11
Views
56
CrossRef citations to date
0
Altmetric
Article

Nucleocytoplasmic Shuttling of Pak5 Regulates Its Antiapoptotic Properties

&
Pages 3215-3230 | Received 17 Aug 2005, Accepted 17 Jan 2006, Published online: 27 Mar 2023

REFERENCES

  • Bagrodia, S., and R. A. Cerione. 1999. PAK to the future. Trends Cell Biol. 9:350–355.
  • Barnes, C. J., R. K. Vadlamudi, S. K. Mishra, R. H. Jacobson, F. Li, and R. Kumar. 2003. Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat. Struct. Biol. 10:622–628.
  • Bokoch, G. M. 2003. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72:743–781.
  • Callow, M. G., F. Clairvoyant, S. Zhu, B. Schryver, D. B. Whyte, J. R. Bischoff, B. Jallal, and T. Smeal. 2002. Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J. Biol. Chem. 277:550–558.
  • Ching, Y. P., V. Y. Leong, C. M. Wong, and H. F. Kung. 2003. Identification of an autoinhibitory domain of p21-activated protein kinase 5. J. Biol. Chem. 238:33621–33624.
  • Clementi, F., D. Cabrini, C. Gotti, and E. Sher. 1986. Pharmacological characterization of cholinergic receptors in a human neuroblastoma cell line. J. Neurochem. 47:291–297.
  • Cotteret, S., Z. M. Jaffer, A. Beeser, and J. Chernoff. 2003. p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol. Cell. Biol. 23:5526–5539.
  • Dan, C., N. Nath, M. Liberto, and A. Minden. 2002. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol. Cell. Biol. 22:567–577.
  • Gnesutta, N., J. Qu, and A. Minden. 2001. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 276:14414–14419.
  • Hofmann, C., M. Shepelev, and J. Chernoff. 2004. The genetics of Pak. J. Cell Sci. 117:4343–4354.
  • Jaffer, Z. M., and J. Chernoff. 2002. p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell. Biol. 34:713–717.
  • Jakobi, R., E. Moertl, and M. A. Koeppel. 2001. p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts. J. Biol. Chem. 276:16624–16634.
  • Kitchens, D. L., E. Y. Snyder, and D. I. Gottlieb. 1994. FGF and EGF are mitogens for immortalized neural progenitors. J. Neurobiol. 25:797–807.
  • Lee, S. R., S. M. Ramos, A. Ko, D. Masiello, K. D. Swanson, M. L. Lu, and S. P. Balk. 2002. AR and ER interaction with a p21-activated kinase (PAK6). Mol. Endocrinol. 16:85–99.
  • Lei, M., W. Lu, W. Meng, M.-C. Parrini, M. J. Eck, B. J. Mayer, and S. C. Harrison. 2000. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102:387–397.
  • Li, X., and A. Minden. 2003. Targeted disruption of the gene for the PAK5 kinase in mice. Mol. Cell. Biol. 23:7134–7142.
  • Matenia, D., B. Griesshaber, X. Y. Li, A. Thiessen, C. Johne, J. Jiao, E. Mandelkow, and E. M. Mandelkow. 2005. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol. Biol. Cell 16:4410–4422.
  • Pandey, A., I. Dan, T. Z. Kristiansen, N. M. Watanabe, J. Voldby, E. Kajikawa, R. Khosravi-Far, B. Blagoev, and M. Mann. 2002. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene 21:3939–3948.
  • Parrini, M. C., M. Lei, S. C. Harrison, and B. J. Mayer. 2002. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol. Cell 9:73–83.
  • Qu, J., M. S. Cammarano, Q. Shi, K. C. Ha, P. deLanerolle, and A. Minden. 2001. Activated PAK4 regulates cell adhesion and anchorage-independent growth. Mol. Cell. Biol. 21:3523–3533.
  • Ryder, E. F., E. Y. Snyder, and C. L. Cepko. 1990. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J. Neurobiol. 21:356–375.
  • Schrantz, N., J. da Silva Correia, B. Fowler, Q. Ge, Z. Sun, and G. M. Bokoch. 2004. Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. J. Biol. Chem. 279:1922–1931.
  • Schurmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H.-G. Wang, J. C. Reed, and G. M. Bokoch. 2000. p21-activated kinase 1 (PAK1) phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20:453–461.
  • Sells, M. A., and J. Chernoff. 1997. Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol. 7:162–167.
  • Sells, M. A., U. G. Knaus, S. Bagrodia, D. M. Ambrose, G. M. Bokoch, and J. Chernoff. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7:202–210.
  • Singh, R., C. Song, Z. Yang, and R. Kumar. 2005. Nuclear localization and chromatin targets of p21-activated kinase. J. Biol. Chem. 280:18130–18137.
  • Yang, F., X. Li, M. Sharma, M. Zarnegar, and Z. Lim. 2001. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 276:15345–15353.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.