The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells

References

• Anderson, R. Α., and S. L. Eliason. 1986. Recombination of homologous DNA fragments transfected into mammalian cells occurs predominantly by terminal pairing. Mol. Cell. Biol. 6:3246–3252.
   PubMedGoogle Scholar
• Brenner, D. Α., A. C. Smigocki, and R. D. Camerini-Otero. 1985. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. Mol. Cell. Biol. 5:684–691.
   PubMed Web of Science ®Google Scholar
• Brenner, D. Α., A. C. Smigocki, and R. D. Camerini-Otero. 1986. Double-strand gap repair results in homologous recombination in mouse L cells. Proc. Natl. Acad. Sci. USA 83:1762–1766.
   PubMedGoogle Scholar
• Capecchi, M. R. 1989. Altering the genome by homologous recombination. Science 244:1288–1292.
   PubMed Web of Science ®Google Scholar
• Chakrabarti, S., and Μ. Μ. Seidman. 1986. Intramolecular recombination between transfected repeated sequences in mammalian cells is nonconservative. Mol. Cell. Biol. 6:2520–2526.
   PubMedGoogle Scholar
• Hasty, P., R. Ramírez-Solis, R. Krumlauf, and A. Bradley. 1991. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (London) 350:243–246.
   PubMed Web of Science ®Google Scholar
• Hasty, P., J. Rivera-Perez, and A. Bradley. 1991. The length of homology required for gene targeting in embryonic stem cells. Mol. Cell. Biol. 11:5586–5591.
   PubMed Web of Science ®Google Scholar
• Hasty, P., J. Rivera-Perez, C. Chang, and A. Bradley. 1991. Targeting frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol. Cell. Biol. 11:4509–4517.
   PubMed Web of Science ®Google Scholar
• Holliday, R. 1964. A mechanism for gene conversion in fungi. Genet. Res. 5:282–304.
   Web of Science ®Google Scholar
• Jasin, M., and P. Berg. 1988. Homologous integration in mammalian cells without target gene selection. Genes Dev. 2:1353–1363.
   PubMed Web of Science ®Google Scholar
• Kucherlapati, R. S., E. M. Eves, K. Song, B. S. Morse, and O. Smithies. 1984. Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proc. Natl. Acad. Sci. USA 81:3153–3157.
   PubMed Web of Science ®Google Scholar
• Lin, F., K. Sperle, and N. Sternberg. 1984. Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. Mol. Cell. Biol. 4:1020–1034.
   PubMedGoogle Scholar
• Lin, F. Μ., Κ. Sperle, and N. Sternberg. 1990. Intermolecular recombination between DNAs introduced into mouse L cells is mediated by a nonconservative pathway that leads to crossover products. Mol. Cell. Biol. 10:103–112.
   PubMedGoogle Scholar
• Lin, F. Μ., Κ. Sperle, and N. Sternberg. 1990. Repair of double-stranded DNA breaks by homologous DNA fragments during transfer of DNA into mouse L cells. Mol. Cell. Biol. 10:113–119.
   PubMed Web of Science ®Google Scholar
• Mansour, S. L., K. R. Thomas, and M. R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (London) 336:348–352.
   PubMed Web of Science ®Google Scholar
• Mansour, S. L., K. R. Thomas, C. Deng, and M. R. Capecchi. 1990. Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc. Natl. Acad. Sci. USA 87:7688–7692.
   PubMed Web of Science ®Google Scholar
• Maryon, E., and D. Carroll. 1991. Involvement of single-stranded tails in homologous recombination of DNA injected into Xenopus laevis oocyte nuclei. Mol. Cell. Biol. 11:3268–3277.
   PubMed Web of Science ®Google Scholar
• Maryon, E., and D. Carroll. 1991. Characterization of recombination intermediates from DNA injected into Xenopus laevis oocytes: evidence for a nonconservative mechanism of homologous recombination. Mol. Cell. Biol. 11:3278–3287.
   PubMedGoogle Scholar
• McMahon, A. P., and A. Bradley. 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62:1073–1085.
   PubMed Web of Science ®Google Scholar
• Melton, D. W., D. S. Konecki, J. Brennand, and C. T. Caskey. 1984. Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc. Natl. Acad. Sci. USA 81:2147–2151.
