25
Views
14
CrossRef citations to date
0
Altmetric
Article

Kap120 Functions as a Nuclear Import Receptor for Ribosome Assembly Factor Rpf1 in Yeast

, &
Pages 3170-3180 | Received 28 Aug 2005, Accepted 30 Jan 2006, Published online: 27 Mar 2023

REFERENCES

  • Aitchison, J. D., G. Blobel, and M. P. Rout. 1996. Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274:624–627.
  • Albertini, M., L. F. Pemberton, J. S. Rosenblum, and G. Blobel. 1998. A novel nuclear import pathway for the transcription factor TFIIS. J. Cell Biol. 143:1447–1455.
  • Allen, N. P., L. Huang, A. Burlingame, and M. Rexach. 2001. Proteomic analysis of nucleoporin interacting proteins. J. Biol. Chem. 276:29268–29274.
  • Aris, J., and G. Blobel. 1988. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J. Cell Biol. 107:17–31.
  • Blondel, M., P. M. Alepuz, L. S. Huang, S. Shaham, G. Ammerer, and M. Peter. 1999. Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev. 13:2284–2300.
  • Boustany, L. M., and M. S. Cyert. 2002. Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site. Genes Dev. 16:608–619.
  • Brent, R., and R. L. Finley. 1997. Understanding gene and allele function with two-hybrid methods. Annu. Rev. Genet. 31:663–704.
  • Christianson, T. W., R. S. Sikorski, M. Dante, J. H. Shero, and P. Hieter. 1992. Multi-functional yeast high-copy-number shuttle vectors. Gene 110:119–122.
  • Conti, E., and E. Izaurralde. 2001. Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell Biol. 13:310–319.
  • Cronshaw, J. M., A. N. Krutchinsky, W. Zhang, B. T. Chait, and M. J. Matunis. 2002. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 158:915–927.
  • DeVit, M. J., and M. Johnston. 1999. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae. Curr. Biol. 9:1231–1241.
  • Ferrigno, P., F. Posas, D. Koepp, H. Saito, and P. A. Silver. 1998. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J. 17:5606–5614.
  • Flach, J., M. Bossie, J. Vogel, A. H. Corbett, T. Jinks, D. A. Willins, and P. A. Silver. 1994. A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm. Mol. Cell. Biol. 14:8399–8407.
  • Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90:1051–1060.
  • Fried, H., and U. Kutay. 2003. Nucleocytoplasmic transport: taking an inventory. Cell. Mol. Life Sci. 60:1659–1688.
  • Görlich, D., and U. Kutay. 1999. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:607–670.
  • Görlich, D., N. Panté, U. Kutay, U. Aebi, and F. R. Bischoff. 1996. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J. 15:5584–5594.
  • Greiner, M., S. Caesar, and G. Schlenstedt. 2004. The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms. Eur. J. Cell Biol. 83:511–520.
  • Grosshans, H., K. Deinert, E. Hurt, and G. Simos. 2001. Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export. J. Cell Biol. 153:745–762.
  • Harnpicharnchai, P., J. Jakovljevic, E. Horsey, T. Miles, J. Roman, M. P. Rout, D. Meagher, B. Imai, Y. Guo, C. J. Brame, J. Shabanowitz, D. F. Hunt, and J. L. Woolford. 2001. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol. Cell 8:505–515.
  • Hellmuth, K., D. M. Lau, F. R. Bischoff, M. Kunzler, E. Hurt, and G. Simos. 1998. Yeast Los1 has properties of an exportin-like nucleocytoplasmic transport factor for tRNA. Mol. Cell. Biol. 18:6374–6386.
  • Hood, J. K., and P. A. Silver. 1998. Cse1p is required for export of Srp1p/importin-α from the nucleus in Saccharomyces cerevisiae. J. Biol. Chem. 273:35142–35146.
  • Huh, W. K., J. V. Falvo, L. C. Gerke, A. S. Carroll, R. W. Howson, J. S. Weissman, and E. K. O'Shea. 2003. Global analysis of protein localization in budding yeast. Nature 425:686–691.
  • Jäkel, S., and D. Görlich. 1998. Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17:4491–4502.
  • Jones, J. S., and L. Prakash. 1990. Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6:363–666.
  • Kaffman, A., N. M. Rank, E. M. O'Neill, L. S. Huang, and E. K. O'Shea. 1998. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature 396:482–486.
  • Kalab, P., K. Weis, and R. Heald. 2002. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295:2452–2456.
  • Kressler, D., P. Linder, and J. de la Cruz. 1999. Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:7897–7912.
  • Künzler, M., and E. C. Hurt. 1998. Cse1p functions as the nuclear export receptor for importin alpha in yeast. FEBS Lett. 433:185–190.
  • Kutay, U., F. R. Bischoff, S. Kostka, R. Kraft, and D. Görlich. 1997. Export of importin α from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061–1071.
  • Kutay, U., E. Izaurralde, F. R. Bischoff, I. W. Mattaj, and D. Görlich. 1997. Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16:1153–1163.
