PBX2 and PBX3, New Homeobox Genes with Extensive Homology to the Human Proto-Oncogene PBX1

REFERENCES

• Allen, J. D., T. Lints, N. A. Jenkins, N. G. Copeland, A. Strasser, R. P. Harvey, and J. M. Adams. 1991. Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis. Genes Dev. 5:509-520.
   PubMed Web of Science ®Google Scholar
• Barad, Μ., Τ. Jack, R. Chadwick, and W. McGinnis. 1988. A novel, tissue-specific, Drosophila homeobox gene? EMBO J. 7:2151-2161.
   PubMedGoogle Scholar
• Baumgartner, S., D. Bopp, M. Burri, and M. Noll. 1987. Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. Genes Dev. 1:1247-1267.
   PubMedGoogle Scholar
• Boncinelli, E., R. Sommo, D. Acampora, M. Pannese, M. D’Esposito, A. Faiedla, and A. Simeone. 1988. Organization of human homeobox genes. Hum. Reprod. (Oxford) 3:880-886.
   PubMedGoogle Scholar
• Bopp, D., M. Burri, S. Baumgartner, G. Frigerio, and M. Noll. 1986. Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila. Cell 47:1033-1040.
   PubMedGoogle Scholar
• Chen-Levy, Z., J. Nourse, and M. L. Cleary. 1989. The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation. Mol. Cell. Biol. 9:701-710.
   PubMed Web of Science ®Google Scholar
• Chou, P. Y., and G. D. Fasman. 1974. Prediction of protein conformation. Biochemistry 13:222-245.
   PubMed Web of Science ®Google Scholar
• Cleary, M. L., T. C. Meeker, S. Levy, E. Lee, M. Trela, J. Sklar, and R. Levy. 1986. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human Β cell lymphoma. Cell 44:97-106.
   PubMed Web of Science ®Google Scholar
• Clerc, R. G., L. M. Corcoran, J. H. LeBowitz, D. Baltimore, and P. A. Sharp. 1988. The B-cell specific Oct-2 protein contains POU-box and homeo-box-type domains. Genes Dev. 2:1570-1581.
   PubMed Web of Science ®Google Scholar
• Derman, E., K. Krauter, L. Walling, C. Weinberger, M. Ray, and J. E. Darnell. 1981. Transcriptional control in the production of liver-specific mRNAs. Cell 23:731-739.
   PubMed Web of Science ®Google Scholar
• Donlon, T. A. 1986. Practical approaches to in situ hybridization. Karyogram 12:3-10.
   Google Scholar
• Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
   PubMed Web of Science ®Google Scholar
• Finney, M., G. Ruvkun, and H. R. Horvitz. 1988. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 55:757-769.
   PubMed Web of Science ®Google Scholar
• Fletcher, C., N. Heintz, and R. G. Roeder. 1987. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51:773-781.
   PubMed Web of Science ®Google Scholar
• Frain, M., G. Swart, P. Monaci, A. Nicosia, S. Stampfli, R. Frank, and R. Cortese. 1989. The liver-specific transcription factor LR-B1 contains a highly diverged homeobox DNA binding domain. Cell 59:145-157.
   PubMed Web of Science ®Google Scholar
• Frigerio, G., M. Burri, D. Bopp, S. Baumgartner, and M. Noll. 1986. Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network. Cell 47:735-746.
   PubMedGoogle Scholar
• Galili, N. et al. Unpublished data.
   Google Scholar
• Gehring, W. J., and Y. Hiromi. 1986. Homeotic genes and the homeobox. Annu. Rev. Genet. 20:147-173.
   PubMed Web of Science ®Google Scholar
• Harper, Μ. Ε., and G. F. Saunder. 1981. Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization. Chromosoma 83:431-439.
   PubMed Web of Science ®Google Scholar
• Hart, C. P., A. Fainsod, and F. H. Ruddle. 1987. Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons. Genomics 1:182-195.
   PubMedGoogle Scholar
• Hatano, M., C. W. M. Roberts, M. Minden, W. M. Crist, and S. J. Korsmeyer. 1991. Deregulation of a homeobox gene, Hox11, by the t(10;14) in Τ cell leukemia. Science 253:79-82.
