Evidence Suggesting that the ARS Elements Associated with Silencers of the Yeast Mating-Type Locus HML Do Not Function as Chromosomal DNA Replication Origins

References

• Abraham, J., K. A. Nasmyth, J. N. Strathern, A. J. S. Klar, and J. B. Hicks. 1984. Regulation of mating-type information in yeast: negative control requiring sequences both 5′ and 3′ to the regulated region. J. Mol. Biol. 176:307-331.
   PubMedGoogle Scholar
• Baker, T. A., and A. Kornberg. 1988. Transcriptional activation of initiation of replication from the E. coli chromosomal origin: an RNA-DNA hybrid near oriC. Cell 55:113-123.
   PubMed Web of Science ®Google Scholar
• Brand, A. H., G. Micklem, and K. Nasmyth. 1987. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation. Cell 51:709-717.
   PubMedGoogle Scholar
• Brewer, B. J., and W. L. Fangman. 1987. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51:463-471.
   PubMed Web of Science ®Google Scholar
• Brewer, B. J., and W. L. Fangman. 1988. A replication fork barrier at the 3′ end of yeast ribosomal RNA genes. Cell 55:637-643.
   PubMed Web of Science ®Google Scholar
• Brewer, B. J., E. P. Sena, and W. L. Fangman. 1988. Analysis of replication intermediates by two-dimensional agarose gel electrophoresis, p. 229-234. In T. Kelly and B. Stillman (ed.), Eukaryotic DNA replication. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Broach, J. R., Y. Li, J. Feldman, M. Jayaram, J. Abraham, K. A. Nasmyth, and J. B. Hicks. 1982. Localization and sequence analysis of yeast origins of DNA replication. Cold Spring Harbor Symp. Quant. Biol. 47:1165-1173.
   Google Scholar
• Campbell, J. L., and C. S. Newlon. 1991. Chromosomal DNA replication, p. 41-146. In J. R. Broach, E. W. Jones, and J. R. Pringle (ed.), The molecular biology of the yeast Saccharomyces, vol. 1, Genome, dynamics, protein synthesis, and energetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Chan, C. S. M., and B.-K. Tye. 1983. Organization of DNA sequences and replication origins at yeast telomeres. Cell 33:563-573.
   PubMed Web of Science ®Google Scholar
• Davis, L. R., D. D. Dubey, and J. A. Huberman. Unpublished data.
   Google Scholar
• DePamphilis, M. L. 1988. Transcriptional elements as components of eukaryotic origins of DNA replication. Cell 52:635-638.
   PubMedGoogle Scholar
• Deshpande, A., and C. S. Newlon. Unpublished data.
   Google Scholar
• Devenish, R. J., and C. S. Newlon. 1982. Isolation and characterization of yeast chromosome III by a method applicable to other circular DNAs. Gene 18:277-288.
   PubMedGoogle Scholar
• Dubey, D. D., and J. A. Huberman. Unpublished data.
   Google Scholar
• Feldman, J. B., J. B. Hicks, and J. R. Broach. 1984. Identification of sites required for repression of a silent mating type locus in yeast. J. Mol. Biol. 178:815-834.
   PubMed Web of Science ®Google Scholar
• Gahn, T. A., and C. L. Schildkraut. 1989. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication. Cell 58:527-535.
   PubMedGoogle Scholar
• Goldman, M. A., G. P. Holmquist, M. C. Gray, L. A. Caston, and A. Nag. 1984. Replication timing of genes and middle repetitive sequences. Science 224:686-692.
   PubMedGoogle Scholar
• Gottschling, D. E., O. M. Aparicio, B. L. Billington, and V. A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63:751-762.
   PubMed Web of Science ®Google Scholar
• Greenfeder, S. A., and C. S. Newlon. Unpublished data.
   Google Scholar
• Hartwell, L. H., R. K. Mortimer, J. Culotti, and M. Culotti. 1973. Genetic control of the cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74:267-286.
   PubMed Web of Science ®Google Scholar
• Hatton, K. S., V. Dhar, E. H. Brown, M. A. Iqbal, S. Stuart, V. T. Didamo, and C. L. Schildkraut. 1988. Replication program of active and inactive multigene families in mammalian cells. Mol. Cell. Biol. 8:2149-2158.
   PubMed Web of Science ®Google Scholar
• Herskowitz, I. 1989. A regulatory hierarchy for cell specialization in yeast. Nature (London) 342:749-757.
   PubMed Web of Science ®Google Scholar
• Hicks, J., J. N. Strathern, and A. J. S. Klar. 1979. Transposable mating type genes in Saccharomyces cerevisiae. Nature (London) 282:478-483.
   PubMed Web of Science ®Google Scholar
• Huberman, J. A., L. D. Spotila, K. A. Nawotka, S. M. El-Assouli, and L. R. Davis. 1987. The in vivo replication origin of the yeast 2pm plasmid. Cell 51:473-481.
   PubMed Web of Science ®Google Scholar
• Huberman, J. A., J. Zhu, L. R. Davis, and C. S. Newlon. 1988. Close association of a DNA replication origin and an ARS element on chromosome III of the yeast, Saccharomyces cerevisiae. Nucleic Acids Res. 16:6373-6384.
   PubMed Web of Science ®Google Scholar
• Ivy, J. M., A. J. S. Klar, and J. B. Hicks. 1986. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae. Mol. Cell. Biol. 6:688-702.
