Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development

REFERENCES

• Asahara, H., S. Tartare-Deckert, T. Nakagawa, T. Ikehara, F. Hirose, T. Hunter, T. Ito, and M. Montminy. 2002. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol. Cell. Biol. 22:2974–2983.
   PubMedGoogle Scholar
• Bachurski, C. J., G. H. Yang, T. A. Currier, R. M. Gronostajski, and D. Hong. 2003. Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol. Cell. Biol. 23:9014–9024.
   PubMedGoogle Scholar
• Bai, L., and J. L. Merchant. 2000. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. J. Biol. Chem. 275:30725–30733.
   PubMed Web of Science ®Google Scholar
• Bai, R. Y., C. Koester, T. Ouyang, S. A. Hahn, M. Hammerschmidt, C. Peschel, and J. Duyster. 2002. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. Nat. Cell Biol. 4:181–190.
   PubMedGoogle Scholar
• Bailey, P., V. Sartorelli, Y. Hamamori, and G. E. Muscat. 1998. The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD. Nucleic Acids Res. 26:5501–5510.
   PubMedGoogle Scholar
• Bannert, N., A. Avots, M. Baier, E. Serfling, and R. Kurth. 1999. GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes. Proc. Natl. Acad. Sci. USA 96:1541–1546.
   PubMedGoogle Scholar
• Barbacci, E., A. Chalkiadaki, C. Masdeu, C. Haumaitre, L. Lokmane, C. Loirat, S. Cloarec, I. Talianidis, C. Bellanne-Chantelot, and S. Cereghini. 2004. HNF1β/TCF2 mutations impair transactivation potential through altered co-regulator recruitment. Hum. Mol. Genet. 13:3139–3149.
   PubMed Web of Science ®Google Scholar
• Barrios-Rodiles, M., K. R. Brown, B. Ozdamar, R. Bose, Z. Liu, R. S. Donovan, F. Shinjo, Y. Liu, J. Dembowy, I. W. Taylor, V. Luga, N. Przulj, M. Robinson, H. Suzuki, Y. Hayashizaki, I. Jurisica, and J. L. Wrana. 2005. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307:1621–1625.
   PubMed Web of Science ®Google Scholar
• Barthel, R., A. V. Tsytsykova, A. K. Barczak, E. Y. Tsai, C. C. Dascher, M. B. Brenner, and A. E. Goldfeld. 2003. Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300. Mol. Cell. Biol. 23:526–533.
   PubMed Web of Science ®Google Scholar
• Bavner, A., J. Matthews, S. Sanyal, J. A. Gustafsson, and E. Treuter. 2005. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res. 33:3561–3569.
   PubMed Web of Science ®Google Scholar
• Bereshchenko, O. R., W. Gu, and R. Dalla-Favera. 2002. Acetylation inactivates the transcriptional repressor BCL6. Nat. Genet. 32:606–613.
   PubMed Web of Science ®Google Scholar
• Bernat, A., N. Avvakumov, J. S. Mymryk, and L. Banks. 2003. Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300. Oncogene 22:7871–7881.
   PubMed Web of Science ®Google Scholar
• Bessa, M., M. K. Saville, and R. J. Watson. 2001. Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator. Oncogene 20:3376–3386.
   PubMedGoogle Scholar
• Bhakat, K. K., T. Izumi, S. H. Yang, T. K. Hazra, and S. Mitra. 2003. Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J. 22:6299–6309.
   PubMed Web of Science ®Google Scholar
• Bhattacharya, S., C. L. Michels, M. K. Leung, Z. P. Arany, A. L. Kung, and D. M. Livingston. 1999. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13:64–75.
   PubMed Web of Science ®Google Scholar
• Biery, M. C., F. J. Stewart, A. E. Stellwagen, E. A. Raleigh, and N. L. Craig. 2000. A simple in vitro Tn7-based transposition system with low target site selectivity for genome and gene analysis. Nucleic Acids Res. 28:1067–1077.
   PubMed Web of Science ®Google Scholar
• Billon, N., D. Carlisi, M. B. Datto, L. A. van Grunsven, A. Watt, X. F. Wang, and B. B. Rudkin. 1999. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18:2872–2882.
   PubMedGoogle Scholar
• Blobel, G. A. 2002. CBP and p300: versatile coregulators with important roles in hematopoietic gene expression. J. Leukoc. Biol. 71:545–556.
   PubMed Web of Science ®Google Scholar
• Bouras, T., M. Fu, A. A. Sauve, F. Wang, A. A. Quong, N. D. Perkins, R. T. Hay, W. Gu, and R. G. Pestell. 2005. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 280:10264–10276.
   PubMed Web of Science ®Google Scholar
• Bowen, H., A. Lapham, E. Phillips, I. Yeung, M. Alter-Koltunoff, B. Z. Levi, V. H. Perry, D. A. Mann, and C. H. Barton. 2003. Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1. J. Biol. Chem. 278:36017–36026.
   PubMedGoogle Scholar
• Braganca, J., J. J. Eloranta, S. D. Bamforth, J. C. Ibbitt, H. C. Hurst, and S. Bhattacharya. 2003. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J. Biol. Chem. 278:16021–16029.
   PubMedGoogle Scholar
• Braganca, J., T. Swingler, F. I. Marques, T. Jones, J. J. Eloranta, H. C. Hurst, T. Shioda, and S. Bhattacharya. 2002. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. J. Biol. Chem. 277:8559–8565.
   PubMedGoogle Scholar
• Burysek, L., W. S. Yeow, B. Lubyova, M. Kellum, S. L. Schafer, Y. Q. Huang, and P. M. Pitha. 1999. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J. Virol. 73:7334–7342.
   PubMed Web of Science ®Google Scholar
• Castillo, A. I., A. M. Jimenez-Lara, R. M. Tolon, and A. Aranda. 1999. Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1). Mol. Endocrinol. 13:1141–1154.
   PubMedGoogle Scholar
• Chakraborty, S., V. Senyuk, S. Sitailo, Y. Chi, and G. Nucifora. 2001. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J. Biol. Chem. 276:44936–44943.
   PubMed Web of Science ®Google Scholar
• Chan, H. M., M. Krstic-Demonacos, L. Smith, C. Demonacos, and N. B. La Thangue. 2001. Acetylation control of the retinoblastoma tumour-suppressor protein. Nat. Cell Biol. 3:667–674.
   PubMed Web of Science ®Google Scholar
• Chan, H. M., and N. B. La Thangue. 2001. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114:2363–2373.
   PubMed Web of Science ®Google Scholar
• Chang, C. W., H. C. Chuang, C. Yu, T. P. Yao, and H. Chen. 2005. Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. Mol. Cell. Biol. 25:8401–8414.
   PubMedGoogle Scholar
• Chen, J., S. S. Halappanavar, J. R. St-Germain, B. K. Tsang, and Q. Li. 2004. Role of Akt/protein kinase B in the activity of transcriptional coactivator p300. Cell. Mol. Life Sci. 61:1675–1683.
