Transforming c-Ki-ras Mutation Is a Preneoplastic Event in Mouse Mammary Carcinogenesis Induced In Vitro by N-Methyl-N-Nitrosourea

Literature Cited

• Balmain, A., and K. Brown. 1988. Oncogene activation in chemical carcinogenesis. Adv. Cancer Res. 51:147–182.
   PubMed Web of Science ®Google Scholar
• Barbacid, M. 1987. ras genes. Annu. Rev. Biochem. 56:779–827.
   PubMed Web of Science ®Google Scholar
• Bos, J. L., E. R. Fearon, S. R. Hamilton, M. Verlaan-de Vries, J. H. van Boom, A. J. van der Eb, and B. Vogelstein. 1987. Prevalence of ras gene mutations in human colorectal cancers. Nature (London) 327:293–297.
   PubMed Web of Science ®Google Scholar
• Dandekar, S., S. Sukumar, H. Zarbl, L. J. T. Young, and R. Cardiff. 1986. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. Mol. Cell. Biol. 6:4104–4108.
   PubMed Web of Science ®Google Scholar
• Daniel, C. W., B. D. Aidells, D. Medina, and L. J. Faulkin. 1975. Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation. Fed. Proc. 34:64–67.
   PubMedGoogle Scholar
• DeOme, K. B., L. J. Faulkin, H. A. Bern, and P. B. Blair. 1959. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 19:515–520.
   PubMed Web of Science ®Google Scholar
• Forrester, K., C. Almoguera, K. Han, W. E. Grizzle, and M. Perucho. 1987. Detection of high incidence of K-ras oncogenes during human coion tumorigenesis. Nature (London) 327:298–303.
   PubMed Web of Science ®Google Scholar
• George, D. L., A. F. Scott, S. Trusko, B. Glick, E. Ford, and D. J. Dorney. 1985. Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J. 4:1199–1203.
   PubMedGoogle Scholar
• Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
   PubMed Web of Science ®Google Scholar
• Guerrero, I., and A. Pellicer. 1987. Mutational activation of oncogenes in animal model systems of carcinogenesis. Mutat. Res. 185:293–308.
   PubMedGoogle Scholar
• Guzman, R. C., R. C. Osborn, J. C. Bartley, W. Imagawa, Β. B. Asch, and S. Nandi. 1987. In vitro transformation of mouse mammary epithelial cells grown serum-free inside collagen gels. Cancer Res. 47:275–280.
   PubMedGoogle Scholar
• Hamamoto, S., W. Imagawa, J. Yang, and S. Nandi. 1988. Morphogenesis of mouse mammary epithelial cells growing within collagen gels: ultrastructural and immunocytochemical characterization. Cell Differ. 22:191–202.
   PubMedGoogle Scholar
• Imagawa, W., Y. Tomooka, S. Hamamoto, and S. Nandi. 1985. Stimulation of mammary epithelial cell growth in vitro: interaction of epidermal growth factor and mammogenic hormones. Endocrinology 116:1514–1524.
   PubMedGoogle Scholar
• Jensen, E. M., R. J. LaPolla, P. E. Kirby, and S. R. Haworth. 1977. In vitro studies of chemical mutagens and carcinogens. I. Stability studies in cell culture medium. J. Natl. Cancer Inst. 59:941–944.
   PubMedGoogle Scholar
• Kumar, R., and M. Barbacid. 1988. Oncogene detection at the single cell level. Oncogene 3:647–651.
   PubMed Web of Science ®Google Scholar
• Liu, E., B. Hjelle, R. Morgan, F. Hecht, and J. M. Bishop. 1987. Mutations of the Kirsten-ras proto-oncogene in human preleukaemia. Nature (London) 330:186–188.
   PubMed Web of Science ®Google Scholar
• Medina, D. 1988. The preneoplastic state in mouse mammary tumorigenesis. Carcinogenesis 9:1113–1119.
   PubMedGoogle Scholar
• Miyamoto, S., R. C. Guzman, R. C. Osborn, and S. Nandi. 1988. Neoplastic transformation of mouse mammary epithelial cells by in vitro exposure to 7V-methyl-7V-nitrosourea. Proc. Natl. Acad. Sci. USA 85:477–481.
   PubMedGoogle Scholar
• Nishmura, S., and T. Sekiya. 1987. Human cancer and cellular oncogenes. Biochem. J. 243:313–327.
   PubMedGoogle Scholar
• Pegg, A. E. 1984. Methylation of the 06 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest. 2:223–231.
   PubMed Web of Science ®Google Scholar
• Quintanilla, M., K. Brown, M. Ramsden, and A. Balmain. 1986. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (London) 322:78–80.
   PubMed Web of Science ®Google Scholar
• Reed, K. C., and D. A. Mann. 1985. Rapid transfer of DNA from agarose gels to nylon membranes. Nucleic Acids Res. 13:7207–7221.
   PubMed Web of Science ®Google Scholar
• Saiki, R. K., T. L. Bugawan, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1986. Analysis of enzymatically amplified β-globin and HLA-DQa DNA with allele-specific oligonucleotide probes. Nature (London) 324:163–166.
   PubMed Web of Science ®Google Scholar
• Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
   PubMed Web of Science ®Google Scholar
• Shih, C., B.-Z. Shilo, M. P. Goldfarb, A. Dannenberg, and R. A. Weinberg. 1979. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc. Natl. Acad. Sci. USA 76:5714–5718.
   PubMed Web of Science ®Google Scholar
• Sukumar, S., V. Natorio, D. Nartin-Zanca, and M. Barbacid. 1983. Induction of mammary carcinomas in rats by nitrosomethylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (London) 306:658–661.
   PubMed Web of Science ®Google Scholar
• Wiseman, R. W., S. J. Stowers, E. C. Miller, M. W. Anderson, and J. A. Miller. 1986. Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 Fl mouse. Proc. Natl. Acad. Sci. USA 83:5825–5829.
   PubMed Web of Science ®Google Scholar
• Yang, J., J. Richards, P. Bowman, R. C. Guzman, J. Enami, K. McCormick, S. Hamamoto, D. Pitelka, and S. Nandi. 1979. Sustained growth and three-dimensional organization of pri mary mammary tumor epithelial cells embedded in collagen gels. Proc. Natl. Acad. Sci. USA 76:3401–3405.
   PubMed Web of Science ®Google Scholar
• Zarbl, H., S. Sukumar, A. V. Arthur, D. Martin-Zanca, and M. Barbacid. 1985. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature (London) 315:382–385.
   PubMed Web of Science ®Google Scholar