36
Views
76
CrossRef citations to date
0
Altmetric
Intracellular Trafficking

Ytm1, Nop7, and Erb1 Form a Complex Necessary for Maturation of Yeast 66S Preribosomes

, , , , &
Pages 10419-10432 | Received 02 Mar 2005, Accepted 20 Sep 2005, Published online: 27 Mar 2023

REFERENCES

  • Adams, C. C., J. Jakovljevic, J. Roman, P. Harnpicharnchai, and J. L. Woolford, Jr. 2002. Saccharomyces cerevisiae nucleolar protein Nop7 is necessary for biogenesis of 60S ribosomal subunits. RNA 8:150–165.
  • Andersen, J. S., C. E. Lyon, A. H. Fox, A. K. L. Leung, Y. W. Lam, H. Steen, M. Mann, and A. I. Lamond. 2002. Directed proteomic analysis of the human nucleolus. Curr. Biol. 12:1–11.
  • Baβler, J., P. Grandi, O. Gadal, T. Lessmann, E. Petfalski, D. Tollervey, J. Lechner, and E. Hurt. 2001. Identification of a 60S pre-ribosomal particle that is closely linked to nuclear export. Mol. Cell 8:517–529.
  • Basu, U., K. Si, J. R. Warner, and U. Maitra. 2001. The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis. Mol. Cell. Biol. 21:1453–1462.
  • Cagney, G., P. Uetz, and S. Fields. 2001. Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Physiol. Genomics 7:27–34.
  • de Beus, E., J. S. Brockenbrough, B. Hong, and J. P. Aris. 1994. Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. J. Cell Biol. 127:1799–1813.
  • Dragon, F., J. E. Gallagher, P. A. Compagnone-Post, B. M. Mitchell, K. A. Porwancher, K. A. Wehner, S. Wormsley, R. E. Settlage, J. Shabanowitz, Y. Osheim, A. L. Beyer, D. F. Hunt, and S. J. Baserga. 2002. A large U3 snoRNP complex which is required for 18S rRNA biogenesis. Nature 417:967–970.
  • Du, Y. C., and B. Stillman. 2002. Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109:835–848.
  • Dunbar, D. A., F. Dragon, S. J. Lee, and S. J. Baserga. 2000. A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis. Proc. Natl. Acad. Sci. USA 97:13027–13032.
  • Emery, B., J. de la Cruz, S. Rocak, O. Deloche, and P. Linder. 2004. Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae.. Mol. Microbiol. 52:141–158.
  • Fatica, A., A. D. Cronshaw, M. Dlakic, and D. Tollervey. 2002. Ssf1p prevents premature processing of an early pre-60S ribosomal particle. Mol. Cell 9:341–351.
  • Fatica, A., and D. Tollervey. 2002. Making ribosomes. Curr. Opin. Cell Biol. 14:313–318.
  • Fatica, A., M. Oeffinger, D. Tollervey, and I. Bozzoni. 2003. Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits. RNA 9:1431–1436.
  • Fromont-Racine, M., B. Senger, C. Saveanu, and F. Fasiolo. 2003. Ribosome assembly in eukaryotes. Gene 313:17–42.
  • Gadal, O., D. Strauss, E. Petfalski, P. E. Gleizes, N. Gas, D. Tollervey, and E. Hurt. 2002. Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing. J. Cell Biol. 157:941–951.
  • Gaudet, R., A. Bohm, and P. B. Sigler. 1996. Crystal structure at 2.4 Å resolution of the complex of transducinβγ and its regulator, phosducin. Cell 87:577–588.
  • Gavin, A. C., M. Bosche, R. Krause, P. Grandi, M. Marzioch, A. Bauer, J. Schultz, J. M. Rick, A. M. Michon, C. M. Cruciat, M. Remor, C. Hofert, M. Schelder, M. Brajenovic, H. Ruffner, A. Merino, K. Klein, M. Hudak, D. Dickson, T. Rudi, V. Gnau, A. Bauch, S. Bastuck, B. Huhse, C. Leutwein, M. A. Heurtier, R. R. Copley, A. Edelmann, E. Querfurth, V. Rybin, G. Drewes, M. Raida, T. Bouwmeester, P. Bork, B. Seraphin, B. Kuster, G. Neubauer, and G. Superti-Furga. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415:141–147.
  • Geerlings, T. H., J. C. Vos, and H. A. Raué. 2000. The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5′→3′ exonucleases. RNA 6:1698–1703.
  • Gelperin, D., L. Horton, J. Beckman, J. Hensold, and S. K. Lemmon. 2001. Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. RNA 9:1268–1283.
