Combinatorial Splicing of Exon Pairs by Two-Site Binding of U1 Small Nuclear Ribonucleoprotein Particle

REFERENCES

• Aebi, Μ., Η. Hornig, R. A. Padgett, J. Reiser, and C. Weissmann. 1986. Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell 47:555-565.
   PubMed Web of Science ®Google Scholar
• Barabino, S. M. L., B. J. Blencowe, U. Ryder, B. S. Sproat, and A. I. Lamond. 1990. Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly. Cell 63:293-302.
   PubMed Web of Science ®Google Scholar
• Beyer, A. L., and Υ. Ν. Osheim. 1988. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev. 2:754-765.
   PubMed Web of Science ®Google Scholar
• Bindereif, Α., and M. R. Green. 1987. An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly? EMBO J. 6:2415-2424.
   PubMed Web of Science ®Google Scholar
• Black, D. L., B. Chabot, and J. A. Steitz. 1985. U2 as well as U1 small nuclear ribonucleoproteins are involved in pre-mRNA splicing. Cell 42:737-750.
   PubMed Web of Science ®Google Scholar
• Bonadio, J., F. Ramirez, and M. Barr. 1990. An intron mutation in the human a1 (I) collagen gene alters the efficiency of pre-mRNA splicing and is associated with osteogenesis imperfecta type II. J. Biol. Chem. 265:2262-2268.
   PubMedGoogle Scholar
• Breitbart, R. E., A. Andreadis, and B. Nadal-Ginard. 1987. Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu. Rev. Biochem. 56:467-495.
   PubMed Web of Science ®Google Scholar
• Brody, E., and J. Abelson. 1985. The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction. Science 228:963-967.
   PubMed Web of Science ®Google Scholar
• Emeson, R. B., F. Hedjran, J. M. Yeakley, J. W. Guise, and M. G. Rosenfeld. 1989. Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor. Nature (London) 341:76-80.
   PubMed Web of Science ®Google Scholar
• Frendewey, D., and W. Keller. 1985. Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences. Cell 42:355-367.
   PubMed Web of Science ®Google Scholar
• Goux-Pelletan, M., D. Libri, D. Y. d’Aubenton-Carafa, M. Fiszman, E. Brody, and J. Marie. 1990. In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch? EMBO J. 9:241-249.
   PubMedGoogle Scholar
• Grabowski, P. J., S. R. Seiler, and P. A. Sharp. 1985. A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell 24:345-353.
   Google Scholar
• Grabowski, P. J., and P. A. Sharp. 1986. Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome. Science 233:1294-1299.
   PubMed Web of Science ®Google Scholar
• Helfman, D. M., R. F. Roscigno, G. J. Mulligan, L. A. Finn, and K. S. Weber. 1990. Identification of two distinct intron elements involved in alternative splicing of β tropomyosin pre-mRNA. Genes Dev. 4:98-110.
   PubMedGoogle Scholar
• Kakizuka, Α., Τ. Ingi, Τ. Murai, and S. Nakanishi. 1990. A set of Ul snRNA-complementary sequences involved in governing alternative RNA splicing of the kininogen genes. J. Biol. Chem. 265:10102-10108.
   PubMedGoogle Scholar
• Konarska, Μ. Μ., and P. A. Sharp. 1987. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell 49:763-774.
   PubMed Web of Science ®Google Scholar
• Kuo, H.-C., F. H. Nasim, and P. J. Grabowski. 1991. Control of alternative splicing by the differential binding of U1 small nuclear ribonucleoprotein particle. Science 251:1045-1050.
   PubMed Web of Science ®Google Scholar
• Leff, S. E., M. G. Rosenfeld, and R. M. Evans. 1986. Complex transcriptional units: diversity in gene expression by alternative RNA processing. Annu. Rev. Biochem. 55:1091-1117.
   PubMed Web of Science ®Google Scholar
• Legrain, P., B. Seraphin, and M. Rosbash. 1988. Commitment of yeast pre-mRNA to the spliceosome pathway does not require U2 snRNP. Mol. Cell. Biol. 8:3755-3760.