   PubMed Web of Science ®Google Scholar
• Chen, J., J. R. St-Germain, and Q. Li. 2005. B56 Regulatory subunit of protein phosphatase 2A mediates valproic acid-induced p300 degradation. Mol. Cell. Biol. 25:525–532.
   PubMed Web of Science ®Google Scholar
• Chen, Q., D. H. Dowhan, D. Liang, D. D. Moore, and P. A. Overbeek. 2002. CREB-binding protein/p300 co-activation of crystallin gene expression. J. Biol. Chem. 277:24081–24089.
   PubMedGoogle Scholar
• Clausen, B. E., C. Burkhardt, W. Reith, R. Renkawitz, and I. Forster. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8:265–277.
   PubMed Web of Science ®Google Scholar
• Cotter, M. A., II, and E. S. Robertson. 2000. Modulation of histone acetyltransferase activity through interaction of Epstein-Barr nuclear antigen 3C with prothymosin alpha. Mol. Cell. Biol 20:5722–5735.
   PubMed Web of Science ®Google Scholar
• Dai, P., H. Akimaru, Y. Tanaka, T. Maekawa, M. Nakafuku, and S. Ishii. 1999. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274:8143–8152.
   PubMed Web of Science ®Google Scholar
• Dai, Y. S., P. Cserjesi, B. E. Markham, and J. D. Molkentin. 2002. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. J. Biol. Chem. 277:24390–24398.
   PubMed Web of Science ®Google Scholar
• Dai, Y. S., and B. E. Markham. 2001. p300 Functions as a coactivator of transcription factor GATA-4. J. Biol. Chem. 276:37178–37185.
   PubMed Web of Science ®Google Scholar
• De Leo, R., S. Miccadei, E. Zammarchi, and D. Civitareale. 2000. Role for p300 in Pax 8 induction of thyroperoxidase gene expression. J. Biol. Chem. 275:34100–34105.
   PubMedGoogle Scholar
• Dietrich, P., I. Dragatsis, S. Xuan, S. Zeitlin, and A. Efstratiadis. 2000. Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mamm. Genome 11:196–205.
   PubMedGoogle Scholar
• Doucas, V., M. Tini, D. A. Egan, and R. M. Evans. 1999. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci. USA 96:2627–2632.
   PubMedGoogle Scholar
• Dowell, P., J. E. Ishmael, D. Avram, V. J. Peterson, D. J. Nevrivy, and M. Leid. 1997. p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 272:33435–33443.
   PubMedGoogle Scholar
• Eckner, R., T. P. Yao, E. Oldread, and D. M. Livingston. 1996. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10:2478–2490.
   PubMed Web of Science ®Google Scholar
• Ema, M., K. Hirota, J. Mimura, H. Abe, J. Yodoi, K. Sogawa, L. Poellinger, and Y. Fujii-Kuriyama. 1999. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18:1905–1914.
   PubMed Web of Science ®Google Scholar
• Emelyanov, A. V., C. R. Kovac, M. A. Sepulveda, and B. K. Birshtein. 2002. The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. J. Biol. Chem. 277:11156–11164.
   PubMedGoogle Scholar
• Erickson, R. L., N. Hemati, S. E. Ross, and O. A. MacDougald. 2001. p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 276:16348–16355.
   PubMedGoogle Scholar
• Ernst, P., J. Wang, M. Huang, R. H. Goodman, and S. J. Korsmeyer. 2001. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol. Cell. Biol. 21:2249–2258.
   PubMed Web of Science ®Google Scholar
• Facchinetti, V., L. Loffarelli, S. Schreek, M. Oelgeschlager, B. Luscher, M. Introna, and J. Golay. 1997. Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. Biochem. J. 324:729–736.
   PubMedGoogle Scholar
• Falvo, J. V., B. M. Brinkman, A. V. Tsytsykova, E. Y. Tsai, T. P. Yao, A. L. Kung, and A. E. Goldfeld. 2000. A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. Proc. Natl. Acad. Sci. USA 97:3925–3929.
   PubMedGoogle Scholar
• Fang, X., E. K. Stachowiak, S. M. Dunham-Ems, I. Klejbor, and M. K. Stachowiak. 2005. Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J. Biol. Chem. 280:28451–28462.
   PubMedGoogle Scholar
• Faniello, M. C., M. A. Bevilacqua, G. Condorelli, B. de Crombrugghe, S. N. Maity, V. E. Avvedimento, F. Cimino, and F. Costanzo. 1999. The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300. J. Biol. Chem. 274:7623–7626.
   PubMed Web of Science ®Google Scholar
• Felzien, L. K., C. Woffendin, M. O. Hottiger, R. A. Subbramanian, E. A. Cohen, and G. J. Nabel. 1998. HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. Proc. Natl. Acad. Sci. USA 95:5281–5286.
   PubMed Web of Science ®Google Scholar
• Fryer, C. J., E. Lamar, I. Turbachova, C. Kintner, and K. A. Jones. 2002. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 16:1397–1411.
   PubMed Web of Science ®Google Scholar
• Fu, M., C. Wang, M. Rao, X. Wu, T. Bouras, X. Zhang, Z. Li, X. Jiao, J. Yang, A. Li, N. D. Perkins, B. Thimmapaya, A. L. Kung, A. Munoz, A. Giordano, M. P. Lisanti, and R. G. Pestell. 2005. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J. Biol. Chem. 280:29728–29742.
   PubMed Web of Science ®Google Scholar
• Fujii, Y., A. Kumatori, and M. Nakamura. 2003. SATB1 makes a complex with p300 and represses gp91(phox) promoter activity. Microbiol. Immunol. 47:803–811.
   PubMed Web of Science ®Google Scholar
• Fukuda, S., T. Kondo, H. Takebayashi, and T. Taga. 2004. Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway. Cell Death Differ. 11:196–202.
   PubMed Web of Science ®Google Scholar
• Furia, B., L. Deng, K. Wu, S. Baylor, K. Kehn, H. Li, R. Donnelly, T. Coleman, and F. Kashanchi. 2002. Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins. J. Biol. Chem. 277:4973–4980.
   PubMed Web of Science ®Google Scholar
• Fuse, H., H. Kitagawa, and S. Kato. 2000. Characterization of transactivational property and coactivator mediation of rat mineralocorticoid receptor activation function-1 (AF-1). Mol. Endocrinol. 14:889–899.
   PubMedGoogle Scholar
• Garcia-Rodriguez, C., and A. Rao. 1998. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J. Exp. Med. 187:2031–2036.
   PubMedGoogle Scholar
• Gingras, S., J. Simard, B. Groner, and E. Pfitzner. 1999. p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Res. 27:2722–2729.
