Integrin-Linked Kinase Mediates Bone Morphogenetic Protein 7-Dependent Renal Epithelial Cell Morphogenesis

REFERENCES

• Bernardini, N., F. Bianchi, and A. Dolfi. 1999. Laminin and beta1 integrin distribution in the early stages of human kidney development. Nephron 81:289–295.
   PubMedGoogle Scholar
• Campana, W. M., R. R. Myers, and A. Rearden. 2003. Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. Glia 41:213–223.
   PubMedGoogle Scholar
• Cantley, L. G., E. J. Barros, M. Gandhi, M. Rauchman, and S. K. Nigam. 1994. Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. Am. J. Physiol. 267:F271–F280.
   PubMedGoogle Scholar
• D'Amico, M., J. Hulit, D. F. Amanatullah, B. T. Zafonte, C. Albanese, B. Bouzahzah, M. Fu, L. H. Augenlicht, L. A. Donehower, K. Takemaru, R. T. Moon, R. Davis, M. P. Lisanti, M. Shtutman, J. Zhurinsky, A. Ben-Ze'ev, A. A. Troussard, S. Dedhar, and R. G. Pestell. 2000. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways. J. Biol. Chem. 275:32649–32657.
   PubMed Web of Science ®Google Scholar
• Davies, J. A., and C. E. Fisher. 2002. Genes and proteins in renal development. Exp. Nephrol. 10:102–113.
   PubMedGoogle Scholar
• Dedhar, D., B. Williams, and G. Hannigan. 1999. Integrin-linked kinase (ILK): a regulator of integrin and growth factor signalling. Trends Cell Biol. 9:319–323.
   PubMed Web of Science ®Google Scholar
• Dedhar, S. 2000. Cell-substrate interactions and signaling through ILK. Curr. Opin. Cell Biol. 12:250–256.
   PubMed Web of Science ®Google Scholar
• Dedhar, S., and G. E. Hannigan. 1996. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr. Opin. Cell Biol. 8:657–669.
   PubMed Web of Science ®Google Scholar
• Delcommenne, M., C. Tan, V. Gray, L. Rue, J. Woodgett, and S. Dedhar. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA 95:11211–11216.
   PubMed Web of Science ®Google Scholar
• Denda, S., L. F. Reichardt, and U. Müller. 1998. Identification of osteopontin as a novel ligand for the integrin α8β1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Mol. Biol. Cell 9:1425–1435.
   PubMed Web of Science ®Google Scholar
• Dudley, A. T., K. M. Lyons, and E. J. Robertson. 1995. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9:2795–2807.
   PubMed Web of Science ®Google Scholar
• Dudley, A. T., and E. J. Robertson. 1997. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev. Dyn. 208:349–362.
   PubMed Web of Science ®Google Scholar
• Friedrich, E. B., S. Sinha, L. Li, S. Dedhar, T. Force, A. Rosenzweig, and R. E. Gerszten. 2002. Role of integrin-linked kinase in leukocyte recruitment. J. Biol. Chem. 277:16371–16375.
   PubMedGoogle Scholar
• Godin, R. E., E. J. Robertson, and A. T. Dudley. 1999. Role of BMP family members during kidney development. Int. J. Dev. Biol. 43:405–411.
   PubMedGoogle Scholar
• Godin, R. E., N. T. Takaesu, E. J. Robertson, and A. T. Dudley. 1998. Regulation of BMP7 expression during kidney development. Development 125:3473–3482.
   PubMed Web of Science ®Google Scholar
• Grisaru, S., D. Cano-Gauci, J. Tee, J. Filmus, and N. D. Rosenblum. 2001. Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. Dev. Biol. 231:31–46.
   PubMedGoogle Scholar
• Gupta, I. R., M. Macias-Silva, S. Kim, X. Zhou, T. D. Piscione, C. Whiteside, J. L. Wrana, and N. D. Rosenblum. 2000. BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. J. Cell Sci. 113:269–278.
   PubMed Web of Science ®Google Scholar
• Hannigan, G., A. A. Troussard, and S. Dedhar. 2005. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat. Rev. Cancer 5:51–63.
   PubMed Web of Science ®Google Scholar
• Hannigan, G. E., C. Leung-Hagesteijn, L. Fitz-Gibbon, M. G. Coppolino, G. Radeva, J. Filmus, J. C. Bell, and S. Dedhar. 1996. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379:91–96.
   PubMed Web of Science ®Google Scholar
• Hida, M., S. Omori, and M. Awazu. 2002. ERK and p38 MAP kinase are required for rat renal development. Kidney Int. 61:1252–1262.
   PubMedGoogle Scholar
• Hu, M. C., T. D. Piscione, and N. D. Rosenblum. 2003. Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development 130:2753–2766.
   PubMed Web of Science ®Google Scholar
• Hu, M. C., D. Wasserman, S. Hartwig, and N. D. Rosenblum. 2004. p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1. J. Biol. Chem. 279:12051–12059.
   PubMed Web of Science ®Google Scholar
• Ishii, T., E. Satoh, and M. Nishimura. 2001. Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells. J. Biol. Chem. 276:42994–43003
   PubMedGoogle Scholar
• Kaneko, Y., K. Kitazato, and Y. Basaki. 2004. Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor. J. Cell Sci. 117:407–415.
   PubMed Web of Science ®Google Scholar
• Kanwar, Y. S., J. Wada, S. Lin, F. R. Danesh, S. S. Chugh, Q. Yang, T. Banerjee, and J. W. Lomasney. 2004. Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am. J. Physiol. Renal Physiol. 286:F202–F215.
