17
Views
12
CrossRef citations to date
0
Altmetric
Gene Expression

Identification of cis-Regulatory Sequences in the Human Angiotensinogen Gene by Transgene Coplacement and Site-Specific Recombination

, , , , , , , , , , & show all
Pages 2938-2945 | Received 30 Jul 2004, Accepted 07 Jan 2005, Published online: 27 Mar 2023

REFERENCES

  • Bader, M., and D. Ganten. 2002. It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system. Circ. Res. 90:8–10.
  • Butler, J. E., and J. T. Kadonaga. 2001. Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs. Genes Dev. 15:2515–2519.
  • Carey, R. M., and H. M. Siragy. 2003. The intrarenal renin-angiotensin system and diabetic nephropathy. Trends Endocrinol. Metab. 14:274–281.
  • Caulfield, M., P. Lavender, M. Farrall, P. Munroe, M. Lawson, P. Turner, and A. J. Clark. 1994. Linkage of the angiotensinogen gene to essential hypertension. N. Engl. J. Med. 330:1629–1633.
  • Chen, J. L., K. L. Huisinga, M. M. Viering, S. A. Ou, C. T. Wu, and P. K. Geyer. 2002. Enhancer action in trans is permitted throughout the Drosophila genome. Proc. Natl. Acad. Sci. USA 99:3723–3728.
  • Davisson, R. L., Y. Ding, D. E. Stec, J. F. Catterall, and C. D. Sigmund. 1999. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol. Genomics 1:3–9.
  • Feldmer, M., M. Kaling, S. Takahashi, J. J. Mullins, and D. Ganten. 1991. Glucocorticoid- and estrogen-responsive elements in the 5′-flanking region of the rat angiotensinogen gene. J. Hypertension 9:1005–1012.
  • Fukamizu, A., K. Sugimura, E. Takimoto, F. Sugiyama, M. S. Seo, S. Takahashi, T. Hatae, N. Kajiwara, K. Yagami, and K. Murakami. 1993. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J. Biol. Chem. 268:11617–11621.
  • Fukamizu, A., S. Takahashi, and K. Murakami. 1990. Expression of the human angiotensinogen gene in human cell lines. J. Cardiovasc. Pharmacol. 16(Suppl. 4):S11–S13.
  • Gaensler, K. M., M. Kitamura, and Y. W. Kan. 1993. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc. Natl. Acad. Sci. USA 90:11381–11385.
  • Gociman, B., A. Rohrwasser, P. Lantelme, T. Cheng, G. Hunter, S. Monson, J. Hunter, E. Hillas, P. Lott, T. Ishigami, and J. M. Lalouel. 2004. Expression of angiotensinogen in proximal tubule as a function of glomerular filtration rate. Kidney Int. 65:2153–2160.
  • Gould, A. B., and D. Green. 1971. Kinetics of the human renin and human substrate reaction. Cardiovasc. Res. 5:86–89.
  • Hertz, R., J. Magenheim, I. Berman, and J. Bar-Tana. 1998. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α. Nature 392:512–516.
  • Ingelfinger, J. R., R. E. Pratt, K. Ellison, and V. J. Dzau. 1986. Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla. J. Clin. Investig. 78:1311–1315.
  • Ingelfinger, J. R., W. M. Zuo, E. A. Fon, K. E. Ellison, and V. J. Dzau. 1990. In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule: an hypothesis for the intrarenal renin angiotensin system. J. Clin. Investig. 85:417–423.
  • Jeunemaitre, X., F. Soubrier, Y. V. Kotelevtsev, R. P. Lifton, C. S. Williams, A. Charru, S. C. Hunt, P. N. Hopkins, R. R. Williams, J. M. Lalouel, et al. 1992. Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169–180.
  • Jiang, S., T. Tanaka, H. Iwanari, H. Hotta, H. Yamashita, J. Kumakura, Y. Watanabe, Y. Uchiyama, H. Aburatani, T. Hamakubo, T. Kodama, and M. Naito. 2003. Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats. Nucl. Recept. 1:5.
  • Kim, H. S., J. H. Krege, K. D. Kluckman, J. R. Hagaman, J. B. Hodgin, C. F. Best, J. C. Jennette, T. M. Coffman, N. Maeda, and O. Smithies. 1995. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA 92:2735–2739.
  • Kim, H. S., G. Lee, S. W. John, N. Maeda, and O. Smithies. 2002. Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proc. Natl. Acad. Sci. USA 99:4602–4607.
  • Lavoie, J. L., K. D. Lake-Bruse, and C. D. Sigmund. 2004. Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am. J. Physiol. Renal Physiol. 286:F965–F788.
  • Lee, E. C., D. Yu, J. Martinez de Velasco, L. Tessarollo, D. A. Swing, D. L. Court, N. A. Jenkins, and N. G. Copeland. 2001. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56–65.
  • Lee, G., and I. Saito. 1998. Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene 216:55–65.
  • Loghman-Adham, M., C. E. Soto, T. Inagami, and L. Cassis. 2004. An intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am. J. Physiol. Renal Physiol. 287:F775–F788.
