16
Views
41
CrossRef citations to date
0
Altmetric
Signal Transduction

Interaction of BAG1 and Hsp70 Mediates Neuroprotectivity and Increases Chaperone Activity

, , , , , , & show all
Pages 3715-3725 | Received 17 Sep 2004, Accepted 19 Jan 2005, Published online: 27 Mar 2023

REFERENCES

  • Alberti, S., J. Demand, C. Esser, N. Emmerich, H. Schild, and J. Hohfeld. 2002. Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome. J. Biol. Chem. 277:45920–45927.
  • Bardelli, A., P. Longati, D. Albero, S. Goruppi, C. Schneider, C. Ponzetto, and P. M. Comoglio. 1996. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J. 15:6205–6212.
  • Beere, H. M., B. B. Wolf, K. Cain, D. D. Mosser, A. Mahboubi, T. Kuwana, P. Tailor, R. I. Morimoto, G. M. Cohen, and D. R. Green. 2000. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat. Cell Biol. 2:469–475.
  • Briknarova, K., S. Takayama, L. Brive, M. L. Havert, D. A. Knee, J. Velasco, S. Homma, E. Cabezas, J. Stuart, D. W. Hoyt, A. C. Satterthwait, M. Llinas, J. C. Reed, and K. R. Ely. 2001. Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein. Nat. Struct. Biol. 8:349–352.
  • Bruening, W., J. Roy, B. Giasson, D. A. Figlewicz, W. E. Mushynski, and H. D. Durham. 1999. Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis. J. Neurochem. 72:693–699.
  • Bukau, B., and A. L. Horwich. 1998. The Hsp70 and Hsp60 chaperone machines. Cell 92:351–366.
  • Cummings, C. J., Y. Sun, P. Opal, B. Antalffy, R. Mestril, H. T. Orr, W. H. Dillmann, and H. Y. Zoghbi. 2001. Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum. Mol. Genet. 10:1511–1518.
  • Currie, R. W., J. A. Ellison, R. F. White, G. Z. Feuerstein, X. Wang, and F. C. Barone. 2000. Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27. Brain Res. 863:169–181.
  • Demand, J., S. Alberti, C. Patterson, and J. Hohfeld. 2001. Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr. Biol. 11:1569–1577.
  • Gassler, C. S., T. Wiederkehr, D. Brehmer, B. Bukau, and M. P. Mayer. 2001. Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor. J. Biol. Chem. 276:32538–32544.
  • Gebauer, M., M. Zeiner, and U. Gehring. 1997. Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity. FEBS Lett. 417:109–113.
  • Hartl, F. U., and M. Hayer-Hartl. 2002. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295:1852–1858.
  • Hohfeld, J., and S. Jentsch. 1997. GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16:6209–6216.
  • Jaattela, M., D. Wissing, K. Kokholm, T. Kallunki, and M. Egeblad. 1998. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 17:6124–6134.
  • Jana, N. R., M. Tanaka, G. Wang, and N. Nukina. 2000. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum. Mol. Genet. 9:2009–2018.
  • Jurgen, B., H. Y. Lin, S. Riemschneider, C. Scharf, P. Neubauer, R. Schmid, M. Hecker, and T. Schweder. 2000. Monitoring of genes that respond to overproduction of an insoluble recombinant protein in Escherichia coli glucose-limited fed-batch fermentations. Biotechnol. Bioeng. 70:217–224.
  • Kelly, S., A. Bieneman, K. Horsburgh, D. Hughes, M. V. Sofroniew, J. McCulloch, and J. B. Uney. 2001. Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro. J. Cereb. Blood Flow Metab. 21:972–981.
  • Kermer, P., M. H. Digicaylioglu, M. Kaul, J. M. Zapata, M. Krajewska, F. Stenner-Liewen, S. Takayama, S. Krajewski, S. A. Lipton, and J. C. Reed. 2003. BAG1 over-expression in brain protects against stroke. Brain Pathol. 13:495–506.
  • Kermer, P., M. Krajewska, J. M. Zapata, S. Takayama, J. Mai, S. Krajewski, and J. C. Reed. 2002. Bag1 is a regulator and marker of neuronal differentiation. Cell Death Differ. 9:405–413.
  • Kudoh, M., D. A. Knee, S. Takayama, and J. C. Reed. 2002. Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells. Cancer Res. 62:1904–1909.
  • Lee, S. H., M. Kim, B. W. Yoon, Y. J. Kim, S. J. Ma, J. K. Roh, J. S. Lee, and J. S. Seo. 2001. Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice. Stroke 32:2905–2912.
  • Luders, J., J. Demand, O. Papp, and J. Hohfeld. 2000. Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function. J. Biol. Chem. 275:14817–14823.
  • Matsuzawa, S., S. Takayama, B. A. Froesch, J. M. Zapata, and J. C. Reed. 1998. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J. 17:2736–2747.
  • Nollen, E. A., J. F. Brunsting, J. Song, H. H. Kampinga, and R. I. Morimoto. 2000. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol. Cell. Biol. 20:1083–1088.
  • O'Neill, E., and W. Kolch. 2004. Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br. J. Cancer 90:283–288.
