Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities

REFERENCES

• Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by TPA-modulated trans-acting factor. Cell 49:729-739.
   PubMed Web of Science ®Google Scholar
• Baniahmad, Α., C. Steiner, A. C. Kohne, and R. Renkawitz. 1990. Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell 61:505-514.
   PubMed Web of Science ®Google Scholar
• Beato, M. 1989. Gene regulation by steroid hormones. Cell 56:335-344.
   PubMed Web of Science ®Google Scholar
• Benbrook, D., and M. Pfahl. 1987. A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. Science 238:788-791.
   PubMedGoogle Scholar
• Buscher, M., H. J. Rahmsdorf, M. Litfin, M. Karin, and P. Herrlich. 1988. Activation of the cFos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene 3:301-311.
   PubMed Web of Science ®Google Scholar
• Chatterjee, V. K. K., J.-K. Lee, A. Rentoumis, and J. L. Jameson. 1989. Negative egulation of the thyroid-stimulating hormone α gene by thyroid hormone: receptor interaction adjacent to the TATA box. Proc. Natl. Acad. Sci. USA 86:9114-9118.
   PubMedGoogle Scholar
• Crone, D. E., H.-S. Kim, and S. R. Spindler. 1990. α and β thyroid hormone receptors bind immediately adjacent to the rat Towth hormone gene TATA box in a negatively hormone-responsive promoter region. J. Biol. Chem. 265:10851-10856.
   PubMedGoogle Scholar
• Curran, T., and B. R. Franza, Jr. 1988. Fos and Jun: the AP-1 connection. Cell 55:395-397.
   PubMed Web of Science ®Google Scholar
• Damm, K., C. C. Thompson, and R. M. Evans. 1989. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature (London) 339:593-597.
   PubMed Web of Science ®Google Scholar
• Darling, D. S., J. Burnside, and W. W. Chin. 1989. Binding of thyroid hormone receptors to the rat thyrotropin-β gene. Mol. Endocrinol. 3:1359-1368.
   PubMedGoogle Scholar
• Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. R. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272.
   PubMed Web of Science ®Google Scholar
• Dobrovic, Α., Β. Houle, A. Belouchi, and W. E. C. Bradley. 1988. erbA-related sequence coding for DNA-binding hormone receptor localized to chromosome 3p21-3p25 and deleted in small cell lung carcinoma. Cancer Res. 48:682-685.
   PubMed Web of Science ®Google Scholar
• Evans, R. M. 1988. The steroid and thyroid hormone receptor family. Science 240:889-895.
   PubMed Web of Science ®Google Scholar
• Fisch, T. M., R. Prynes, and R. G. Roeder. 1987. c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate, and the calcium ionophone. Mol. Cell. Biol. 7:3490-3502.
   PubMed Web of Science ®Google Scholar
• Fisch, T. M., R. Prynes, and R. G. Roeder. 1989. An AP-1 binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-0-tetradecanoyl phorbol-13-acetate. Mol. Cell. Biol. 9:1327-1331.
   PubMed Web of Science ®Google Scholar
• Forman, B. M., C.-R. Yang, M. Au, J. Casanova, J. Ghysdael, and Η. Η. Samuels. 1989. A domain containing leucine-zipper-like motifs mediate novel in vivo interaction between the thyroid hormone and retinoic acid receptors. Mol. Endocrinol. 3:1610-1626.
   PubMedGoogle Scholar
• Frykberg, L., S. Palmieri, H. Beug, T. Graf, M. J. Hayman, and B. Vennstrom. 1983. Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell 32:227-238.
   PubMed Web of Science ®Google Scholar
• Gandrillon, O., P. Jurdic, M. Benchaibi, J. H. Xiao, J. Ghysdael, and J. Samarut. 1987. Expression of the v-erbA oncogene in chicken embryo fibroblasts stimulates their proliferation in vitro and enhances tumor growth in vivo. Cell 49:687-697.
   PubMedGoogle Scholar
• Gilman, Μ. Ζ. 1988. The cFos serum response element responds to protein kinase C-dependent and independent signals but not to cAMP. Genes Dev. 3:394-402.
