Normal Immune Development and Glucocorticoid-Induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor

REFERENCES

• Ashwell, J. D., F. W. Lu, and M. S. Vacchio. 2000. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18:309–345.
   PubMed Web of Science ®Google Scholar
• Beato, M., P. Herrlich, and G. Schutz. 1995. Steroid hormone receptors: many actors in search of a plot. Cell 83:851–857.
   PubMed Web of Science ®Google Scholar
• Brewer, J. A., B. P. Sleckman, W. Swat, and L. J. Muglia. 2002. Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development. J. Immunol. 169:1309–1318.
   PubMed Web of Science ®Google Scholar
• Choi, J. W., S. Y. Lee, and Y. Choi. 1996. Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 168:78–84.
   PubMed Web of Science ®Google Scholar
• Cohen, J. J., and R. C. Duke. 1984. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:38–42.
   PubMed Web of Science ®Google Scholar
• Frankfurt, O., and S. T. Rosen. 2004. Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr. Opin. Oncol. 16:553–563.
   PubMed Web of Science ®Google Scholar
• Gratiot-Deans, J., R. Merino, G. Nunez, and L. A. Turka. 1994. Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. Proc. Natl. Acad. Sci. USA 91:10685–10689.
   PubMedGoogle Scholar
• Hakem, R., A. Hakem, G. S. Duncan, J. T. Henderson, M. Woo, M. S. Soengas, A. Elia, J. L. de la Pompa, D. Kagi, W. Khoo, J. Potter, R. Yoshida, S. A. Kaufman, S. W. Lowe, J. M. Penninger, and T. W. Mak. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94:339–352.
   PubMed Web of Science ®Google Scholar
• Harrigan, M. T., G. Baughman, N. F. Campbell, and S. Bourgeois. 1989. Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes. Mol. Cell. Biol. 9:3438–3446.
   PubMedGoogle Scholar
• Hasserjian, R. P., J. C. Aster, F. Davi, D. S. Weinberg, and J. Sklar. 1996. Modulated expression of notch1 during thymocyte development. Blood 88:970–976.
   PubMed Web of Science ®Google Scholar
• Heiber, M., J. M. Docherty, G. Shah, T. Nguyen, R. Cheng, H. H. Heng, A. Marchese, L. C. Tsui, X. Shi, S. R. George, et al. 1995. Isolation of three novel human genes encoding G protein-coupled receptors. DNA Cell Biol. 14:25–35.
   PubMed Web of Science ®Google Scholar
• Hoffmann, R., L. Bruno, T. Seidl, A. Rolink, and F. Melchers. 2003. Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte development. J. Immunol. 170:1339–1353.
   PubMedGoogle Scholar
• Im, D. S., C. E. Heise, T. Nguyen, B. F. O'Dowd, and K. R. Lynch. 2001. Identification of a molecular target of psychosine and its role in globoid cell formation. J. Cell Biol. 153:429–434.
   PubMed Web of Science ®Google Scholar
• Ishii, S., Y. Kihara, and T. Shimizu. 2005. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J. Biol. Chem. 280:9083–9087.
   PubMed Web of Science ®Google Scholar
• Jondal, M., A. Pazirandeh, and S. Okret. 2004. Different roles for glucocorticoids in thymocyte homeostasis? Trends Immunol. 25:595–600.
   PubMed Web of Science ®Google Scholar
• Kanazawa, T., and Y. Kozutsumi. 2002. Biological function of sphingolipids involved in cytokinesis. Tanpakushitsu Kakusan Koso 47:394–399.
   PubMedGoogle Scholar
• Kuida, K., T. F. Haydar, C. Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M. S. Su, P. Rakic, and R. A. Flavell. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325–337.
   PubMed Web of Science ®Google Scholar
• Le, L. Q., J. H. Kabarowski, Z. Weng, A. B. Satterthwaite, E. T. Harvill, E. R. Jensen, J. F. Miller, and O. N. Witte. 2001. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity 14:561–571.
   PubMed Web of Science ®Google Scholar
• Lei, H. Y., M. J. Tang, and N. Tsao. 1997. Intracellular alkalinization in dexamethasone-induced thymocyte apoptosis. Apoptosis 2:304–312.
   PubMed Web of Science ®Google Scholar
• Liu, C. P., J. W. Kappler, and P. Marrack. 1996. Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage. J. Exp. Med. 184:1619–1630.