   PubMed Web of Science ®Google Scholar
• He, X., M. N. Treacy, D. M. Simmons, H. A. Ingraham, and H. W. Swanson, and M. G. Rosenfeld. 1989. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature (London) 340:35-42.
   PubMed Web of Science ®Google Scholar
• Heim, S., and F. Mitelman. 1987. Cancer cytogenetics, p. 70. Alan R. Liss, Inc., New York.
   Google Scholar
• Herr, W., R. A. Sturm, R. G. Clerc, L. M. Corcoran, D. Baltimore, P. A. Sharp, H. A. Ingraham, M. G. Rosenfeld, M. Finney, G. Ruvkun, and H. R. Horvitz. 1988. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2 and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2:1513-1516.
   PubMed Web of Science ®Google Scholar
• Hunger, S. P., N. Galili, A. J. Carroll, W. M. Crist, M. P. Link, and M. L. Cleary. 1991. The t(l;19) (q23;pl3) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood 77:687-693.
   PubMed Web of Science ®Google Scholar
• Ingraham, Η. Α., R. Chen, H. J. Mangalam, H. P. Elsholtz, S. E. Flynn, C. R. Lin, D. M. Simmons, L. Swanson, and M. G. Rosenfeld. 1988. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55:519-529.
   PubMed Web of Science ®Google Scholar
• Joyner, A. L., K. Herrup, B. A. Auerbach, C. A. Davis, and J. Rossant. 1991. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251:1239-1243.
   PubMed Web of Science ®Google Scholar
• Joyner, A. L., and G. R. Martin. 1987. En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev. 1:29-38.
   PubMed Web of Science ®Google Scholar
• Kamps, M. P., A. T. Look, and D. Baltimore. 1991. The human t(l;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev. 5:358-368.
   PubMed Web of Science ®Google Scholar
• Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(l;19) translocation protein in pre-B ALL. Cell 60:547-555.
   PubMed Web of Science ®Google Scholar
• Kilchherr, F., A. Baumgartner, D. Bopp, E. Frei, and M. Noll. 1986. Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis. Nature (London) 321:493-499.
   Google Scholar
• Kissinger, C. R., B. Liu, L. Martin-Blanco, T. B. Romberg, and C. O. Pabo. 1990. Crystal structure of an engrailed homeo-domain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell 63:579-590.
   PubMed Web of Science ®Google Scholar
• Kohler, S., N. Galili, J. L. Sklar, T. A. Donlon, K. G. Blume, and M. L. Cleary. 1990. Expression of bcr-abl fusion transcripts following bone marrow transplantation for Philadelphia chromosome-positive leukemia. Leukemia 4:541-547.
   PubMed Web of Science ®Google Scholar
• Kongsuwan, K., J. Allen, and J. M. Adams. 1989. Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia. Nucleic Acids Res. 17:1881-1892.
   PubMed Web of Science ®Google Scholar
• Kornfeld, R., R. B. Saint, P. A. Beachy, P. J. Harte, D. A. Peattie, and D. S. Hogness. 1989. Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes Dev. 3:243-258.
   PubMedGoogle Scholar
• Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8132.
   PubMed Web of Science ®Google Scholar
• Kristie, T. M., and P. A. Sharp. 1990. Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV a-trans-activator protein. Genes Dev. 4:2383-2396.
   PubMedGoogle Scholar
• Lonai, P., and A. Orr-Urtreger. 1990. Homeogenes in mammalian development and the evolution of the cranium and central nervous system? FASEB J. 4:1436-1443.
   PubMedGoogle Scholar
• Macdonald, P. M., P. Ingham, and G. Struhl. 1986. Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box. Cell 47:721-734.
   PubMedGoogle Scholar
• Mavilio, F., A. Simeone, A. Giampaolo, A. Faiella, V. Zappavigna, D. Acampora, G. Poiana, G. Russo, C. Peschle, and E. Boncinelli. 1986. Differential and stage-related expression in embryonic tissues of a new human homeobox gene. Nature (London) 324:644-668.
