E. J., and L. F. Reichardt. 2001. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 24:677–736.
- Huber, A. B., A. L. Kolodkin, D. D. Ginty, and J. F. Cloutier. 2003. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu. Rev. Neurosci. 26:509–563.
- Hynds, D. L., M. L. Spencer, D. A. Andres, and D. M. Snow. 2003. Rit promotes MEK-independent neurite branching in human neuroblastoma cells. J. Cell Sci. 116:1925–1935.
- Im, E., F. C. von Lintig, J. Chen, S. Zhuang, W. Qui, S. Chowdhury, P. F. Worley, G. R. Boss, and R. B. Pilz. 2002. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene 21:6356–6365.
- Iwasaki, S., M. Iguchi, K. Watanabe, R. Hoshino, M. Tsujimoto, and M. Kohno. 1999. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2. J. Biol. Chem. 274:26503–26510.
- Kimmelman, A., T. Tolkacheva, M. V. Lorenzi, M. Osada, and A. M. Chan. 1997. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. Oncogene 15:2675–2685.
- Kimmelman, A. C., N. Nunez Rodriguez, and A. M. Chan. 2002. R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade. Mol. Cell. Biol. 22:5946–5961.
- Kimura, K., S. Hattori, Y. Kabuyama, Y. Shizawa, J. Takayanagi, S. Nakamura, S. Toki, Y. Matsuda, K. Onodera, and Y. Fukui. 1994. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 269:18961–18967.
- Lee, C. H. J., N. G. Della, C. E. Chew, and D. J. Zack. 1996. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J. Neurosci. 16:6784–6794.
- Leppa, S., R. Saffrich, W. Ansorge, and D. Bohmann. 1998. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17:4404–4413.
- Markus, A., T. D. Patel, and W. D. Snider. 2002. Neurotrophic factors and axonal growth. Curr. Opin. Neurobiol. 12:523–531.
- Matsumoto, K., T. Asano, and T. Endo. 1997. Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. Oncogene 15:2409–2417.
- Miura, T., S. Tanaka, A. Seichi, M. Arai, T. Goto, H. Katagiri, T. Asano, H. Oda, and K. Nakamura. 2000. Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1. Exp. Neurol. 166:115–126.
- Morooka, T., and E. Nishida. 1998. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J. Biol. Chem. 273:24285–24288.
- Morrison, D. K., and R. J. Davis. 2003. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev Biol. 19:91–118.
- Nassar, N., G. Horn, C. Herrmann, A. Scherer, F. McCormick, and A. Wittinghofer. 1995. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature 375:554–560.
- New, L., Y. Li, B. Ge, H. Zhong, J. Mansbridge, K. Liu, and J. Han. 2001. SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway. J. Cell Biochem. 83:585–596.
- Park, K. S., R. D. Lee, S. K. Kang, S. Y. Han, K. L. Park, K. H. Yang, Y. S. Song, H. J. Park, Y. M. Lee, Y. P. Yun, K. W. Oh, D. J. Kim, Y. W. Yun, S. J. Hwang, S. E. Lee, and J. T. Hong. 2004. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Exp. Cell Res. 297:424–433.
- Pearson, G., R. Bumeister, D. O. Henry, M. H. Cobb, and M. A. White. 2000. Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. J. Biol. Chem. 275:37303–37306.
- Pittman, R. N., S. Wang, A. J. DiBenedetto, and J. C. Mills. 1993. A system for characterizing cellular and molecular events in programmed neuronal cell death. J. Neurosci. 13:3669–3680.
- Pritchard, C. A., L. Hayes, L. Wojnowski, A. Zimmer, R. M. Marais, and J. C. Norman. 2004. B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Mol. Cell. Biol. 24:5937–5952.
- Quilliam, L. A., J. F. Rebhun, and A. F. Castro. 2002. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71:391–444.
- Reuther, G. W., and C. J. Der. 2000. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr. Opin. Cell Biol. 12:157–165.
- Rosario, M., H. F. Paterson, and C. J. Marshall. 2001. Activation of the Ral and phosphatidylinositol 3′ kinase signaling pathways by the Ras-related protein TC21. Mol. Cell. Biol. 21:3750–3762.
- Roux, P. P., and J. Blenis. 2004. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68:320–344.
- Rusanescu, G., H. Qi, S. M. Thomas, J. S. Brugge, and S. Halegoua. 1995. Calcium influx induces neurite growth through a Src-Ras signaling cassette. Neuron 15:1415–1425.
- Rusyn, E. V., E. R. Reynolds, H. Shao, T. M. Grana, T. O. Chan, D. A. Andres, and A. D. Cox. 2000. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene 19:4685–4694.
- Saez, R., A. M. Chan, T. Miki, and S. A. Aaronson. 1994. Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes. Oncogene 9:2977–2982.
