Negative Autoregulation of the neu Gene Is Mediated by a Novel Enhancer

References

• Angel, P., K. Hattori, T. Smeal, and M. Karin. 1988. The jun proto-oncogene is positively autoregulated by its product, jun/ AP-1. Cell 55:875–885.
   PubMed Web of Science ®Google Scholar
• Bargmann, C. I., M.-C. Hung, and R. A. Weinberg. 1986. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature (London) 319:226–230.
   PubMed Web of Science ®Google Scholar
• Bargmann, C. I., M.-C. Hung, and R. A. Weinberg. 1986. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of pl85. Cell 45:649–657.
   PubMed Web of Science ®Google Scholar
• Bargmann, C. I., and R. A. Weinberg. 1988. Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene. Proc. Natl. Acad. Sci. USA 85:5394–5398.
   PubMed Web of Science ®Google Scholar
• Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745–2752.
   PubMed Web of Science ®Google Scholar
• Clark, A. J. L., S. Ishii, N. Richert, G. T. Merlino, and I. Pastan. 1985. EGF regulates the expression of its own receptor. Proc. Natl. Acad. Sci. USA 84:8374–8378.
   Google Scholar
• Coffey, R. J., R. Derynck, J. N. Wilcox, T. S. Bringman, A. S. Goustin, H. L. Moses, and M. R. Pittlelkow. 1988. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature (London) 328:817–820.
   Google Scholar
• Dignam, J. D., R. M. Lebowitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Dutta, Α., Μ. Υ. Stoeckle, and Η. Hanafusa. 1990. Serum and v-src increase the level of a CCAAT-binding factor required for transcription from a retroviral long terminal repeat. Genes Dev. 4:243–254.
   PubMedGoogle Scholar
• Earp, H. S., K. S. Austin, J. Blaisde, R. A. Rubin, K. G. Nelson, L. W. Lee, and J. W. Grisham. 1986. EGF stimulates EGF receptor synthesis. J. Biol. Chem. 261:4777–4780.
   PubMed Web of Science ®Google Scholar
• Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230:912–216.
   PubMed Web of Science ®Google Scholar
• Gauthier, R. C., A. Fernandez, and N. J. Lamb. 1990. Ras-induced c-fos expression and proliferation in living rat fibroblasts involves C-kinase activation and the serum response element pathway. EMBO J. 9:171–180.
   PubMedGoogle Scholar
• Gorman, C. M., L. F. Moffat, and Β. Η. Howard. 1983. Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   Google Scholar
• Hearing, P., and T. Shenk. 1985. Sequence-independent auto-regulation of the adenovirus type 5 E1A transcription unit. Mol. Cell. Biol. 5:3214–3221.
   PubMedGoogle Scholar
• Hermonat, P. L., B. A. Spalholz, and P. M. Howley. 1988. The bovine papillomavirus P2443 promoter is E2 trans-responsive: evidence for E2 autoregulation. EMBO J. 7:2815–2822.
   PubMedGoogle Scholar
• Hudson, L. G., A. P. Ertl, and G. N. Gill. 1990. Structure and inducible regulation of the human c-erbB2/neu promoter. J. Biol. Chem. 265:4389–4393.
   PubMedGoogle Scholar
• Hung, M.-C., A. L. Schechter, P.-Y. M. Chevray, D. F. Stern, and R. A. Weinberg. 1986. Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles. Proc. Natl. Acad. Sci. USA 83:261–264.
   PubMedGoogle Scholar
• Hung, M.-C., and P. C. Wensink. 1984. Different restriction enzyme-generated sticky DNA ends can be joined in vitro. Nucleic Acids Res. 12:1863–1874.
   PubMedGoogle Scholar
• Hung, M.-C., D.-H. Yan, and X.-Y. Zhao. 1989. Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation. Proc. Natl. Acad. Sci. USA 86:2545–2548.
   PubMed Web of Science ®Google Scholar
• Hung, M.-C., X. Zhang, D.-H. Yan, H.-Z. Zhang, G. He, T. Zhang, and D. Shi. 1992. Aberrant expression of the c-erbB-2/ neu protooncogene in ovarian cancer. Cancer Lett. 61:95–103.
   PubMed Web of Science ®Google Scholar
• Jamal, S., and E. Ziff. 1990. Transactivation of c-fos and actin genes by raf as a step in early response to transmembrane signals. Nature (London) 344:463–466.
