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Article

A Novel RNA Binding Domain in Tetrahymena Telomerase p65 Initiates Hierarchical Assembly of Telomerase Holoenzyme

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Pages 2029-2036 | Received 02 Nov 2005, Accepted 31 Dec 2005, Published online: 27 Mar 2023

REFERENCES

  • Aigner, S., J. Lingner, K. J. Goodrich, C. A. Grosshans, A. Shevchenko, M. Mann, and T. R. Cech. 2000. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 19:6230–6239.
  • Aigner, S., J. Postberg, H. J. Lipps, and T. R. Cech. 2003. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry 42:5736–5747.
  • Chen, J. L., and C. W. Greider. 2004. Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends Biochem. Sci. 29:183–192.
  • Collins, K., and L. Gandhi. 1998. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc. Natl. Acad. Sci. USA 95:8485–8490.
  • Collins, K., and J. R. Mitchell. 2002. Telomerase in the human organism. Oncogene 21:564–579.
  • Kelleher, C., M. T. Teixeira, K. Forstemann, and J. Lingner. 2002. Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem. Sci. 27:572–579.
  • Lai, C. K., M. C. Miller, and K. Collins. 2003. Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol. Cell 11:1673–1683.
  • McCormick-Graham, M., and D. P. Romero. 1995. Ciliate telomerase RNA structural features. Nucleic Acids Res. 23:1091–1097.
  • Mitchell, J. R., J. Cheng, and K. Collins. 1999. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19:567–576.
  • O'Connor, C. M., C. K. Lai, and K. Collins. 2005. Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J. Biol. Chem. 280:17533–17539.
  • Ohndorf, U. M., C. Steegborn, R. Knijff, and P. Sondermann. 2001. Contributions of the individual domains in human La protein to its RNA 3′-end binding activity. J. Biol. Chem. 276:27188–27196.
  • Prathapam, R., K. L. Witkin, C. M. O'Connor, and K. Collins. 2005. A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nat. Struct. Mol. Biol. 12:252–257.
  • Seto, A. G., A. J. Zaug, S. G. Sobel, S. L. Wolin, and T. R. Cech. 1999. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 401:177–180.
  • Weinrich, S. L., R. Pruzan, L. Ma, M. Ouellette, V. M. Tesmer, S. E. Holt, A. G. Bodnar, S. Lichsteiner, N. W. Kim, J. B. Trager, R. D. Taylor, R. Carlos, W. H. Andrews, W. E. Wright, J. W. Shay, C. B. Harley, and G. B. Morin. 1997. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17:498–502.
  • Witkin, K. L., and K. Collins. 2004. Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev. 18:1107–1118.
  • Wolin, S. L., and T. Cedervall. 2002. The La protein. Annu. Rev. Biochem. 71:375–403.
  • Zaug, A. J., and T. R. Cech. 1995. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA 1:363–374.

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