   PubMedGoogle Scholar
• Giordano, A., and M. L. Avantaggiati. 1999. p300 and CBP: partners for life and death. J. Cell. Physiol. 181:218–230.
   PubMed Web of Science ®Google Scholar
• Giot, L., J. S. Bader, C. Brouwer, A. Chaudhuri, B. Kuang, Y. Li, Y. L. Hao, C. E. Ooi, B. Godwin, E. Vitols, G. Vijayadamodar, P. Pochart, H. Machineni, M. Welsh, Y. Kong, B. Zerhusen, R. Malcolm, Z. Varrone, A. Collis, M. Minto, S. Burgess, L. McDaniel, E. Stimpson, F. Spriggs, J. Williams, K. Neurath, N. Ioime, M. Agee, E. Voss, K. Furtak, R. Renzulli, N. Aanensen, S. Carrolla, E. Bickelhaupt, Y. Lazovatsky, A. DaSilva, J. Zhong, C. A. Stanyon, R. L. Finley, Jr., K. P. White, M. Braverman, T. Jarvie, S. Gold, M. Leach, J. Knight, R. A. Shimkets, M. P. McKenna, J. Chant, and J. M. Rothberg. 2003. A protein interaction map of Drosophila melanogaster. Science 302:1727–1736.
   PubMed Web of Science ®Google Scholar
• Girdwood, D., D. Bumpass, O. A. Vaughan, A. Thain, L. A. Anderson, A. W. Snowden, E. Garcia-Wilson, N. D. Perkins, and R. T. Hay. 2003. P300 transcriptional repression is mediated by SUMO modification. Mol. Cell 11:1043–1054.
   PubMedGoogle Scholar
• Gizard, F., B. Lavallee, F. DeWitte, and D. W. Hum. 2001. A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. J. Biol. Chem. 276:33881–33892.
   PubMed Web of Science ®Google Scholar
• Gomez-Gonzalo, M., I. Benedicto, M. Carretero, E. Lara-Pezzi, A. Maldonado-Rodriguez, R. Moreno-Otero, M. M. Lai, and M. Lopez-Cabrera. 2004. Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity. Virology 328:120–130.
   PubMedGoogle Scholar
• Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553–1577.
   PubMed Web of Science ®Google Scholar
• Gronroos, E., U. Hellman, C. H. Heldin, and J. Ericsson. 2002. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell 10:483–493.
   PubMed Web of Science ®Google Scholar
• Guidez, F., L. Howell, M. Isalan, M. Cebrat, R. M. Alani, S. Ivins, I. Hormaeche, M. J. McConnell, S. Pierce, P. A. Cole, J. Licht, and A. Zelent. 2005. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 25:5552–5566.
   PubMed Web of Science ®Google Scholar
• Hasan, S., P. O. Hassa, R. Imhof, and M. O. Hottiger. 2001. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature 410:387–391.
   PubMed Web of Science ®Google Scholar
• Hashimoto, K., K. Zanger, A. N. Hollenberg, L. E. Cohen, S. Radovick, and F. E. Wondisford. 2000. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J. Biol. Chem. 275:33365–33372.
   PubMedGoogle Scholar
• Hennet, T., F. K. Hagen, L. A. Tabak, and J. D. Marth. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA 92:12070–12074.
   PubMedGoogle Scholar
• Hirai, M., K. Ono, T. Morimoto, T. Kawamura, H. Wada, T. Kita, and K. Hasegawa. 2004. FOG-2 competes with GATA-4 for a transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. J. Biol. Chem. 279:37640–37650.
   PubMedGoogle Scholar
• Hirose, T., R. Fujii, H. Nakamura, S. Aratani, H. Fujita, M. Nakazawa, K. Nakamura, K. Nishioka, and T. Nakajima. 2003. Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP. Int. J. Mol. Med. 11:705–712.
   PubMedGoogle Scholar
• Hoffmeister, A., A. Ropolo, S. Vasseur, G. V. Mallo, H. Bodeker, B. Ritz-Laser, G. R. Dressler, M. I. Vaccaro, J. C. Dagorn, S. Moreno, and J. L. Iovanna. 2002. The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J. Biol. Chem. 277:22314–22319.
   PubMed Web of Science ®Google Scholar
• Hong, S., S. H. Kim, M. A. Heo, Y. H. Choi, M. J. Park, M. A. Yoo, H. D. Kim, H. S. Kang, and J. Cheong. 2004. Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock. FEBS Lett. 559:165–170.
   PubMed Web of Science ®Google Scholar
• Hong, W., R. J. Resnick, C. Rakowski, D. Shalloway, S. J. Taylor, and G. A. Blobel. 2002. Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol. Cancer Res. 1:48–55.
   PubMedGoogle Scholar
• Hsu, L. C., S. Liu, F. Abedinpour, R. D. Beech, J. M. Lahti, V. J. Kidd, J. A. Greenspan, and C. Y. Yeung. 2003. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Mol. Cell. Biol. 23:8773–8785.
   PubMedGoogle Scholar
• Huang, S. M., and M. R. Stallcup. 2000. Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors. Mol. Cell. Biol. 20:1855–1867.
   PubMed Web of Science ®Google Scholar
• Hussain, M. A., and J. F. Habener. 1999. Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. J. Biol. Chem. 274:28950–28957.
   PubMed Web of Science ®Google Scholar
• Hwang, S., Y. Gwack, H. Byun, C. Lim, and J. Choe. 2001. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J. Virol. 75:9509–9516.
   PubMedGoogle Scholar
• Iioka, T., K. Furukawa, A. Yamaguchi, H. Shindo, S. Yamashita, and T. Tsukazaki. 2003. P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J. Bone Miner. Res. 18:1419–1429.
   PubMedGoogle Scholar
• Ikeda, K., T. Stuehler, and M. Meisterernst. 2002. The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms. Genes Cells 7:49–58.
   PubMedGoogle Scholar
• Ikeda, K., Y. Watanabe, H. Ohto, and K. Kawakami. 2002. Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol. Cell. Biol. 22:6759–6766.
   PubMed Web of Science ®Google Scholar
• Ikonen, T., J. J. Palvimo, and O. A. Janne. 1997. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J. Biol. Chem. 272:29821–29828.
   PubMedGoogle Scholar
• Iwasaki, T., W. W. Chin, and L. Ko. 2001. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J. Biol. Chem. 276:33375–33383.
   PubMedGoogle Scholar
• Jameson, S. C. 2002. Maintaining the norm: T-cell homeostasis. Nat. Rev. Immunol. 2:547–556.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., and A. Nordheim. 1996. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228:831–837.
   PubMed Web of Science ®Google Scholar
• Janknecht, R., N. J. Wells, and T. Hunter. 1998. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 12:2114–2119.
