The SIR1 Gene of Saccharomyces cerevisiae and Its Role as an Extragenic Suppressor of Several Mating-Defective Mutants

REFERENCES

• Abraham, J., K. A. Nasmyth, J. N. Strathern, A. J. S. Klar, and J. B. Hicks. 1984. Regulation of mating-type information in yeast: negative control requiring sequences both 5′ and 3′ to the regulated region. J. Mol. Biol. 176:307–331.
   PubMedGoogle Scholar
• Alberts, B., and R. Stemglanz. 1990. Chromatin contract to silence. Nature (London) 344:193–194.
   PubMed Web of Science ®Google Scholar
• Ausubel, F. M., R. Brent, R. E. Kingston, D. M. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. John Wiley & Sons, Inc., New York.
   Google Scholar
• Brand, A. Personal communication.
   Google Scholar
• Brand, A. H., L. Breeden, J. Abraham, R. Stemglanz, and K. Nasmyth. 1985. Characterization of a “silencer” in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41:41–48.
   PubMed Web of Science ®Google Scholar
• Brand, A. H., G. Micklem, and K. Nasmyth. 1987. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation. Cell 51:709–719.
   PubMedGoogle Scholar
• Brill, S. J., and R. Stemglanz. 1988. Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell 54:403–411.
   PubMed Web of Science ®Google Scholar
• Buchman, A. R., W. J. Kimmerly, J. Rine, and R. D. Kornberg. 1988. Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:210–225.
   PubMed Web of Science ®Google Scholar
• Diffley, J. F. X., and B. Stillman. 1989. Similarity between the transcriptional silencer binding proteins ABF1 and RAP1. Science 246:1034–1038.
   PubMedGoogle Scholar
• Feldman, J. B., J. B. Hicks, and J. R. Broach. 1984. Identification of sites required for repression of a silent mating type locus in yeast. J. Mol. Biol. 178:815–834.
   PubMed Web of Science ®Google Scholar
• Herskowitz, I., and Y. Oshima. 1981. Control of cell type in Saccharomyces cerevisiae: mating type and mating-type interconversion, p. 181-209. In J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Ivy, J. M., A. J. S. Klar, and J. B. Hicks. 1986. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae. Mol. Cell. Biol. 6:688–702.
   Google Scholar
• Johnson, L. M., P. S. Kayne, E. S. Kahn, and M. Grunstein. 1990. Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87:6286–6290.
   PubMedGoogle Scholar
• Kayne, P. S., U. Kim, M. Han, J. R. Mullen, F. Yoshizaki, and M. Grunstein. 1988. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55:27–39.
   PubMed Web of Science ®Google Scholar
• Kimmerly, W. J., and J. Rine. 1987. Replication and segregation of plasmids containing cis-acting regulatory sites of silent mating-type genes in Saccharomyces cerevisiae are controlled by the SIR genes. Mol. Cell. Biol. 7:4225–4237.
   PubMedGoogle Scholar
• Langford, C. J., and D. Gallwitz. 1983. Evidence for an intron- contained sequence required for the splicing of yeast RNA polymerase II transcripts. Cell 33:519–527.
   PubMed Web of Science ®Google Scholar
• Mahoney, D. J., and J. R. Broach. 1989. The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers. Mol. Cell. Biol. 9:4621–4630.
   PubMedGoogle Scholar
• Mayer, S. A., and C. L. Dieckmann. 1989. The yeast CPB1 gene produces two differentially regulated transcripts by alternative 3′-end formation. Mol. Cell. Biol. 9:4161–4169.
   PubMedGoogle Scholar
• Miller, A. M., R. Stemglanz, and K. A. Nasmyth. 1984. The role of DNA replication in the repression of the yeast matingtype silent loci. Cold Spring Harbor Symp. Quant. Biol. 49:105–113.
   PubMedGoogle Scholar
• Mullen, J., and R. Stemglanz. Unpublished data.
   Google Scholar
• Mullen, J. R. 1989. Ph.D. thesis, State University of New York, Stony Brook.
   Google Scholar
• Mullen, J. R., P. S. Kayne, R. P. Moerschell, S. Tsunasawa, M. Gribskov, M. Colavito-Shepanski, M. Grunstein, F. Sherman, and R. Stemglanz. 1989. Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J. 8:2067–2075.
   PubMedGoogle Scholar
• Nasmyth, K. A. 1982. The regulation of yeast mating-type chromatin structure by SIR: an action at a distance affecting both transcription and transposition. Cell 30:567–578.
   PubMed Web of Science ®Google Scholar
• Pillus, L. Personal communication.
   Google Scholar
• Pillus, L., and J. Rine. 1989. Epigenetic inheritance of transcriptional states in S. cerevisiae. Cell 59:637–647.
   PubMed Web of Science ®Google Scholar
• Rine, J., and I. Herskowitz. 1987. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae Genetics 116:9–22.
   PubMed Web of Science ®Google Scholar
• Rine, J., J. N. Strathern, J. B. Hicks, and I. Herskowitz. 1979. A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic matingtype loci. Genetics 93:887–901.
   Google Scholar
• Rose, M. D., F. Winston, and P. Hieter. 1988. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Shore, D., and K. Nasmyth. 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51:721–732.
   PubMed Web of Science ®Google Scholar
• Shore, D., M. Squire, and K. Nasmyth. 1984. Characterization of two genes required for the position-effect control of yeast mating type genes. EMBO J. 3:2817–2823.
   PubMedGoogle Scholar
• Shore, D., D. J. Stillman, A. H. Brand, and K. A. Nasmyth. 1987. Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication. EMBO J. 6:461–467.
   PubMed Web of Science ®Google Scholar
• Strathern, J. N., A. J. S. Klar, J. B. Hicks, J. A. Abraham, J. M. Ivy, K. A. Nasmyth, and C. McGill. 1982. Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 31:183–192.
   PubMed Web of Science ®Google Scholar
• Whiteway, M., R. Freedman, S. Van Arsdell, J. W. Szostak, and J. Thorner. 1987. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol. Cell. Biol. 7:3713–3722.
   PubMed Web of Science ®Google Scholar
• Whiteway, M., and J. W. Szostak. 1985. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternate developmental pathways. Cell 43:483–492.
   PubMed Web of Science ®Google Scholar