   PubMed Web of Science ®Google Scholar
• Jones, E. (Carnegie Mellon University). 1991. Personal communication.
   Google Scholar
• Jones, E. W. 1990. Vacuolar proteases in yeast Saccharomyces cerevisiae. Methods Enzymol. 185:372-386.
   PubMedGoogle Scholar
• Kimmerly, W. J., and J. Rine. 1987. Replication and segregation of plasmids containing cis-acting regulatory sites of silent mating-type genes in Saccharomyces cerevisiae are controlled by the SIR genes. Mol. Cell. Biol. 7:4225-4237.
   PubMedGoogle Scholar
• Klar, A. J. S., J. N. Strathern, J. B. Hicks, and D. Prudente. 1983. Efficient production of a ring derivative of chromosome III by the mating-type switching mechanism in Saccharomyces cerevisiae. Mol. Cell. Biol. 3:803-810.
   PubMedGoogle Scholar
• Linskens, M. H. K., and J. A. Huberman. 1988. Organization of replication of ribosomal DNA in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:4927-4935.
   PubMed Web of Science ®Google Scholar
• Linskens, M. H. K., and J. A. Huberman. 1990. Ambiguities in results obtained with 2D gel replicon mapping techniques. Nucleic Acids Res. 18:647-652.
   PubMedGoogle Scholar
• Mahoney, D. J., and J. R. Broach. 1989. The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers. Mol. Cell. Biol. 9:4621-4630.
   PubMedGoogle Scholar
• Mahoney, D. J., R. Marquardt, G.-J. Shei, A. B. Rose, and J. R. Broach. 1991. Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression. Genes Dev. 5:605-615.
   PubMedGoogle Scholar
• Marshall, M., D. Mahoney, A. Rose, J. B. Hicks, and J. R. Broach. 1987. Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 7:4441-4452.
   PubMedGoogle Scholar
• Miller, A. M., and K. A. Nasmyth. 1984. Role of DNA replication in the repression of silent mating type loci in yeast. Nature (London) 312:247-251.
   PubMedGoogle Scholar
• Mortimer, R. K., and J. R. Johnston. 1986. Genealogy of principal strains of the Yeast Genetic Stock Center. Genetics 113:35-43.
   PubMed Web of Science ®Google Scholar
• Nawotka, K. A., and J. A. Huberman. 1988. Two-dimensional gel electrophoretic method for mapping DNA replicons. Mol. Cell. Biol. 8:1408-1413.
   PubMedGoogle Scholar
• Newlon, C. S. Unpublished data.
   Google Scholar
• Newlon, C. S., R. P. Green, K. J. Hardeman, K. E. Kim, L. R. Lipchitz, T. G. Palzkill, S. Synn, and S. T. Woody. 1986. Structure and organization of yeast chromosome III, p. 211-223. In J. Hicks (ed.), Yeast cell biology. Alan R. Liss, Inc., New York.
   Google Scholar
• Newlon, C. S., L. R. Lipchitz, I. Collins, A. Deshpande, R. J. Devenish, R. P. Green, H. L. Klein, T. G. Palzkill, R. Ren, S. Synn, and S. T. Woody. Analysis of a circular derivative of Saccharomyces cerevisiae chromosome III: a physical map and identification and location of ARS elements. Genetics, in press.
   Google Scholar
• Potashkin, J. A., and J. A. Huberman. 1986. Characterization of DNA sequences associated with residual nuclei of Saccharomyces cerevisiae. Exp. Cell Res. 165:29-40.
   PubMedGoogle Scholar
• Reynolds, A. E., R. M. McCarroll, C. S. Newlon, and W. L. Fangman. 1989. Time of replication of ARS elements along yeast chromosome III. Mol. Cell. Biol. 9:4488-4494.
   PubMedGoogle Scholar
• Rine, J., and I. Herskowitz. 1987. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116:9-22.
   PubMed Web of Science ®Google Scholar
• Snyder, M., R. J. Sapolsky, and R. W. Davis. 1988. Transcription interferes with elements important for chromosome maintenance in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:2184-2194.
   PubMedGoogle Scholar
• Strathern, J. (Frederick Cancer Research Facility). 1991. Personal communication.
   Google Scholar
• Strathern, J. N., C. S. Newlon, I. Herskowitz, and J. B. Hicks. 1979. Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion. Cell 18:309-319.
   PubMedGoogle Scholar
• Struhl, K., D. T. Stinchcomb, S. Scherer, and R. W. Davis. 1979. High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc. Natl. Acad. Sci. USA 76:1035-1039.
   PubMed Web of Science ®Google Scholar
• Synn, S., and C. S. Newlon. Unpublished data.
   Google Scholar
• Umek, R. M., M. H. K. Linskens, D. Kowalski, and J. A. Huberman. 1989. New beginnings in studies of eukaryotic DNA replication origins. Biochim. Biophys. Acta 1007:1-14.
   PubMedGoogle Scholar
• Yang, L., and M. Botchan. 1990. Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element. J. Virol. 64:5903-5911.
   PubMedGoogle Scholar
• Yoshikawa, A., and K. Isono. 1990. Chromosome III of Saccharomyces cerevisiae: an ordered clone bank, a detailed restriction map, and analysis of transcripts suggest the presence of 160 genes. Yeast 6:383-401.
   PubMed Web of Science ®Google Scholar
• Zhu, J., C. S. Newlon, and J. A. Huberman. Unpublished data.
   Google Scholar