   PubMedGoogle Scholar
• Jayaraman, G., R. Srinivas, C. Duggan, E. Ferreira, S. Swaminathan, K. Somasundaram, J. Williams, C. Hauser, M. Kurkinen, R. Dhar, S. Weitzman, G. Buttice, and B. Thimmapaya. 1999. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. J. Biol. Chem. 274:17342–17352.
   PubMed Web of Science ®Google Scholar
• Ji, A., D. Dao, J. Chen, and W. R. MacLellan. 2003. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. Gene 318:35–43.
   PubMedGoogle Scholar
• Jung, S. Y., A. Malovannaya, J. Wei, B. W. O'Malley, and J. Qin. 2005. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol. Endocrinol. 19:2451–2465.
   PubMedGoogle Scholar
• Kaida, A., Y. Ariumi, K. Baba, M. Matsubae, T. Takao, and K. Shimotohno. 2005. Identification of a novel p300-specific associating protein, phosphoribosylpyrophosphate synthetase subunit 1 (PRS 1). Biochem. J. 391:239–247.
   PubMedGoogle Scholar
• Kakita, T., K. Hasegawa, T. Morimoto, S. Kaburagi, H. Wada, and S. Sasayama. 1999. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. J. Biol. Chem. 274:34096–34102.
   PubMedGoogle Scholar
• Kalkhoven, E. 2004. CBP and p300: HATs for different occasions. Biochem. Pharmacol. 68:1145–1155.
   PubMed Web of Science ®Google Scholar
• Kang-Decker, N., C. Tong, F. Boussouar, D. J. Baker, W. Xu, A. A. Leontovich, W. R. Taylor, P. K. Brindle, and J. M. Van Deursen. 2004. Loss of CBP causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency. Cancer Cell 5:177–189.
   PubMedGoogle Scholar
• Karetsou, Z., A. Kretsovali, C. Murphy, O. Tsolas, and T. Papamarcaki. 2002. Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. EMBO Rep. 3:361–366.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., F. Boussovar, K. Boyd, W. Xu, M. Biesen, J. Rehg, T. A. Baudino, J. L. Cleveland, and P. K. Brindle. 2005. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 24:3846–3858.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., F. Boussouar, P. A. Ney, C. W. Jackson, J. Rehg, J. M. van Deursen, and P. K. Brindle. 2002. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419:738–743.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., P. K. Brindle, C. A. Schnabel, C. E. J. Pritchard, M. L. Cleary, and J. M. A. van Deursen. 1999. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol. Cell. Biol. 19:764–776.
   PubMed Web of Science ®Google Scholar
• Kaul, S., J. A. Blackford, Jr., J. Chen, V. V. Ogryzko, and S. S. Simons, Jr. 2000. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Mol. Endocrinol. 14:1010–1027.
   PubMedGoogle Scholar
• Kawamura, T., K. Ono, T. Morimoto, M. Akao, E. Iwai-Kanai, H. Wada, N. Sowa, T. Kita, and K. Hasegawa. 2004. Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Circ. Res. 94:1492–1499.
   PubMed Web of Science ®Google Scholar
• Kennell, J. A., E. E. O'Leary, B. M. Gummow, G. D. Hammer, and O. A. MacDougald. 2003. T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol. Cell. Biol. 23:5366–5375.
   PubMedGoogle Scholar
• Kim, J. H., E. J. Cho, S. T. Kim, and H. D. Youn. 2005. CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat. Struct. Mol. Biol. 12:423–428.
   PubMedGoogle Scholar
• Kim, J. H., H. Li, and M. R. Stallcup. 2003. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol. Cell 12:1537–1549.
   PubMed Web of Science ®Google Scholar
• Kim, R. H., K. C. Flanders, S. Birkey Reffey, L. A. Anderson, C. S. Duckett, N. D. Perkins, and A. B. Roberts. 2001. SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276:46297–46304.
   PubMedGoogle Scholar
• Kishikawa, S., T. Murata, H. Kimura, K. Shiota, and K. K. Yokoyama. 2002. Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins. Eur. J. Biochem. 269:2961–2970.
   PubMedGoogle Scholar
• Ko, L., G. R. Cardona, and W. W. Chin. 2000. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc. Natl. Acad. Sci. USA 97:6212–6217.
   PubMedGoogle Scholar
• Kobayashi, A., K. Numayama-Tsuruta, K. Sogawa, and Y. Fujii-Kuriyama. 1997. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J. Biochem. (Tokyo) 122:703–710.
   PubMed Web of Science ®Google Scholar
• Kovacs, K. A., M. Steinmann, P. J. Magistretti, O. Halfon, and J. R. Cardinaux. 2003. CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. J. Biol. Chem. 278:36959–36965.
   PubMedGoogle Scholar
• Koyanagi, M., M. Hijikata, K. Watashi, O. Masui, and K. Shimotohno. 2005. Centrosomal P4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-kappaB. J. Biol. Chem. 280:12430–12437.
   PubMedGoogle Scholar
• Kumar, B. R., V. Swaminathan, S. Banerjee, and T. K. Kundu. 2001. p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation. J. Biol. Chem. 276:16804–16809.
   PubMed Web of Science ®Google Scholar
• Kung, A. L., V. I. Rebel, R. T. Bronson, L. E. Ch'ng, C. A. Sieff, D. M. Livingston, and T. P. Yao. 2000. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 14:272–277.
   PubMed Web of Science ®Google Scholar
• Kwon, H. S., B. Huang, T. G. Unterman, and R. A. Harris. 2004. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53:899–910.
   PubMed Web of Science ®Google Scholar
• Labalette, C., C. A. Renard, C. Neuveut, M. A. Buendia, and Y. Wei. 2004. Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and β-catenin. Mol. Cell. Biol. 24:10689–10702.
   PubMedGoogle Scholar
• Lamprecht, C., and C. R. Mueller. 1999. D-site binding protein transactivation requires the proline- and acid-rich domain and involves the coactivator p300. J. Biol. Chem. 274:17643–17648.
   PubMedGoogle Scholar
• Lau, P., P. Bailey, D. H. Dowhan, and G. E. Muscat. 1999. Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD. Nucleic Acids Res. 27:411–420.
   PubMedGoogle Scholar
• Laurance, M. E., R. P. Kwok, M. S. Huang, J. P. Richards, J. R. Lundblad, and R. H. Goodman. 1997. Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms. J. Biol. Chem. 272:2646–2651.
   PubMedGoogle Scholar
• Legube, G., and D. Trouche. 2003. Regulating histone acetyltransferases and deacetylases. EMBO Rep. 4:944–947.
   PubMed Web of Science ®Google Scholar
• Leong, G. M., N. Subramaniam, L. L. Issa, J. B. Barry, T. Kino, P. H. Driggers, M. J. Hayman, J. A. Eisman, and E. M. Gardiner. 2004. Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. Biochem. Biophys. Res. Commun. 315:1070–1076.
   PubMedGoogle Scholar
• Li, M., G. Pascual, and C. K. Glass. 2000. Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20:4699–4707.
