Transactivation of Pancreas-Specific Gene Sequences in Somatic Cell Hybrids

References

• Blau, H. M., G. K. Pavlath, E. C. Hardeman, C. P. Chiu, L. Silberstein, S. G. Webster, S. C. Miller, and C. Webster. 1985. Plasticity of the differentiated state. Science 230:758–766.
   PubMed Web of Science ®Google Scholar
• Blau, M. B., and D. Baltimore. 1991. Differentiation requires continuous regulation. J. Cell Biol. 112:781–783.
   PubMedGoogle Scholar
• Boulet, A. M., C. R. Erwin, and W. J. Rutter. 1986. Cell specific enhancers in the rat exocrine pancreas. Proc. Natl. Acad. Sci. USA 83:3599–3603.
   PubMed Web of Science ®Google Scholar
• Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
   PubMed Web of Science ®Google Scholar
• Chen, S., L. C. Teicher, D. Kazim, R. E. Pollack, and L. S. Wise. 1989. Commitment of mouse fibroblasts to adipocyte differentiation by DNA transfection. Science 244:582–585.
   PubMedGoogle Scholar
• Chin, A. C., and R. E. K. Fournier. 1987. A genetic analysis of extinction: trans-regulation of 16 liver-specific genes in hepatoma-fibroblast hybrid cells. Proc. Natl. Acad. Sci. USA 84:1614–1618.
   PubMed Web of Science ®Google Scholar
• Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
   PubMed Web of Science ®Google Scholar
• Cleveland, D., M. A. Lopata, R. J. MacDonald, N. J. Cowan, W. J. Rutter, and M. W. Kirschner. 1980. Number and evolutionary conservation of alpha and beta-tubulin and cytoplasmic beta and gamma-actin genes using specific cloned cDNA probes. Cell 20:95–105.
   PubMed Web of Science ®Google Scholar
• Cockell, M., B. J. Stevenson, M. Strubin, O. Hagenbuchle, and P. K. Wellauer. 1989. Identification of a cell-specific DNA binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol. Cell. Biol. 9:2464–2476.
   PubMedGoogle Scholar
• Darlington, G. J., H. P. Bernhard, and F. H. Ruddle. 1974. Human serum albumin phenotype activation in mouse hepatoma-human leukocyte cell hybrids. Science 185:859–862.
   PubMedGoogle Scholar
• Davis, R. L., H. Weintraub, and A. B. Lassar. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987–1000.
   PubMed Web of Science ®Google Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Glisin, V., R. Crkvenjakov, and C. Byus. 1974. Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry 13:2633–2637.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
   PubMed Web of Science ®Google Scholar
• Hammer, R. E., G. H. Swift, D. M. Ornitz, C. J. Quaife, R. D. Palmiter, R. L. Brinster, and R. J. MacDonald. 1987. The rat elastase 1 regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol. Cell. Biol. 7:2956–2967.
   PubMed Web of Science ®Google Scholar
• Han, J. H., L. Rall, and W. J. Rutter. 1986. Selective expression of rat pancreatic genes during embryonic development. Proc. Natl. Acad. Sci. USA 83:110–114.
   PubMedGoogle Scholar
• Hardeman, E. C., A. Minty, P. Benton-Vosman, L. Kedes, and H. M. Blau. 1988. In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. J. Cell Biol. 106:1027–1034.
   PubMedGoogle Scholar
• Hofstetter, P., Z. Kikinis, M. S. Altus, D. Pearson, and Y. Nagamine. 1987. A new genetic approach for studying hormonal regulation of urokinase-type plasminogen activator gene expression in LLC-PK1 cells. Mol. Cell. Biol. 7:4535–4541.
   PubMedGoogle Scholar
• Howard, G., P. R. Keller, T. M. Johnson, and M. H. Meisler. 1989. Binding of a pancreatic nuclear protein is correlated with amylase enhancer activity. Nucleic Acids Res. 17:8185–8195.
   PubMedGoogle Scholar
• Keller, S. A., M. P. Rosenberg, T. M. Johnson, G. Howard, and M. H. Meisler. 1990. Regulation of amylase gene expression in diabetic mice is mediated by a cis-acting upstream element close to the pancreas-specific enhancer. Genes Dev. 4:1316–1321.
   PubMedGoogle Scholar
• Killary, A. M., and R. E. K. Fournier. 1984. A genetic analysis of extinction: trans-dominant loci regulate expression of liverspecific traits in hepatoma hybrid cells. Cell 38:523–534.
   PubMedGoogle Scholar
• Kioussis, D., F. Eiferman, P. Van-deRijn, M. B. Gorin, R. S. Ingram, and S. M. Tilghman. 1981. The evolution of alphafetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J. Biol. Chem. 256:1960–1967.
   PubMedGoogle Scholar
• Kruse, F., C. T. Komro, C. H. Michnoff, and R. J. MacDonald. 1988. The cell-specific elastase I enhancer comprises two domains. Mol. Cell. Biol. 8:893–902.