   Google Scholar
• Glass, C. K., and J. M. Holloway. 1990. Regulation of gene expression by the thyroid hormone receptor. Biochim. Biophy. Acta 1032:157-176.
   PubMedGoogle Scholar
• Glass, C. K., J. M. Holloway, O. V. Devary, and M. G. Rosenfeld. 1988. The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell 54:313-323.
   PubMed Web of Science ®Google Scholar
• Graupner, G., K. N. Wills, M. Tzukerman, X.-K. Zhang, and M. Pfahl. 1989. Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity. Nature (London) 340:653-656.
   PubMed Web of Science ®Google Scholar
• Green, S., and P. Chambon. 1988. Nuclear receptors enhance our understanding of transcription regulation. Trends Genet. 4:309-314.
   PubMed Web of Science ®Google Scholar
• Hedley, A. J., S. J. Jones, D. J. Spiegelhalter, P. Clements, P. D. Bewsher, J. G. Simpson, and R. D. Weir. 1981. Breast cancer in thyroid disease: fact or fallacy. Lancet i:131-133.
   Google Scholar
• Hermann, T., X.-K. Zhang, M. Tzukerman, Κ. Ν. Wills, G. Graupner, and M. Pfahl. 1991. Regulatory functions of a non-ligand binding thyroid hormone receptor isoform. Cell Regul. 2:565-574.
   PubMedGoogle Scholar
• Hoeck, W., M. Pfahl, R. Jaggi, and B. Groner. 1990. Ligand-induced downregulation of glucocorticoid receptors is enhanced by the expression of oncogenes. UCLA Symp. Mol. Cell. Biol. 115:99-113.
   Google Scholar
• Hopp, T. P., K. S. Prickett, V. L. Price, R. T. Libby, C. J. March, D. P. Cerretti, D. L. Urdal, and P. J. Conlon. 1988. A short polypeptide marker sequence useful for recombinant protein identification and purification. Bio/Technology 6:1204-1210.
   Web of Science ®Google Scholar
• Hudson, L. G., J. B. Santon, C. K. Glass, and G. N. Gill. 1990. Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression. Cell 62:1165-1175.
   PubMedGoogle Scholar
• Husmann, M., T. Pietsch, B. Fleischer, C. Weisgerber, and D. Bitter-Suermann. 1989. Embryonic neural cell adhesion molecules on human natural killer cells. Eur. J. Immunol. 19:1761-1762.
   PubMedGoogle Scholar
• Jansson, M., L. Philipson, and B. Vennstrom. 1983. Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus? EMBO J. 2:561-565.
   PubMedGoogle Scholar
• Jonat, C., H. J. Rahmsdorf, K.-K. Park, A. C. B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204.
   PubMed Web of Science ®Google Scholar
• Kahn, P., B. Adkins, H. Beug, and T. Graf. 1984. Src- and fps-containing avian sarcoma viruses transform chicken erythroid cells. Proc. Natl. Acad. Sci. USA 81:7122-7126.
   PubMedGoogle Scholar
• Kahn, P., L. Frykberg, C. Brady, I. Stanley, H. Beug, B. Vennstrom, and T. Graf. 1986. v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation. Cell 45:349-356.
   PubMedGoogle Scholar
• Karin, M. 1990. The AP-1 complex and its role in transcriptional control by protein kinase C, p. 143-161. In P. Cohen and G. Foulkes (ed.), Molecular aspects of cellular regulation, vol. 6. Elsevier, Amsterdam.
   Google Scholar
• Koenig, R. J., M. A. Lazar, R. A. Hodin, G. A. Brent, P. R. Larsen, W. W. Chin, and D. D. Moore. 1989. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature (London) 337:659-660.
   PubMedGoogle Scholar
• Koenig, R. J., R. L. Warne, G. A. Brent, J. W. Harvey, P. R. Larsen, and D. D. Moore. 1988. Isolation of a cDNA clone encoding a biological active thyroid hormone receptor. Proc. Natl. Acad. Sci. USA 85:5031-5035.
   PubMedGoogle Scholar
• Kok, K., J. Osinga, B. Carritt, M. B. Davis, A. H. van der Hout, A. Y. van der Veen, R. M. Landsvater, L. F. Μ. Η. de Leij, H. H. Berendsen, P. E. Postmus, S. Poppema, and C. H. C. M. Buys. 1987. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature (London) 330:578-581.
