1
Views
2
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

A Novel, Plasmid-Based System for Studying Gene Rearrangements in Mammalian Cells

&
Pages 3915-3924 | Received 02 Feb 1991, Accepted 08 May 1991, Published online: 01 Apr 2023

REFERENCES

  • Aviv, H., and P. Leder. 1972. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69:1408–1412.
  • Bishop, J. M. 1987. The molecular genetics of cancer. Science 235:305–311.
  • Blackwell, T. K., M. W. Moore, G. D. Yancopoulos, H. Suh, S. Lutzker, E. Selsing, and F. W. Alt. 1986. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (London) 324:585–589.
  • Blatt, C., D. Aberdam, R. Schwartz, and L. Sachs. 1988. DNA rearrangement of a homeobox gene in myeloid leukaemic cells. EMBO J. 7:4283–1290.
  • Bookstein, R., E. Y.-H. P. Lee, A. Peccei, and W.-H. H. 1989. Human retinoblastoma gene: long-range mapping and analysis of its deletion in a breast cancer cell line. Mol. Cell. Biol. 9:1628–1634.
  • Brodeur, G. M., R. C. Seeger, M. Schwab, H. E. Varmus, and J. M. Bishop. 1984. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224:1121–1124.
  • Canning, S., and T. P. Dryja. 1989. Short direct repeats at the breakpoints of deletions of the retinoblastoma gene. Proc. Natl. Acad. Sci. USA 86:5044–5048.
  • Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
  • Dasgupta, P., A. J. Linnenbach, A. J. Giaccia, T. D. Stamato, and E. P. Reddy. 1989. Molecular cloning of the breakpoint region on chromosome 6 in cutaneous malignant melanoma: evidence for deletion in the c-myb locus and translocation of a segment of chromosome 12. Oncogene 4:1201–1205.
  • DeMarini, D. M., H. E. Brockman, F. J. de Serres, H. H. Evans, L. F. Stankowski, Jr., and A. W. Hsie. 1989. Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective. Mutat. Res. 220:11–29.
  • Doll, R. 1978. An epidemiological perspective of the biology of cancer. Cancer Res. 38:3573–3683.
  • Everett, R. D., D. Baty, and P. Chambon. 1983. The repeated G/C motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res. 11:2447–2464.
  • Fearon, E. F., K. R. Cho, J. M. Nigro, S. E. Kern, J. W. Simons, J. M. Ruppert, S. R. Hamilton, A. C. Preisinger, G. Thomas, K. W. Kinzler, and B. Vogelstein. 1990. Identification of a chromosome 18 gene that is altered in colorectal cancers. Science 247:49–56.
  • Foulds, L. 1975. Neoplastic development. Academic Press, New York.
  • Gattoni, S., P. Kirschmeir, I. B. Weinstein, J. Escobedo, and D. Dina. 1982. Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells. Mol. Cell. Biol. 2:42–51.
  • Gattoni-Celli, S., W.-L. W. Hsiao, and I. B. Weinstein. 1983. Rearranged c-mos locus in a MOPC 21 murine myeloma cell line and its persistence in hybridomas. Nature (London) 306:795–796.
  • German, J. 1983. Chromosome mutation and neoplasia. Alan R. Liss, New York.
  • Gerondakis, S., S. Cory, and J. Adams. 1984. Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange. Cell 36:973–982.
  • Higgins, M. J., M. F. Hansen, W. K. Cavenee, and M. Lalande. 1989. Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus. Mol. Cell. Biol. 9:1–5.
  • Hsiao, W.-L. W., T. Wu, and I. B. Weinstein. 1986. Oncogene- induced transformation of a rat embryo fibroblast cell line is enhanced by tumor promoters. Mol. Cell. Biol. 6:1943–1950.
  • Jung, V., S. B. Pestka, and S. Pestka. 1990. Efficient cloning of PCR generated DNA containing terminal restriction endonuclease recognition sites. Nucleic Acids Res. 18:6156.
  • Kazazian, H. H., Jr., C. Wong, H. Youssoufian, A. F. Scott, D. G. Phillips, and S. E. Antonarakis. 1988. Haemophilia A resulting from de novo insertion of L7 sequences represents a novel mechanism for mutation in man. Nature (London) 332: 164–166.
  • Krauss, R. S., G. Windgasse, and I. B. Weinstein. Unpublished data.
  • Luria, S. E., and M. Delbruck. 1943. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491–511.
  • Martin-Zanca, D., S. H. Hughes, and M. Barbacid. 1986. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (London) 319: 743–748.
  • McKnight, S., and R. Tjian. 1986. Transcriptional selectivity of viral genes in mammalian cells. Cell 46:795–805.
  • McKnight, S. L. 1982. Functional relationships between transcriptional control signals of the thymidine kinase gene of the herpes simplex virus. Cell 31:355–365.
  • McKnight, S. L., E. R. Gavis, R. Kingsbury, and R. Axel. 1981. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell 25:385–398.
  • McKnight, S. L., R. C. Kingsbury, A. Spence, and M. Smith. 1984. The distal transcriptional signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell 37:253–262.
  • Meuth, M. 1989. Illegitimate recombination, p. 833–860. In D. E. Berg and M. M. Howe (ed.), Mobile DNA. American Society for Microbiology, Washington, D.C.
  • Miles, C., G. Sargent, G. Phear, and M. Meuth. 1990. DNA sequence analysis of gamma radiation-induced deletions and insertions at the APRT locus of hamster cells. Mol. Carcinogen. 3:233–242.