   PubMedGoogle Scholar
• Libri, D., Μ. Goux-Pelletan, Ε. Brody, and M. Fiszman. 1990. Exon as well as intron sequences are cis-regulating elements for the mutually exclusive alternative splicing of the β tropomyosin gene. Mol. Cell. Biol. 10:5036-5046.
   PubMedGoogle Scholar
• Mount, S. M., I. Pettersson, M. Hinterberger, A. Karmas, and J. A. Steitz. 1983. The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro. Cell 33:509-518.
   PubMed Web of Science ®Google Scholar
• Nasim, F. H., P. A. Spears, Η. Μ. Hoffmann, H.-C. Kuo, and P. J. Grabowski. 1990. A sequential splicing mechanism promotes selection of an optional exon by repositioning a downstream 5′ splice site in preprotachykinin pre-mRNA. Genes Dev. 4:1172-1184.
   PubMedGoogle Scholar
• Parker, R., P. G. Siliciano, and C. Guthrie. 1987. Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell 49:229-239.
   PubMed Web of Science ®Google Scholar
• Reed, R., and T. Maniatis. 1988. The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes Dev. 2:1268-1276.
   PubMedGoogle Scholar
• Robberson, B. L., G. J. Cote, and S. M. Berget. 1990. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell. Biol. 10:84-94.
   PubMed Web of Science ®Google Scholar
• Ruby, S. W., and J. Abelson. 1988. An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. Science 242:1028-1035.
   PubMed Web of Science ®Google Scholar
• Ruskin, B., and M. R. Green. 1985. An RNA processing activity that debranches RNA lariats. Science 229:135-140.
   PubMed Web of Science ®Google Scholar
• Ruskin, B., P. D. Zamore, and M. R. Green. 1988. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell 52:207-219.
   PubMed Web of Science ®Google Scholar
• Seraphin, B., L. Kretzner, and M. Rosbash. 1988. A U1 snRNA: pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site? EMBO J. 7:2533-2538.
   PubMed Web of Science ®Google Scholar
• Seraphin, B., and M. Rosbash. 1989. Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing. Cell 59:349-358.
   PubMed Web of Science ®Google Scholar
• Siliciano, P. G., and C. Guthrie. 1988. 5′ splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev. 2:1258-1267.
   PubMed Web of Science ®Google Scholar
• Smith, C. W. J., and B. Nadal-Ginard. 1989. Mutually exclusive splicing of alpha tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing. Cell 56:749-758.
   PubMed Web of Science ®Google Scholar
• Smith, C. W. J., J. G. Patton, and B. Nadal-Ginard. 1989. Alternative splicing in the control of gene expression. Annu. Rev. Genet. 23:527-577.
   PubMed Web of Science ®Google Scholar
• Steitz, J. Α., D. L. Black, V. Gerke, K. A. Parker, A. Kramer, D. Frendewey, and W. Keller. 1988. Functions of the abundant U-snRNPs, p. 115-154. In M. L. Birnsteil (ed.), Structure and function of major and minor small nuclear ribonucleoprotein particles. Springer-Verlag, New York.
   Google Scholar
• Talerico, M., and S. M. Berget. 1990. Effect of 5′ splice site mutations on splicing of the preceding intron. Mol. Cell. Biol. 10:6299-6305.
   PubMed Web of Science ®Google Scholar
• Treisman, R., S. Orkin, and T. Maniatis. 1983. Specific transcription and RNA splicing defects in five cloned β-thalassemia genes. Nature (London) 302:591-596.
   PubMed Web of Science ®Google Scholar
• Weil, D., M. Bernard, N. Combates, M. K. Wirtz, D. W. Hollister, B. Steinmann, and F. Ramirez. 1988. Identification of a mutation that causes exon skipping during collagen pre-mRNA splicing in an Ehlors-Danlos syndrome variant. J. Biol. Chem. 263:8561-8564.
   PubMed Web of Science ®Google Scholar
• Zhuang, Y., and A. M. Weiner. 1986. A compensatory base change in Ul snRNA suppresses a 5′ splice site mutation. Cell 46:827-835.
   PubMed Web of Science ®Google Scholar