29
Views
45
CrossRef citations to date
0
Altmetric
Article

The p110 Isoform of the CDP/Cux Transcription Factor Accelerates Entry into S Phase

, , , , , & show all
Pages 2441-2455 | Received 26 Sep 2005, Accepted 29 Dec 2005, Published online: 27 Mar 2023

REFERENCES

  • Alevizopoulos, K., J. Vlach, S. Hennecke, and B. Amati. 1997. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16:5322–5333.
  • Andres, V., M. D. Chiara, and V. Mahdavi. 1994. A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins. Genes Dev. 8:245–257.
  • Aufiero, B., E. J. Neufeld, and S. H. Orkin. 1994. Sequence-specific DNA binding of individual Cut repeats of the human CCAAT displacement/Cut homeodomain protein. Proc. Natl. Acad. Sci. USA 91:7757–7761.
  • Aziz, F., A. J. van Wijnen, J. L. Stein, and G. S. Stein. 1998. HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition. J. Cell Physiol. 177:453–464.
  • Aziz, F., A. J. Vanwijnen, P. S. Vaughan, S. J. Wu, A. R. Shakoori, J. B. Lian, K. J. Soprano, J. L. Stein, and G. S. Stein. 1998. The integrated activities of Irf-2 (Hinf-M), Cdp/Cut (Hinf-D) and H4tf-2 (Hinf-P) regulate transcription of a cell cycle controlled human histone H4 gene—mechanistic differences between distinct H4 genes. Mol. Biol. Rep. 25:1–12.
  • Blanc, R. 1942. The production of wing scalloping in Drosophila melanogaster. Univ. Calif. Publ. Zool. 49:1–31.
  • Bodmer, R., S. Barbel, S. Shepherd, J. W. Jack, L. Y. Jan, and Y. N. Jan. 1987. Transformation of sensory organs by mutations of the cut locus of D. melanogaster. Cell 51:293–307.
  • Braun, W. 1942. The effect of puncture on the developing wing of several mutants of Drosophila melanogaster. J. Exp. Zool. 84:325–350.
  • Cai, H. N., and M. Levine. 1997. The gypsy insulator can function as a promoter-specific silencer in the Drosophila embryo. EMBO J. 16:1732–1741.
  • Chattopadhyay, S., C. E. Whitehurst, and J. Chen. 1998. A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression. J. Biol. Chem. 273:29838–29846.
  • Coqueret, O., G. Berube, and A. Nepveu. 1998. The mammalian Cut homeodomain protein functions as a cell-cycle dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase. EMBO J. 17:4680–4694.
  • De Vos, J., T. Thykjaer, K. Tarte, M. Ensslen, P. Raynaud, G. Requirand, F. Pellet, V. Pantesco, T. Reme, M. Jourdan, J. F. Rossi, T. Orntoft, and B. Klein. 2002. Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays. Oncogene 21:6848–6857.
  • Dorsett, D. 1993. Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila. Genetics 134:1135–1144.
  • Ellis, T., L. Gambardella, M. Horcher, S. Tschanz, J. Capol, P. Bertram, W. Jochum, Y. Barrandon, and M. Busslinger. 2001. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev. 15:2307–2319.
  • Geng, Y., Q. Yu, W. Whoriskey, F. Dick, K. Y. Tsai, H. L. Ford, D. K. Biswas, A. B. Pardee, B. Amati, T. Jacks, A. Richardson, N. Dyson, and P. Sicinski. 2001. Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc. Natl. Acad. Sci. USA 98:13138–13143.
  • Goulet, B., A. Baruch, N. S. Moon, M. Poirier, L. L. Sansregret, A. Erickson, M. Bogyo, and A. Nepveu. 2004. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol. Cell 14:207–219.
  • Goulet, B., P. Watson, M. Poirier, L. Leduy, G. Berube, S. Meterissian, P. Jolicoeur, and A. Nepveu. 2002. Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells. Cancer Res. 62:6625–6633.
  • Gudas, J. M., M. Payton, S. Thukral, E. Chen, M. Bass, M. O. Robinson, and S. Coats. 1999. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Mol. Cell. Biol. 19:612–622.
  • Harada, R., G. Berube, O. J. Tamplin, C. Denis-Larose, and A. Nepveu. 1995. DNA-binding specificity of the cut repeats from the human cut-like protein. Mol. Cell. Biol. 15:129–140.
  • Harada, R., D. Dufort, C. Denis-Larose, and A. Nepveu. 1994. Conserved cut repeats in the human cut homeodomain protein function as DNA binding domains. J. Biol. Chem. 269:2062–2067.
  • Hertweck, H. 1931. Anatomie und variabilitaet des nerven-systems und der sinneorgane von Drosophila melanogaster. J. Exp. Zool. 139:559–663.
  • Holthuis, J., T. A. Owen, A. J. van Wijnen, K. L. Wright, A. Ramsey-Ewing, M. B. Kennedy, R. Carter, S. C. Cosenza, K. J. Soprano, J. B. Lian, J. L. Stein, and G. S. Stein. 1990. Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D. Science 247:1454–1457.
