Definition of the Minimal Simian Virus 40 Large Τ Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product

LITERATURE CITED

• Ausubel, F. M., R. Brent, R. E. Kingston, D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. John Wiley & Sons, Inc., New York.
   Google Scholar
• Benedict, W. F., A. L. Murphree, A. Banerjee, C. A. Spina, M. C. Sparkes, and R. S. Sparkes. 1983. Patient with chromosome 13 deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science 219:973–975.
   PubMed Web of Science ®Google Scholar
• Bernards, R., G. M. Schackleford, M. R. Gerber, J. M. Horowitz, S. H. Friend, M. Schartl, E. Bogenmann, J. M. Rapaport, T. McGee, T. P. Dryja, and R. A. Weinberg. 1989. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc. Natl. Acad. Sci. USA 86:6474–6478.
   PubMed Web of Science ®Google Scholar
• Cavenee, W. K., T. P. Dryja, R. A. Phillips, W. F. Benedict, R. Godbout, B. L. Gallie, A. L. Murphree, L. C. Strong, and R. L. White. 1983. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (London) 305:779–784.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Shew, C. Huang, W. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large T antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, D. Lynch, Y. Furukawa, J. Griffin, H. Piwnica-Worms, C. Huang, and D. M. Livingston. 1989. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085–1095.
   PubMed Web of Science ®Google Scholar
• Dryja, T. P., W. Cavenee, R. White, J. M. Rapaport, R. Petersen, D. M. Albert, and G. Bruns. 1984. Homozygosity of chromosome 13 in retinoblastoma. N. Engl. J. Med. 310:550–553.
   PubMed Web of Science ®Google Scholar
• Dyson, N., P. M. Howley, K. Munger, and E. Harlow. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937.
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., J. W. Ludlow, E. Marsilio, J. A. Decaprio, R. C. Millikan, S. H. Cheng, E. Paucha, and D. M. Livingston. 1989. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both pllORB and a second cellular protein, pl20. Cell 58:257–267.
   PubMedGoogle Scholar
• Figge, J., and T. F. Smith. 1988. Cell-division sequence motif. Nature (London) 334:109.
   PubMed Web of Science ®Google Scholar
• Figge, J., T. Webster, T. F. Smith, and E. Paucha. 1988. Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins. J. Virol. 62:1814–1818.
   PubMedGoogle Scholar
• Friend, S. H., R. Bernards, S. Rogelj, R. A. Weinberg, J. M. Rapaport, D. M. Alberts, and T. P. Dryja. 1986. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (London) 323:643–646.
   PubMed Web of Science ®Google Scholar
• Friend, S. H., T. P. Dryja, and R. A. Weinberg. 1988. Oncogenes and tumor-suppressing genes. N. Engl. J. Med. 318:618–622.
   PubMed Web of Science ®Google Scholar
• Friend, S. H., J. M. Horowitz, M. R. Gerber, X. Wang, E. Bogenmann, F. P. Li, and R. A. Weinberg. 1987. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc. Natl. Acad. Sci. USA 84:9059–9063.
   PubMed Web of Science ®Google Scholar
• Fung, Y.-K. T., A. L. Murphree, A. T'Ang, J. Qian, S. H. Hinrichs, and W. F. Benedict. 1987. Structural evidence for the authenticity of the human retinoblastoma gene. Science 236:1657–1661.
   PubMed Web of Science ®Google Scholar
• Godbout, R., T. P. Dryja, J. Squire, B. L. Gallie, and R. A. Phillips. 1983. Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma. Nature (London) 304:451–453.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59–72.
   PubMed Web of Science ®Google Scholar
• Green, M. R. 1989. When the products of oncogenes and anti-oncogenes meet. Cell 56:1–3.
   PubMed Web of Science ®Google Scholar
• Harbour, J. W., S.-L. Lai, J. Whang-Peng, A. F. Gazdar, J. D. Minna, and F. J. Kaye. 1988. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353–356.