   PubMed Web of Science ®Google Scholar
• Li, S., C. M. Armstrong, N. Bertin, H. Ge, S. Milstein, M. Boxem, P. O. Vidalain, J. D. Han, A. Chesneau, T. Hao, D. S. Goldberg, N. Li, M. Martinez, J. F. Rual, P. Lamesch, L. Xu, M. Tewari, S. L. Wong, L. V. Zhang, G. F. Berriz, L. Jacotot, P. Vaglio, J. Reboul, T. Hirozane-Kishikawa, Q. Li, H. W. Gabel, A. Elewa, B. Baumgartner, D. J. Rose, H. Yu, S. Bosak, R. Sequerra, A. Fraser, S. E. Mango, W. M. Saxton, S. Strome, S. Van Den Heuvel, F. Piano, J. Vandenhaute, C. Sardet, M. Gerstein, L. Doucette-Stamm, K. C. Gunsalus, J. W. Harper, M. E. Cusick, F. P. Roth, D. E. Hill, and M. Vidal. 2004. A map of the interactome network of the metazoan C. elegans. Science 303:540–543.
   PubMed Web of Science ®Google Scholar
• Li, S., B. Aufiero, R. L. Schiltz, and M. J. Walsh. 2000. Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Proc. Natl. Acad. Sci. USA 97:7166–7171.
   PubMed Web of Science ®Google Scholar
• Liu, Y., G. L. Borchert, and J. M. Phang. 2004. Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J. Biol. Chem. 279:18694–18700.
   PubMedGoogle Scholar
• Long, J., G. Wang, I. Matsuura, D. He, and F. Liu. 2004. Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). Proc. Natl. Acad. Sci. USA 101:99–104.
   PubMed Web of Science ®Google Scholar
• Ma, Z. Q., Z. Liu, E. S. Ngan, and S. Y. Tsai. 2001. Cdc25B functions as a novel coactivator for the steroid receptors. Mol. Cell. Biol. 21:8056–8067.
   PubMed Web of Science ®Google Scholar
• MacLellan, W. R., G. Xiao, M. Abdellatif, and M. D. Schneider. 2000. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol. Cell. Biol. 20:8903–8915.
   PubMedGoogle Scholar
• Macpartlin, M., S. X. Zeng, H. Lee, D. Stauffer, Y. Jin, M. Thayer, and H. Lu. 2005. p300 regulates p63 transcriptional activity. J. Biol. Chem. 280:30604–30610.
   PubMedGoogle Scholar
• Mahmud, D. L., M. G-Amlak, D. K. Deb, L. C. Platanias, S. Uddin, and A. Wickrema. 2002. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene 21:1556–1562.
   PubMedGoogle Scholar
• Major, M. L., R. Lepe, and R. H. Costa. 2004. Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol. Cell. Biol. 24:2649–2661.
   PubMed Web of Science ®Google Scholar
• Mandolesi, G., S. Gargano, M. Pennuto, B. Illi, R. Molfetta, L. Soucek, L. Mosca, A. Levi, R. Jucker, and S. Nasi. 2002. NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction. FEBS Lett. 510:50–56.
   PubMedGoogle Scholar
• Marambaud, P., P. H. Wen, A. Dutt, J. Shioi, A. Takashima, R. Siman, and N. K. Robakis. 2003. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114:635–645.
   PubMed Web of Science ®Google Scholar
• Masumi, A., and K. Ozato. 2001. Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. J. Biol. Chem. 276:20973–20980.
   PubMed Web of Science ®Google Scholar
• Mathew, S., E. Mascareno, and M. A. Siddiqui. 2004. A ternary complex of transcription factors, Nished and NFATc4, and co-activator p300 bound to an intronic sequence, intronic regulatory element, is pivotal for the up-regulation of myosin light chain-2v gene in cardiac hypertrophy. J. Biol. Chem. 279:41018–41027.
   PubMedGoogle Scholar
• Matt, T., M. A. Martinez-Yamout, H. J. Dyson, and P. E. Wright. 2004. The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2. Biochem. J. 381:685–691.
   PubMedGoogle Scholar
• McManus, K. J., and M. J. Hendzel. 2001. CBP, a transcriptional coactivator and acetyltransferase. Biochem. Cell Biol. 79:253–266.
   PubMed Web of Science ®Google Scholar
• Mehra-Chaudhary, R., H. Matsui, and R. Raghow. 2001. Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem. J. 353:13–22.
   PubMedGoogle Scholar
• Messina, D. N., J. Glasscock, W. Gish, and M. Lovett. 2004. An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression. Genome Res. 14:2041–2047.
   PubMedGoogle Scholar
• Meyers, E. N., M. Lewandoski, and G. R. Martin. 1998. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 18:136–141.
   PubMed Web of Science ®Google Scholar
• Misra, P., C. Qi, S. Yu, S. H. Shah, W. Q. Cao, M. S. Rao, B. Thimmapaya, Y. Zhu, and J. K. Reddy. 2002. Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. J. Biol. Chem. 277:20011–20019.
   PubMedGoogle Scholar
• Mizukami, J., and T. Taniguchi. 1997. The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP. Biochem. Biophys. Res. Commun. 240:61–64.
   PubMed Web of Science ®Google Scholar
• Molinari, S., F. Relaix, M. Lemonnier, B. Kirschbaum, B. Schafer, and M. Buckingham. 2004. A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300. Mol. Cell. Biol. 24:2944–2957.
   PubMedGoogle Scholar
• Monroy, M. A., D. D. Ruhl, X. Xu, D. K. Granner, P. Yaciuk, and J. C. Chrivia. 2001. Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP. J. Biol. Chem. 276:40721–40726.
   PubMedGoogle Scholar
• Morris, L., K. E. Allen, and N. B. La Thangue. 2000. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. Nat. Cell. Biol. 2:232–239.
   PubMed Web of Science ®Google Scholar
• Murray, P. J., L. Wang, C. Onufryk, R. I. Tepper, and R. A. Young. 1997. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. J. Immunol. 158:315–321.
   PubMed Web of Science ®Google Scholar
• Nakashima, K., M. Yanagisawa, H. Arakawa, N. Kimura, T. Hisatsune, M. Kawabata, K. Miyazono, and T. Taga. 1999. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284:479–482.
   PubMed Web of Science ®Google Scholar
• Novak, A., C. Guo, W. Yang, A. Nagy, and C. G. Lobe. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28:147–155.
   PubMed Web of Science ®Google Scholar
• Nowling, T. K., L. R. Johnson, M. S. Wiebe, and A. Rizzino. 2000. Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator. J. Biol. Chem. 275:3810–3818.
   PubMedGoogle Scholar
• Nucifora, F. C., Jr., M. Sasaki, M. F. Peters, H. Huang, J. K. Cooper, M. Yamada, H. Takahashi, S. Tsuji, J. Troncoso, V. L. Dawson, T. M. Dawson, and C. A. Ross. 2001. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291:2423–2428.
