15
Views
67
CrossRef citations to date
0
Altmetric
Gene Expression

The Mcp Element from the bithorax Complex Contains an Insulator That Is Capable of Pairwise Interactions and Can Facilitate Enhancer-Promoter Communication

, , , &
Pages 3682-3689 | Received 23 Nov 2004, Accepted 03 Feb 2005, Published online: 27 Mar 2023

REFERENCES

  • Bantignies, F., C. Grimaud, S. Lavrov, M. Gabut, and G. Cavalli. 2003. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila.. Genes Dev. 17:2406–2420.
  • Barges, S., J. Mihaly, M. Galloni, K. Hagstrom, M. Muller, G. Shanower, P. Schedl, H. Gyurkovics, and F. Karch. 2000. The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain. Development 127:779–790.
  • Bondarenko, V. A., Y. V. Liu, Y. I. Jiang, and V. M. Studitsky. 2003. Communication over a large distance: enhancers and insulators. Biochem. Cell. Biol. 81:241–251.
  • Boulet, A. M., A. Lloyd, and S. Sakonju. 1991. Molecular definition of the morphogenetic and regulatory functions and the cis-regulatory elements of the Drosophila Abd-B homeotic gene. Development 111:393–405.
  • Busturia, A., and M. Bienz. 1993. Silencers in abdominal-B, a homeotic Drosophila gene. EMBO J. 12:1415–1425.
  • Busturia, A., C. D. Wightman, and S. Sakonju. 1997. A silencer is required for maintenance of transcriptional repression throughout Drosophila development. Development 124:4343–4350.
  • Busturia, A., A. Lloyd, F. Bejarano, M. Zavortink, H. Xin, and S. Sakonju. 2001. The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression. Development 128:2163–2173.
  • Cai, H. N., and P. Shen. 2001. Effects of cis arrangement of chromatin insulators on enhancer-blocking activity. Science 291:493–495.
  • Celniker, S. E., S. Sharma, D. J. Keelan, and E. B. Lewis. 1990. The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J. 9:4227–4286.
  • Dejardin, J., and G. Cavalli. 2004. Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module. EMBO J. 23:857–868.
  • Dorsett, D. 1999. Distant liaisons: long range enhancer-promoter interactions in Drosophila.. Curr. Opin. Genet. 9:505–514.
  • Duncan, I. 1987. The bithorax complex. Annu. Rev. Genet. 21:285–319.
  • Galloni, M., H. Gyurkovics, P. Schedl, and F. Karch. 1993. The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex. EMBO J. 12:1087–1097.
  • Gerasimova, T. I., and V. G. Corces. 2001. Chromatin insulators and boundaries: effects on transcription and nuclear organization. Annu. Rev. Genet. 35:193–208.
  • Geyer, P. K., and V. G. Corces. 1987. Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster.. Genes Dev. 1:996–1004.
  • Gyurkovics, H., J. Gausz, J. Kummer, and F. Karch. 1990. A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J. 9:2579–2585.
  • Hagstrom, K., M. Muller, and P. Schedl. 1996. Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. Genes Dev. 10:3202–3215.
  • Hagstrom, K., M. Muller, and P. Schedl. 1997. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. Genetics 146:1365–1380.
  • Karch, F., B. Weiffenbach, M. Peifer, W. Bender, I. Duncan, S. Celniker, M. Crosby, and E. B. Lewis. 1985. The abdominal region of the bithorax complex. Cell 43:81–96.
  • Karch, F., M. Galloni, L. Sipos, J. Gausz, H. Gyurkovics, and P. Schedl. 1994. Mcp and Fab-7: molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster.. Nucleic Acids Res. 22:3138–3146.
  • Kares, R. E., and G. M. Rubin. 1984. Analysis of P transposable element functions in Drosophila.. Cell 38:135–146.
  • Kuhn, E. J., and P. K. Geyer. 2003. Genomic insulators: connecting properties to mechanism. Curr. Opin. Cell Biol. 15:259–265.
