References
- Acland, P., M. Dixon, G. Peters, and C. Dickson. 1990. Subcellular fate of the int-2 oncoprotein is determined by choice of initiation codon. Nature (London) 343:662–665.
- Bishop, J. 1991. Molecular themes in oncogenesis. Cell 64:235–248.
- Bouchard, L., L. Lamarre, P. J. Tremblay, and P. Jolicoeur. 1989. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 57:931–936.
- Bradley, R. S., and A. M. C. Brown. 1990. The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J. 9:1569–1575.
- Brown, A. M. C., R. S. Wildin, T. J. Prendergast, and H. E. Varmus. 1986. A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 46:1001–1009.
- Callahan, R. Personal communication.
- Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloro- form extraction. Anal. Biochem. 162:156–159.
- Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991–1995.
- Cory, S., and J. M. Adams. 1988. Transgenic mice and oncogenesis. Annu. Rev. Immunol. 6:25–49.
- Dickson, C., and G. Peters. 1987. Potential oncogene product related to growth factors. Nature (London) 326:833–834.
- Dickson, C., R. Smith, S. Brookes, and G. Peters. 1984. Tumor- igenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2. Cell 37:529–536.
- Dickson, C., R. Smith, S. Brookes, and G. Peters. 1990. Proviral insertions within the int-2 gene can generate multiple anomalous transcripts but leave the protein-coding domain intact. J. Virol. 64:784–793.
- Dixon, M., R. Deed, P. Acland, R. Moore, A. Whyte, G. Peters, and C. Dickson. 1989. Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2. Mol. Cell. Biol. 9:4896–4902.
- Fearon, E. R., and B. Vogelstein. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759–767.
- Fung, Y.-K. T., G. M. Shackleford, A. M. C. Brown, G. S. Sanders, and H. E. Varmus. 1985. Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Mol. Cell. Biol. 5:3337–3344.
- Gallahan, D., and R. Callahan. 1986. Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech ID-induced mammary tumors. J. Virol. 61:66–74.
- Goldfarb, M. 1990. The fibroblast growth factor family. Cell Growth Differ. 1:439–445.
- Goldfarb, M., R. Deed, D. MacAllan, W. Walther, C. Dickson, and G. Peters. 1991. Cell transformation by int-2, a member of the fibroblast growth factor family. Oncogene 6:65–71.
- Gray, D. A., D. P. Jackson, D. H. Percy, and V. L. Morris. 1986. Activation of int-1 and int-2 loci in GRf mammary tumors. Virology 154:271–278.
- Hanahan, D. 1988. Dissecting multistep tumorigenesis in transgenic mice. Annu. Rev. Genet. 22:479–519.
- Haupt, Y., W. S. Alexander, G. Barri, S. P. Klinken, and J. M. Adams. 1991. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eu-myc transgenic mice. Cell 65:753–763.
- Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the mouse embryo, a laboratory manual, p. 174–176, 271. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- Hunter, T. 1991. Cooperation between oncogenes. Cell 64:249–270.
- Johnson, D. E., P. L. Lee, J. Lu, and L. T. Williams. 1990. Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol. Cell. Biol. 10:4728–4736.
- Keegan, K., D. Johnson, L. Williams, and M. Hayman. 1991. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc. Natl. Acad. Sci. USA 88:1095–1099.
- Kitajewski, J. Unpublished data.
- Kwan, H. Unpublished data.
- Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (London) 304:596–602.
- Leder, A., P. K. Pattengale, A. Kuo, T. A. Stewart, and P. Leder. 1986. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45:485–495.
- Liotta, L. A., P. S. Steeg, and W. G. Stetler-Stevenson. 1991. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327–336.
- Mangues, R., I. Seidman, A. Pellicer, and J. W. Gordon. 1990. Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene. Oncogene 5:1491–1497.
- Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual, p. 109–112. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- Matsui, Y., S. Halter, J. Holt, B. Hogan, and R. Coffey. 1990. Development of mammary hyperplasia and neoplasia in MMTV-TGFa transgenic mice. Cell 61:1147–1155.
- Medina, D. 1982. Mammary tumors, p. 373–396. In H. L. Foster, J. D. Small, and J. G. Fox, (ed.), The mouse in biomedical research, vol. IV. Academic Press, Inc., New York.
- Mester, J., E. Wagenaar, M. Sluyser, and R. Nusse. 1987. Activation of int-1 and int-2 mammary oncogenes in hormonedependent and -independent mammary tumors of GR mice. J. Virol. 61:1073–1078.
- Muller, W. J., F. S. Lee, C. Dickson, G. Peters, P. Pattengale, and P. Leder. 1990. The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J. 9:907–913.
- Muller, W. J., E. Sinn, P. K. Pattengale, R. Wallace, and P. Leder. 1988. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105–115.