  • Rajdev, S., K. Hara, Y. Kokubo, R. Mestril, W. Dillmann, P. R. Weinstein, and F. R. Sharp. 2000. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann. Neurol. 47:782–791.
  • Rokutan, K., T. Hirakawa, S. Teshima, Y. Nakano, M. Miyoshi, T. Kawai, E. Konda, H. Morinaga, T. Nikawa, and K. Kishi. 1998. Implications of heat shock/stress proteins for medicine and disease. J. Med. Investig. 44:137–147.
  • Roth, W., C. Grimmel, L. Rieger, H. Strik, S. Takayama, S. Krajewski, R. Meyermann, J. Dichgans, J. C. Reed, and M. Weller. 2000. Bag-1 and Bcl-2 gene transfer in malignant glioma: modulation of cell cycle regulation and apoptosis. Brain Pathol. 10:223–234.
  • Sacchetti, A., V. Cappetti, P. Marra, R. Dell'Arciprete, T. El Sewedy, C. Crescenzi, and S. Alberti. 2001. Green fluorescent protein variants fold differentially in prokaryotic and eukaryotic cells. J. Cell. Biochem. 81:117–128.
  • Saleh, A., S. M. Srinivasula, L. Balkir, P. D. Robbins, and E. S. Alnemri. 2000. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat. Cell Biol. 2:476–483.
  • Schulz, J. B., D. Bremen, J. C. Reed, J. Lommatzsch, S. Takayama, U. Wullner, P. A. Loschmann, T. Klockgether, and M. Weller. 1997. Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J. Neurochem. 69:2075–2086.
  • Sippel, R. S., and H. Chen. 2002. Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation. Surgery 132:1035–1039.
  • Sondermann, H., C. Scheufler, C. Schneider, J. Hohfeld, F. U. Hartl, and I. Moarefi. 2001. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science 291:1553–1557.
  • Song, J., M. Takeda, and R. I. Morimoto. 2001. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell Biol. 3:276–282.
  • Takaoka, A., M. Adachi, H. Okuda, S. Sato, A. Yawata, Y. Hinoda, S. Takayama, J. C. Reed, and K. Imai. 1997. Anti-cell death activity promotes pulmonary metastasis of melanoma cells. Oncogene 14:2971–2977.
  • Takayama, S., D. N. Bimston, S. Matsuzawa, B. C. Freeman, C. Aime-Sempe, Z. Xie, R. I. Morimoto, and J. C. Reed. 1997. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16:4887–4896.
  • Takayama, S., and J. C. Reed. 2001. Molecular chaperone targeting and regulation by BAG family proteins. Nat. Cell Biol. 3:E237–E241.
  • Takayama, S., T. Sato, S. Krajewski, K. Kochel, S. Irie, J. A. Millan, and J. C. Reed. 1995. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80:279–284.
  • Takayama, S., Z. Xie, and J. C. Reed. 1999. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J. Biol. Chem. 274:781–786.
  • Tanaka, S., K. Kitagawa, T. Ohtsuki, Y. Yagita, K. Takasawa, M. Hori, and M. Matsumoto. 2002. Synergistic induction of HSP40 and HSC70 in the mouse hippocampal neurons after cerebral ischemia and ischemic tolerance in gerbil hippocampus. J. Neurosci. Res. 67:37–47.
  • Terada, K., and M. Mori. 2000. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J. Biol. Chem. 275:24728–24734.
  • Thomas, J. G., and F. Baneyx. 1996. Protein misfolding and inclusion body formation in recombinant Escherichia coli cells overexpressing Heat-shock proteins. J. Biol. Chem. 271:11141–11147.
  • Townsend, P. A., R. I. Cutress, C. J. Carroll, K. M. Lawrence, T. M. Scarabelli, G. Packham, A. Stephanou, and D. S. Latchman. 2004. BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. J. Biol. Chem. 279:20723–20728.
  • Townsend, P. A., R. I. Cutress, A. Sharp, M. Brimmell, and G. Packham. 2003. BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. Cancer Res. 63:4150–4157.
  • Wang, H. G., S. Takayama, U. R. Rapp, and J. C. Reed. 1996. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. USA 93:7063–7068.
  • Watanabe, M., M. Dykes-Hoberg, V. C. Culotta, D. L. Price, P. C. Wong, and J. D. Rothstein. 2001. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol. Dis. 8:933–941.
  • Wiese, S., R. Gotz, W. Rossoll, U. Schweizer, S. Takajama, M. Berzaghi, S. Jablonka, B. Holtmann, J. C. Reed, U. R. Rapp, and M. Sendtner. 2002. Essential role for BAG-1 in differentiation and survival of neurons, CD-ROM program no. 618.4. Abstract Viewer/Itinerary Planner. Society for Neuroscience, Washington, D.C.
  • Young, J. C., I. Moarefi, and F. U. Hartl. 2001. Hsp90: a specialized but essential protein-folding tool. J. Cell Biol. 154:267–273.
  • Zeiner, M., M. Gebauer, and U. Gehring. 1997. Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J. 16:5483–5490.
  • Zeiner, M., and U. Gehring. 1995. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl. Acad. Sci. USA 92:11465–11469.
  • Zhong, L. T., T. Sarafian, D. J. Kane, A. C. Charles, S. P. Mah, R. H. Edwards, and D. E. Bredesen. 1993. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA 90:4533–4537.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.