   PubMed Web of Science ®Google Scholar
• Harlow, E., B. R. Franza, Jr., and C. Schley. 1985. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol. 55:533–546.
   PubMed Web of Science ®Google Scholar
• Harlow, E., L. V. Crawford, D. C. Pirn, and N. M. Williamson. 1981. Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol. 39:861–869.
   PubMed Web of Science ®Google Scholar
• Harris, H. 1988. The analysis of malignancy by cell fusion: the position in 1988. Cancer Res. 48:3302–3306.
   PubMedGoogle Scholar
• Hong, F. D., H.-S. Huang, H. To, L.-S. Young, A. Oro, R. Bookstein, E. Y.-H. P. Lee, and W.-H. Lee. 1989. Structure of the human retinoblastoma gene. Proc. Natl. Acad. Sci. USA 86:5502–5506.
   PubMed Web of Science ®Google Scholar
• Horowitz, J. M., D. W. Yandell, S.-H. Park, S. Canning, P. Whyte, K. Buchkovich, E. Harlow, R. A. Weinberg, and T. P. Dryja. 1989. Point mutational inactivation of the retinoblastoma antioncogene. Science 243:937–940.
   PubMed Web of Science ®Google Scholar
• Hu, Q., N. Dyson, and E. Harlow. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9:1147–1155.
   PubMed Web of Science ®Google Scholar
• Huang, H.-J. S., J.-K. Yee, J.-Y. Shew, P.-L. Chen, R. Bookstein, T. Friedmann, E. Y.-H. P. Lee, and W.-H. Lee. 1988. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242:1563–1566.
   PubMed Web of Science ®Google Scholar
• Kalderon, D., and A. E. Smith. 1984. In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology 139:109–137.
   PubMed Web of Science ®Google Scholar
• Klein, G. 1987. The approaching era of the tumor suppressor genes. Science 238:1539–1545.
   PubMed Web of Science ®Google Scholar
• Knudson, A. G., Jr. 1971. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68:820–823.
   PubMed Web of Science ®Google Scholar
• Kouzarides, T., and E. Ziff. 1989. Leucine zippers of fos, jun, and GCN4 dictate dimerization specificity and thereby control DNA binding. Nature (London) 340:568–571.
   PubMedGoogle Scholar
• Kozak, M. 1987. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J. Mol. Biol. 196:947–950.
   PubMed Web of Science ®Google Scholar
• Lee, W.-H., R. Bookstein, F. Hong, L.-J. Young, J.-Y. Shew, and E. Y.-H. P. Lee. 1987. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235:1394–1399.
   PubMed Web of Science ®Google Scholar
• Lee, W.-H., J.-Y. Shew, F. D. Hong, T. W. Sery, L. A. Donoso, L.-J. Young, R. Bookstein, and E. Y.-H. P. Lee. 1987. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature (London) 329:642–645.
   PubMed Web of Science ®Google Scholar
• Lee, E. Y.-H. P., H. To, J.-Y. Shew, R. Bookstein, P. Scully, and W.-H. Lee. 1988. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 241:218–221.
   PubMed Web of Science ®Google Scholar
• Ludlow, J. W., J. A. DeCaprio, C.-M. Huang, W.-H. Lee, E. Paucha, and D. M. Livingston. 1989. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell 56:57–65.
   PubMed Web of Science ®Google Scholar
• Ludlow, J. W., J. Shon, J. M. Pipas, D. M. Livingston, and J. Decaprio. 1990. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60:387–396.
   PubMed Web of Science ®Google Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• McGee, T. L., D. W. Yandell, and T. P. Dryja. 1989. Structure and partial genomic sequence of the human retinoblastoma susceptibility gene. Gene 80:119–128.
   PubMed Web of Science ®Google Scholar
• Melton, D. A., P. A. Kreig, M. R. Rebagliati, K. Zinn, and M. R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035–7056.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371–378.