   PubMed Web of Science ®Google Scholar
• Ohshima, T., E. Yoshida, T. Nakajima, K. I. Yagami, and A. Fukamizu. 2001. Effects of interaction between parvovirus minute virus of mice NS1 and coactivator CBP on NS1- and p53-transactivation. Int. J. Mol. Med. 7:49–54.
   PubMedGoogle Scholar
• O'Sullivan, A., H. C. Chang, Q. Yu, and M. H. Kaplan. 2004. STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. J. Biol. Chem. 279:7339–7345.
   PubMed Web of Science ®Google Scholar
• Oswald, F., B. Tauber, T. Dobner, S. Bourteele, U. Kostezka, G. Adler, S. Liptay, and R. M. Schmid. 2001. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol. Cell. Biol. 21:7761–7774.
   PubMed Web of Science ®Google Scholar
• Pan, J., C. Jin, T. Murata, and K. K. Yokoyama. 2003. Sequence specific transcription factor, JDP2 interacts with histone and inhibits p300-mediated histone acetylation. Nucleic Acids Res. Suppl. 2003:305–306.
   Google Scholar
• Papoutsopoulou, S., and R. Janknecht. 2000. Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Mol. Cell. Biol. 20:7300–7310.
   PubMedGoogle Scholar
• Park, S. R., E. K. Lee, B. C. Kim, and P. H. Kim. 2003. p300 cooperates with Smad3/4 and Runx3 in TGFbeta1-induced IgA isotype expression. Eur. J. Immunol. 33:3386–3392.
   PubMedGoogle Scholar
• Pauleau, A. L., R. Rutschman, R. Lang, A. Pernis, S. S. Watowich, and P. J. Murray. 2004. Enhancer-mediated control of macrophage-specific arginase I expression. J. Immunol. 172:7565–7573.
   PubMed Web of Science ®Google Scholar
• Pedeux, R., S. Sengupta, J. C. Shen, O. N. Demidov, S. Saito, H. Onogi, K. Kumamoto, S. Wincovitch, S. H. Garfield, M. McMenamin, M. Nagashima, S. R. Grossman, E. Appella, and C. C. Harris. 2005. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol. Cell. Biol. 25:6639–6648.
   PubMed Web of Science ®Google Scholar
• Pelletier, G., V. Y. Stefanovsky, M. Faubladier, I. Hirschler-Laszkiewicz, J. Savard, L. I. Rothblum, J. Cote, and T. Moss. 2000. Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol. Cell 6:1059–1066.
   PubMed Web of Science ®Google Scholar
• Peng, Y. C., D. E. Breiding, F. Sverdrup, J. Richard, and E. J. Androphy. 2000. AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. J. Virol. 74:5872–5879.
   PubMedGoogle Scholar
• Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523–527.
   PubMed Web of Science ®Google Scholar
• Pfitzner, E., R. Jahne, M. Wissler, E. Stoecklin, and B. Groner. 1998. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5- mediated suppression of the glucocorticoid response. Mol. Endocrinol. 12:1582–1593.
   PubMed Web of Science ®Google Scholar
• Phan, H. M., A. W. Xu, C. Coco, G. Srajer, S. Wyszomierski, Y. A. Evrard, R. Eckner, and S. Y. Dent. 2005. GCN5 and p300 share essential functions during early embryogenesis. Dev. Dyn. 233:1337–1347.
   PubMedGoogle Scholar
• Pitkanen, J., V. Doucas, T. Sternsdorf, T. Nakajima, S. Aratani, K. Jensen, H. Will, P. Vahamurto, J. Ollila, M. Vihinen, H. S. Scott, S. E. Antonarakis, J. Kudoh, N. Shimizu, K. Krohn, and P. Peterson. 2000. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275:16802–16809.
   PubMed Web of Science ®Google Scholar
• Postigo, A. A., J. L. Depp, J. J. Taylor, and K. L. Kroll. 2003. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22:2453–2462.
   PubMedGoogle Scholar
• Qiu, Y., M. Guo, S. Huang, and R. Stein. 2002. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol. Cell. Biol. 22:412–420.
   PubMed Web of Science ®Google Scholar
• Ramirez, S., S. Ait-Si-Ali, P. Robin, D. Trouche, A. Harel-Bellan, and S. Ait Si Ali. 1997. The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element. J. Biol. Chem. 272:31016–31021.
   PubMed Web of Science ®Google Scholar
• Rausa, F. M., Y. Tan, and R. H. Costa. 2003. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol. Cell. Biol. 23:437–449.
   PubMed Web of Science ®Google Scholar
• Rebel, V. I., A. L. Kung, E. A. Tanner, H. Yang, R. T. Bronson, and D. M. Livingston. 2002. Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc. Natl. Acad. Sci. USA 99:14789–14794.
   PubMed Web of Science ®Google Scholar
• Rossow, K. L., and R. Janknecht. 2001. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 61:2690–2695.
   PubMed Web of Science ®Google Scholar
• Rossow, K. L., and R. Janknecht. 2003. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene 22:151–156.
   PubMed Web of Science ®Google Scholar
• Sartorelli, V., J. Huang, Y. Hamamori, and L. Kedes. 1997. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol. 17:1010–1026.
   PubMed Web of Science ®Google Scholar
• See, R. H., D. Calvo, Y. Shi, H. Kawa, M. P. Luke, and Z. Yuan. 2001. Stimulation of p300-mediated transcription by the kinase MEKK1. J. Biol. Chem. 276:16310–16317.
   PubMedGoogle Scholar
• Seibler, J., D. Schubeler, S. Fiering, M. Groudine, and J. Bode. 1998. DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs. Biochemistry 37:6229–6234.
   PubMed Web of Science ®Google Scholar
• SenBanerjee, S., Z. Lin, G. B. Atkins, D. M. Greif, R. M. Rao, A. Kumar, M. W. Feinberg, Z. Chen, D. I. Simon, F. W. Luscinskas, T. M. Michel, M. A. Gimbrone, Jr., G. Garcia-Cardena, and M. K. Jain. 2004. KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. J. Exp. Med. 199:1305–1315.
   PubMed Web of Science ®Google Scholar
• Shen, G., V. Hebbar, S. Nair, C. Xu, W. Li, W. Lin, Y. S. Keum, J. Han, M. A. Gallo, and A. N. Kong. 2004. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J. Biol. Chem. 279:23052–23060.
   PubMed Web of Science ®Google Scholar
• Shen, W. F., K. Krishnan, H. J. Lawrence, and C. Largman. 2001. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol. Cell. Biol. 21:7509–7522.
   PubMedGoogle Scholar
• Shetty, S., T. Takahashi, H. Matsui, R. Ayengar, and R. Raghow. 1999. Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300). Biochem. J. 339:751–758.
