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Gene Expression

Activation of the Silent Endogenous Cholesterol-7-Alpha- Hydroxylase Gene in Rat Hepatoma Cells: a New Complementation Group Having Resistance to 25-Hydroxycholesterol

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Pages 2049-2056 | Received 13 Nov 1990, Accepted 11 Jan 1991, Published online: 31 Mar 2023

REFERENCES

  • Aviv, H., and P. Leder. 1972. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69:1408–1412.
  • Ayaki, Y., E. Kok, and N. B. Javitt. 1989. Cholic acid synthesis from 26-hydroxycholesterol and 3-hydroxy-5-cholesteroic acid in the rabbit. J. Biol. Chem. 264:3818–3821.
  • Beato, M. 1987. Gene regulation by steroid hormones. Cell 56:335–344.
  • Borchardt, R. A., and R. A. Davis. 1987. Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion. J. Biol. Chem. 262:16394–16402.
  • Chang, E., and A. J. Perlman. 1987. Multiple hormones regulate angiotensinogen messenger ribonucleic acid levels in a rat hepatoma cell line. Endocrinology 121:513–519.
  • Chang, T.-Y., and C. C. Y. Chang. 1982. Revenants of a Chinese hamster ovary cell mutant resistant to suppression by an analogue of cholesterol. Isolation and partial biochemical characterization. Biochemistry 21:5316–5323.
  • Chen, H. W., W. K. Carenee, and A. A. Kandutsch. 1979. Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol cross-resistance to 7-keto cholesterol, 20-α hydroxycholesterol and serum. J. Biol. Chem. 254:715–720.
  • Chiang, J. Y. L., W. F. Miller, and G. M. Lin. 1990. Regulation of cholesterol 7-α-hydroxylase in the liver. J. Biol. Chem. 265:3889–3897.
  • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloro- form extraction. Anal. Biochem. 162:156–159.
  • Clarke, C. F., A. M. Fogelman, and P. A. Edwards. 1984. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3- methylglutaryl coenzyme A reductase. J. Biol. Chem. 259:10439–10447.
  • Danielsson, J. 1972. Relationship between diurnal variations in biosynthesis of cholesterol and bile acids. Steroids 20:63–72.
  • Davis, R. A., P. M. Hyde, J.-C. W. Kuan, M. Malone-McNeal, and J. Archambault-Schexnayder. 1983. Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability. J. Biol. Chem. 258:3661-3667.
  • Deininger, P. L., D. J. Jolly, C. M. Rubin, T. Friedmann, and C. W. Schmid. 1981. Base sequence studies of 300 nucleotide renatured repeated human DNA clones. J. Mol. Biol. 151:17–33.
  • Drevon, C. A., D. B. Weinstein, and D. Steinberg. 1980. Regulation of cholesterol esterification and biosynthesis in monolayer cultures of normal adult rat hepatocytes. J. Biol. Chem. 255:9128–9137.
  • Everson, G. T., and M. A. Polokoff. 1986. HepG2: a human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation. J. Biol. Chem. 261:2197–2201.
  • Gunning, P., P. Ponte, H. Okayama, J. Engel, H. Blau, and L. Kedes. 1983. Isolation and characterization of full-length cDNA clones for human α-, β-, and γ-actin mRNAs: skeletal but cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol. Cell Biol. 3:787–795.
  • Havekes, L. M., H. Verboom, E. DeWit, S. H. Yap, and H. M. G. Princen. 1986. Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins. Hepatology 6:1356–1360.
  • Hylemon, P. B., E. C. Gurley, W. M. Kubaska, T. R. Whitehead, P. S. Guzelian, and Z. R. Vlahcevic. 1985. Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism. J. Biol. Chem. 260:1015–1019.
  • Jelinek, D. F., S. Andersson, C. A. Slaughter, and D. W. Russell. 1990. Cloning and regulation of cholesterol 7-α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265:8190–8197.