   Google Scholar
• McGinnis, W., R. L. Garber, J. Wire, A. Kuroiwa, and W. J. Gehring. 1984. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other meta-zoans. Cell 37:403-408.
   PubMed Web of Science ®Google Scholar
• McGinnis, W., M. S. Levine, E. Hafen, A. Kuroiwa, and W. J. Gehring. 1984. A conserved DNA sequence in homeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (London) 308:428-433.
   PubMedGoogle Scholar
• Mermod, N., E. A. O’Neill, T. J. KeUy, and R. Tjian. 1989. The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain. Cell 58:741-753.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371-378.
   PubMed Web of Science ®Google Scholar
• Monica, K., Z. Chen-Levy, and M. L. Cleary. 1990. Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2. Nature (London) 346:189-191.
   PubMedGoogle Scholar
• Mul, Y. M., C. P. Verryzer, and P. C. Van Der Vliet. 1990. Transcription factors NFI and NFIII/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication. J. Virol. 64:5510-5518.
   PubMed Web of Science ®Google Scholar
• Nicosia, Α., P. Monaci, L. Tomei, R. De Francesco, M. Nuzzo, H. Stunnenberg, and R. Cortese. 1990. A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell 61:1225-1236.
   PubMed Web of Science ®Google Scholar
• Nourse, J., J. D. Mellentin, N. Galili, J. Walkinson, E. Stanbridge, S. D. Smith, and M. L. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535-545.
   PubMed Web of Science ®Google Scholar
• O’Neill, Ε. Α., C. Fletcher, C. R. Burrow, N. Heintz, R. G. Roeder, and T. J. Kelly. 1988. Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III. Science 241:1210-1213.
   PubMedGoogle Scholar
• Poole, S. J., L. M. Kauvar, B. Drees, and T. Romberg. 1985. The engrailed locus of Drosophila: structural analysis of an embryonic transcript. Cell 40:37-43.
   PubMedGoogle Scholar
• Rey-Campos, J., T. Chouard, M. Yaniv, and S. Cereghini. 1991. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1? EMBO J. 10:1445-1457.
   PubMed Web of Science ®Google Scholar
• Santoro, C., N. Mermod, P. C. Andrews, and R. Tjian. 1988. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature (London) 334:218-224.
   PubMedGoogle Scholar
• Scott, M. P., J. W. Tamkun, and G. W. Hartzel ΙII. 1989. The structure and function of the homeodomain. Biochim. Biophys. Acta 989:25-48.
   PubMed Web of Science ®Google Scholar
• Scott, M. P., and A. J. Weiner. 1984. Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. USA 81:4115-4119.
   PubMedGoogle Scholar
• Shapiro, Μ. Β., and P. Senapathy. 1987. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15:7155-7174.
   PubMed Web of Science ®Google Scholar
• Sturm, R. Α., G. Das, and W. Herr. 1988. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 2:1582-1599.
   PubMed Web of Science ®Google Scholar
• Verryzer, C. P., A. J. Kal, and P. C. Van der Vhet. 1990. The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication? EMBO J. 9:1883-1888.
   PubMedGoogle Scholar
• Wharton, Κ. Α., Β. Yedvobnick, V. G. Finnerty, and S. Artavanis-Tsakonas. 1985. opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell 40:55-62.
   PubMedGoogle Scholar
• Wright, C. V. E., K. W. Y. Cho, G. Oliver, and Ε. Μ. DeRobertis. 1989. Vertebrate homeodomain proteins: families of region-specific transcription factors. Trends Biochem. Sci. 14:52-56.
   PubMedGoogle Scholar
• Zamrod, Z., and W. E. Stumph. 1990. U4B snRNA gene enhancer activity requires functional octamer and SPH motifs. Nucleic Acids Res. 18:7323-7330.
   PubMedGoogle Scholar
• Zhou, D., and T. S. Benedict Yen. 1991. The ubiquitous transcription factor Oct-1 and the liver-specific factor HNF-1 are both required to activate transcription of a hepatitis Β virus promoter. Mol. Cell. Biol. 11:1353-1359.
   PubMedGoogle Scholar