Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

REFERENCES

• Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117:515–526.
   PubMed Web of Science ®Google Scholar
• Artavanis-Tsakonas, S., M. D. Rand, and R. J. Lake. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770–776.
   PubMed Web of Science ®Google Scholar
• Bertocci, B., A. De Smet, E. Flatter, A. Dahan, J. C. Bories, C. Landreau, J. C. Weill, and C. A. Reynaud. 2002. DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J. Immunol. 168:3702–3706.
   PubMedGoogle Scholar
• Corpet, F. 1988. Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res. 16:10881–10890.
   PubMed Web of Science ®Google Scholar
• Cui, X. Y., Q. D. Hu, M. Tekaya, Y. Shimoda, B. T. Ang, D. Y. Nie, L. Sun, W. P. Hu, M. Karsak, T. Duka, Y. Takeda, L. Y. Ou, G. S. Dawe, F. G. Yu, S. Ahmed, L. H. Jin, M. Schachner, K. Watanabe, Y. Arsenijevic, and Z. C. Xiao. 2004. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J. Biol. Chem. 279:25858–25865.
   PubMed Web of Science ®Google Scholar
• Deftos, M. L., Y. W. He, E. W. Ojala, and M. J. Bevan. 1998. Correlating notch signaling with thymocyte maturation. Immunity 9:777–786.
   PubMed Web of Science ®Google Scholar
• Eagar, T. N., Q. Tang, M. Wolfe, Y. He, W. S. Pear, and J. A. Bluestone. 2004. Notch 1 signaling regulates peripheral T cell activation. Immunity 20:407–415.
   PubMed Web of Science ®Google Scholar
• Endo, Y., N. Osumi, and Y. Wakamatsu. 2003. Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development. Dev. Growth Differ. 45:241–248.
   PubMedGoogle Scholar
• Frey, S., B. Bertocci, F. Delbos, L. Quint, J. C. Weill, and C. A. Reynaud. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9:127–134.
   PubMedGoogle Scholar
• Frolova, E., and D. Beebe. 2000. The expression pattern of a novel Deltex homologue during chicken embryogenesis. Mech. Dev. 92:285–289.
   PubMedGoogle Scholar
• Gorman, M. J., and J. R. Girton. 1992. A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131:99–112.
   PubMed Web of Science ®Google Scholar
• Gupta-Rossi, N., O. Le Bail, H. Gonen, C. Brou, F. Logeat, E. Six, A. Ciechanover, and A. Israel. 2001. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276:34371–34378.
   PubMedGoogle Scholar
• Gupta-Rossi, N., S. Storck, P. J. Griebel, C. A. Reynaud, J. C. Weill, and A. Dahan. 2003. Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Mol. Immunol. 39:791–799.
   PubMed Web of Science ®Google Scholar
• Harman, B. C., E. J. Jenkinson, and G. Anderson. 2003. Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors. J. Immunol. 170:1299–1303.
   PubMedGoogle Scholar
• Hu, Q. D., B. T. Ang, M. Karsak, W. P. Hu, X. Y. Cui, T. Duka, Y. Takeda, W. Chia, N. Sankar, Y. K. Ng, E. A. Ling, T. Maciag, D. Small, R. Trifonova, R. Kopan, H. Okano, M. Nakafuku, S. Chiba, H. Hirai, J. C. Aster, M. Schachner, C. J. Pallen, K. Watanabe, and Z. C. Xiao. 2003. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115:163–175.
   PubMed Web of Science ®Google Scholar
• Izon, D. J., J. C. Aster, Y. He, A. Weng, F. G. Karnell, V. Patriub, L. Xu, S. Bakkour, C. Rodriguez, D. Allman, and W. S. Pear. 2002. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16:231–243.
   PubMedGoogle Scholar
• Jehn, B. M., I. Dittert, S. Beyer, K. von der Mark, and W. Bielke. 2002. c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. J. Biol. Chem. 277:8033–8040.
