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Transcriptional Regulation

Molecular Characterization of the lam Locus and Sequences Involved in Regulation by the AmdR Protein of Aspergillus nidulans

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Pages 337-346 | Received 24 Jul 1991, Accepted 14 Oct 1991, Published online: 01 Apr 2023

References

  • Adams, T. H., and W. E. Timberlake. 1990. Upstream elements repress premature expression of an Aspergillus developmental regulatory gene. Mol. Cell. Biol. 10:4912–4919.
  • Andrianopoulos, A., and M. J. Hynes. 1988. Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol. Cell. Biol. 8:3532–3541.
  • Andrianopoulos, A., and M. J. Hynes. 1990. Sequence and functional analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol. Cell. Biol. 10:3194–3203.
  • Arst, H. N. 1976. Integrator gene in Aspergillus nidulans. Nature (London) 262:231–234.
  • Arst, H. N., and D. J. Cove. 1973. Nitrogen metabolite repression in Aspergillus nidulans. Mol. Gen. Genet. 126:111–141.
  • Arst, H. N., H. A. Penfold, and C. R. Bailey. 1978. Lactam utilisation in Aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene intA. Mol. Gen. Genet. 166:321–327.
  • Baum, J. A., R. Geever, and N. H. Giles. 1987. Expression of qa-lF activator protein: identification of upstream binding sites in the qa gene cluster and localization of the DNA-binding domain. Mol. Cell. Biol. 7:1256–1266.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Carcoma, J., E. Maldonado, P. Cortes, M. Ahn, I. Ha, Y. Kasai, J. Flint, and D. Reinberg. 1990. A TATA-like sequence located downstream of the transcription initiation site is required for expression of an RNA polymerase II transcribed gene. Genes Dev. 4:1611–1622.
  • Clutterbuck, A. J. 1974. Aspergillus nidulans genetics, p. 447–510. In R. C. King, (ed.), Handbook of genetics, vol. 1. Plenum Press, New York.
  • Clutterbuck, A. J. 1984. Loci and linkage map of the filamentous fungus Aspergillus nidulans, p. 265–273. In S. J. O'Brien (ed.), Genetic maps, vol. 3. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Corrick, C. M., A. P. Twomey, and M. J. Hynes. 1987. The nucleotide sequence of the amdS gene of Aspergillus nidulans and the molecular characterization of 5' mutations. Gene 53:6371.
  • Cove, D. J. 1966. The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim. Biophys. Acta 113:51–56.
  • Dale, R. M., B. A. McClure, and J. P. Houchins. 1985. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing. Application to sequencing the com mitochondrial 18S rDNA. Plasmid 13:141–151.
  • Davis, M. A., C. S. Cobbett, and M. J. Hynes. 1988. An amdS-lacZ fusion for studying gene regulation in Aspergillus. Gene 63:199–212.
  • Davis, M. A., and M. J. Hynes. 1987. Complementation of areA- regulatory gene mutations of Aspergillus nidulans by the heterologous gene nit-2 of Neurospora crassa. Proc. Natl. Acad. Sci. USA 84:3753–3757.
  • Durrens, P., P. M. Green, H. N. Arst, and C. Scazzocchio. 1986. Heterologous insertion of transforming DNA and generation of new deletions associated with transformation in Aspergillus nidulans. Mol. Gen. Genet. 203:544–549.
  • Eisenberg, D., E. Scharwz, M. Komaromy, and R. Wall. 1984. Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J. Mol. Biol. 179:125–142.
  • Forsburg, S. L., and L. Guarente. 1989. Identification and characterization of HAP4: a third component of the CCAAT- bound HAP2/HAP3 heteromer. Genes Dev. 3:1166–1178.
  • Fu, Y.-H., and G. A. Marzluf. 1990. nit-2, the major positiveacting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc. Natl. Acad. Sci. USA 87:5331–5335.
  • Geever, R. F., L. Huiet, J. A. Baum, B. M. Tyler, V. B. Patel, B. J. Rutledge, M. E. Case, and N. H. Giles. 1989. DNA sequence, organisation and regulation of the qa gene cluster of Neurospora crassa. J. Mol. Biol. 207:15–34.
