p21-Activated Kinase 1 Regulates Microtubule Dynamics by Phosphorylating Tubulin Cofactor B

REFERENCES

• Banerjee, M., D. Worth, D. Prowse, and M. Nikolic. 2002. Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis. Curr. Biol. 12:1233–1239.
   PubMedGoogle Scholar
• Bokoch, G. M. 2003. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72:743–781.
   PubMed Web of Science ®Google Scholar
• Cassimeris, L. 1999. Accessory protein regulation of microtubule dynamics throughout the cell cycle. Curr. Opin. Cell Biol. 11:134–141.
   PubMed Web of Science ®Google Scholar
• Cau, J., S. Faure, M. Comps, C. Delsert, and N. Morin. 2001. A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization. J. Cell Biol. 155:1029–1042.
   PubMed Web of Science ®Google Scholar
• Daub, H. F., K. F. Gevaert, J. F. Vandekerckhove, A. F. Sobel, and A. Hall. 2001. Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine. J. Biol. Chem. 276:1677–1680.
   PubMed Web of Science ®Google Scholar
• Desai, A., and T. J. Mitchison. 1997. Microtubule polymerization dynamics. Annu. Rev. Cell Dev. Biol. 13:83–117.
   PubMed Web of Science ®Google Scholar
• Jordan, M. A., and L. Wilson. 1998. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr. Opin. Cell Biol. 10:123–130.
   PubMed Web of Science ®Google Scholar
• Kramer, A. F., K. F. Neben, and A. D. Ho. 2002. Centrosome replication, genomic instability and cancer. Leukemia 16:767–775.
   PubMed Web of Science ®Google Scholar
• Kumar, R., and R. K. Vadlamudi. 2002. Emerging functions of p21-activated kinases in human cancer cells. J. Cell. Physiol. 193:133–144.
   PubMedGoogle Scholar
• Li, F., L. Adam, R. K. Vadlamudi, H. Zhou, H. F. Zhou, S. Sen, J. Chernoff, M. Mandal, and R. Kumar. 2002. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep. 3:767–773.
   PubMedGoogle Scholar
• Lopez-Fanarraga, M., J. Avila, A. Guasch, M. Coll, and J. C. Zabala. 2001. Postchaperonin tubulin folding cofactors and their role in microtubule dynamics. J. Struct. Biol. 135:219–229.
   PubMed Web of Science ®Google Scholar
• Montagna, C. F., E. R. Andrechek, H. F. Padilla-Nash, W. J. Muller, and T. Ried. 2002. Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 21:890–898.
   PubMed Web of Science ®Google Scholar
• Ottilie, S., P. J. Miller, D. F. Johnson, C. L. Creasy, M. A. Sells, S. Bagrodia, S. L. Forsburg, and J. Chernoff. 1995. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J. 14:5908–5919.
   PubMedGoogle Scholar
• Qyang, Y., P. Yang, H. Du, H. Lai, H. Kim, and S. Marcus. 2002. The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe. Mol. Microbiol. 44:325–334.
   PubMedGoogle Scholar
• Radcliffe, P. A., D. Hirata, L. Vardy, and T. Toda. 1999. Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast. Mol. Biol. Cell 10:2987–3001.
   PubMedGoogle Scholar
• Radcliffe, P. A., and T. Toda. 2000. Characterization of fission yeast alp11 mutants defines three functional domains within tubulin-folding cofactor B. Mol. Gen. Genet. 263:752–760.
   PubMedGoogle Scholar
• Salisbury, J. L. 1995. Centrin, centrosomes, and mitotic spindle poles. Curr. Opin. Cell Biol. 7:39–45.
   PubMed Web of Science ®Google Scholar
• Schürmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch. 2000. p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20:453–461.
   PubMed Web of Science ®Google Scholar
• Sells, M. A., A. Pfaff, and J. Chernoff. 2000. Temporal and spatial distribution of activated Pak1 in fibroblasts. J. Cell Biol. 151:1449–1458.
   PubMed Web of Science ®Google Scholar
• Sherline, P. F., and R. Mascardo. 1982. Epidermal growth factor-induced centrosomal separation: mechanism and relationship to mitogenesis. J. Cell Biol. 95:316–322.
   PubMedGoogle Scholar
• Szymanski, D. 2002. Tubulin folding cofactors: half a dozen for a dimer. Curr. Biol. 19:R767–R769.
   Google Scholar
• Thiel, D. A., M. Reeder, A. F. Pfaff, T. R. Coleman, M. A. Sells, and J. Chernoff. 2002. Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr. Biol. 12:1227–1232.
   PubMedGoogle Scholar
• Tian, G., A. Bhamidipati, N. J. Cowan, and S. A. Lewis. 1999. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J. Biol. Chem. 274:24054–24058.
   PubMedGoogle Scholar
• Tian, G., Y. Huang, H. Rommelaere, J. Vandekerckhove, C. Ampe, and N. J. Cowan. 1996. Pathway leading to correctly folded beta-tubulin. Cell 86:287–296.
   PubMed Web of Science ®Google Scholar
• Tian, G., S. A. Lewis, B. Feierbach, T. Stearns, H. Rommelaere, C. Ampe, and N. J. Cowan. 1997. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. J. Cell Biol. 138:821–832.
   PubMedGoogle Scholar
• Vadlamudi, R. K., L. Adam, R. A. Wang, M. Mandal, D. Nguyen, A. Sahin, J. Chernoff, M. C. Hung, and R. Kumar. 2000. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J. Biol. Chem. 275:36238–36244.
   PubMed Web of Science ®Google Scholar
• Vadlamudi, R. K., F. Li, L. Adam, D. Nguyen, Y. Ohta, T. P. Stossel, and R. Kumar. 2002. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat. Cell Biol. 4:681–690.
   PubMed Web of Science ®Google Scholar
• Waterman-Storer, C. M., R. A. Worthylake, B. P. Liu, K. F. Burridge, and E. D. Salmon. 1999. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat. Cell Biol. 1:45–50.
   PubMedGoogle Scholar