- Nusse, R., A. Brown, J. Papkoff, P. Scambler, G. Shackleford, A. McMahon, R. Moon, and H. Varmus. 1991. A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 64:231–232.
- Nusse, R., H. Theunissen, E. Wagenaar, F. Rijsewijk, A. Gennissen, A. Otte, E. Schuuring, and A. van Ooyen. 1990. The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus. Mol. Cell. Biol. 10:4170–4179.
- Nusse, R., A. van Ooyen, D. Cox, Y. K. Fung, and H. E. Varmus. 1984. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature (London) 307:131–136.
- Nusse, R., and H. E. Varmus. 1982. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31:99–109.
- Ornitz, D., R. Moreadith, and P. Leder. 1991. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc. Natl. Acad. Sci. USA 88:698–702.
- Palmiter, R. D., and R. L. Brinster. 1986. Germ-line transformation of mice. Annu. Rev. Genet. 20:465–500.
- Papkoff, J., A. M. C. Brown, and H. E. Varmus. 1987. The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Mol. Cell. Biol. 7:3978–3984.
- Papkoff, J., and B. Schryver. 1990. Secreted int-1 protein is associated with the cell surface. Mol. Cell. Biol. 10:2723–2730.
- Pecenka, V., and H. Kwan. Unpublished results.
- Peters, G., S. Brookes, R. Smith, and C. Dickson. 1983. Tumor- igenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors. Cell 33:364–377.
- Peters, G., S. Brookes, R. Smith, M. Placzek, and C. Dickson. 1989. The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc. Natl. Acad. Sci. USA 86:5678–5682.
- Peters, G., A. E. Lee, and C. Dickson. 1986. Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumor virus. Nature (London) 320:628–630.
- Rijsewijk, F., L. van Deemter, E. Wagenaar, A. Sonnenberg, and R. Nusse. 1987. Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J. 6:127–132.
- Roelink, H., E. Waganaar, S. Lopes da Silva, and R. Nusse. 1990. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc. Natl. Acad. Sci. USA 87:4519–4523.
- Roop, B. R., T. M. Krieg, T. Mehrel, C. K. Cheng, and S. H. Yuspa. 1988. Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res. 48:3245–3252.
- Ruley, H. E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (London) 304:602–606.
- Shackleford, G., C. A. MacArthur, H. Kwan, and H. E. Varmus. Unpublished data.
- Singer, P. A., K. Trevor, and R. G. Oshima. 1986. Molecular cloning and characterization of the endo B cytokeratin expressed in preimplantation mouse embryos. Biol. Chem. 261:538–547.
- Sinn, E., W. Muller, P. Pattengale, I. Tepler, R. Wallace, and P. Leder. 1987. Coexpression of MMTV/v-Ha-ras and MMTV/c- myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49:465–475.
- Smith, G., T. Mehrel, and D. Roop. 1990. Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium. Cell Growth Differ. 1:161–170.
- Smith, R., G. Peters, and C. Dickson. 1988. Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors. EMBO J. 7:1013–1023.
- Stewart, T. A., P. K. Pattengale, and P. Leder. 1984. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38:627–637.
- Taylor-Papadimitriou, J., and E. B. Lane. 1987. Keratin expression in the mammary gland, p. 181–215. In M. C. Neville and C. W. Daniel (ed.), The mammary gland. Plenum Publishing Corp., New York.
- Tremblay, P. J., F. Pothier, T. Hoang, G. Tremblay, S. Brownstein, A. Liszauer, and P. Jolicoeur. 1989. Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues. Mol. Cell. Biol. 9:854–859.
- Tsukamoto, A. S., R. Grosschedl, R. C. Guzman, T. Parslow, and H. E. Varmus. 1988. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55:619–625.
- van Lohuizen, M., S. Verbeek, P. Krimpenfort, J. Domen, C. Saris, T. Radaszkiewicz, and A. Berns. 1989. Predisposition to lymphonagenesis in pim-1 transgenic mice: co-operation with C-myc and N-myc in murine leukemia virus-induced tumors. Cell 56:673–682.
- van Lohuizen, M., S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, and A. Berns. 1991. Identification of cooperating oncogenes in Eu-myc transgenic mice by provirus tagging. Cell 65:737–752.
- van Ooyen, A., and R. Nusse. 1984. Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell 39:233–240.
- Verbeek, S., M. van Lohuizen, M. van der Valk, J. Domen, G. Kraal, and A. Berns. 1991. Mice bearing the Eµ-myc and Eµ-pim-l transgenes develop pre-B-cell leukemia prenatally. Mol. Cell. Biol. 11:1176–1179.
- Weinberg, R. A. 1985. The action of oncogenes in the cytoplasm and the nucleus. Science 230:770–776.
- Weinberg, R. A. (ed.). 1989. Oncogenes and the molecular origins of cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.