Low K⁺ Promotes NF-κB/DNA Binding in Neuronal Apoptosis Induced by K⁺ Loss

REFERENCES

• Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
   PubMed Web of Science ®Google Scholar
• Bakalkin, G., T. Yakovleva, and L. Terenius. 1993. NF-kappa B-like factors in the murine brain. Developmentally-regulated and tissue-specific expression. Brain Res. Mol. Brain Res. 20:137–146.
   PubMedGoogle Scholar
• Barbiero, G., F. Duranti, G. Bonelli, J. S. Amenta, and F. M. Baccino. 1995. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp. Cell Res. 217:410–418.
   PubMed Web of Science ®Google Scholar
• Barkett, M., and T. D. Gilmore. 1999. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18:6910–6924.
   PubMed Web of Science ®Google Scholar
• Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167–170.
   PubMed Web of Science ®Google Scholar
• Bhakar, A. L., L. L. Tannis, C. Zeindler, M. P. Russo, C. Jobin, D. S. Park, S. MacPherson, and P. A. Barker. 2002. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J. Neurosci. 22:8466–8475.
   PubMed Web of Science ®Google Scholar
• Boise, L. H., M. Gonzalez-Garcia, C. E. Postema, L. Ding, T. Lindsten, L. A. Turka, X. Mao, G. Nunez, and C. B. Thompson. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597–608.
   PubMed Web of Science ®Google Scholar
• Chen, F. E., D. B. Huang, Y. Q. Chen, and G. Ghosh. 1998. Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA. Nature 391:410–413.
   PubMed Web of Science ®Google Scholar
• Denk, A., T. Wirth, and B. Baumann. 2000. NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival. Cytokine Growth Factor Rev. 11:303–320.
   PubMed Web of Science ®Google Scholar
• Dixon, E. P., D. T. Stephenson, J. A. Clemens, and S. P. Little. 1997. Bcl-Xshort is elevated following severe global ischemia in rat brains. Brain Res. 776:222–229.
   PubMedGoogle Scholar
• Fridmacher, V., B. Kaltschmidt, B. Goudeau, D. Ndiaye, F. M. Rossi, J. Pfeiffer, C. Kaltschmidt, A. Israel, and S. Memet. 2003. Forebrain-specific neuronal inhibition of nuclear factor-κB activity leads to loss of neuroprotection. J. Neurosci. 23:9403–9408.
   PubMed Web of Science ®Google Scholar
• Gabriel, C., C. Justicia, A. Camins, and A. M. Planas. 1999. Activation of nuclear factor-κB in the rat brain after transient focal ischemia. Brain Res. Mol. Brain Res. 65:61–69.
   PubMedGoogle Scholar
• Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109(Suppl.):S81–S96.
   PubMed Web of Science ®Google Scholar
• Glasgow, J. N., T. Wood, and J. R. Perez-Polo. 2000. Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter. J. Neurochem. 75:1377–1389.
   PubMedGoogle Scholar
• Grewal, S. S., A. M. Horgan, R. D. York, G. S. Withers, G. A. Banker, and P. J. Stork. 2000. Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. J. Biol. Chem. 275:3722–3728.
   PubMedGoogle Scholar
• Grilli, M., M. Pizzi, M. Memo, and P. Spano. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 274:1383–1385.
   PubMed Web of Science ®Google Scholar
• Guan, K. L., and J. E. Dixon. 1991. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192:262–267.
   PubMed Web of Science ®Google Scholar
• Guerrini, L., F. Blasi, and S. Denis-Donini. 1995. Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proc. Natl. Acad. Sci. USA 92:9077–9081.
   PubMedGoogle Scholar
• Hamanoue, M., G. Middleton, S. Wyatt, E. Jaffray, R. T. Hay, and A. M. Davies. 1999. p75-mediated NF-κB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol. Cell. Neurosci. 14:28–40.
   PubMed Web of Science ®Google Scholar
• Huber, K. M., M. D. Mauk, and P. T. Kelly. 1995. Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels. J. Neurophysiol. 73:270–279.
   PubMed Web of Science ®Google Scholar
• Hughes, F. M., Jr., C. D. Bortner, G. D. Purdy, and J. A. Cidlowski. 1997. Intracellular K+ suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272:30567–30576.
   PubMed Web of Science ®Google Scholar
• Hughes, F. M., Jr., and J. A. Cidlowski. 1999. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Adv. Enzyme Regul. 39:157–171.
   PubMedGoogle Scholar
• Kaltschmidt, B., M. Uherek, B. Volk, P. A. Baeuerle, and C. Kaltschmidt. 1997. Transcription factor NF-κB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94:2642–2647.
   PubMed Web of Science ®Google Scholar
• Kaltschmidt, C., B. Kaltschmidt, H. Neumann, H. Wekerle, and P. A. Baeuerle. 1994. Constitutive NF-κB activity in neurons. Mol. Cell. Biol. 14:3981–3992.
   PubMed Web of Science ®Google Scholar
• Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965–1977.
   PubMed Web of Science ®Google Scholar
• Krichevsky, A. M., and K. S. Kosik. 2002. RNAi functions in cultured mammalian neurons. Proc. Natl. Acad. Sci. USA 99:11926–11929.
   PubMed Web of Science ®Google Scholar
• Leung, T. H., A. Hoffmann, and D. Baltimore. 2004. One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell 118:453–464.
   PubMed Web of Science ®Google Scholar
• Liou, H. C., and D. Baltimore. 1993. Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr. Opin. Cell Biol. 5:477–487.
