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Gene Expression

Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression

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Pages 2475-2485 | Received 14 Jul 2004, Accepted 07 Dec 2004, Published online: 27 Mar 2023

REFERENCES

  • Avilion, A. A., S. K. Nicolis, L. H. Pevny, L. Perez, N. Vivian, and R. Lovell-Badge. 2003. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17:126–140.
  • Ben-Shushan, E., J. R. Thompson, L. J. Gudas, and Y. Bergman. 1998. Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol. Cell. Biol. 18:1866–1878.
  • Chambers, I., D. Colby, M. Robertson, J. Nichols, S. Lee, S. Tweedie, and A. Smith. 2003. Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643–655.
  • Czermin, B., R. Melfi, D. McCabe, V. Seitz, A. Imhof, and V. Pirrotta. 2002. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111:185–196.
  • Dailey, L., H. Yuan, and C. Basilico. 1994. Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Mol. Cell. Biol. 14:7758–7769.
  • Davis, S., T. H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N. Y. Ip, and G. D. Yancopoulos. 1993. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260:1805–1808.
  • Erhardt, S., I. H. Su, R. Schneider, S. Barton, A. J. Bannister, L. Perez-Burgos, T. Jenuwein, T. Kouzarides, A. Tarakhovsky, and M. A. Surani. 2003. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130:4235–4248.
  • Hart, A. H., L. Hartley, M. Ibrahim, and L. Robb. 2004. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev. Dyn. 230:187–198.
  • Hatano, S., M. Tada, H. Kimura, S. Yamaguchi, T. Kono, T. Nakano, H. Suemori, N. Nakatsuji, and T. Tada. 2005. Pluripotential competence of cells associated with Nanog activity. Mech. Dev. 122:67–79.
  • Kimura, H., M. Tada, N. Nakatsuji, and T. Tada. 2004. Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol. Cell. Biol. 24:5710–5720.
  • Kubota, H., S. Matsumoto, S. Yokota, H. Yanagi, and T. Yura. 1999. Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2. FEBS Lett. 461:125–129.
  • Laible, G., A. Wolf, R. Dorn, G. Reuter, C. Nislow, A. Lebersorger, D. Popkin, L. Pillus, and T. Jenuwein. 1997. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16:3219–3232.
  • Luster, T. A., L. R. Johnson, T. K. Nowling, K. A. Lamb, S. Philipsen, and A. Rizzino. 2000. Effects of three Sp1 motifs on the transcription of the FGF-4 gene. Mol. Reprod. Dev. 57:4–15.
  • Luster, T. A., and A. Rizzino. 2003. Regulation of the FGF-4 gene by a complex distal enhancer that functions in part as an enhanceosome. Gene 323:163–172.
  • Mitsui, K., Y. Tokuzawa, H. Itoh, K. Segawa, M. Murakami, K. Takahashi, M. Maruyama, M. Maeda, and S. Yamanaka. 2003. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631–642.
  • Nichols, J., B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius, I. Chambers, H. Scholer, and A. Smith. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379–391.
  • Nishimoto, M., A. Fukushima, A. Okuda, and M. Muramatsu. 1999. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol. Cell. Biol. 19:5453–5465.
  • Nishimoto, M., S. Miyagi, T. Katayanagi, M. Tomioka, M. Muramatsu, and A. Okuda. 2003. The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors. Biochem. Biophys. Res. Commun. 302:581–586.
  • Niswander, L., and G. R. Martin. 1992. Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114:755–768.
  • Niwa, H., J. Miyazaki, and A. G. Smith. 2000. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24:372–376.
  • O'Carroll, D., S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein. 2001. The Polycomb-group gene Ezh2 is required for early mouse development. Mol. Cell. Biol. 21:4330–4336.
  • Sadowski, H. B., and M. Z. Gilman. 1993. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 362:79–83.
  • Saitou, M., S. C. Barton, and M. A. Surani. 2002. A molecular programme for the specification of germ cell fate in mice. Nature 418:293–300.
  • Scholer, H. R., A. K. Hatzopoulos, R. Balling, N. Suzuki, and P. Gruss. 1989. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 8:2543–2550.
  • Schuldiner, M., J. Itskovitz-Eldor, and N. Benvenisty. 2003. Selective ablation of human embryonic stem cells expressing a “suicide” gene. Stem Cells 21:257–265.
  • Smith, A. G., J. K. Heath, D. D. Donaldson, G. G. Wong, J. Moreau, M. Stahl, and D. Rogers. 1988. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336:688–690.
  • Stewart, C. 1980. Aggregation between teratocarcinoma cells and preimplantation mouse embryos. J. Embryol. Exp. Morphol. 58:289–302.
  • Stewart, C. L., P. Kaspar, L. J. Brunet, H. Bhatt, I. Gadi, F. Kontgen, and S. J. Abbondanzo. 1992. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359:76–79.
  • Suzuki, N., H. Rohdewohld, T. Neuman, P. Gruss, and H. R. Scholer. 1990. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J. 9:3723–3732.
  • Tada, T., and M. Tada. 2001. Toti-/pluripotential stem cells and epigenetic modifications. Cell Struct. Funct. 26:149–160.
  • Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94:3801–3804.
  • Thomson, J. A., J. Itskovitz-Eldor, S. S. Shapiro, M. A. Waknitz, J. J. Swiergiel, V. S. Marshall, and J. M. Jones. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147.
  • Tokuzawa, Y., E. Kaiho, M. Maruyama, K. Takahashi, K. Mitsui, M. Maeda, H. Niwa, and S. Yamanaka. 2003. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol. Cell. Biol. 23:2699–2708.
  • Tomioka, M., M. Nishimoto, S. Miyagi, T. Katayanagi, N. Fukui, H. Niwa, M. Muramatsu, and A. Okuda. 2002. Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res. 30:3202–3213.
  • Wang, S. H., M. S. Tsai, M. F. Chiang, and H. Li. 2003. A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells. Gene Expr. Patterns 3:99–103.
  • Ware, C. B., M. C. Horowitz, B. R. Renshaw, J. S. Hunt, D. Liggitt, S. A. Koblar, B. C. Gliniak, H. J. McKenna, T. Papayannopoulou, B. Thoma, L. Cheng, P. J. Donovan, J. J. Peschon, P. F. Bartlett, C. R. Willis, B. D. Wright, M. K. Carpenter, B. L. Davison, and D. P. Gearing. 1995. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 121:1283–1299.
  • Wiebe, M. S., P. J. Wilder, D. Kelly, and A. Rizzino. 2000. Isolation, characterization, and differential expression of the murine Sox-2 promoter. Gene 246:383–393.
  • Williams, R. L., D. J. Hilton, S. Pease, T. A. Willson, C. L. Stewart, D. P. Gearing, E. F. Wagner, D. Metcalf, N. A. Nicola, and N. M. Gough. 1988. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684–687.
  • Winnier, G., M. Blessing, P. A. Labosky, and B. L. Hogan. 1995. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:2105–2116.
  • Yeom, Y. I., G. Fuhrmann, C. E. Ovitt, A. Brehm, K. Ohbo, M. Gross, K. Hubner, and H. R. Scholer. 1996. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122:881–894.
  • Ying, Q. L., J. Nichols, I. Chambers, and A. Smith. 2003. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115:281–292.
  • Yuan, H., N. Corbi, C. Basilico, and L. Dailey. 1995. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 9:2635–2645.

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