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Cell Growth and Development

The Int-2/Fgf-3 Oncogene Product Is Secreted and Associates with Extracellular Matrix: Implications for Cell Transformation

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Pages 5929-5936 | Received 17 Jul 1991, Accepted 10 Sep 1991, Published online: 31 Mar 2023

REFERENCES

  • Abraham, J. Α., A. Mergia, J. L. Whang, A. Tumolo, J. Friedman, K. A. Hjerrild, D. Gospodarowicz, and J. C. Fiddes. 1986. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science 233:545-548.
  • Acland, P., M. Dixon, G. Peters, and C. Dickson. 1990. Subcellular fate of the Int-2 oncoprotein is determined by choice of initiation codon. Nature (London) 343:662-665.
  • Bashkin, P., S. Doctrow, M. Klagsbrun, C. M. Svahn, J. Folkman, and I. Vlodavsky. 1989. Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 28:1737-1743.
  • Blam, S. B., R. Mitchell, E. Tischer, J. S. Rubin, M. Silva, S. Silver, J. C. Fiddes, J. A. Abraham, and S. A. Aaronson. 1988. Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene 3:129-136.
  • Bradley, R. S., and A. M. C. Brown. 1990. The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix? EMBO J. 9:1569-1575.
  • Burgess, W. H., and T. Maciag. 1989. The heparin binding (fibroblast) growth factor family proteins. Annu. Rev. Biochem. 58:575-606.
  • Delli-Bovi, P., A. M. Curatola, K. M. Newman, Y. Sato, D. Moscatelli, R. M. Hewick, D. B. Rifkin, and C. Basilico. 1988. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol. Cell. Biol. 8:2475-2484.
  • Dickson, C., P. Acland, R. Smith, M. Dixon, R. Deed, D. MacAllan, W. Walther, F. Fuller-Pace, P. Kiefer, and G. Peters. 1990. Characterization of int-2: a member of the fibroblast growth factor family. J. Cell Sci. Suppl. 13:87-96.
  • Dickson, C., R. Deed, M. Dixon, and G. Peters. 1989. The structure and function of the int-2 oncogene. Prog. Growth Factor Res. 1:123-132.
  • Dickson, C., R. Smith, S. Brookes, and G. Peters. 1984. Tumor-igenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2. Cell 37:529-536.
  • Dixon, M., R. Deed, P. Acland, R. Moore, A. Whyte, G. Peters, and C. Dickson. 1989. Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2. Mol. Cell. Biol. 9:4896-4902.
  • Dorner, A. J., and R. J. Kaufman. 1990. Analysis of synthesis, processing, and secretion of proteins expressed in mammalian cells. Methods Enzymol. 185:577-596.
  • Fuller-Pace, F., P. Kiefer, G. Peters, and C. Dickson. Unpublished data.
  • Fuller-Pace, F., G. Peters, and C. Dickson. 1991. Cell transformation by kFGF requires secretion but not glycosylation. J. Cell. Biol., in press.
  • Goldfarb, M., R. Deed, D. MacAllan, W. Walther, C. Dickson, and G. Peters. 1991. Cell transformation by Int-2-a member of the fibroblast growth factor family. Oncogene 6:65-71.
  • Gospodarowicz, D., and J. Chen. 1986. Heparin protects acidic and basic FGF from inactivation. J. Cell. Physiol. 128:475-484.
  • Jaye, M., R. Howk, W. Burgess, G. A. Ricca, I.-M. Chiu, M. W. Ravera, S. J. O’Brien, W. S. Modi, T. Maciag, and W. N. Drohan. 1986. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science 233:541-545.
  • Klagsbrun, M. 1990. The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix. Curr. Opin. Cell Biol. 2:857-863.
  • Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
  • Maries, I., J. Adelaide, F. Raybaud, M.-G. Mattei, F. Coulier, J. Planche, O. de Lapeyriere, and D. Birnbaum. 1989. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. Oncogene 4:335-340.
  • Miyagawa, K., H. Sakamoto, T. Yoshida, Y. Yamashita, Y. Mitsui, M. Furusawa, S. Maeda, F. Takaku, T. Sugimura, and M. Terada. 1988. hst-1 transforming protein: expression in silkworm cells and characterization as a novel heparin-binding growth factor. Oncogene 3:383-389.
  • Muller, W. J., F. S. Lee, C. Dickson, G. Peters, P. Pattengale, and P. Leder. 1990. The int-2 gene product acts as an epithelial growth factor in transgenic mice? EMBO J. 9:907-913.
  • Nusse, R., A. Brown, J. Papkoff, P. Scambler, G. Shackleford, A. McMahon, R. Moon, and H. Varmus. 1991. A new nomenclature for int-1 and related genes: the Wnt gene family? Cell 64:231.
  • Papkoff, J. 1989. Inducible overexpression and secretion of int-1 protein. Mol. Cell. Biol. 9:3377-3384.
  • Papkoff, J., and B. Schryver. 1990. Secreted int-l protein is associated with the cell surface. Mol. Cell. Biol. 10:2723-2730.
  • Quarto, N., D. Talarico, R. Florkiewicz, C. Basilico, and D. B. Rifkin. 1989. Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf. Oncogene Res. 5:101-110.
  • Rifkin, D. B., and D. Moscatelli. 1989. Recent developments in the cell biology of basic fibroblast growth factor. J. Cell Biol. 109:1-6.
  • Rogelj, S., R. A. Weinberg, P. Fanning, and M. Klagsbrun. 1988. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature (London) 331:173-175.
  • Ruoslahti, E., and Y. Yamaguchi. 1991. Proteoglycans as modulators of growth factor activities. Cell 64:867-869.
  • Saksela, O., D. Moscatelli, A. Sommer, and D. B. Rifkin. 1988. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J. Cell Biol. 107:743-751.
  • Talarico, D., and C. Basilico. 1991. The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway. Mol. Cell. Biol. 11:1138-1145.
  • Tarentino, A. L., C. M. Gomez, and Τ. Η. J. Plummer. 1985. Deglycosylation of asparagine-linked glycans by peptide: N-gly-cosidase F. Biochemistry 24:4665-4671.
  • Tarentino, A. L., and F. Maley. 1974. Purification and properties of an endo-β-N-acetylglucosaminidase from Streptomyces griseus. J. Biol. Chem. 249:811-817.
  • Thomas, K. A. 1988. Transforming potential of fibroblast growth factor genes. Trends Biochem. Sci. 13:327-328.
  • Thornton, S. C., S. N. Mueller, and Ε. Μ. Levine. 1983. Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science 222:623-625.
  • Vlodavsky, I., G. M. Lui, and D. Gospodarowicz. 1980. Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular marix versus plastic. Cell 19:607-616.
  • Yayon, Α., Μ. Klagsbrun, J. D. Esko, P. Leder, and D. M. Ornitz. 1991. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64:841-848.
  • Zhan, X., B. Bates, X. Hu, and M. Goldfarb. 1988. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol. Cell. Biol. 8:3487-3495.
  • Zhan, X., A. Culpepper, M. Reddy, J. Loveless, and M. Goldfarb. 1987. Human oncogenes detected by a defined medium culture assay. Oncogene 1:369-376.

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