  • Navar, L. G., and A. Nishiyama. 2004. Why are angiotensin concentrations so high in the kidney. Curr. Opin. Nephrol. Hypertens. 13:107–115.
  • Nibu, Y., S. Takahashi, K. Tanimoto, K. Murakami, and A. Fukamizu. 1994. Identification of cell type-dependent enhancer core element located in the 3′-downstream region of the human angiotensinogen gene. J. Biol. Chem. 269:28598–28605.
  • Nibu, Y., K. Tanimoto, S. Takahashi, H. Ono, K. Murakami, and A. Fukamizu. 1994. A cell type-dependent enhancer core element is located in exon 5 of the human angiotensinogen gene. Biochem. Biophys. Res. Commun. 205:1102–1108.
  • Odom, D. T., N. Zizlsperger, D. B. Gordon, G. W. Bell, N. J. Rinaldi, H. L. Murray, T. L. Volkert, J. Schreiber, P. A. Rolfe, D. K. Gifford, E. Fraenkel, G. I. Bell, and R. A. Young. 2004. Control of pancreas and liver gene expression by HNF transcription factors. Science 303:1378–1381.
  • Osoegawa, K., A. G. Mammoser, C. Wu, E. Frengen, C. Zeng, J. J. Catanese, and P. J. de Jong. 2001. A bacterial artificial chromosome library for sequencing the complete human genome. Genome Res. 11:483–496.
  • Parsch, J. 2004. Functional analysis of Drosophila melanogaster gene regulatory sequences by transgene coplacement. Genetics 168:559–561.
  • Richoux, J. P., J. L. Cordonnier, J. Bouhnik, E. Clauser, P. Corvol, J. Menard, and G. Grignon. 1983. Immunocytochemical localization of angiotensinogen in rat liver and kidney. Cell Tissue Res. 233:439–451.
  • Siegal, M. L., and D. L. Hartl. 1998. An experimental test for lineage-specific position effects on alcohol dehydrogenase (Adh) genes in Drosophila. Proc. Natl. Acad. Sci. USA 95:15513–15518.
  • Siegal, M. L., and D. L. Hartl. 1996. Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 144:715–726.
  • Sladek, F. M., W. M. Zhong, E. Lai, and J. E. Darnell, Jr. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353–2365.
  • Takahashi, S., A. Fukamizu, T. Hasegawa, M. Yokoyama, T. Nomura, M. Katsuki, and K. Murakami. 1991. Expression of the human angiotensinogen gene in transgenic mice and transfected cells. Biochem. Biophys. Res. Commun. 180:1103–1109.
  • Takahashi, S., A. Fukamizu, T. Hatae, Y. Yamada, F. Sugiyama, N. Kajiwara, K. Yagami, and K. Murakami. 1992. Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen. J. Vet. Med. Sci. 54:1191–1193.
  • Tamura, K., K. Tanimoto, S. Takahashi, M. Sagara, A. Fukamizu, and K. Murakami. 1992. Structure and expression of the mouse angiotensinogen gene. Jpn. Heart J. 33:113–124.
  • Tamura, K., S. Umemura, M. Ishii, K. Tanimoto, K. Murakami, and A. Fukamizu. 1994. Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter. J. Clin. Investig. 93:1370–1379.
  • Tanimoto, K., Q. Liu, F. Grosveld, J. Bungert, and J. D. Engel. 2000. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev. 14:2778–2794.
  • Tanimoto, K., F. Sugiyama, Y. Goto, J. Ishida, E. Takimoto, K. Yagami, A. Fukamizu, and K. Murakami. 1994. Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269:31334–31337.
  • Taraviras, S., A. P. Monaghan, G. Schutz, and G. Kelsey. 1994. Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev. 48:67–79.
  • Tokunaga, K., H. Taniguchi, K. Yoda, M. Shimizu, and S. Sakiyama. 1986. Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. Nucleic Acids Res. 14:2829.
  • Webster, N., J. R. Jin, S. Green, M. Hollis, and P. Chambon. 1988. The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 transactivator. Cell 52:169–178.
  • Yanai, K., K. Hirota, K. Taniguchi-Yanai, Y. Shigematsu, Y. Shimamoto, T. Saito, S. Chowdhury, M. Takiguchi, M. Arakawa, Y. Nibu, F. Sugiyama, K. Yagami, and A. Fukamizu. 1999. Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. J. Biol. Chem. 274:34605–34612.
  • Yanai, K., Y. Nibu, K. Murakami, and A. Fukamizu. 1996. A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene. J. Biol. Chem. 271:15981–15986.
  • Yanai, K., T. Saito, K. Hirota, H. Kobayashi, K. Murakami, and A. Fukamizu. 1997. Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity. J. Biol. Chem. 272:30558–30562.
  • Yang, G., D. C. Merrill, M. W. Thompson, J. E. Robillard, and C. D. Sigmund. 1994. Functional expression of the human angiotensinogen gene in transgenic mice. J. Biol. Chem. 269:32497–32502.
  • Yang, G., and C. D. Sigmund. 1998. Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension 31:734–740.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.