   PubMed Web of Science ®Google Scholar
• Johnson, A. C., S. Ishii, Y. Jinno, I. Pastan, and G. T. Merlino. 1988. Epidermal growth factor receptor gene promoter. J. Biol. Chem. 263:5693–5699.
   PubMed Web of Science ®Google Scholar
• Kim, S.-J., P. Angel, R. Lafyatis, K. Hattori, Κ. Υ. Kim, Μ. Β. Sporn, M. Karin, and A. B. Roberts. 1990. Autoinduction of transforming growth factor baltal is mediated by the AP-1 complex. Mol. Cell. Biol. 10:1492–1497.
   PubMed Web of Science ®Google Scholar
• Konig, H., H. Ponta, U. Rahmsdorf, M. Buscher, A. Schonthal, H. J. Rahmsdorf, and P. Herrlich. 1989. Autoregulation of fos: the dyad symmetry element as the major target of repression. EMBO J. 8:2559–2566.
   PubMedGoogle Scholar
• Kraus, M. H., N. C. Popescu, S. C. Amsbaugh, and C. R. King. 1987. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6:605–610.
   PubMed Web of Science ®Google Scholar
• Larsen, P. L., and C. Tibbetts. 1987. Adenovirus E1A gene autorepression: revertants of an E1A promoter mutation encode altered E1A proteins. Proc. Natl. Acad. Sci. USA 84:8185–8189.
   PubMedGoogle Scholar
• Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490–5491.
   PubMed Web of Science ®Google Scholar
• Lupu, R., R. Colomer, G. Zugmaier, J. Sarup, M. Shepard, D. Slamon, and Μ. Ε. Lippman. 1990. Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2 Science 249:1552–1555.
   PubMed Web of Science ®Google Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Matin, Α., Κ. L. Cheng, T.-C. Suen, and M.-C. Hung. 1989. Effect of glucocorticoids on oncogene transformed NIH3T3 cells. Oncogene 5:111–116.
   Google Scholar
• Moses, H. L., Ε. Υ. Yang, and J. A. Pietenpol. 1990. TGF-b stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63:245–247.
   PubMed Web of Science ®Google Scholar
• Myers, R. M., D. C. Rio, A. K. Robbins, and R. Tjian. 1981. SV40 gene expression is modulated by the cooperative binding of Τ antigen to DNA. Cell 25:373–384.
   PubMed Web of Science ®Google Scholar
• Norton, P. Α., and J. M. Coffin. 1985. Bacterial β-galactosidase as a marker of Rous sarcoma virus gene expression and replication. Mol. Cell. Biol. 5:281–290.
   PubMedGoogle Scholar
• Paulsson, Y., A. Hammacher, C. H. Heldin, and B. Westermark. 1987. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature (London) 328:715–717.
   PubMed Web of Science ®Google Scholar
• Penn, L. J., M. W. Brooks, Ε. Μ. Laufer, and H. Land. 1990. Negative autoregulation of c-myc transcription. EMBO J. 9:1113–1121.
   PubMed Web of Science ®Google Scholar
• Sassone-Corsi, P., J. C. Sisson, and I. M. Verma. 1988. Transcriptional autoregulation of the proto-oncogene fos. Nature (London) 334:314–319.
   PubMed Web of Science ®Google Scholar
• Schneider, P. M., M.-C. Hung, S. M. Chiocca, J. Manning, X.-Y. Zhao, K. Fang, and J. A. Roth. 1989. Differentiated expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. Cancer Res. 49:4955–5237.
   PubMedGoogle Scholar
• Schonthal, Α., P. Herrlich, H. J. Rahmsdorf, and H. Ponta. 1988. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbal esters. Cell 54:325–334.
   PubMed Web of Science ®Google Scholar
• Schwab, M., and L. C. Amler. 1990. Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer. Genes Chromosomes Cancer 1:181–193.
   PubMed Web of Science ®Google Scholar
• Semba, K., N. Kamata, K. Toyoshima, and T. Yamamoto. 1985. A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc. Natl. Acad. Sci. USA 82:6497–6501.
   PubMed Web of Science ®Google Scholar
• Serfling, E. 1989. Autoregulation—a common property of eukaryotic transcription factors? Trends Genet. 5:131–133.
