7
Views
9
CrossRef citations to date
0
Altmetric
Cell and Organelle Structure and Assembly

A Putative Zinc Finger Protein, Saccharomyces cerevisiae Vpsl8p, Affects Late Golgi Functions Required for Vacuolar Protein Sorting and Efficient α-Factor Prohormone Maturation

, &
Pages 5813-5824 | Received 24 May 1991, Accepted 26 Aug 1991, Published online: 31 Mar 2023

REFERENCES

  • Altschul, S., W. Gish, W. Miller, E. Meyers, and D. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
  • Ammerer, G., C. P. Hunter, J. H. Rothman, G. C. Saari, L. A. Valls, and T. H. Stevens. 1986. PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors. Mol. Cell. Biol. 6:2490-2499.
  • Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987. Current protocols in molecular biology. John Wiley & Sons, New York.
  • Balzi, E., W. Chen, S. Ulaszewski, E. Capieaux, and A. Goffeau. 1987. The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J. Biol. Chem. 262:16871-16879.
  • Bankaitis, V. Α., L. M. Johnson, and S. D. Emr. 1986. Isolation of yeast mutants defective in protein targeting to the vacuole. Proc. Natl. Acad. Sci. USA 83:9075-9079.
  • Banta, L. M., J. S. Robinson, D. J. Klionsky, and S. D. Emr. 1988. Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J. Cell. Biol. 107:1369-1383.
  • Banta, L. M., T. A. Vida, P. K. Herman, and S. D. Emr. 1990. Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis. Mol. Cell. Biol. 10:4638-4649.
  • Berg, J. 1989. Metal binding domains in nucleic acid binding and gene regulatory protein. Prog. Inorg. Chem. 37:143-185.
  • Berg, J. 1990. Zinc fingers and other metal binding domains. J. Biol. Chem. 265:6513-6516.
  • Berg, J. Μ. 1986. Potential metal binding domains in nucleic acid binding proteins. Science 232:485-487.
  • Bussey, H. 1988. Proteases and the processing of precursors to secreted proteins in yeast. Yeast 4:17-26.
  • Casadaban, M. J., and S. N. Cohen. 1980. Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J. Mol. Biol. 138:179-207.
  • Chan, R. K., L. M. Melnick, L. C. Blair, and J. Thorner. 1983. Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae. J. Bacteriol. 155:903-906.
  • Dmochowska, Α., D. Dignard, D. Henning, D. Thomas, and H. Bussey. 1987. Yeast KEX1 gene encodes a putative protease with a carboxypeptidase Β like function involved in killer toxin and α-factor processing. Cell 50:573-584.
  • Dulic, V., and H. Riezman. 1989. Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast? EMBO J. 8:1349-1359.
  • Finley, D., E. Ozkaynak, and A. Varshavsky. 1987. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation and other stresses. Cell 48:1035-1046.
  • Froehner, S. 1989. Expression of RNA transcripts for the postsynaptic 43 kDa protein in innervated and denervated rat skeletal muscle? FEBS Lett. 249:229-233.
  • Fuller, R. S., A. J. Brake, and J. Thorner. 1989. Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246:482-486.
  • Fuller, R. S., R. E. Sterne, and J. Thorner. 1988. Enzymes required for yeast prohormone processing. Annu. Rev. Physiol. 50:345-362.
  • Graham, T. R., and S. D. Emr. 1991. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J. Cell Biol. 114:207-218.
  • Haarer, B., S. Lillie, A. Adams, V. Magdolen, W. Bandlow, and S. Brown. 1990. Purification of profilin from Saccharomyces cerevisiae and analysis of profilin deficient mutants. J. Cell Biol. 110:105-114.
  • Hasilik, Α., and W. Tanner. 1978. Biosynthesis of the vacuolar yeast glycoprotein carboxypeptidase Y. Conversion of precursor into the enzyme. Eur. J. Biochem. 85:599-608.
  • Herman, P. K., and S. D. Emr. 1990. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:6742-6754.
  • Herman, P. K., J. H. Stack, J. A. DeModena, and S. D. Emr. 1991. A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole. Cell 64:425-437.
  • Horazdovsky, B. Unpublished data.
  • Horazdovsky, B., and S. Emr. Unpublished data.
  • Ito, H., Y. Fukada, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
  • Johnston, M. 1987. Genetic evidence that zinc is an essential co-factor in the DNA binding domain of GAL4 protein. Nature (London) 328:353-355.
  • Jones, E. 1983. Genetic approaches to the study of protease function and proteolysis in Saccharomyces cerevisiae, p. 167-203. In J. F. T. Spencer, D. M. Spencer, and A. R. W. Smith (ed.), Yeast genetics. Springer-Verlag, Inc. New York.