  • Labrador, M., and V. G. Corces. 2002. Setting the boundaries of chromatin domains and nuclear organization. Cell 111:151–154.
  • Lewis, E. B. 1978. A gene complex controlling segmentation in Drosophila.. Nature 276:565–570.
  • Lin, Q., D. Wu, and J. Zhou. 2003. The promoter targeting sequence facilitates and restricts a distant enhancer to a single promoter in the Drosophila embryo. Development 130:519–526.
  • Lin, Q., Q. Chen, L. Lin, and J. Zhou. 2004. The Promoter Targeting Sequence mediates epigenetically heritable transcription memory. Genes Dev. 18:2639–2651.
  • Majumder, P., and H. N. Cai. 2003. The functional analysis of insulator interactions in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 100:5223–5228.
  • Martin, M., Y. B. Meng, and W. Chia. 1989. Regulatory elements involved in the tissue-specific expression of the yellow gene of Drosophila.. Mol. Gen. Genet. 218:118–126.
  • McCall, K., M. B. O'Connor, and W. Bender. 1994. Enhancer traps in the Drosophila bithorax complex mark parasegmental domains. Genetics 138:387–399.
  • Melnikova, L., F. Juge, N. Gruzdeva, A. Mazur, G. Cavalli, and P. Georgiev. 2004. Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila.. Proc. Natl. Acad. Sci. USA 101:14806–14811.
  • Mihaly, J., I. Hogga, J. Gausz, H. Gyurkovics, and F. Karch. 1997. In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. Development 124:1809–1820.
  • Mihaly, J., I. Hogga, S. Barges, M. Galloni, R. K. Mishra, K. Hagstrom, M. Muller, P. Schedl, L. Sipos, J. Gausz, H. Gyurkovics, and F. Karch. 1998. Chromatin domain boundaries in the Bithorax complex. Cell. Mol. Life Sci. 54:60–70.
  • Mihaly, J., R. K. Mishra, and F. Karch. 1998. A conserved sequence motif in Polycomb-response elements. Mol. Cell 1:1065–1066.
  • Muller, M., K. Hagstrom, H. Gyurkovics, V. Pirrotta, and P. Schedl. 1999. The Mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions. Genetics 153:1333–1356.
  • Muravyova, E., A. Golovnin, E. Gracheva, A. Parshikov, T. Belenkaya, V. Pirrotta, and P. Georgiev. 2001. Loss of insulator activity by paired Su(Hw) chromatin insulators. Science 291:495–498.
  • Oki, M., and R. T. Kamakaka. 2002. Blockers and barriers to transcription: competing activities. Curr. Opin. Cell Biol. 14:299–304.
  • Qian, S., B. Varjavand, and V. Pirrotta. 1992. Molecular analysis of the zeste-white interaction reveals a promoter-proximal element essential for distant enhancer-promoter communication. Genetics 131:79–90.
  • Rubin, G. M., and A. C. Spradling. 1982. Genetic transformation of Drosophila with transposable element vectors. Science 218:348–353.
  • Sanchez-Herrero, E., I. Vernos, R. Marco, and G. Morato. 1985. Genetic organization of Drosophila bithorax complex. Nature 313:108–113.
  • Sanchez-Herrero, E. 1991. Control of the expression of the bithorax complex abdominal-A and abdominal-B by cis-regulatory regions in Drosophila embryos. Development 111:437–448.
  • Spradling, A. C., and G. M. Rubin. 1982. Transposition of cloned P elements into germline chromosomes. Science 218:341–347.
  • Udvardy, A. 1999. Dividing the empire: boundary chromatin elements delimit the territory of enhancers. EMBO J. 18:1–8.
  • West, A. G., M. Gaszner, and G. Felsenfeld. 2002. Insulators: many functions, many mechanisms. Genes Dev. 16:271–288.
  • Zhou, J., S. Barolo, P. Szymanski, and M. Levine. 1996. The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo. Genes Dev. 10:3195–3201.
  • Zhou, J., H. Ashe, C. Burks, and M. Levine. 1999. Characterization of the transvection mediating region of the abdominal-B locus in Drosophila.. Development 126:3057–3065.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.