Identification of a GTPase-Activating Protein Homolog in Schizosaccharomyces pombe

References

• Adari, H., D. R. Lowy, B. M. Willumsen, C. J. Der, and F. McCormick. 1988. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518-521.
   PubMed Web of Science ®Google Scholar
• Anderson, D., C. A. Koch, L. Grey, C. Ellis, M. Moran, and T. Powson. 1990. Binding of SH2 domains of phospholipase Cγ-1, GAP, and Src to activated growth factor receptors. Science 250:979-982.
   PubMed Web of Science ®Google Scholar
• Ballester, R., D. Marchuck, M. Boguski, A. Saulino, R. Letcher, M. Wigler, and F. Collins. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851-859.
   PubMed Web of Science ®Google Scholar
• Beach, D., M. Piper, and P. Nurse. 1982. Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol. Gen. Genet. 187:326-329.
   PubMedGoogle Scholar
• Beckner, S. K., S. Hattori, and T. Shih. 1985. The ras oncogene product p21 is not a regulatory component of adenylate cyclase. Nature (London) 317:71-72.
   PubMed Web of Science ®Google Scholar
• Birchmeier, C., D. Broek, and M. Wigler. 1985. RAS proteins can induce meiosis in Xenopus oocytes. Cell 43:615-621.
   PubMed Web of Science ®Google Scholar
• Bourne, H. R., D. A. Sanders, and F. McCormick. 1990. The GTPase superfamily: a conserved switch for diverse cell functions. Nature (London) 348:125-132.
   PubMed Web of Science ®Google Scholar
• Broek, D., T. Toda, T. Michaelis, L. Levin, C. Birchmeier, M. Zoller, S. Powers, and M. Wigler. 1987. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell 48:789-799.
   PubMed Web of Science ®Google Scholar
• Buchberg, A. M., L. S. Clevetand, N. A. Jenkins, and N. G. Copeland. 1990. Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway. Nature (London) 347:291-294.
   PubMed Web of Science ®Google Scholar
• Cales, C., J. F. Hancock, C. J. Marshall, and A. Hall. 1988. The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (London) 332:548-551.
   PubMed Web of Science ®Google Scholar
• Camonis, J. H., M. Kalekine, B. Gongre, H. Garreau, E. Boy-Marcotte, and M. Jacquet. 1986. Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae. EMBO J. 5:375-380.
   PubMedGoogle Scholar
• Dayhoff, M. O., R. M. Schwartz, and B. C. Orcutt. 1978. A model of evolutionary change in proteins, p. 345-352. In M. O. Dayhoff (ed.), Atlas of protein sequence and structure, vol. 5, suppl. 3. National Biomedical Research Foundation, Washington, D.C.
   Google Scholar
• Egel, R., and M. Egel-Mitani. 1974. Premeiotic DNA synthesis in fission yeast. Exp. Cell Res. 88:127-134.
   PubMedGoogle Scholar
• Fukui, Y., and Y. Kaziro. 1985. Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe. EMBO J. 4:687-691.
   PubMed Web of Science ®Google Scholar
• Fukui, Y., Y. Kaziro, and M. Yamamoto. 1986. Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe. EMBO J. 5:1991-1993.
   PubMedGoogle Scholar
• Fukui, Y., T. Kozasa, Y. Kaziro, T. Takeda, and M. Yamamoto. 1986. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Cell 44:329-336.
   PubMed Web of Science ®Google Scholar
• Fukui, Y., S. Miyake, M. Satoh, and M. Yamamoto. 1989. Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the rasl gene product. Mol. Cell. Biol. 9:5617-5622.
   PubMedGoogle Scholar
• Fukui, Y., and M. Yamamoto. 1988. Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1-. Mol. Gen. Genet. 215:26-31.
   PubMedGoogle Scholar
• Grimm, C., J. Kohli, J. Murray, and K. Maundrell. 1988. Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker. Mol. Gen. Genet. 215:81-86.
   PubMedGoogle Scholar
• Gutz, H., H. Heslot, U. Leupold, and N. Loprieno. 1974. Schizosaccharomyces pombe, p. 395-446. In R. D. King (ed.), Handbook of genetics, vol. 1. Plenum Publishing Corp., New York.
   Google Scholar
• Henikoff, S. 1984. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene 28:351-359.
   PubMed Web of Science ®Google Scholar
• Hughes, D. A., Y. Fukui, and M. Yamamoto. 1990. Homologous activators of ras in fission and budding yeast. Nature (London) 344:355-357.
   PubMedGoogle Scholar
• Iino, Y., and M. Yamamoto. 1985. Mutants of Schizosaccharomyces pombe which sporulate in the haploid state. Mol. Gen. Genet. 198:416-421.
   PubMedGoogle Scholar
• Kataoka, T., S. Powers, C. McGill, O. Fasano, J. Strathern, J. Broach, and M. Wigler. 1984. Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37:437-455.
   PubMed Web of Science ®Google Scholar
• Leupold, U. 1987. Sex appeal in fission yeast. Curr. Genet. 12:543-545.