  • Jelinek, D. F., and D. W. Russell. 1990. Structure of the rat gene encoding cholesterol 7-α-hydroxylase. Biochemistry 29:7781–7785.
  • Kovanen, P. T., D. W. Bilheimer, J. L. Goldstein, J. J. Jaramillo, and M. S. Brown. 1981. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc. Natl. Acad. Sci. USA 78:1194–1198.
  • Leighton, J. K., S. Dueland, and R. A. Davis. 1990. Abstr. Annu. Meet. Council Arteriosclerosis. Arteriosclerosis 10:785a.
  • Li, Y. C., D. P. Wang, and J. Y. L. Chiang. 1990. Regulation of cholesterol 7 α-hydroxylase in the liver. J. Biol. Chem. 265:12012–12019.
  • Metherall, J. E., J. L. Goldstein, K. L. Luskey, and M. S. Brown. 1989. Loss of transcriptional repression of three sterol- regulated genes in mutant hamster cells. J. Biol. Chem. 264:15634–15641.
  • Mitropoulis, K. A., and S. Balasubramanians. 1976. The role of glucocorticoids in the regulation of the diurnal rhythm of hepatic β-hydroxy=β-methylglutaryl-coenzyme A reductase and cholesterol 7-α-hydroxylase. Biochem. J. 160:49–55.
  • Myant, N. B., and K. A. Mitropoulis. 1977. Cholesterol-7-alpha- hydroxylase. J. Lipid Res. 18:135–153.
  • Noshiro, M., and K. Okudu. 1990. Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 α-hydroxylase. FEBS Lett. 268:137–140.
  • Osborne, T. F., G. Gil, J. L. Goldstein, and M. S. Brown. 1988. Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulating elements. J. Biol. Chem. 263:3380–3387.
  • Polokoff, M. A., and G. T. Everson. 1986. Hepatocyte-hepatoma cell hybrids. Characterization and demonstration of bile acid synthesis. J. Biol. Chem. 261:4085–4089.
  • Princen, H. M. G., C. M. G. Huijsmans, F. Kuipers, R. J. Vonk, and H. J. M. Kempen. 1986. Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 α-hydroxylase. J. Clin. Invest. 78:1064–1071.
  • Princen, H. M. G., P. Meijer, and B. Hoffee. 1989. Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7-α-hydroxylase. Biochem. J. 262:341–348.
  • Silver, G., L. M. Reid, and K. S. Krauter. 1990. Dexamethasone-mediated regulation of 3-methylcholanthrene-induced cytochrome P-450d mRNA accumulation in primary rat hepatocyte cultures. J. Biol. Chem. 265:3134–3138.
  • Simmons, D. L., P. McQuiddy, and C. B. Kasper. 1987. Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. J. Biol. Chem. 262:326–332.
  • Sinensky, M. 1978. Defective regulation of cholesterol biosynthesis and plasma membrane fluidity in a Chinese hamster ovary cell mutant. Proc. Natl. Acad. Sci. USA 75:1247–1249.
  • Siperstein, M. D., M. E. Jayko, I. L. Charkoff, and W. E. Dauben. 1952. Nature of the metabolic products of 14C-choles- terol excreted in bile and feces. Proc. Soc. Exp. Biol. Med. 81:720–724.
  • Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
  • Straka, M. S., L. H. Junker, L. Zaccaro, D. L. Zogg, S. Dueland, G. T. Everson, and R. A. Davis. 1990. Substrate stimulation of 7-alpha-hydroxylase, an enzyme located in the cholesterol-poor endoplasmic reticulum. J. Biol. Chem. 265:7145–7149.
  • Südhof, T. C., D. W. Russell, M. S. Brown, and J. L. Goldstein. 1987. 42 bp element from LDL receptor gene counters endproduct repression by sterols when inserted into viral TK promoter. Cell 48:1061–1069.
  • Swell, L., C. C. Schwartz, J. Gustafsson, H. Danielsson, and Z. R. Vlahcevic. 1981. A quantitative evaluation of the conversion of 25-hydroxycholesterol to bile acids in man. Biochim. Biophys. Acta 663:163–168.

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