   PubMed Web of Science ®Google Scholar
• Klinowska, T. C., J. V. Soriano, G. M. Edwards, J. M. Oliver, A. J. Valentijn, R. Montesano, and C. H. Streuli. 1999. Laminin and β1 integrins are crucial for normal mammary gland development in the mouse. Dev. Biol. 215:13–32.
   PubMedGoogle Scholar
• Korhonen, M., J. Ylanne, L. Laitinen, and I. Virtanen. 1990. Distribution of beta 1 and beta 3 integrins in human fetal and adult kidney. Lab. Investig. 62:616–625.
   PubMed Web of Science ®Google Scholar
• Kumar, A. S., I. Naruszewicz, P. Wang, C. Leung-Hagesteijn, and G. E. Hannigan. 2004. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Oncogene 23:3454–3461.
   PubMed Web of Science ®Google Scholar
• Leung-Hagesteijn, C., A. Mahendra, I. Naruszewicz, and G. E. Hannigan. 2001. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. EMBO J. 20:2160–2170.
   PubMed Web of Science ®Google Scholar
• Luo, G., C. Hofmann, A. L. Bronckers, M. Sohocki, A. Bradley, and G. Karsenty. 1995. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9:2808–2820.
   PubMed Web of Science ®Google Scholar
• Martinez, G., Y. Mishina, and J. F. Bertram. 2002. BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int. J. Dev. Biol. 46:525–533.
   PubMedGoogle Scholar
• Miller, M. G., I. Naruszewicz, A. S. Kumar, T. Ramlal, and G. E. Hannigan. 2003. Integrin-linked kinase is a positive mediator of L6 myoblast differentiation. Biochem. Biophys. Res. Commun. 310:796–803.
   PubMedGoogle Scholar
• Mills, J., M. Digicaylioglu, A. T. Legg, C. E. Young, S. S. Young, A. M. Barr, L. Fletcher, T. P. O'Connor, and S. Dedhar. 2003. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. J. Neurosci. 23:1638–1648.
   PubMedGoogle Scholar
• Muller, U., D. Wang, S. Denda, J. J. Meneses, R. A. Pedersen, and L. F. Reichardt. 1997. Integrin α8β1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell 88:603–613.
   PubMed Web of Science ®Google Scholar
• Persad, S., S. Attwell, V. Gray, M. Delcommenne, A. Troussard, J. Sanghera, and S. Dedhar. 2000. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc. Natl. Acad. Sci. USA 97:3207–3212.
   PubMed Web of Science ®Google Scholar
• Persad, S., and S. Dedhar. 2003. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev. 22:375–384.
   PubMed Web of Science ®Google Scholar
• Piscione, T. D., T. Phan, and N. D. Rosenblum. 2001. BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Am. J. Physiol. Renal Physiol. 280:F19–F33.
   PubMed Web of Science ®Google Scholar
• Piscione, T. D., and N. D. Rosenblum. 2002. The molecular control of renal branching morphogenesis: current knowledge and emerging insights. Differentiation 70:227–246.
   PubMed Web of Science ®Google Scholar
• Piscione, T. D., T. D. Yager, I. R. Gupta, B. Grinfeld, Y. Pei, L. Attisano, J. L. Wrana, and N. D. Rosenblum. 1997. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. Am. J. Physiol. 273:F961–F975.
   PubMedGoogle Scholar
• Rauchman, M. I., S. K. Nigam, E. Delpire, and S. R. Gullans. 1993. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am. J. Physiol. 265:F416–F424.
   PubMedGoogle Scholar
• Saelman, E. U., P. J. Keely, and S. A. Santoro. 1995. Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis. J. Cell Sci. 108:3531–3540.
   PubMed Web of Science ®Google Scholar
• Sakai, T., S. Li, D. Docheva, C. Grashoff, K. Sakai, G. Kostka, A. Braun, A. Pfeifer, P. D. Yurchenco, and R. Fassler. 2003. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17:926–940.
   PubMed Web of Science ®Google Scholar
• Somasiri, A., A. Howarth, D. Goswami, S. Dedhar, and C. D. Roskelley. 2001. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J. Cell Sci. 114:1125–1136.
   PubMed Web of Science ®Google Scholar
• Tan, C., S. Cruet-Hennequart, A. Troussard, L. Fazli, P. Costello, K. Sutton, J. Wheeler, M. Gleave, J. Sanghera, and S. Dedhar. 2004. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 5:79–90.
   PubMed Web of Science ®Google Scholar
• Tan, C., A. Mui, and S. Dedhar. 2002. Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κB-dependent manner. J. Biol. Chem. 277:3109–3116.
   PubMedGoogle Scholar
• Tu, Y., F. Li, S. Goicoechea, and C. Wu. 1999. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol. Cell. Biol. 19:2425–2434.
   PubMed Web of Science ®Google Scholar
• Tu, Y., F. Li, and C. Wu. 1998. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol. Biol. Cell 9:3367–3382.
   PubMed Web of Science ®Google Scholar
• White, D. E., R. D. Cardiff, S. Dedhar, and W. J. Muller. 2001. Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20:7064–7072.
   PubMed Web of Science ®Google Scholar
• Wu, C. 1999. Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction. J. Cell Sci. 112:4485–4489.
   PubMed Web of Science ®Google Scholar
• Yoganathan, N., A. Yee, Z. Zhang, D. Leung, J. Yan, L. Fazli, D. Kojic, P. Costello, M. Jabali, S. Dedhar, and J. Sanghera. 2002. Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacol. Ther. 93:233.
   PubMed Web of Science ®Google Scholar
• Zent, R., K. T. Bush, M. L. Pohl, V. Quaranta, N. Koshikawa, Z. Wang, J. A. Kreidberg, H. Sakurai, R. O. Stuart, and S. K. Nigam. 2001. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev. Biol. 238:289–302.
   PubMed Web of Science ®Google Scholar