   PubMed Web of Science ®Google Scholar
• Murphree, A. L., and W. F. Benedict. 1984. Retinoblastoma: clues to human oncogenesis. Science 223:1028–1033.
   PubMed Web of Science ®Google Scholar
• Murphy, C. I., B. Weiner, I. Bikel, H. Piwnica-Worms, M. K. Bradley, and D. M. Livingston. 1988. Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells. J. Virol. 62:2951–2959.
   PubMedGoogle Scholar
• Pelham, H. R. B., and R. J. Jackson. 1976. An efficient mRNA-dependent translation system from reticulocyte lysates. Eur. J. Biochem. 67:247–256.
   PubMedGoogle Scholar
• Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
   PubMed Web of Science ®Google Scholar
• Shew, J.-Y., P.-L. Chen, R. Bookstein, E. Y.-H. P. Lee, and W.-H. Lee. 1990. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen. Cell Growth Differ. 1:17–25.
   PubMedGoogle Scholar
• Shew, J.-Y., B. T.-Y. Lin, P.-L. Chen, B. Y. Tseng, T. L. Yang-Feng, and W.-H. Lee. 1990. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation. Proc. Natl. Acad. Sci. USA 87:6–10.
   PubMed Web of Science ®Google Scholar
• Simanis, V., and D. P. Lane. 1985. An immunoaffinity purification procedure for SV40 large T-antigen. Virology 144:88–100.
   PubMed Web of Science ®Google Scholar
• Skuse, G. R., and P. T. Rowley. 1989. Tumor suppressor genes and inherited predisposition to malignancy. Semin. Oncol. 16:128–137.
   PubMedGoogle Scholar
• Sparkes, R. S., A. L. Murphree, R. W. Lingua, M. C. Sparkes, L. L. Field, S. J. Funderburk, and W. F. Bendict. 1983. Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science 219:971–973.
   PubMed Web of Science ®Google Scholar
• Summers, M. D., and G. E. Smith. 1987. A manual of methods for baculovirus vectors and insect cell culture procedures. Texas Agricultural Experiment Station, College Station.
   Google Scholar
• T'Ang, A., J. M. Varley, S. Chakraborty, A. L. Murphree, and Y.-K. T. Fung. 1988. Structural rearrangement of the retinoblastoma gene in human breast cancer. Science 242:263–266.
   PubMed Web of Science ®Google Scholar
• Varley, J. M., J. Armour, J. E. Swallow, A. J. Jeffreys, B. A. J. Ponder, A. T'Ang, Y.-K. T. Fung, W. J. Brammar, and R. A. Walker. 1989. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene 4:725–729.
   PubMed Web of Science ®Google Scholar
• Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911–916.
   PubMed Web of Science ®Google Scholar
• Weichselbaum, R. R., M. Beckett, and A. Diamond. 1988. Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. Proc. Natl. Acad. Sci. USA 85:2106–2109.
   PubMed Web of Science ®Google Scholar
• Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow. 1988. Association between an oncogene and an antioncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (London) 334:124–129.
   PubMed Web of Science ®Google Scholar
• Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67–75.
   PubMed Web of Science ®Google Scholar
• Yandell, D. W., T. A. Campbell, S. H. Dayton, R. Petersen, D. Walton, J. B. Little, A. McConkie-Rosell, E. G. Buckley, and T. P. Dryja. 1989. Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. N. Engl. J. Med. 321:1689–1695.
   PubMed Web of Science ®Google Scholar
• Yokota, J., T. Akiyama, Y.-K. T. Fung, W. F. Benedict, Y. Namba, M. Hanaoka, M. Wada, T. Terasaki, Y. Shimosato, T. Sugimura, and M. Terada. 1988. Altered expression of the retinoblastoma (RB) gene in small-cell lung carcinoma of the lung. Oncogene 3:471–475.
   PubMed Web of Science ®Google Scholar