- Sakabe, K., H. Teramoto, M. Zohar, B. Behbahani, H. Miyazaki, H. Chikumi, and J. S. Gutkind. 2002. Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway. FEBS Lett. 511:15–20.
- Satoh, T., and Y. Kaziro. 1995. Measurement of Ras-bound guanine nucleotide in stimulated hematopoietic cells. Methods Enzymol. 255:149–155.
- Segal, R. A., and M. E. Greenberg. 1996. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19:463–489.
- Self, A. J., E. Caron, H. F. Paterson, and A. Hall. 2001. Analysis of R-Ras signalling pathways. J. Cell Sci. 114:1357–1366.
- Shao, H., and D. A. Andres. 2000. A novel RalGEF-like protein, RGL3, as a candidate effector for Rit and Ras. J. Biol. Chem. 275:26914–26924.
- Shao, H., K. Kadono-Okuda, B. S. Finlin, and D. A. Andres. 1999. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch. Biochem. Biophys. 371:207–219.
- Sjogreen, B., P. Wiklund, and P. A. Ekstrom. 2000. Mitogen activated protein kinase inhibition by PD98059 blocks nerve growth factor stimulated axonal outgrowth from adult mouse dorsal root ganglia in vitro. Neuroscience 100:407–416.
- Snider, W. D., F. Q. Zhou, J. Zhong, and A. Markus. 2002. Signaling the pathway to regeneration. Neuron 35:13–16.
- Spencer, M. L., H. Shao, and D. A. Andres. 2002. Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase. J. Biol. Chem. 277:20160–20168.
- Spencer, M. L., H. Shao, H. M. Tucker, and D. A. Andres. 2002. Nerve growth factor-dependent activation of the small GTPase Rin. J. Biol. Chem. 277:17605–17615.
- Stork, P. J. 2003. Does Rap1 deserve a bad Rap. Trends Biochem. Sci. 28:267–275.
- Storm, S. M., J. L. Cleveland, and U. R. Rapp. 1990. Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene 5:345–351.
- Szeberenyi, J., H. Cai, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10:5324–5332.
- Takai, Y., T. Sasaki, and T. Matozaki. 2001. Small GTP-binding proteins. Physiol. Rev. 81:153–208.
- Takeda, K., and H. Ichijo. 2002. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Genes Cells 7:1099–1111.
- Vaudry, D., P. J. Stork, P. Lazarovici, and L. E. Eiden. 2002. Signaling pathways for PC12 cell differentiation: making the right connections. Science 296:1648–1649.
- Vossler, M. R., H. Yao, R. D. York, M. G. Pan, C. S. Rim, and P. J. Stork. 1997. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73–82.
- Watson, F. L., H. M. Heerssen, A. Bhattacharyya, L. Klesse, M. Z. Lin, and R. A. Segal. 2001. Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat. Neurosci. 4:981–988.
- Wes, P. D., M. Yu, and C. Montell. 1996. RIC, a calmodulin-binding Ras-like GTPase. EMBO J. 15:5839–5848.
- Wiese, S., G. Pei, C. Karch, J. Troppmair, B. Holtmann, U. R. Rapp, and M. Sendtner. 2001. Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons. Nat. Neurosci. 4:137–142.
- Wood, K. W., H. Qi, G. D'Arcangelo, R. C. Armstrong, T. M. Roberts, and S. Halegoua. 1993. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc. Natl. Acad. Sci. USA 90:5016–5020.
- Wood, K. W., C. Sarnecki, T. M. Roberts, and J. Blenis. 1992. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68:1041–1050.
- Wooten, M. W., M. L. Vandenplas, M. L. Seibenhener, T. Geetha, and M. T. Diaz-Meco. 2001. Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol. Cell. Biol. 21:8414–8427.
- Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326–1331.
- Xing, J., J. M. Kornhauser, Z. Xia, E. A. Thiele, and M. E. Greenberg. 1998. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell. Biol. 18:1946–1955.
- Yamaguchi, O., T. Watanabe, K. Nishida, K. Kashiwase, Y. Higuchi, T. Takeda, S. Hikoso, S. Hirotani, M. Asahi, M. Taniike, A. Nakai, I. Tsujimoto, Y. Matsumura, J. Miyazaki, K. R. Chien, A. Matsuzawa, C. Sadamitsu, H. Ichijo, M. Baccarini, M. Hori, and K. Otsu. 2004. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J. Clin. Investig. 114:937–943.
- York, R. D., H. Yao, T. Dillon, C. L. Ellig, S. P. Eckert, E. W. McCleskey, and P. J. Stork. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622–626.
- Zhang, B. H., and K. L. Guan. 2000. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 19:5429–5439.