   PubMedGoogle Scholar
• Shibanuma, M., J. R. Kim-Kaneyama, S. Sato, and K. Nose. 2004. A LIM protein, Hic-5, functions as a potential coactivator for Sp1. J. Cell. Biochem. 91:633–645.
   PubMedGoogle Scholar
• Shikama, N., H. M. Chan, M. Krstic-Demonacos, L. Smith, C. W. Lee, W. Cairns, and N. B. La Thangue. 2000. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol. Cell. Biol. 20:8933–8943.
   PubMed Web of Science ®Google Scholar
• Shikama, N., W. Lutz, R. Kretzschmar, N. Sauter, J. F. Roth, S. Marino, J. Wittwer, A. Scheidweiler, and R. Eckner. 2003. Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 22:5175–5185.
   PubMed Web of Science ®Google Scholar
• Shiseki, M., M. Nagashima, R. M. Pedeux, M. Kitahama-Shiseki, K. Miura, S. Okamura, H. Onogi, Y. Higashimoto, E. Appella, J. Yokota, and C. C. Harris. 2003. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res. 63:2373–2378.
   PubMed Web of Science ®Google Scholar
• Sierra, J., A. Villagra, R. Paredes, F. Cruzat, S. Gutierrez, A. Javed, G. Arriagada, J. Olate, M. Imschenetzky, A. J. Van Wijnen, J. B. Lian, G. S. Stein, J. L. Stein, and M. Montecino. 2003. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol. Cell. Biol. 23:3339–3351.
   PubMedGoogle Scholar
• Simone, C., P. Stiegler, S. V. Forcales, L. Bagella, A. De Luca, V. Sartorelli, A. Giordano, and P. L. Puri. 2004. Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300. Oncogene 23:2177–2187.
   PubMedGoogle Scholar
• Slepak, T. I., K. A. Webster, J. Zang, H. Prentice, A. O'Dowd, M. N. Hicks, and N. H. Bishopric. 2001. Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D. J. Biol. Chem. 276:7575–7585.
   PubMedGoogle Scholar
• Smit, D. J., A. G. Smith, P. G. Parsons, G. E. Muscat, and R. A. Sturm. 2000. Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. Eur. J. Biochem. 267:6413–6422.
   PubMedGoogle Scholar
• Song, C. Z., K. Keller, K. Murata, H. Asano, and G. Stamatoyannopoulos. 2002. Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J. Biol. Chem. 277:7029–7036.
   PubMedGoogle Scholar
• Steffan, J. S., A. Kazantsev, O. Spasic-Boskovic, M. Greenwald, Y. Z. Zhu, H. Gohler, E. E. Wanker, G. P. Bates, D. E. Housman, and L. M. Thompson. 2000. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA 97:6763–6768.
   PubMed Web of Science ®Google Scholar
• Sterner, D. E., and S. L. Berger. 2000. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64:435–459.
   PubMed Web of Science ®Google Scholar
• Strano, S., O. Monti, N. Pediconi, A. Baccarini, G. Fontemaggi, E. Lapi, F. Mantovani, A. Damalas, G. Citro, A. Sacchi, G. Del Sal, M. Levrero, and G. Blandino. 2005. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage. Mol. Cell 18:447–459.
   PubMed Web of Science ®Google Scholar
• Sugihara, T. M., E. I. Kudryavtseva, V. Kumar, J. J. Horridge, and B. Andersen. 2001. The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300. J. Biol. Chem. 276:33036–33044.
   PubMedGoogle Scholar
• Sun, Z., J. Pan, W. X. Hope, S. N. Cohen, and S. P. Balk. 1999. Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer 86:689–696.
   PubMedGoogle Scholar
• Swenson, J. J., E. Holley-Guthrie, and S. C. Kenney. 2001. Epstein-Barr virus immediate-early protein BRLF1 interacts with CBP, promoting enhanced BRLF1 transactivation. J. Virol. 75:6228–6234.
   PubMedGoogle Scholar
• Takemaru, K. I., and R. T. Moon. 2000. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J. Cell Biol. 149:249–254.
   PubMed Web of Science ®Google Scholar
• Tanaka, Y., I. Naruse, T. Maekawa, H. Masuya, T. Shiroishi, and S. Ishii. 1997. Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc. Natl. Acad. Sci. USA 94:10215–10220.
   PubMed Web of Science ®Google Scholar
• Tatematsu, K., N. Yoshimoto, T. Koyanagi, C. Tokunaga, T. Tachibana, Y. Yoneda, M. Yoshida, T. Okajima, K. Tanizawa, and S. Kuroda. 2005. Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins. J. Biol. Chem. 280:22937–22944.
   PubMedGoogle Scholar
• Tini, M., A. Benecke, S. J. Um, J. Torchia, R. M. Evans, and P. Chambon. 2002. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol. Cell 9:265–277.
   PubMed Web of Science ®Google Scholar
• Tohkin, M., M. Fukuhara, G. Elizondo, S. Tomita, and F. J. Gonzalez. 2000. Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A. Mol. Pharmacol. 58:845–851.
   PubMed Web of Science ®Google Scholar
• Topper, J. N., M. R. DiChiara, J. D. Brown, A. J. Williams, D. Falb, T. Collins, and M. A. Gimbrone, Jr. 1998. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. USA 95:9506–9511.
   PubMedGoogle Scholar
• Toyama, T., and H. Iwase. 2004. p33ING1b and estrogen receptor (ER) alpha. Breast Cancer 11:33–37.
   PubMedGoogle Scholar
• Tsuda, M., S. Takahashi, Y. Takahashi, and H. Asahara. 2003. Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. J. Biol. Chem. 278:27224–27229.
   PubMed Web of Science ®Google Scholar
• Vadlamudi, R. K., R. A. Wang, A. Mazumdar, Y. Kim, J. Shin, A. Sahin, and R. Kumar. 2001. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J. Biol. Chem. 276:38272–38279.
   PubMed Web of Science ®Google Scholar
• Valineva, T., J. Yang, R. Palovuori, and O. Silvennoinen. 2005. The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J. Biol. Chem. 280:14989–14996.
   PubMed Web of Science ®Google Scholar
• van der Horst, A., L. G. Tertoolen, L. M. de Vries-Smits, R. A. Frye, R. H. Medema, and B. M. Burgering. 2004. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279:28873–28879.
   PubMed Web of Science ®Google Scholar
• van Wely, K. H., A. C. Molijn, A. Buijs, M. A. Meester-Smoor, A. J. Aarnoudse, A. Hellemons, P. den Besten, G. C. Grosveld, and E. C. Zwarthoff. 2003. The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. Oncogene 22:699–709.
   PubMed Web of Science ®Google Scholar
• Verma, U. N., Y. Yamamoto, S. Prajapati, and R. B. Gaynor. 2004. Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J. Biol. Chem. 279:3509–3515.