  • Lei, E. P., and P. A. Silver. 2002. Protein and RNA export from the nucleus. Dev. Cell 2:261–272.
  • Longtine, M. S., A. McKenzie, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953–961.
  • Matuschewski, K., H.-P. Hauser, M. Treier, and S. Jentsch. 1996. Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions. J. Biol. Chem. 271:2789–2794.
  • Maurer, P., M. Redd, J. Solsbacher, F. R. Bischoff, M. Greiner, A. V. Podtelejnikov, M. Mann, K. Stade, K. Weis, and G. Schlenstedt. 2001. The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol. Biol. Cell 12:539–549.
  • Mingot, J.-M., S. Kostka, R. Kraft, E. Hartmann, and D. Görlich. 2001. Importin 13: a novel mediator of nuclear import and export. EMBO J. 20:3685–3694.
  • Mosammaparast, N., Y. Guo, J. Shabanowitz, D. F. Hunt, and L. F. Pemberton. 2002. Pathways mediating the nuclear import of histones H3 and H4 in yeast. J. Biol. Chem. 277:862–868.
  • Mosammaparast, N., K. R. Jackson, Y. Guo, C. J. Brame, J. Shabanowitz, D. F. Hunt, and L. F. Pemberton. 2001. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J. Cell Biol. 153:251–262.
  • Oeffinger, M., M. Dlakic, and D. Tollervey. 2004. A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. Genes Dev. 18:196–209.
  • Ohno, M., M. Fornerod, and I. W. Mattaj. 1998. Nucleocytoplasmic transport: the last 200 nanometers. Cell 92:327–336.
  • Pemberton, L. F., J. S. Rosenblum, and G. Blobel. 1999. Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J. Cell Biol. 145:1407–1417.
  • Plafker, S. M., and I. G. Macara. 2000. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. EMBO J. 19:5502–5513.
  • Plafker, S. M., and I. G. Macara. 2002. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Mol. Cell. Biol. 22:1266–1275.
  • Polizotto, R. S., and M. S. Cyert. 2001. Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p. J. Cell Biol. 154:951–960.
  • Rexach, M., and G. Blobel. 1995. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83:683–692.
  • Ribbeck, K., and D. Görlich. 2001. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 20:1320–1330.
  • Rosenblum, J. S., L. F. Pemberton, and G. Blobel. 1997. A nuclear import pathway for a protein involved in tRNA maturation. J. Cell Biol. 139:1655–1661.
  • Rout, M. P., and J. D. Aitchison. 2001. The nuclear pore complex as a transport machine. J. Biol. Chem. 276:16593–16596.
  • Rout, M. P., J. D. Aitchison, A. Suprapto, K. Hjertaas, Y. Zhao, and B. T. Chait. 2000. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148:635–652.
  • Rout, M. P., G. Blobel, and J. D. Aitchison. 1997. A distinct nuclear import pathway used by ribosomal proteins. Cell 89:715–725.
  • Schlenstedt, G., C. Saavedra, J. D. J. Loeb, C. N. Cole, and P. A. Silver. 1995. The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+RNA in the cytoplasm. Proc. Natl. Acad. Sci. USA 92:225–229.
  • Schlenstedt, G., E. Smirnova, R. Deane, J. Solsbacher, U. Kutay, D. Görlich, H. Ponstingl, and F. R. Bischoff. 1997. Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J. 16:6237–6249.
  • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
  • Solsbacher, J., P. Maurer, F. R. Bischoff, and G. Schlenstedt. 1998. Cse1p is involved in export of yeast importin α from the nucleus. Mol. Cell. Biol. 18:6805–6815.
  • Solsbacher, J., P. Maurer, F. Vogel, and G. Schlenstedt. 2000. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin α. Mol. Cell. Biol. 20:8468–8479.
  • Stade, K., C. S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90:1041–1050.
  • Stage-Zimmermann, T., U. Schmidt, and P. A. Silver. 2000. Factors affecting nuclear export of the 60S ribosomal subunit in vivo. Mol. Biol. Cell 11:3777–3789.
  • Suntharalingam, M., and S. R. Wente. 2003. Peering through the pore: nuclear pore complex structure, assembly, and function. Dev. Cell 4:775–789.
  • Titov, A. A., and G. Blobel. 1999. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J. Cell Biol. 147:235–246.
  • Venema, J., and D. Tollervey. 1999. Ribosome synthesis in Saccharomyces cerevisiae. Annu. Rev. Genet. 33:261–311.
  • Wehner, K. A., and S. J. Baserga. 2002. The sigma70-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol. Cell 9:329–339.
  • Weis, K. 2003. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112:441–451.
  • Winzeler, E. A., et al. 1999. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901–906.
  • Yoshida, K., and G. Blobel. 2001. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J. Cell Biol. 152:729–740.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.