   PubMed Web of Science ®Google Scholar
• Lazar, Μ. Α., R. A. Hodin, and W. W. Chin. 1989. Human carboxyl-terminal variant of α-type c-erbA inhibits transactivation by thyroid hormone receptors without binding thyroid hormone. Proc. Natl. Acad. Sci. USA 86:7771-7774.
   PubMedGoogle Scholar
• Lee, W. M. F., C. Lin, and T. Curran. 1988. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified Fos protein. Mol. Cell. Biol. 8:5521-5527.
   PubMedGoogle Scholar
• Lemaire, M., and L. Baugnet-Mahieu. 1986. Thyroid function in women with breast cancer. Eur. J. Cancer Clin. Oncol. 22:301-307.
   PubMedGoogle Scholar
• Lopez, C. Z., W. Hsiao, and I. B. Weinstein. 1989. Effects of triiodothyronine and tamoxifen on cell transformation induced by an activated c-Ha-ras oncogene. Cancer Res. 49:895-898.
   PubMedGoogle Scholar
• Lucibello, F. C., E. P. Slater, K. U. Jooss, M. Beato, and R. Muller. 1990. Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB? EMBO J. 9:2827-2834.
   PubMedGoogle Scholar
• Miller, A. D., T. Curran, and I. M. Verma. 1984. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell 36:51-60.
   PubMed Web of Science ®Google Scholar
• Mitsuhashi, T., G. E. Tennyson, and V. M. Nikodem. 1988. Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone. Proc. Natl. Acad. Sci. USA 85:5804-5808.
   PubMedGoogle Scholar
• Miyajima, N., R. Horiuchi, Y. Shibuya, S.-I. Fukushige, K.-I. Matsubara, K. Toyoshima, and T. Yamamoto. 1989. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57:31-39.
   PubMed Web of Science ®Google Scholar
• Mordacq, J. M., and D. I. H. Linzer. 1989. Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes Dev. 3:760-769.
   PubMedGoogle Scholar
• Nakai, Α., A. Sakurai, G. I. Bell, and L. J. DeGroot. 1988. Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. Mol. Endocrinol. 2:1087-1092.
   PubMedGoogle Scholar
• Nicholson, R. C., S. Mader, S. Nagpal, M. Leid, C. Rochette-Egly, and P. Chambon. 1990. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site? EMBO J. 9:4443-4454.
   PubMed Web of Science ®Google Scholar
• Nielson, D. Α., T.-C. Chang, and D. J. Shapiro. 1989. A highly sensitive, mixed-phase assay for chloramphenicol acetyltrans-ferase activity in transfected cells. Anal. Biochem. 179:19-23.
   PubMedGoogle Scholar
• Norman, C., M. Runswick, P. Pollock, and R. Treisman. 1988. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 55:989-1003.
   PubMed Web of Science ®Google Scholar
• Oppenheimer, J. H., and Η. Η. Samuels (ed.). 1983. Molecular basis of thyroid hormone action, p. 413-483. Academic Press, New York.
   Google Scholar
• Pfahl, M., M. Tzukerman, X.-K. Zhang, J. M. Lehmann, T. Hermann, Κ. Ν. Wills, and G. Graupner. 1990. Rapid procedures for nuclear retinoic acid receptor cloning and their analysis. Methods Enzymol. 189:256-270.
   PubMedGoogle Scholar
• Ransone, A. J., and I. M. Verma. 1990. Nuclear proto-onco-genes Fos and Jun. Annu. Rev. Cell Biol. 6:539-557.
   PubMedGoogle Scholar
• Sap, J., A. Munoz, K. Damm, Y. Goldberg, J. Ghysdael, A. Leutz, H. Beug, and B. Vennstrom. 1986. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (London) 324:635-640.
   PubMed Web of Science ®Google Scholar
• Sap, J., A. Munoz, J. Schmitt, H. Stunnenberg, and B. Vennstrom. 1989. Repression of transcription mediated at a hormone response element by the v-erbA oncogene product. Nature (London) 340:242-244.