  • Gurr, S. J., S. E. Unkles, and J. R. Kinghorn. 1987. The structure and organisation of nuclear genes of filamentous fungi, p. 93–139. In J. R. Kinghorn (ed.), Gene structure in eukaryotic microbes. IRL Press, Oxford.
  • Hynes, M. J. 1978. Multiple independent control mechanisms affecting the acetamidase of Aspergillus nidulans. Mol. Gen. Genet. 161:59–65.
  • Hynes, M. J. 1980. A mutation, adjacent to the gene amdS, defining the site of action of positive-control gene amdR in Aspergillus nidulans. J. Bacteriol. 142:400–406.
  • Hynes, M. J., A. Andrianopoulos, M. A. Davis, R. van Heeswijck, M. E. Katz, T. G. Littlejohn, I. B. Richardson, and J. A. Saleeba. 1989. Multiple circuits regulating the amdS gene of Aspergillus nidulans, p. 63–71. In H. Nevalainen and M. Pentilla (ed.), Proceedings of the EMBO-Alko Workshop on Molecular Biology of Filamentous Fungi, vol. 6. Foundation for Biotechnical and Industrial Fermentation Research, Helsinki, Finland.
  • Hynes, M. J., C. M. Corrick, J. M. Kelly, and T. G. Littlejohn. 1988. Identification of the sites of action for regulatory genes controlling the amdS gene of Aspergillus nidulans. Mol. Cell. Biol. 8:2589–2596.
  • Hynes, M. J., C. M. Corrick, and J. A. King. 1983. Isolation of genomic clones containing the amdS gene of Aspergillus nidulans and their use in analysis of structural and regulatory mutations. Mol. Cell. Biol. 3:1430–1439.
  • Hynes, M. J., and J. A. Pateman. 1970. The genetic analysis of regulation of amidase synthesis in Aspergillus nidulans. II. Mutants resistant to fluoracetamide. Mol. Gen. Genet. 108:107–116.
  • Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem. 58:799–839.
  • Johnston, M. 1987. A model fungal regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol. Rev. 51:458–476.
  • Johnstone, I. L., P. C. McCabe, P. Greaves, S. J. Gurr, G. E. Cole, M. A. D. Brow, S. E. Unkles, A. J. Clutterbuck, J. R. Kinghorn, and M. A. Innis. 1990. Isolation and characterization of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene 90:181–192.
  • Katz, M. E. Unpublished data.
  • Katz, M. E., and M. J. Hynes. 1989. Gene function identified by interspecific transformation. Gene 78:167–171.
  • Katz, M. E., and M. J. Hynes. 1989. Characterization of the amdR-controlled lamA and lamB genes of Aspergillus nidulans. Genetics 122:331–339.
  • Katz, M. E., and M. J. Hynes. 1989. Isolation and analysis of the actetate regulatory gene, facB, from Aspergillus nidulans. Mol. Cell. Biol. 9:5696–5701.
  • Kelly, J. M., and M. J. Hynes. 1987. Multiple copies of the amdS gene of Aspergillus nidulans cause titration of trans-acting regulatory proteins. Curr. Genet. 12:21–31.
  • Littlejohn, T. G. Unpublished data.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Messing, J. 1983. New M13 vectors for cloning. Methods Enzymol. 101C:20–78.
  • Norrander, J., T. Kempe, and J. Messing. 1983. Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis. Gene 26:101–106.
  • Reed, K. C., and D. A. Mann. 1985. Rapid transfer of DNA from agarose gels to nylon membranes. Nucleic Acids Res. 13:7207–7221.
  • Richardson, I. B., S. K. Hurley, and M. J. Hynes. 1989. Cloning and molecular characterization of the amdR controlled gatA gene of Aspergillus nidulans. Mol. Gen. Genet. 217:118–125.
  • Sanger, F., A. R. Coulson, B. G. Barrell, A. J. H. Smith, and B. A. Roe. 1980. Cloning of single-stranded bacteriophage as an aid to rapid DNA sequencing. J. Mol. Biol. 143:161–178.
  • Smale, S. T., and D. Baltimore. 1989. The "initiator" as a transcription control element. Cell 57:103–113.
  • Smale, S. T., M. C. Schmidt, A. J. Berk, and D. Baltimore. 1990. Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proc. Natl. Acad. Sci. USA 87:4509–4513.
  • Van Heeswijck, R., and M. J. Hynes. 1991. The amdR product and a CCAAT-binding factor bind to adjacent, possibly overlapping DNA sequences in the promoter region of the Aspergillus nidulans amdS gene. Nucleic Acids Res. 19:2655–2660.

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