   PubMed Web of Science ®Google Scholar
• Kishi, N., Z. Tang, Y. Maeda, A. Hirai, R. Mo, M. Ito, S. Suzuki, K. Nakao, T. Kinoshita, T. Kadesch, C. Hui, S. Artavanis-Tsakonas, H. Okano, and K. Matsuno. 2001. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int. J. Dev. Neurosci. 19:21–35.
   PubMedGoogle Scholar
• Kuroda, K., H. Han, S. Tani, K. Tanigaki, T. Tun, T. Furukawa, Y. Taniguchi, H. Kurooka, Y. Hamada, S. Toyokuni, and T. Honjo. 2003. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18:301–312.
   PubMed Web of Science ®Google Scholar
• Lai, E. C. 2004. Notch signaling: control of cell communication and cell fate. Development 131:965–973.
   PubMed Web of Science ®Google Scholar
• Lai, E. C. 2002. Protein degradation: four E3s for the notch pathway. Curr. Biol. 12:R74–R78.
   PubMedGoogle Scholar
• Le Borgne, R., and F. Schweisguth. 2003. Notch signaling: endocytosis makes delta signal better. Curr. Biol. 13:R273–R275.
   PubMedGoogle Scholar
• Loder, F., B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190:75–89.
   PubMed Web of Science ®Google Scholar
• Martinez Arias, A., V. Zecchini, and K. Brennan. 2002. CSL-independent Notch signalling: a checkpoint in cell fate decisions during development. Curr. Opin. Genet. Dev. 12:524–533.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., R. J. Diederich, M. J. Go, C. M. Blaumueller, and S. Artavanis-Tsakonas. 1995. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121:2633–2644.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., D. Eastman, T. Mitsiades, A. M. Quinn, M. L. Carcanciu, P. Ordentlich, T. Kadesch, and S. Artavanis-Tsakonas. 1998. Human deltex is a conserved regulator of Notch signalling. Nat. Genet. 19:74–78.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., M. Ito, K. Hori, F. Miyashita, S. Suzuki, N. Kishi, S. Artavanis-Tsakonas, and H. Okano. 2002. Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development 129:1049–1059.
   PubMedGoogle Scholar
• McGill, M. A., and C. J. McGlade. 2003. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J. Biol. Chem. 278:23196–23203.
   PubMed Web of Science ®Google Scholar
• McKenzie, G. J., L. L. Young, E. Briend, J. R. Lamb, M. J. Dallman, and B. R. Champion. 2003. Notch signalling in the regulation of peripheral T-cell function. Semin. Cell Dev. Biol. 14:127–134.
   PubMed Web of Science ®Google Scholar
• Mitsiadis, T. A., O. Gayet, N. Zhang, and P. Carroll. 2001. Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression. Mech. Dev. 109:399–403.
   PubMedGoogle Scholar
• Ng, W. F., P. J. Duggan, F. Ponchel, G. Matarese, G. Lombardi, A. D. Edwards, J. D. Isaacs, and R. I. Lechler. 2001. Human CD4(+) CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 98:2736–2744.
   PubMed Web of Science ®Google Scholar
• Nie, L., M. Xu, A. Vladimirova, and X. H. Sun. 2003. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22:5780–5792.
   PubMed Web of Science ®Google Scholar
• Oberg, C., J. Li, A. Pauley, E. Wolf, M. Gurney, and U. Lendahl. 2001. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J. Biol. Chem. 276:35847–35853.
   PubMed Web of Science ®Google Scholar
• Ordentlich, P., A. Lin, C. P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsakonas, and T. Kadesch. 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18:2230–2239.
   PubMed Web of Science ®Google Scholar
• Pampeno, C. L., and D. Meruelo. 1996. A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas. Cell Growth Differ. 7:1113–1123.