   PubMedGoogle Scholar
• Shih, C., L. C. Padhy, M. Murray, and R. A. Weinberg. 1981. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (London) 290:261–263.
   PubMed Web of Science ®Google Scholar
• Sistonen, L., E. Holtta, H. Lehvaslaiho, L. Lehtola, and K. Alitalo. 1989. Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter, and ornithine decarboxylase. J. Cell Biol. 109:1191–1199.
   Google Scholar
• Slamon, D. J., G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire. 1987. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177–182.
   PubMed Web of Science ®Google Scholar
• Slamon, D. J., W. Godolphin, L. A. Jones, J. A. Holt, S. G. Wong, D. E. Keith, W. J. Levin, S. G. Stuart, J. Udove, A. Ullrich, and M. F. Press. 1989. Studies of the HER/neu proto-oncogene in human breast and ovarian cancer. Science 244:707–712.
   PubMed Web of Science ®Google Scholar
• Smith, D. H., D. M. Kegler, and Ε. Β. Ziff. 1985. Vector expression of adenovirus type 5 E1a proteins: evidence for E1a autoregulation. Mol. Cell. Biol. 5:2684–2696.
   PubMedGoogle Scholar
• Stern, D. F., P. A. Heffernan, and R. A. Weinberg. 1986. p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Mol. Cell. Biol. 6:1729–1740.
   PubMed Web of Science ®Google Scholar
• Stern, D. F., M. P. Kamps, and H. Cao. 1988. Oncogenic activation of p185 neu stimulates tyrosine phosphorylation in vivo. Mol. Cell. Biol. 8:3969–3973.
   PubMed Web of Science ®Google Scholar
• Suen, T.-C., and M.-C. Hung. 1990. Multiple cis- and transacting elements involved in regulation of the neu gene. Mol. Cell. Biol. 10:6306–6315.
   PubMedGoogle Scholar
• Suen, T.-C., and M.-C. Hung. 1991. c-myc reverses wen-induced transformed morphology by transcriptional repression. Mol. Cell. Biol. 11:354–362.
   PubMed Web of Science ®Google Scholar
• Tal, M., M. Wetzler, Z. Josefberg, A. Deutch, M. Gutman, D. Assaf, R. Kris, Y. Shiloh, D. Givol, and J. Schlessinger. 1988. Sporadic amplification of the HER2/NEU protooncogene in adenocarcinomas of various tissues. Cancer Res. 48:1517–1520.
   PubMed Web of Science ®Google Scholar
• Thompson, K. L., and M. R. Rosner. 1989. Regulation of EGF receptor gene expression by retinoic acid and EGF. J. Biol. Chem. 264:3230–3234.
   PubMed Web of Science ®Google Scholar
• Van de Vijver, M. J., W. J. Mooi, P. Wisman, J. L. Peterse, and R. Nuss. 1988. Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA. Oncogene 2:175–178.
   PubMedGoogle Scholar
• Yan, D.-H., L.-S. Chang, and M.-C. Hung. 1991. Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1A gene products. Oncogene 6:343–345.
   PubMed Web of Science ®Google Scholar
• Yan, D.-H., and M.-C. Hung. 1991. Identification and characterization of a novel enhancer for the rat neu promoter. Mol. Cell. Biol. 11:1875–1882.
   PubMedGoogle Scholar
• Yarden, Y., and R. A. Weinberg. 1989. Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene. Proc. Natl. Acad. Sci. USA 86:3179–3183.
   PubMed Web of Science ®Google Scholar
• Yu, D., and M.-C. Hung. 1991. Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in NIH3T3 cells. Oncogene 6:1991–1996.
   PubMedGoogle Scholar
• Yu, D., K. Scorsone, and M.-C. Hung. 1991. Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene. Mol. Cell. Biol. 11:1745–1750.
   PubMed Web of Science ®Google Scholar
• Yu, D., T.-C. Suen, D.-H. Yan, L.-S. Chang, and M.-C. Hung. 1990. Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products. Proc. Natl. Acad. Sci. USA 87:4499–4503.
   PubMedGoogle Scholar
• Zhang, X., E. Silva, D. Gershenson, and M.-C. Hung. 1989. Amplification and rearrangement of c-erbB proto-oncogenes in cancer of human female genital tract. Oncogene 4:985–989.
   PubMed Web of Science ®Google Scholar
• Zhao, X., and M.-C. Hung. Unpublished data.
   Google Scholar