   Google Scholar
• Levitzki, A., J. Rudick, I. Pastan, W. C. Vass, and D. R. Lowy. 1986. Adenylate cyclase activity of NIH3T3 cells morphologically transformed by ras genes. FEBS Lett. 197:134-138.
   PubMedGoogle Scholar
• Marshall, M. S., W. S. Hill, S. N. Assunta, U. S. Vogel, M. D. Schaber, E. M. Scolnick, R. A. F. Dixon, I. S. Sigal, and J. B. Gibbs. 1989. A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity. EMBO J. 8:1105-1110.
   PubMedGoogle Scholar
• Martin, G. A., D. Viskochil, G. Bollag, P. C. McCabe, W. J. Crosier, H. Haubruck, L. Conroy, R. Clark, P. O’Connell, R. M. Cawthon, M. A. Innis, and F. McCormick. 1990. The Gap-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63:843-849.
   PubMed Web of Science ®Google Scholar
• McCormick, F. 1989. ras GTPase activating protein: signal transmitter and signal terminator. Cell 56:5-8.
   PubMed Web of Science ®Google Scholar
• Nadin-Davis, S. A., A. Nasim, and D. Beach. 1986. Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J. 5:2963-2971.
   PubMedGoogle Scholar
• Nadin-Davis, S. A., R. C. A. Yang, S. A. Narang, and A. Nasim. 1986. The cloning and characterization of a RAS gene from Schizosaccharomyces pombe. J. Mol. Evol. 23:41-51.
   PubMedGoogle Scholar
• Okazaki, K., N. Okazaki, K. Kume, S. Jinno, K. Tanaka, and H. Okayama. 1990. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by frtws-complementation of Schizosaccharomyces pombe. Nucleic Acids Res. 18:6485-6489.
   PubMed Web of Science ®Google Scholar
• Robinson, L. C., J. B. Gibbs, M. S. Marshall, and K. Tatchell. 1987. CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 235:1218-1221.
   PubMed Web of Science ®Google Scholar
• Rothstein, R. 1983. One step gene disruption in yeast. Methods Enzym. 101:202-211.
   PubMed Web of Science ®Google Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
   PubMed Web of Science ®Google Scholar
• Sipiczki, M., and L. Ferenczy. 1977. Protoplast fusion of Schizosaccharomyces pombe auxotrophic mutants of identical mating-type. Mol. Gen. Genet. 151:77-81.
   PubMedGoogle Scholar
• Sugimoto, A., D. A. Hughes, and M. Yamamoto. Unpublished data.
   Google Scholar
• Tanaka, K., K. Matsumoto, and A. Toh-e. 1989. IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 9:757-768.
   PubMed Web of Science ®Google Scholar
• Tanaka, K., M. Nakafuku, T. Satoh, M. Marshall, J. Gibbs, K. Matsumoto, Y. Kaziro, and A. Toh-e. 1990. S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell 60:803-807.
   PubMed Web of Science ®Google Scholar
• Tanaka, K., M. Nakafuku, F. Tamanoi, Y. Kaziro, K. Matsumoto, and A. Toh-e. 1990. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol. Cell. Biol. 10:4303-4313.
   PubMed Web of Science ®Google Scholar
• Tatchell, K., D. T. Chaleff, D. DeFeo-Jones, and E. M. Scolnick. 1984. Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability. Nature (London) 309:523-527.
   PubMed Web of Science ®Google Scholar
• Toda, T., I. Uno, T. Ishikawa, S. Powers, T. Kataoka, D. Broek, S. Cameron, J. Broach, K. Matsumoto, and M. Wigler. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40:27-36.
   PubMed Web of Science ®Google Scholar
• Trahey, M., and F. McCormick. 1987. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542-545.
   PubMed Web of Science ®Google Scholar
• Trahey, M., G. Wong, R. Halenbeck, B. Rubinfeld, G. Martin, M. Ladner, C. Long, W. Crosier, K. Watt, K. Koths, and F. McCormick. 1988. Molecular cloning of two types of GAP complementary DNA from human placenta. Science 242:1697-1700.
   PubMed Web of Science ®Google Scholar
• Vogel, U. S., R. A. F. Dixon, M. D. Schaber, R. E. Diehl, M. S. Marshall, E. M. Scolnick, I. S. Sigal, and J. B. Gibbs. 1988. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (London) 335:90-93.
   PubMed Web of Science ®Google Scholar
• Watanabe, Y., Y. Iino, K. Furuhata, C. Shimoda, and M. Yamamoto. 1988. The S. pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP. EMBO J. 7:761-767.
   PubMedGoogle Scholar
• Xu, G., B. Lin, K. Tanaka, D. Dunn, D. Wood, R. Gesteland, R. White, R. Weiss, and F. Tamanoi. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835-841.
   PubMed Web of Science ®Google Scholar
• Xu, G., P. O’Connell, D. Viskochil, R. Cawthon, M. Robertson, M. Culver, D. Dunn, J. Stevens, R. Gesteland, R. White, and R. Weiss. 1990. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 62:599-608.
   PubMed Web of Science ®Google Scholar