   PubMedGoogle Scholar
• Pui, J. C., D. Allman, L. Xu, S. DeRocco, F. G. Karnell, S. Bakkour, J. Y. Lee, T. Kadesch, R. R. Hardy, J. C. Aster, and W. S. Pear. 1999. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11:299–308.
   PubMed Web of Science ®Google Scholar
• Radtke, F., A. Wilson, S. J. Mancini, and H. R. MacDonald. 2004. Notch regulation of lymphocyte development and function. Nat. Immunol. 5:247–253.
   PubMed Web of Science ®Google Scholar
• Radtke, F., A. Wilson, G. Stark, M. Bauer, J. van Meerwijk, H. R. MacDonald, and M. Aguet. 1999. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10:547–558.
   PubMed Web of Science ®Google Scholar
• Ramain, P., K. Khechumian, L. Seugnet, N. Arbogast, C. Ackermann, and P. Heitzler. 2001. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr. Biol. 11:1729–1738.
   PubMed Web of Science ®Google Scholar
• Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and P. Salmon. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483–492.
   PubMed Web of Science ®Google Scholar
• Saito, T., S. Chiba, M. Ichikawa, A. Kunisato, T. Asai, K. Shimizu, T. Yamaguchi, G. Yamamoto, S. Seo, K. Kumano, E. Nakagami-Yamaguchi, Y. Hamada, S. Aizawa, and H. Hirai. 2003. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18:675–685.
   PubMed Web of Science ®Google Scholar
• Schweisguth, F. 2004. Notch signaling activity. Curr. Biol. 14:R129–R138.
   PubMed Web of Science ®Google Scholar
• Sestan, N., S. Artavanis-Tsakonas, and P. Rakic. 1999. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286:741–746.
   PubMed Web of Science ®Google Scholar
• Takeyama, K., R. C. Aguiar, L. Gu, C. He, G. J. Freeman, J. L. Kutok, J. C. Aster, and M. A. Shipp. 2003. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J. Biol. Chem. 278:21930–21937.
   PubMedGoogle Scholar
• Tanigaki, K., H. Han, N. Yamamoto, K. Tashiro, M. Ikegawa, K. Kuroda, A. Suzuki, T. Nakano, and T. Honjo. 2002. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. 3:443–450.
   PubMed Web of Science ®Google Scholar
• Tanigaki, K., M. Tsuji, N. Yamamoto, H. Han, J. Tsukada, H. Inoue, M. Kubo, and T. Honjo. 2004. Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20:611–622.
   PubMed Web of Science ®Google Scholar
• Torres, R., and R. Kühn. 1997. Laboratory protocols for conditional gene targeting. Oxford University Press, Oxford, United Kingdom.
   Google Scholar
• Wilson, A., H. R. MacDonald, and F. Radtke. 2001. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194:1003–1012.
   PubMed Web of Science ®Google Scholar
• Witt, C. M., W. J. Won, V. Hurez, and C. A. Klug. 2003. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J. Immunol. 171:2783–2788.
   PubMed Web of Science ®Google Scholar
• Wolfer, A., A. Wilson, M. Nemir, H. R. MacDonald, and F. Radtke. 2002. Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta lineage thymocytes. Immunity 16:869–879.
   PubMed Web of Science ®Google Scholar
• Wu, G., S. Lyapina, I. Das, J. Li, M. Gurney, A. Pauley, I. Chui, R. J. Deshaies, and J. Kitajewski. 2001. SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol. Cell. Biol. 21:7403–7415.
   PubMed Web of Science ®Google Scholar
• Xu, T., and S. Artavanis-Tsakonas. 1990. Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics 126:665–677.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N., S. Yamamoto, F. Inagaki, M. Kawaichi, A. Fukamizu, N. Kishi, K. Matsuno, K. Nakamura, G. Weinmaster, H. Okano, and M. Nakafuku. 2001. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. J. Biol. Chem. 276:45031–45040.
   PubMed Web of Science ®Google Scholar