  • Ishii, H., K. Mimori, Y. Yoshikawa, M. Mori, Y. Furukawa, and A. Vecchione. 2005. Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells. DNA Cell Biol. 24:173–179.
  • Jack, J., and Y. DeLotto. 1992. Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin. Genetics 131:353–363.
  • Jack, J., and Y. DeLotto. 1995. Structure and regulation of a complex locus: the cut gene of Drosophila. Genetics 139:1689–1700.
  • Jack, J., D. Dorsett, Y. Delotto, and S. Liu. 1991. Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development 113:735–747.
  • Jack, J. W. 1985. Molecular organization of the cut locus of Drosophila melanogaster. Cell 42:869–876.
  • Johnson, T. K., and B. H. Judd. 1979. Analysis of the cut locus of Drosophila melanogaster. Genetics 92:485–502.
  • Kauffman, M. G., S. J. Noga, T. J. Kelly, and A. D. Donnenberg. 1990. Isolation of cell cycle fractions by counterflow centrifugal elutriation. Anal. Biochem. 191:41–46.
  • Last, T. J., A. J. van Wijnen, M. C. de Ridder, G. S. Stein, and J. L. Stein. 1999. The homeodomain transcription factor CDP/cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes. Mol. Biol. Rep. 26:185–194.
  • Lauper, N., A. R. Beck, S. Cariou, L. Richman, K. Hofmann, W. Reith, J. M. Slingerland, and B. Amati. 1998. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene 17:2637–2643.
  • Ledford, A. W., J. G. Brantley, G. Kemeny, T. L. Foreman, S. E. Quaggin, P. Igarashi, S. M. Oberhaus, M. Rodova, J. P. Calvet, and G. B. Vanden Heuvel. 2002. Deregulated expression of the homeobox gene cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev. Biol. 245:157–171.
  • Lee, K. A. W., A. Bindereif, and M. R. Green. 1988. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Tech. 5:22–31.
  • Lievens, P. M. J., J. J. Donady, C. Tufarelli, and E. J. Neufeld. 1995. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. J. Biol. Chem. 270:12745–12750.
  • Liu, S., and J. Jack. 1992. Regulatory interactions and role in cell type specification of the Malpighian tubules by the cut, Kruppel, and caudal genes of Drosophila. Dev. Biol. 150:133–143.
  • Liu, S., E. McLeod, and J. Jack. 1991. Four distinct regulatory regions of the cut locus and their effect on cell type specification in Drosophila. Genetics 127:151–159.
  • Lukas, J., T. Herzinger, K. Hansen, M. C. Moroni, D. Resnitzky, K. Helin, S. I. Reed, and J. Bartek. 1997. Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11:1479–1492.
  • Luo, W., and D. G. Skalnik. 1996. CCAAT displacement protein competes with multiple transcriptional activators for binding to four sites in the proximal gp91(phox) promoter. J. Biol. Chem. 271:18203–18210.
  • Luong, M. X., C. M. van der Meijden, D. Xing, R. Hesselton, E. S. Monuki, S. N. Jones, J. B. Lian, J. L. Stein, G. S. Stein, E. J. Neufeld, and A. J. van Wijnen. 2002. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol. Cell. Biol. 22:1424–1437.
  • Majumdar, A., R. Nagaraj, and U. Banerjee. 1997. Strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes Dev. 11:1341–1353.
  • Micchelli, C. A., E. J. Rulifson, and S. S. Blair. 1997. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124:1485–1495.
  • Michl, P., A. R. Ramjaun, O. E. Pardo, P. H. Warne, M. Wagner, R. Poulsom, C. D'Arrigo, K. Ryder, A. Menke, T. Gress, and J. Downward. 2005. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7:521–532.
  • Modolell, J., W. Bender, and M. Meselson. 1983. Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element. Proc. Natl. Acad. Sci. USA 80:1678–1682.
  • Moon, N. S., G. Berube, and A. Nepveu. 2000. CCAAT displacement activity involves Cut repeats 1 and 2, not the Cut homeodomain. J. Biol. Chem. 275:31325–31334.
  • Moon, N. S., P. Premdas, M. Truscott, L. Leduy, G. Berube, and A. Nepveu. 2001. S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein. Mol. Cell. Biol. 21:6332–6345.
  • Moon, N. S., W. Rong Zeng, P. Premdas, M. Santaguida, G. Berube, and A. Nepveu. 2002. Expression of N-terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas. Int. J. Cancer 100:429–432.
  • Nepveu, A. 2001. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development. Gene 270:1–15.
  • Neufeld, E. J., D. G. Skalnik, P. M. Lievens, and S. H. Orkin. 1992. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat. Genet. 1:50–55.
  • Neumann, C. J., and S. M. Cohen. 1996. A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122:3477–3485.
  • Ohtsubo, M., A. M. Theodoras, J. Schumacher, J. M. Roberts, and M. Pagano. 1995. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15:2612–2624.
  • Parisi, T., A. R. Beck, N. Rougier, T. McNeil, L. Lucian, Z. Werb, and B. Amati. 2003. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22:4794–4803.