  • Mitelman, F. 1984. Restricted number of chromosomal regions implicated in aetiology of human cancer and leukaemia. Nature (London) 310:325–327.
  • Moolgavkar, S. H., and A. G. Knudson. 1981. Mutation and cancer: a model for human carcinogenesis. J. Natl. Cancer Inst. 66:1037–1052.
  • Morse, B., P. G. Rothberg, V. J. South, J. M. Spandorfer, and S. M. Astrin. 1988. Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature (London) 333:87–90.
  • Muriel, W. J., J. Cole, and A. R. Lehmann. 1987. Molecular analysis of ouabain-resistant mutants of the mouse lymphoma cell line L5178Y. Mutagenesis 2:383–389.
  • Murnane, J. P. 1986. Inducible gene expression by DNA rearrangements in human cells. Mol. Cell. Biol. 6:549–558.
  • Murnane, J. P., and M. J. Yezzi. 1988. Association of high rate of recombination with amplification of dominant selectable gene in human cells. Somatic Cell Mol. Genet. 14:273–286.
  • Murphy, A. J. M., and A. Efstratiadis. 1987. Cloning vectors for expression of cDNA libraries in mammalian cells. Proc. Natl. Acad. Sci. USA 84:8277–8281.
  • Ochman, H., A. S. Gerber, and D. L. Hartl. 1988. Genetic applications of an inverse polymerase chain reaction. Genetics 120:621–623.
  • Park, M., M. Dean, C. S. Cooper, M. Schmidt, S. J. O’Brien, D. G. Blair, and G. F. Vande Woude. 1986. Mechanism of met gene activation. Cell 45:895–904.
  • Perucho, M., D. Hanahan, and M. Wigler. 1980. Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22:309–317.
  • Rechavi, G., D. Givol, and E. Canaani. 1982. Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element. Nature (London) 300:607–611.
  • Rigby, P. W. J., M. Dieckmann, C. Rhodes, and P. Berg. 1977. Labeling of deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:237–258.
  • Roberts, J. M., and R. Axel. 1982. Gene amplification and gene correction in somatic cells. Cell 29:109–119.
  • Rohdewohld, H., H. Weiher, W. Reik, R. Jaenish, and M. Breindl. 1987. Retrovirus integration and chromosome structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J. Virol. 61:336–343.
  • Rovinski, B., D. Munroe, J. Peacock, M. Mowat, A. Bernstein, and S. Benchimol. 1987. Deletion of 5′-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation. Mol. Cell. Biol. 7:847–853.
  • Rowley, J. D. 1984. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res. 44:3159–3168.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
  • Schnipper, L. E., V. Chan, J. Sedivy, P. Jat, and P. A. Sharp. 1989. Gene activation by induced rearrangements. Cancer Res. 49:6640–6644.
  • Schulz, M., U. Freisem-Rabien, R. Jessberger, and W. Doerfler. 1987. Transcriptional activities of mammalian genomes at sites of recombination with foreign DNA. J. Virol. 61:344–353.
  • Skandalis, A., and B. W. Glickman. 1990. Endogenous gene systems for the study of mutational specificity in mammalian cells. Cancer Cells 2:79–83.
  • Slamon, D. J., G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire. 1987. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177–182.
  • Stark, G. R., and G. M. Wahl. 1984. Gene amplification. Annu. Rev. Biochem. 53:447–491.
  • Takahashi, T., M. M. Nau, I. Chiba, M. J. Birrer, R. K. Rosenberg, M. Vinocour, M. Levitt, H. Pass, A. F. Gazdar, and J. D. Minna. 1989. p53: a frequent target for genetic abnormalities in lung cancer. Science 246:491–494.
  • T’Ang, A., J. M. Varley, S. Chakraborty, A. L. Murphree, and Y.-K. T. Fung. 1988. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 242:263–266.
  • Thacker, J., and A. N. Ganesh. 1989. Molecular analysis of spontaneous and ethyl methanesulphonate-induced mutations of the hprt gene in hamster cells. Mutat. Res. 210:103–112.
  • Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619–630.
  • Tlsty, T. D., B. H. Margolin, and K. Lum. 1989. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc. Natl. Acad. Sci. USA 86:9441–9445.
  • Varmus, H. E. 1984. The molecular genetics of cellular oncogenes. Annu. Rev. Genet. 18:553–612.
  • Wahl, G. M., M. Stern, and G. R. Stark. 1979. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci. USA 76:3683–3687.
  • Wang, Y., V. M. Maher, R. M. Liskay, and J. J. McCormick. 1988. Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells. Mol. Cell. Biol. 8:196–202.
  • Weinstein, I. B. 1988. The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment—twenty-seventh G. H. A. Clowes memorial award lecture. Cancer Res. 48:4135–4143.
  • Weinstein, I. B., W. L. Hsiao, L.-L. Hsieh, T. A. Dragani, C. Peraino, and M. Begemann. 1988. A possible role of retrotrans- posons in carcinogenesis, p. 289–297. In M. E. Lambert, J. F. McDonald, and I. B. Weinstein (ed.), Banbury report 30: eukaryotic transposable elements as mutagenic agents. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Ymer, S., W. Q. J. Tucker, C. J. Sanderson, A. J. Hapel, H. D. Campbell, and I. G. Young. 1985. Constitutive synthesis of interleukin-3 by leukemia cell line WEHI-3B is due to retroviral insertion near the gene. Nature (London) 317:255–257.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.