   PubMed Web of Science ®Google Scholar
• Malone, M. H., Z. Wang, and C. W. Distelhorst. 2004. The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J. Biol. Chem. 279:52850–52859.
   PubMed Web of Science ®Google Scholar
• Mick, V. E., T. K. Starr, T. M. McCaughtry, L. K. McNeil, and K. A. Hogquist. 2004. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173:5434–5444.
   PubMedGoogle Scholar
• Milan, G., A. Zambon, M. Cavinato, P. Zanovello, A. Rosato, and D. Collavo. 1999. Dissecting the immune response to Moloney murine sarcoma/leukemia virus-induced tumors by means of a DNA vaccination approach. J. Virol. 73:2280–2287.
   PubMedGoogle Scholar
• Munitic, I., J. A. Williams, Y. Yang, B. Dong, P. J. Lucas, N. El Kassar, R. E. Gress, and J. D. Ashwell. 2004. Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood 104:4165–4172.
   PubMed Web of Science ®Google Scholar
• Murphy, K. M., A. B. Heimberger, and D. Y. Loh. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250:1720–1723.
   PubMed Web of Science ®Google Scholar
• Owens, G. P., W. E. Hahn, and J. J. Cohen. 1991. Identification of mRNAs associated with programmed cell death in immature thymocytes. Mol. Cell. Biol. 11:4177–4188.
   PubMed Web of Science ®Google Scholar
• Radu, C. G., A. Nijagal, J. McLaughlin, L. Wang, and O. N. Witte. 2005. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc. Natl. Acad. Sci. USA 102:1632–1637.
   PubMed Web of Science ®Google Scholar
• Reichardt, H. M., K. H. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, R. Bock, P. Gass, W. Schmid, P. Herrlich, P. Angel, and G. Schutz. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531–541.
   PubMed Web of Science ®Google Scholar
• Stefanelli, C., F. Bonavita, I. Stanic, G. Farruggia, E. Falcieri, I. Robuffo, C. Pignatti, C. Muscari, C. Rossoni, C. Guarnieri, and C. M. Caldarera. 1997. ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis. Biochem. J. 322:909–917.
   PubMedGoogle Scholar
• Tomura, H., C. Mogi, K. Sato, and F. Okajima. 2005. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 17:1466–1476.
   PubMed Web of Science ®Google Scholar
• Tosa, N., M. Murakami, W. Y. Jia, M. Yokoyama, T. Masunaga, C. Iwabuchi, M. Inobe, K. Iwabuchi, T. Miyazaki, K. Onoe, M. Iwata, and T. Uede. 2003. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int. Immunol. 15:741–749.
   PubMed Web of Science ®Google Scholar
• Vinuesa, C. G., and C. C. Goodnow. 2004. Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. Immunity 20:669–679.
   PubMed Web of Science ®Google Scholar
• Wang, J. Q., J. Kon, C. Mogi, M. Tobo, A. Damirin, K. Sato, M. Komachi, E. Malchinkhuu, N. Murata, T. Kimura, A. Kuwabara, K. Wakamatsu, H. Koizumi, T. Uede, G. Tsujimoto, H. Kurose, T. Sato, A. Harada, N. Misawa, H. Tomura, and F. Okajima. 2004. TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J. Biol. Chem. 279:45626–45633.
   PubMed Web of Science ®Google Scholar
• Weng, Z., A. C. Fluckiger, S. Nisitani, M. I. Wahl, L. Q. Le, C. A. Hunter, A. A. Fernal, M. M. Le Beau, and O. N. Witte. 1998. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc. Natl. Acad. Sci. USA 95:12334–12339.
   PubMed Web of Science ®Google Scholar
• Whitfield, P. D., P. C. Sharp, R. Taylor, and P. Meikle. 2001. Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry. J. Lipid Res. 42:2092–2095.
   PubMedGoogle Scholar
• Xu, Y., and G. Casey. 1996. Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. Genomics 35:397–402.
   PubMed Web of Science ®Google Scholar
• Yoshida, H., Y. Y. Kong, R. Yoshida, A. J. Elia, A. Hakem, R. Hakem, J. M. Penninger, and T. W. Mak. 1998. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94:739–750.
   PubMed Web of Science ®Google Scholar