  • Pattison, S., D. G. Skalnik, and A. Roman. 1997. CCAAT displacement protein, a regulator of differentiation-specific gene expression, binds a negative regulatory element within the 5′ end of the human papillomavirus type 6 long control region. J. Virol. 71:2013–2022.
  • Payton, M., S. Scully, G. Chung, and S. Coats. 2002. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. Oncogene 21:8529–8534.
  • Quaggin, S. E., G. B. Vandenheuvel, K. Golden, R. Bodmer, and P. Igarashi. 1996. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to drosophila cut. J. Biol. Chem. 271:22624–22634.
  • Resnitzky, D., L. Hengst, and S. I. Reed. 1995. Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1. Mol. Cell. Biol. 15:4347–4352.
  • Resnitzky, D., and S. I. Reed. 1995. Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol. 15:3463–3469.
  • Rigant, G., a. Shevchenko, B. Rutz, M. Wilm, M. Mann, and B. Seraphin. 1999. A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17:1030–1032.
  • Rosenberg, A. R., F. Zindy, F. Le Deist, H. Mouly, P. Metezeau, C. Brechot, and E. Lamas. 1995. Overexpression of human cyclin A advances entry into S phase. Oncogene 10:1501–1509.
  • Santaguida, M., Q. Ding, G. Berube, M. Truscott, P. Whyte, and A. Nepveu. 2001. Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). J. Biol. Chem. 276:45780–45790.
  • Santaguida, M. T., and A. Nepveu. 2005. Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1. J. Biol. Chem. 280:32712–32721.
  • Sinclair, A. M., J. A. Lee, A. Goldstein, D. Xing, S. Liu, R. Ju, P. W. Tucker, E. J. Neufeld, and R. H. Scheuermann. 2001. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood 98:3658–3667.
  • Skalnik, D. G., E. C. Strauss, and S. H. Orkin. 1991. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J. Biol. Chem. 266:16736–16744.
  • Stunkel, W., Z. Huang, S. H. Tan, M. J. O'Connor, and H. U. Bernard. 2000. Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA. J. Virol. 74:2489–2501.
  • Superti-Furga, G., A. Barberis, E. Schreiber, and M. Busslinger. 1989. The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts. Biochim. Biophys. Acta 1007:237–242.
  • Todaro, G. J., and H. Green. 1963. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17:299–313.
  • Truscott, M., L. Raynal, P. Premdas, B. Goulet, L. Leduy, G. Berube, and A. Nepveu. 2003. CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter. Mol. Cell. Biol. 23:3013–3028.
  • Tufarelli, C., Y. Fujiwara, D. C. Zappulla, and E. J. Neufeld. 1998. Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev. Biol. 200:69–81.
  • Valarche, I., J. P. Tissier-Seta, M. R. Hirsch, S. Martinez, C. Goridis, and J. F. Brunet. 1993. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development 119:881–896.
  • van den Ent, F. M., A. J. van Wijnen, J. B. Lian, J. L. Stein, and G. S. Stein. 1994. Cell cycle controlled histone H1, H3, and H4 genes share unusual arrangements of recognition motifs for HiNF-D supporting a coordinate promoter binding mechanism. J. Cell Physiol. 159:515–530.
  • van Wijnen, A. J., T. K. Choi, T. A. Owen, K. L. Wright, J. B. Lian, R. Jaenisch, J. L. Stein, and G. S. Stein. 1991. Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice. Proc. Natl. Acad. Sci. USA 88:2573–2577.
  • van Wijnen, A. J., C. Cooper, P. Odgren, F. Aziz, A. De Luca, R. A. Shakoori, A. Giordano, P. J. Quesenberry, J. B. Lian, G. S. Stein, and J. L. Stein. 1997. Cell cycle-dependent modifications in activities of pRb-related tumor suppressors and proliferation-specific CDP/cut homeodomain factors in murine hematopoietic progenitor cells. J. Cell. Biochem. 66:512–523.
  • van Wijnen, A. J., M. F. van Gurp, M. C. de Ridder, C. Tufarelli, T. J. Last, M. Birnbaum, P. S. Vaughan, A. Giordano, W. Krek, E. J. Neufeld, J. L. Stein, and G. S. Stein. 1996. CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F. Proc. Natl. Acad. Sci. USA 93:11516–11521.
  • van Wijnen, A. J., K. L. Wright, J. B. Lian, J. L. Stein, and G. S. Stein. 1989. Human H4 histone gene transcription requires the proliferation-specific nuclear factor HiNF-D. Auxiliary roles for HiNF-C (Sp1-like) and HiNF-A (high mobility group-like). J. Biol. Chem. 264:15034–15042.
  • Wright, K. L., R. T. Dell'Orco, A. J. van Wijnen, J. L. Stein, and G. S. Stein. 1992. Multiple mechanisms regulate the proliferation-specific histone gene transcription factor HiNF-D in normal human diploid fibroblasts. Biochemistry 31:2812–2818.
  • Zariwala, M., J. Liu, and Y. Xiong. 1998. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene 17:2787–2798.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.