   PubMed Web of Science ®Google Scholar
• Vervoorts, J., J. M. Luscher-Firzlaff, S. Rottmann, R. Lilischkis, G. Walsemann, K. Dohmann, M. Austen, and B. Luscher. 2003. Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep. 4:484–490.
   PubMed Web of Science ®Google Scholar
• Vo, N. K., and R. H. Goodman. 2001. CBP and p300 in transcriptional regulation. J. Biol. Chem. 276:13505–13508.
   PubMed Web of Science ®Google Scholar
• Voegel, J. J., M. J. Heine, M. Tini, V. Vivat, P. Chambon, and H. Gronemeyer. 1998. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17:507–519.
   PubMed Web of Science ®Google Scholar
• Wada, H., K. Hasegawa, T. Morimoto, T. Kakita, T. Yanazume, and S. Sasayama. 2000. A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene. J. Biol. Chem. 275:25330–25335.
   PubMedGoogle Scholar
• Wallberg, A. E., S. Yamamura, S. Malik, B. M. Spiegelman, and R. G. Roeder. 2003. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol. Cell 12:1137–1149.
   PubMed Web of Science ®Google Scholar
• Wang, A., T. Ikura, K. Eto, and M. S. Ota. 2004. Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry. Biochem. Biophys. Res. Commun. 325:1509–1516.
   PubMedGoogle Scholar
• Wang, H., R. Fang, J. Y. Cho, T. A. Libermann, and P. Oettgen. 2004. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. J. Biol. Chem. 279:25241–25250.
   PubMed Web of Science ®Google Scholar
• Wang, W., S. B. Lee, R. Palmer, L. W. Ellisen, and D. A. Haber. 2001. A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1. J. Biol. Chem. 276:16810–16816.
   PubMedGoogle Scholar
• Wansa, K. D., J. M. Harris, and G. E. Muscat. 2002. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J. Biol. Chem. 277:33001–33011.
   PubMed Web of Science ®Google Scholar
• Weaver, B. K., K. P. Kumar, and N. C. Reich. 1998. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol. Cell. Biol. 18:1359–1368.
   PubMed Web of Science ®Google Scholar
• Wherry, E. J., and R. Ahmed. 2004. Memory CD8 T-cell differentiation during viral infection. J. Virol. 78:5535–5545.
   PubMed Web of Science ®Google Scholar
• Williams, C. J., T. Naito, P. G. Arco, J. R. Seavitt, S. M. Cashman, B. De Souza, X. Qi, P. Keables, U. H. Von Andrian, and K. Georgopoulos. 2004. The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity 20:719–733.
   PubMedGoogle Scholar
• Wu, L., J. Liu, P. Gao, M. Nakamura, Y. Cao, H. Shen, and J. D. Griffin. 2005. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J. 24:2391–2402.
   PubMed Web of Science ®Google Scholar
• Xu, W., H. Chen, K. Du, H. Asahara, M. Tini, B. M. Emerson, M. Montminy, and R. M. Evans. 2001. A transcriptional switch mediated by cofactor methylation. Science 294:2507–2511.
   PubMed Web of Science ®Google Scholar
• Yahata, T., M. P. de Caestecker, R. J. Lechleider, S. Andriole, A. B. Roberts, K. J. Isselbacher, and T. Shioda. 2000. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J. Biol. Chem. 275:8825–8834.
   PubMedGoogle Scholar
• Yamamoto, H., F. Kihara-Negishi, T. Yamada, M. Suzuki, T. Nakano, and T. Oikawa. 2002. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. Cell Growth Differ. 13:69–75.
   PubMedGoogle Scholar
• Yamamoto, Y., U. N. Verma, S. Prajapati, Y. T. Kwak, and R. B. Gaynor. 2003. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 423:655–659.
   PubMed Web of Science ®Google Scholar
• Yanagi, Y., Y. Masuhiro, M. Mori, J. Yanagisawa, and S. Kato. 2000. p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor. Biochem. Biophys. Res. Commun. 269:410–414.
   PubMed Web of Science ®Google Scholar
• Yang, C., L. H. Shapiro, M. Rivera, A. Kumar, and P. K. Brindle. 1998. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol. Cell. Biol. 18:2218–2229.
   PubMed Web of Science ®Google Scholar
• Yang, H., C. H. Lin, G. Ma, M. O. Baffi, and M. G. Wathelet. 2003. Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. J. Biol. Chem. 278:15495–15504.
   PubMed Web of Science ®Google Scholar
• Yang, T., R. J. Davis, and C. W. Chow. 2001. Requirement of two NFATc4 transactivation domains for CBP potentiation. J. Biol. Chem. 276:39569–39576.
   PubMedGoogle Scholar
• Yao, T. P., S. P. Oh, M. Fuchs, N. D. Zhou, L. E. Ch'ng, D. Newsome, R. T. Bronson, E. Li, D. M. Livingston, and R. Eckner. 1998. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93:361–372.
   PubMed Web of Science ®Google Scholar
• Yi, M., G. X. Tong, B. Murry, and C. R. Mendelson. 2002. Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1). J. Biol. Chem. 277:2997–3005.
   PubMedGoogle Scholar
• Yin, X., D. R. Warner, E. A. Roberts, M. M. Pisano, and R. M. Greene. 2005. Identification of novel CBP interacting proteins in embryonic orofacial tissue. Biochem. Biophys. Res. Commun. 329:1010–1017.
   PubMedGoogle Scholar
• Yin, X., D. R. Warner, E. A. Roberts, M. M. Pisano, and R. M. Greene. 2005. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein-C53. Int. J. Mol. Med. 16:251–256.
   PubMedGoogle Scholar
• Yin, X., D. R. Warner, E. A. Roberts, M. M. Pisano, and R. M. Greene. 2005. Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1). J. Interferon Cytokine Res. 25:321–327.
   PubMedGoogle Scholar
• Yu, C. T., M. H. Feng, H. M. Shih, and M. Z. Lai. 2002. Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol. Cell. Biol. 22:4556–4566.
   PubMedGoogle Scholar
• Zhang, W., J. W. Nisbet, B. Albrecht, W. Ding, F. Kashanchi, J. T. Bartoe, and M. D. Lairmore. 2001. Hum. T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300. J. Virol. 75:9885–9895.
   PubMedGoogle Scholar
• Zhang, Z., and C. T. Teng. 2003. Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res. 31:2196–2208.
   PubMedGoogle Scholar
• Zhao, F., R. McCarrick-Walmsley, P. Akerblad, M. Sigvardsson, and T. Kadesch. 2003. Inhibition of p300/CBP by early B-cell factor. Mol. Cell. Biol. 23:3837–3846.
   PubMedGoogle Scholar
• Zhu, Q., G. Wani, M. A. Wani, and A. A. Wani. 2001. Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53. Cancer Res. 61:64–70.
   PubMedGoogle Scholar