   PubMed Web of Science ®Google Scholar
• Meselson, M. S., and C. M. Radding. 1975. A general model for genetic recombination. Proc. Natl. Acad. Sci. USA 72:358–361.
   PubMed Web of Science ®Google Scholar
• Murnane, J. P., M. J. Yezzi, and B. R. Young. 1990. Recombination events during integration of transfected DNA into normal human cells. Nucleic Acids Res. 18:2733–2738.
   PubMed Web of Science ®Google Scholar
• Orr-Weaver, T. L., J. W. Szostak, and R. J. Rothstein. 1981. Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. USA 78:6354–6358.
   PubMed Web of Science ®Google Scholar
• Pennington, S. L., and J. H. Wilson. 1991. Gene targeting in Chinese hamster ovary cells is conservative. Proc. Natl. Acad. Sci. USA 88:9498–9502.
   PubMedGoogle Scholar
• Resnick, M. A. 1976. The repair of double-strand breaks in DNA: a model involving recombination. J. Theor. Biol. 59:97–106.
   PubMed Web of Science ®Google Scholar
• Robertson, E. J. 1987. Embryo-derived stem cell lines, p. 71–112. In E. J. Robertson (ed.), Teratocarcinomas and embryonic stem cells: a practical approach. IRL Press, Oxford.
   Google Scholar
• Schultes, N. P., and J. W. Szostak. 1991. A poly(dA-dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:322–328.
   PubMedGoogle Scholar
• Shulman, M. J., L. Nissen, and C. Collins. 1990. Homologous recombination in hybridoma cells: dependence on time and fragment length. Mol. Cell. Biol. 10:4466–4472.
   PubMed Web of Science ®Google Scholar
• Siedman, Μ. Μ. 1987. Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative. Mol. Cell. Biol. 7:3561–3565.
   PubMedGoogle Scholar
• Smithies, O., R. G. Gregg, S. S. Boggs, M. A. Koralewski, and R. S. Kucherlapati. 1985. Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination. Nature (London) 317:230–234.
   PubMed Web of Science ®Google Scholar
• Song, K., L. Chekuri, S. Rauth, S. Ehrlich, and R. Kucherlapati. 1985. Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. Mol. Cell. Biol. 5:3331–3336.
   PubMed Web of Science ®Google Scholar
• Soriano, P., C. Montgomery, R. Geske, and A. Bradley. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693–702.
   PubMed Web of Science ®Google Scholar
• Sun, H., D. Treco, and J. W. Szostak. 1991. Extensive 3-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell 64:1155–1161.
   PubMed Web of Science ®Google Scholar
• Szostak, J. W., T. L. Orr-Weaver, R. J. Rothstein, and F. W. Stahl. 1983. The double strand break repair model for recombination. Cell 33:25–35.
   PubMed Web of Science ®Google Scholar
• Thomas, K. R., and M. R. Capecchi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503–512.
   PubMed Web of Science ®Google Scholar
• Valancius, V., and O. Smithies. 1991. Double-strand break repair in a mammalian gene targeting reaction. Mol. Cell. Biol. 11:4389–4397.
   PubMedGoogle Scholar
• Wake, C. T., F. Vernaleone, and J. H. Wilson. 1985. Topological requirements for homologous recombination among DNA molecules transfected into mammalian cells. Mol. Cell. Biol. 5:2080–2089.
   PubMedGoogle Scholar
• Waldman, A. S., and R. M. Liskay. 1987. Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells. Proc. Natl. Acad. Sci. USA 84:5340–5344.
   PubMedGoogle Scholar
• Waldman, A. S., and R. M. Liskay. 1988. Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology. Mol. Cell. Biol. 8:5350–5357.
   PubMedGoogle Scholar
• Wilson, J. H., P. B. Berget, and J. M. Pipas. 1982. Somatic cells efficiently join unrelated DNA segments end to end. Mol. Cell. Biol. 2:1258–1269.
   PubMed Web of Science ®Google Scholar
• Zheng, H., P. Hasty, M. A. Brenneman, M. Grompe, R. A. Gibbs, J. H. Wilson, and A. Bradley. 1991. Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells. Proc. Natl. Acad. Sci. USA 88:8067–8071.
   PubMedGoogle Scholar
• Zheng, H., and J. Wilson. 1990. Gene targeting in normal and amplified cell lines. Nature (London) 344:170–173.
   PubMedGoogle Scholar