   PubMed Web of Science ®Google Scholar
• Logsdon, C. D., J. Moessner, J. A. Williams, and I. D. Goldfine. 1985. Glucocorticoids increase amylase mRNA levels, secretory organelles, and secretion in pancreatic acinar AR42J cells. J. Cell Biol. 100:1200–1208.
   PubMed Web of Science ®Google Scholar
• McCormick, A., D. Wu, J.-L. Castrillo, S. Dana, J. Strobl, E. B. Thompson, and M. Karin. 1988. Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell 55:379–389.
   PubMed Web of Science ®Google Scholar
• Miller, S. C., G. K. Pavlath, B. T. Blakely, and H. M. Blau. 1988. Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons. Genes Dev. 2:330–340.
   PubMedGoogle Scholar
• Mulligan, R. C., and P. Berg. 1980. Expression of a bacterial gene in mammalian cells. Science 209:1422–1427.
   PubMed Web of Science ®Google Scholar
• Mulligan, R. C., and P. Berg. 1981. Selection for animal cells that express the Escherichia coli gene coding for xanthine- guanine phosphoribosyltransferase. Proc. Natl. Acad. Sci. USA 78:2072–2076.
   PubMed Web of Science ®Google Scholar
• Murre, C., P. S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD and myc proteins. Cell 56:777–783.
   PubMed Web of Science ®Google Scholar
• Nelson, C., L.-P. Shen, A. Meister, E. Fodor, and W. J. Rutter. 1990. Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev. 4:1035–1043.
   PubMedGoogle Scholar
• Ornitz, D. M., R. E. Hammer, A. Messing, R. D. Palmiter, and R. L. Brinster. 1987. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 238:188–193.
   PubMed Web of Science ®Google Scholar
• Osborn, L., M. P. Rosenberg, S. A. Keller, and M. H. Meisler. 1987. Tissue-specific and insulin-dependent expression of a pancreatic amylase gene in transgenic mice. Mol. Cell. Biol. 7:326–334.
   PubMedGoogle Scholar
• Petrucco, S., P. K. Wellauer, and O. Hagenbuchle. 1990. The DNA-binding activity of transcription factor PTF 1 parallels the synthesis of pancreas-specific mRNAs during mouse development. Mol. Cell. Biol. 10:254–264.
   PubMedGoogle Scholar
• Pinney, D. F., S. H. Pearson-White, S. F. Konieczny, K. E. Latham, and C. P. Emerson, Jr. 1988. Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway. Cell 53:781–793.
   PubMed Web of Science ®Google Scholar
• Rao, M. S., V. Subbarao, and J. K. Reddy. 1986. Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion. Cell Differ. 18:109–117.
   PubMedGoogle Scholar
• Reddy, J. K., M. S. Rao, S. A. Qureshi, M. K. Reddy, D. G. Scarpelli, and N. D. Lalwani. 1984. Induction and origin of hepatocytes in rat pancreas. J. Cell Biol. 98:2082–2090.
   PubMed Web of Science ®Google Scholar
• Richardson, K. K., J. Fostel, and T. R. Skopek. 1983. Nucleotide sequence of the xanthine guanine phosphoribosyl transferase gene of E. coli. Nucleic Acids Res. 11:8809–8816.
   PubMedGoogle Scholar
• Roux, E., M. Strubin, O. Hagenbuchle, and P. K. Wellaner. 1989. The cell-specific transcription factor PTF-1 contains two different subunits that interact with the DNA. Genes Dev. 3:1613–1624.
   PubMedGoogle Scholar
• Rutter, W. J., A. R. Przybyla, R. J. MacDonald, J. D. Harding, J. M. Chirgwin, and R. L. Pictet. 1978. Pancreas development: an analysis of differentiation at the transcriptional level. In G. F. Saunders (ed.), Cell differentiation and neoplasia. Raven Press, New York.
   Google Scholar
• Samuelson, L. C., P. R. Keller, G. J. Darlington, and M. H. Meisler. 1988. Glucocorticoid and developmental regulation of amylase mRNAs in mouse liver cells. Mol. Cell. Biol. 8:3857–3863.
   PubMedGoogle Scholar
• Spear, B. T., and S. M. Tilghman. 1990. Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons. Mol. Cell. Biol. 10:5047–5054.
   PubMedGoogle Scholar
• Tang, D. C., and M. W. Taylor. 1990. Transcriptional activation of the adenosine phosphoribosyl transferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element. J. Virol. 64:2907–2911.
   PubMedGoogle Scholar
• Weintraub, H. 1985. Assembly and propagation of repressed and derepressed chromosomal states. Cell 42:705–711.
   PubMed Web of Science ®Google Scholar
• Weintraub, H., S. J. Tapscott, R. L. Davis, M. J. Thayer, M. A. Adam, A. B. Lassar, and A. D. Miller. 1989. Activation of muscle specific genes in pigment, nerve, fat, liver and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86:5434–5438.
   PubMed Web of Science ®Google Scholar
• Wright, W. E., D. A. Sassoon, and V. K. Lin. 1989. Myogenin: a factor regulating myogenesis has a domain homologous to MyoD. Cell 56:607–617.
   PubMed Web of Science ®Google Scholar