   PubMed Web of Science ®Google Scholar
• Schonthal, Α., P. Herrich, H. J. Rahmsdorf, and H. Ponta. 1988. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54:325-334.
   PubMed Web of Science ®Google Scholar
• Schiile, R., P. Rangarajan, S. Kliewer, L. J. Ransone, J. Bolado, N. Yang, I. M. Verma, and R. M. Evans. 1990. Functional antagonism between oncoprotein cJun and the glucocorticoid receptor. Cell 62:1217-1226.
   PubMedGoogle Scholar
• Schiile, R., K. Umensono, D. J. Mangelsdorf, J. Bolado, J. W. Pike, and R. M. Evans. 1990. Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell 61:497-504.
   PubMedGoogle Scholar
• Schutte, J., J. D. Minna, and M. J. Birrer. 1989. Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single gene. Proc. Natl. Acad. Sci. USA 86:2257-2261.
   PubMed Web of Science ®Google Scholar
• Schutte, J., J. Viallet, M. Nau, S. Segal, J. Fedorko, and J. Minna. 1989. Jun-B inhibits and c-Fos stimulates the transforming and trans-activities of c-Jun. Cell 59:987-997.
   PubMed Web of Science ®Google Scholar
• Siegried, Z., and E. Ziff. 1989. Transcriptional activation by serum; PDGF and TPA through the cFos dyad symmetry element: cell type specific regulation for induction. Oncogene 4:3-11.
   PubMedGoogle Scholar
• Takatani, O., T. Okumoto, H. Kosano, M. Nishida, and H. Hiraide. 1989. Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women. Cancer Res. 49:3109-3112.
   PubMedGoogle Scholar
• Thomas, B. S., R. D. Bulbrook, M. J. Goodman, M. J. Russell, M. Quinlan, J. L. Hayward, and O. Takatani. 1986. Thyroid function and the incidence of breast cancer in Hawaiian, British and Japanese women. Int. J. Cancer 38:325-329.
   PubMedGoogle Scholar
• Thomas, B. S., R. D. Bulbrook, M. J. Russell, J. L. Hayward, and R. R. Millis. 1983. Thyroid function in early breast cancer. Eur. J. Cancer Clin. Oncol. 19:1215-1219.
   Google Scholar
• Thompson, C. C., C. Weinberger, R. Lebo, and R. M. Evans. 1987. Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. Science 237:1610-1613.
   PubMed Web of Science ®Google Scholar
• Vorherr, H. 1987. Thyroid function in benign and malignant breast disease. Eur. J. Cancer Clin. Oncol. 23:255-257.
   PubMedGoogle Scholar
• Weinberger, C., C. C. Thompson, E. S. Ong, R. Lebo, D. J. Gruol, and R. M. Evans. 1986. The c-erb-A gene encodes a thyroid hormone receptor. Nature (London) 324:641-646.
   PubMed Web of Science ®Google Scholar
• Wondisford, F. E., E. A. Farr, S. Radovick, K. J. Steinfelder, J. M. Moates, J. H. McClaskey, and B. D. Weintraub. 1989. Thyroid hormone inhibition of human thyrotropin β-subunit gene expression is mediated by a cis-acting element located in the first exon. J. Biol. Chem. 264:14601-14604.
   PubMedGoogle Scholar
• Yamamoto, K. R. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev Genet. 19:209-252.
   PubMed Web of Science ®Google Scholar
• Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between cJun and glucocorticoid receptor: mutual inhibition of DNA-binding due to direct protein-protein interaction. Cell 62:1205-1215.
   PubMed Web of Science ®Google Scholar
• Yang-Yen, H.-F., X.-K. Zhang, G. Graupner, M. Tzukerman, B. Sakamoto, M. Karin, and M. Pfahl. New Biol., in press.
   Google Scholar
• Zenke, M., A. Munoz, J. Sap, B. Vennstrom, and H. Beug. 1990. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Cell 61:1035-1049.
   PubMedGoogle Scholar
• Zhang, X.-K., and M. Pfahl. Unpublished data.
   Google Scholar
• Zhang, X.-K., K. N. Wills, G. Graupner, M. Tzukerman, T. Hermann, and M. Pfahl. 1991. Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles. New Biol. 3:169-181.
   PubMedGoogle Scholar