   PubMed Web of Science ®Google Scholar
• Liou, H. C., Z. Jin, J. Tumang, S. Andjelic, K. A. Smith, and M. L. Liou. 1999. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 11:361–371.
   PubMed Web of Science ®Google Scholar
• Mattson, M. P., C. Culmsee, Z. Yu, and S. Camandola. 2000. Roles of nuclear factor κB in neuronal survival and plasticity. J. Neurochem. 74:443–456.
   PubMed Web of Science ®Google Scholar
• Meffert, M. K., J. M. Chang, B. J. Wiltgen, M. S. Fanselow, and D. Baltimore. 2003. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci. 6:1072–1078.
   PubMed Web of Science ®Google Scholar
• Michaelidis, T. M., M. Sendtner, J. D. Cooper, M. S. Airaksinen, B. Holtmann, M. Meyer, and H. Thoenen. 1996. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 17:75–89.
   PubMed Web of Science ®Google Scholar
• Montague, J. W., C. D. Bortner, F. M. Hughes, Jr., and J. A. Cidlowski. 1999. A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Steroids 64:563–569.
   PubMed Web of Science ®Google Scholar
• Motoyama, N., F. Wang, K. A. Roth, H. Sawa, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, and S. Fujii. 1995. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506–1510.
   PubMed Web of Science ®Google Scholar
• Nijhawan, D., N. Honarpour, and X. Wang. 2000. Apoptosis in neural development and disease. Annu. Rev. Neurosci. 23:73–87.
   PubMed Web of Science ®Google Scholar
• O'Neill, L. A., and C. Kaltschmidt. 1997. NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20:252–258.
   PubMed Web of Science ®Google Scholar
• Pecci, A., L. R. Viegas, J. L. Baranao, and M. Beato. 2001. Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-X gene. J. Biol. Chem. 276:21062–21069.
   PubMedGoogle Scholar
• Pelletier, M. R., and J. J. Hablitz. 1996. Tetraethylammonium-induced synaptic plasticity in rat neocortex. Cereb. Cortex 6:771–780.
   PubMedGoogle Scholar
• Pizzi, M., F. Goffi, F. Boroni, M. Benarese, S. E. Perkins, H. C. Liou, and P. Spano. 2002. Opposing roles for NF-κB/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1β. J. Biol. Chem. 277:20717–20723.
   PubMed Web of Science ®Google Scholar
• Reddy, R., D. Smith, G. Wayman, Z. Wu, E. C. Villacres, and D. R. Storm. 1995. Voltage-sensitive adenylyl cyclase activity in cultured neurons. A calcium-independent phenomenon. J. Biol. Chem. 270:14340–14346.
   PubMedGoogle Scholar
• Roth, K. A., N. Motoyama, and D. Y. Loh. 1996. Apoptosis of bcl-x-deficient telencephalic cells in vitro. J. Neurosci. 16:1753–1758.
   PubMed Web of Science ®Google Scholar
• Schmidt-Ullrich, R., S. Memet, A. Lilienbaum, J. Feuillard, M. Raphael, and A. Israel. 1996. NF-κB activity in transgenic mice: developmental regulation and tissue specificity. Development 122:2117–2128.
   PubMedGoogle Scholar
• Scott, M. L., T. Fujita, H. C. Liou, G. P. Nolan, and D. Baltimore. 1993. The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev. 7:1266–1276.
   PubMed Web of Science ®Google Scholar
• Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell 80:321–330.
   PubMed Web of Science ®Google Scholar
• Shou, Y., N. Li, L. Li, J. L. Borowitz, and G. E. Isom. 2002. NF-κB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis. J. Neurochem. 81:842–852.
   PubMed Web of Science ®Google Scholar
• Sun, S. C., P. A. Ganchi, D. W. Ballard, and W. C. Greene. 1993. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259:1912–1915.
   PubMed Web of Science ®Google Scholar
• Thompson, G. J., C. Langlais, K. Cain, E. C. Conley, and G. M. Cohen. 2001. Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. Biochem. J. 357:137–145.
   PubMedGoogle Scholar
• Tsukahara, T., M. Kannagi, T. Ohashi, H. Kato, M. Arai, G. Nunez, Y. Iwanaga, N. Yamamoto, K. Ohtani, M. Nakamura, and M. Fujii. 1999. Induction of Bcl-xL expression by human T-cell leukemia virus type 1 Tax through NF-κB in apoptosis-resistant T-cell transfectants with Tax. J. Virol. 73:7981–7987.
   PubMed Web of Science ®Google Scholar
• Wang, Y., and J. P. Durkin. 1995. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but not N-methyl-d-aspartate, activates mitogen-activated protein kinase through G-protein βγ subunits in rat cortical neurons. J. Biol. Chem. 270:22783–22787.
   PubMed Web of Science ®Google Scholar
• Yu, S. P., C. Yeh, U. Strasser, M. Tian, and D. W. Choi. 1999. NMDA receptor-mediated K+ efflux and neuronal apoptosis. Science 284:336–339.
   PubMed Web of Science ®Google Scholar
• Yu, S. P., C. H. Yeh, S. L. Sensi, B. J. Gwag, L. M. Canzoniero, Z. S. Farhangrazi, H. S. Ying, M. Tian, L. L. Dugan, and D. W. Choi. 1997. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278:114–117.
   PubMed Web of Science ®Google Scholar
• Zaidi, A. U., C. D'Sa-Eipper, J. Brenner, K. Kuida, T. S. Zheng, R. A. Flavell, P. Rakic, and K. A. Roth. 2001. Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21:169–175.
   PubMedGoogle Scholar