  • Grandi, P., V. Rybin, J. Bassler, E. Petfalski, D. Strauss, M. Marzioch, T. Schafer, B. Kuster, H. Tschochner, D. Tollervey, A. C. Gavin, and E. Hurt. 2002. 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol. Cell 10:105–115.
  • Harnpicharnchai, P., J. Jakovljevic, E. Horsey, T. Miles, J. Roman, M. Rout, D. Meagher, B. Imai, Y. Guo, C. J. Brame, J. Shabanowitz, D. F. Hunt., and J. L. Woolford, Jr. 2001. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol. Cell 8:505–515.
  • Hedges, J., M. West, and A. R. Johnson. 2005. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J. 24:567–579.
  • Henry, Y., H. Wood, J. P. Morrissey, E. Petfalski, S. Kearsey, and D. Tollervey. 1994. The 5′ end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site. EMBO J. 10:2452–2463.
  • Ho, Y., A. Gruhler, A. Heilbut, G. D. Bader, L. Moore, S. L. Adams, A. Millar, P. Taylor, K. Bennett, K. Boutilier, L. Yang, C. Wolting, I. Donaldson, S. Schandorff, J. Shewnarane, M. Vo, J. Taggart, M. Goudreault, B. Muskat, C. Alfarano, D. Dewar, Z. Lin, K. Michalickova, A. R. Willems, H. Sassi, P. A. Nielsen, K. J. Rasmussen, J. R. Andersen, L. E. Johansen, L. H. Hansen, H. Jespersen, A. Podtelejnikov, E. Nielsen, J. Crawford, V. Poulsen, B. D. Sorensen, J. Matthiesen, R. C. Hendrickson, F. Gleeson, T. Pawson, M. F. Moran, D. Durocher, M. Mann, C. W. Hogue, D. Figeys, and M. Tyers. 2002. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415:180–183.
  • Hong, B., J. S. Brockenbrough, P. Wu, and J. P. Aris. 1997. Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. Mol. Cell. Biol. 17:378–388.
  • Horsey, E. W., J. Jakovljevic, T. D. Miles, P. Harnpicharnchai, and J. L. Woolford, Jr. 2004. Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10:813–827.
  • Huber, M. D., J. H. Dworet, K. Shire, L. Frappier, and M. A. McAlear. 2000. The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing. J. Biol. Chem. 275:28764–28773.
  • Hurt, E., S. Hannus, B. Schmeizl, D. Lau, D. Tollervey, and G. Simos. 1999. A novel in vivo assay reveals inhibition of ribosomal nuclear export in Ran-cycle and nucleoporin mutants. J. Cell Biol. 144:389–401.
  • James, P., J. Halladay, and E. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425–1436.
  • Kallstrom, G., J. Hedges, and A. Johnson. 2003. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol. Cell. Biol. 23:4344–4355.
  • Kaser, A., E. Bogengruber, M. Hallegger, E. Doppler, G. Lepperdinger, M. Jantsch, M. Breitenbach, and G. Kreil. 2001. Brix from Xenopus laevis and Brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. Biol. Chem. 382:1637–1647.
  • Krogan, N. J., W. T. Peng, G. Cagney, M. D. Robinson, R. Haw, G. Zhong, X. Guo, X. Zhang, V. Canadien, D. P. Richards, B. K. Beattie, A. Lalev, W. Zhang, A. P. Davierwala, S. Mnaimneh, A. Starostine, A. P. Tikuisis, J. Grigull, N. Datta, J. E. Bray, T. R. Hughes, A. Emili, and J. F. Greenblatt. 2004. High-definition macromolecular composition of yeast RNA-processing complexes. Mol. Cell 13:225–239.
  • Lambright, D. G., J. Sondek, A. Bohm, N. P. Skiba, H. E. Hamm, and P. B. Sigler. 1996. The 2Å crystal structure of a heterotrimeric G protein. Nature 379:311–319.
  • Lapik, Y. R., C. J. Fernandes, L. F. Lau, and D. G. Pestov. 2004. Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol. Cell 15:17–29.
  • Lerch-Gaggl, A., J. Haque, J. Li, G. Ning, P. Traktman, and S. A. Duncan. 2002. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J. Biol. Chem. 277:45347–45355.
  • Matsuzaki, F., S. Matsumoto, and I. Yahara. 1988. Truncation of the carboxy-terminal domain of yeast β-tubulin causes temperature-sensitive growth and hypersensitivity to antimitotic drugs. J. Cell Biol. 107:1427–1435.
  • Milkereit, P., O. Gadal, A. Podtelejnikov, S. Trumtel, N. Gas, E. Petfalski, D. Tollervey, M. Mann, E. Hurt, and H. Tschochner. 2001. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105:499–509.
