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Article

Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice

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Pages 2037-2043 | Received 02 Dec 2005, Accepted 21 Dec 2005, Published online: 27 Mar 2023

REFERENCES

  • Baerlocher, G. M., J. Mak, T. Tien, and P. M. Lansdorp. 2002. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 47:89–99.
  • Baumann, P., and T. R. Cech. 2001. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171–1175.
  • Bianchi, A., S. Smith, L. Chong, P. Elias, and T. de Lange. 1997. TRF1 is a dimer and bends telomeric DNA. EMBO J. 16:1785–1794.
  • Blackburn, E. H. 2005. Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett. 579:859–862.
  • Blasco, M. A., H. W. Lee, M. P. Hande, E. Samper, P. M. Lansdorp, R. A. DePinho, and C. W. Greider. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25–34.
  • Broccoli, D., L. Chong, S. Oelmann, A. A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M. M. Le Beau, and T. de Lange. 1997. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum. Mol. Genet. 6:69–76.
  • Broccoli, D., A. Smogorzewska, L. Chong, and T. de Lange. 1997. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17:231–235.
  • Bryan, T. M., and T. R. Cech. 1999. Telomerase and the maintenance of chromosome ends. Curr. Opin. Cell Biol. 11:318–324.
  • Chi, N. W., and H. F. Lodish. 2000. Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J. Biol. Chem. 275:38437–38444.
  • Chiang, Y. J., M. T. Hemann, K. S. Hathcock, L. Tessarollo, L. Feigenbaum, W. C. Hahn, and R. J. Hodes. 2004. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol. Cell. Biol. 24:7024–7031.
  • Chiang, Y. J., S. H. Kim, L. Tessarollo, J. Campisi, and R. J. Hodes. 2004. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol. Cell. Biol. 24:6631–6634.
  • Cook, B. D., J. N. Dynek, W. Chang, G. Shostak, and S. Smith. 2002. Role for the related poly(ADP-ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22:332–342.
  • Dynek, J. N., and S. Smith. 2004. Resolution of sister telomere association is required for progression through mitosis. Science 304:97–100.
  • Fritsch, R. D., X. Shen, G. P. Sims, K. S. Hathcock, R. J. Hodes, and P. E. Lipsky. 2005. Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J. Immunol. 175:6489–6497.
  • Gu, H., J. D. Marth, P. C. Orban, H. Mossmann, and K. Rajewsky. 1994. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103–106.
  • Hathcock, K. S., Y. J. Chiang, and R. J. Hodes. 2005. In vivo regulation of telomerase activity and telomere length. Immunol. Rev. 205:104–113.
  • Houghtaling, B. R., L. Cuttonaro, W. Chang, and S. Smith. 2004. A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr. Biol. 14:1621–1631.
  • Kaminker, P. G., S. H. Kim, R. D. Taylor, Y. Zebarjadian, W. D. Funk, G. B. Morin, P. Yaswen, and J. Campisi. 2001. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J. Biol. Chem. 276:35891–35899.
  • Karlseder, J., L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange. 2003. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. 23:6533–6541.
  • Kim, S. H., P. Kaminker, and J. Campisi. 1999. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23:405–412.
  • Kishi, S., X. Z. Zhou, Y. Ziv, C. Khoo, D. E. Hill, Y. Shiloh, and K. P. Lu. 2001. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J. Biol. Chem. 276:29282–29291.
  • Lakso, M., J. G. Pichel, J. R. Gorman, B. Sauer, Y. Okamoto, E. Lee, F. W. Alt, and H. Westphal. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93:5860–5865.
  • Lansdorp, P. M., N. P. Verwoerd, F. M. van de Rijke, V. Dragowska, M. T. Little, R. W. Dirks, A. K. Raap, and H. J. Tanke. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:685–691.
  • Le, S., J. K. Moore, J. E. Haber, and C. W. Greider. 1999. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152:143–152.
  • Li, B., S. Oestreich, and T. de Lange. 2000. Identification of human Rap1: implications for telomere evolution. Cell 101:471–483.
  • Lombard, D. B., and L. Guarente. 2000. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60:2331–2334.
  • Lyons, R. J., R. Deane, D. K. Lynch, Z. S. Ye, G. M. Sanderson, H. J. Eyre, G. R. Sutherland, and R. J. Daly. 2001. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J. Biol. Chem. 276:17172–17180.
  • Opresko, P. L., C. von Kobbe, J. P. Laine, J. Harrigan, I. D. Hickson, and V. A. Bohr. 2002. Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J. Biol. Chem. 277:41110–41119.
  • Ritchie, K. B., and T. D. Petes. 2000. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155:475–479.
  • Sbodio, J. I., and N. W. Chi. 2002. Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. J. Biol. Chem. 277:31887–31892.
  • Sbodio, J. I., H. F. Lodish, and N. W. Chi. 2002. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem. J. 361:451–459.
  • Smith, S., and T. de Lange. 2000. Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10:1299–1302.
  • Smith, S., and T. de Lange. 1997. TRF1, a mammalian telomeric protein. Trends Genet. 13:21–26.
  • Smith, S., I. Giriat, A. Schmitt, and T. de Lange. 1998. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484–1487.
  • Tessarollo, L. 2001. Gene knockouts: manipulating mouse embryonic stem cells. Methods Mol. Biol. 158:47–63.
  • van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740–743.
  • Ye, J. Z., J. R. Donigian, M. van Overbeek, D. Loayza, Y. Luo, A. N. Krutchinsky, B. T. Chait, and T. de Lange. 2004. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279:47264–47271.
  • Zhou, X. Z., and K. P. Lu. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347–359.
  • Zhu, X. D., L. Niedernhofer, B. Kuster, M. Mann, J. H. Hoeijmakers, and T. de Lange. 2003. ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol. Cell 12:1489–1498.

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