  • Jones, E. W. 1977. Proteinase mutants of Saccharomyces cerevisiae. Genetics 85:23-33.
  • Jones, E. W. 1984. The synthesis and function of proteases in Saccharomyces: genetic approaches. Annu. Rev. Genet. 18:233-270.
  • Julius, D., L. Blair, A. Brake, G. Sprague, and J. Thorner. 1983. Yeast α-factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell 32:839-852.
  • Julius, D., A. Brake, L. Blair, R. Kunisawa, and J. Thorner. 1984. Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor. Cell 37:1075-1089.
  • Klionsky, D. J., L. M. Banta, and S. D. Emr. 1988. Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information. Mol. Cell. Biol. 8:2105-2116.
  • Klionsky, D. J., and S. D. Emr. 1989. Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase? EMBO J. 8:2241-2250.
  • Klionsky, D. J., P. K. Herman, and S. D. Emr. 1990. The fungal vacuole: composition, function, and biogenesis. Microbiol. Rev. 54:266-292.
  • Kunkel, T. 1985. Rapid and efficient site specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:5463-5467.
  • Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydrophobic character of a protein. J. Mol. Biol. 157:105-132.
  • Ladjimi, M., and Kantrowitz. 1987. Catalytic regulatory subunit interactions and allosteric effects in aspartate transcarbamylase. J. Biol. Chem. 262:312-318.
  • Laughon, Α., and R. F. Gesteland. 1984. Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol. Cell. Biol. 4:260-267.
  • Liu, F., and M. R. Green. 1991. A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein. Cell 61:1217-1224.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Maraganore, J. 1987. Structural elements for protein phospholipid interactions may be shared in protein kinase C and phospholipase A2. Trends Biochem. Sci. 12:176-177.
  • Miller, J. H. 1972. Experiments in molecular genetics, p. 352-355. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Payne, G. Personal communication.
  • Payne, G. S., T. B. Hasson, M. S. Hasson, and R. Schekman. 1987. Genetic and biochemical characterization of clathrin-deficient Saccharomyces cerevisiae. Mol. Cell. Biol. 7:3888-3898.
  • Pearson, W., and D. Lipman. 1988. Improved tools for biological sequence analysis. Proc. Natl. Acad. Sci. USA 85:2444-2448.
  • Preston, R. Α., Μ. F. Manolson, K. Becherer, E. Weidenhammer, D. Kirkpatrick, R. Wright, and E. W. Jones. 1991. Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:5801-5812.
  • Pringle, J. R., R. A. Preston, A. E. M. Adams, T. Stearns, D. G. Drubin, B. K. Haarer, and E. W. Jones. 1989. Fluorescence microscopy methods for yeast. Methods Cell Biol. 31:357-435.
  • Raymond, C. K., P. J. O’Hara, G. Eichinger, J. H. Rothman, and Τ. Η. Stevens. 1990. Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle. J. Cell Biol. 111:877-892.
  • Robinson, J. Unpublished data.
  • Robinson, J. S., D. J. Klionsky, L. M. Banta, and S. D. Emr. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8:4936-4948.
  • Rose, M., P. Novick, J. Thomas, D. Botstein, and G. Fink. 1987. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere containing shuttle vector. Gene 60:237-243.
  • Rothman, J. H., I. Howald, and Τ. Η. Stevens. 1989. Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae? EMBO J. 8:2057-2065.
  • Rothman, J. H., C. K. Raymond, T. Gilbert, P. J. O’Hara, and Τ. Η. Stevens. 1990. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61:1063-1074.
  • Rothman, J. H., and Τ. Η. Stevens. 1986. Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell 47:1041-1051.
  • Sanger, F., F. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
  • Sherman, F., G. R. Fink, and J. B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Stevens, Τ., Β. Esmon, and R. Schekman. 1982. Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Υ to the vacuole. Cell 30:439-448.
  • Teichert, U., B. Mechler, H. Muller, and D. H. Wolf. 1989. Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survival. J. Biol. Chem. 264:16037-16045.
  • Woolford, C. Α., C. K. Dixon, M. F. Manolson, R. Wright, and E. W. Jones. 1990. Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae. Genetics 125:739-752.
  • Yano, R., and M. Nomura. 1991. Suppressor analysis of temperature-sensitive mutations of the largest subunit of RNA polymerase I in Saccharomyces cerevisiae: a suppressor gene encodes the second largest subunit of RNA polymerase. Mol. Cell. Biol. 11:754-764.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.