  • Milkereit, P., D. Strauss, J. Bassler, O. Gadal, H. Kuhn, S. Schutz, N. Gas, J. Lechner, E. Hurt, and H. Tschochner. 2003. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. J. Biol. Chem. 278:4072–4081.
  • Morita, D., K. Miyoshi, Y. Matsui, A. Toh-E, H. Shinkawa, T. Miyakawa, and K. Mizuta. 2002. Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27SB pre-rRNA to 25S rRNA and the 60S ribosomal subunit assembly in Saccharomyces cerevisiae.. J. Biol. Chem. 32:28780–28786.
  • Neer, E. J., and T. F. Smith. 1996. G protein heterodimers: new structures propel new questions. Cell 84:175–178.
  • Nissan, T. A., J. Baβler, E. Petfalski, D. Tollervey, and E. Hurt. 2002. Pre-60S particles on the road to ribosomes. EMBO J. 21:5539–5547.
  • Oeffinger, M., A. Leung, A. Lamond, and D. Tollervey. 2002. Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis. RNA 8:626–636.
  • Ouspenski, I., S. J. Elledge, and B. R. Brinkley. 1999. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res. 27:3001–3008.
  • Pestov, D. G., M. G. Stockelman, Z. Strezoska, and L. F. Lau. 2001. ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. Nucleic Acids Res. 29:3621–3630.
  • Pestov, D. G., Ž. Strezoska, and L. F. Lau. 2001. Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G1/S transition. Mol. Cell. Biol. 21:4246–4255.
  • Raué, H. A. 2003. Pre-ribosomal RNA processing and assembly in Saccharomyces cerevisiae. The machine that makes the machine, p. 1–24. In M. O. J. Olson (ed.), The nucleolus. Kluwer Academic/Plenum Publishers, Dordrecht, The Netherlands.
  • Rigaut, G., A. Shevchenko, B. Rutz, M. Wilm, M. Mann, and B. Seraphin. 1999. A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17:1030–1032.
  • Ripmaster, T. L., G. P. Vaughn, and J. L. Woolford, Jr. 1992. A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Proc. Natl. Acad. Sci. USA 89:11131–11135.
  • Saveanu, C., D. Bienvenu, A. Namane, P. E. Gleizes, N. Gas, A. Jacquier, and M. Fromont-Racine. 2001. Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. EMBO J. 20:6475–6484.
  • Saveanu, C., A. Namane, P.-E. Gleizes, A. Lebreton, J.-C. Rousselle, J. Noaillac-Depeyre, N. Gas, A. Jacquier, and M. Fromont-Racine. 2003. Sequential protein association with nascent 60S ribosomal particles. Mol. Cell. Biol. 23:4449–4460.
  • Schäfer, T., D. Strauβ, E. Petfalski, D. Tollervey, and E. Hurt. 2003. The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J. 22:1370–1380.
  • Scherl, A., Y. Coute, C. Deon, A. Calle, K. Kindbeiter, J.-C. Sanchez, A. Greco, D. Hochstrasser, and J. J. Diza. 2002. Functional proteomic analysis of the human nucleolus. Mol. Biol. Cell 13:4100–4109.
  • Smith, T. F., C. Gaitatzes, K. Sacena, and E. J. Neer. 1999. The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 24:181–185.
  • Sondek, J., A. Bohm, D. G. Lambright, H. E. Hamm, and P. B. Sigler. 1996. Crystal structure of a G protein βγ dimer at 2.1Å resolution. Nature 379:369–374.
  • Strezoska, Ž., D. G. Pestov, and L. F. Lau. 2000. Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5.8S rRNA processing and 60S ribosome biogenesis. Mol. Cell. Biol. 20:5516–5528.
  • Strezoska, Z., D. G. Pestov, and L. F. Lau. 2002. Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. J. Biol. Chem. 277:29617–29625.
  • Tsujii, R., K. Miyoshi, A. Tsuno, Y. Matsui, A. Toh-e, T. Miyakawa, and K. Mizuta. 2000. Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly. Genes Cells 5:543–553.
  • Venema, J., R. J. Planta, and H. A. Raue. 1998. In vivo mutational analysis of ribosomal RNA in Saccharomyces cerevisiae. Methods Mol. Biol. 77:257–270.
  • Wall, M. A., D. E. Coleman, E. Lee, J. A. Iniguez-Lluhi, B. A. Posner, A. G. Gilman, and S. R. Sprang. 1995. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83:1047–1058.
  • Wehner, K. A., and S. J. Baserga. 2002. The σ70-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol. Cell 9:329–339.
  • Zanchin, N. I., P. Roberts, A. DeSilva, F. Sherman, and D. S. Goldfarb. 1997. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Mol. Cell. Biol. 17:5001–5015.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.