Two Species of Human CRK cDNA Encode Proteins with Distinct Biological Activities

REFERENCES

• Bryant, D., and J. T. Parsons. 1982. Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation. J. Virol. 44:683–691.
   PubMedGoogle Scholar
• Courtneidge, S. A. 1985. Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation. EMBO J. 4:1471–1477.
   PubMedGoogle Scholar
• Drubin, D. G., J. Mulholland, Z. Zhu, and D. Botstein. 1990. Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature (London) 343:288–290.
   PubMed Web of Science ®Google Scholar
• Emori, Y., Y. Homma, H. Sorimachi, H. Kawasaki, O. Nakanishi, K. Suzuki, and T. Takenawa. 1989. A second type of rat phosphoinositide-specific phospholipase C containing a src- related sequence not essential for phosphoinositide-hydrolyzing activity. J. Biol. Chem. 264:21885–21890.
   PubMedGoogle Scholar
• Escobedo, J. A., S. Navankasattusa, W. M. Kavanaugh, D. Milfay, V. A. Fried, and L. T. Williams. 1991. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor. Cell 65:75–82.
   PubMed Web of Science ®Google Scholar
• Espino, P. C., R. Harvey, R. L. Schweickgardt, G. A. White, A. E. Smith, and S. H. Cheng. 1990. The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation. Oncogene 5:283–293.
   PubMedGoogle Scholar
• Franz, W. M., P. Berger, and J. Y. J. Wang. 1989. Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential. EMBO J. 8:137–147.
   PubMed Web of Science ®Google Scholar
• Harlow, E., and E. Lane. 1988. Antibodies. A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Ikeda, H., J. Trowsdale, and I. Saito. 1988. Mulcos: a vector for amplification and simultaneous expression of two foreign genes in mammalian cells. Gene 71:19–27.
   PubMedGoogle Scholar
• Jackson, P., and D. Baltimore. 1989. N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl. EMBO J. 8:449–456.
   PubMed Web of Science ®Google Scholar
• Kato, J. Y., T. Takeya, C. Grandori, H. Iba, J. B. Levy, and H. Hanafusa. 1986. Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol. Cell. Biol. 6:4155–4160.
   PubMed Web of Science ®Google Scholar
• Kimura, G., A. Itagaki, and J. Summers. 1975. Rat cell line 3Y1and its virogenic polyoma- and SV40-transformed derivatives. Int. J. Cancer 15:694–706.
   PubMedGoogle Scholar
• Kriz, R., and J. L. Knopf. Personal communication.
   Google Scholar
• Koch, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668–674.
   PubMed Web of Science ®Google Scholar
• Kornbluth, S., S. H. Cheng, W. Markland, Y. Fukui, and H. Hanafusa. 1990. Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability. J. Virol. 64:1584–1589.
   PubMedGoogle Scholar
• Levy, J. B., and J. S. Brugge. 1989. Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts. Mol. Cell. Biol. 9:3332–3341.
   PubMedGoogle Scholar
• Marshall, C. P., and H. Hanafusa. Personal communication.
   Google Scholar
• Martinez, R., B. Mathey-Prevot, A. Bernards, and D. Baltimore. 1987. Neuronal pp60c-src contains a six amino acid insertion relative to its non-neuronal counterpart. Science 237:411–415.
   PubMedGoogle Scholar
• Matsuda, M., B. J. Mayer, Y. Fukui, and H. Hanafusa. 1990. Binding of oncoprotein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 248:1537–1539.
   PubMedGoogle Scholar
• Matsuda, M., B. J. Mayer, and H. Hanafusa. 1991. Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Mol. Cell. Biol. 11:1607–1613.
   PubMedGoogle Scholar
• Matsuda, M., C. T. Reichman, and H. Hanafusa. 1992. Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-γ and Src. J. Virol. 66:115–121.
   PubMedGoogle Scholar
• Mayer, B. J., M. Hamaguchi, and H. Hanafusa. 1988. A novel viral oncogene with structural similarity to phospholipase C. Nature (London) 332:272–275.
   PubMed Web of Science ®Google Scholar
• Mayer, B. J., M. Hamaguchi, and H. Hanafusa. 1989. Characterization of P47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. Cold Spring Harbor Symp. Quant. Biol. 53:907–914.
   Google Scholar
• Mayer, B. J., and H. Hanafusa. 1990. Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. Proc. Natl. Acad. Sci. USA 87:2638–2642.
   PubMed Web of Science ®Google Scholar
• Mayer, B. J., and H. Hanafusa. 1990. Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains, and correlation between increased cellular phosphotyrosine and transformation. J. Virol. 64:3581–3589.
   PubMedGoogle Scholar
• Mount, S. M. 1982. A catalogue of splice junction sequences. Nucleic Acids Res. 10:459–472.
   PubMed Web of Science ®Google Scholar
• Otsu, M., I. Hiles, I. Gout, M. J. Fry, F. Ruiz-Larrea, G. Panayotou, A. Thompson, R. Dhand, J. Hsuan, N. Totty, A. D. Smith, S. J. Morgan, and M. D. Waterfiled. 1991. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell 65:91–104.
   PubMed Web of Science ®Google Scholar
• Pawson, T. 1988. Non-catalytic domains of cytoplasmic proteintyrosine kinases: regulatory elements in signal transduction. Oncogene Res. 3:491–495.
   Google Scholar
• Popovic, M., M. G. Sarngadharan, E. Read, and R. C. Gallo. 1984. Detection, isolation, and continuous production of cyto- pathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497–500.
   PubMed Web of Science ®Google Scholar
• Potts, W. M., A. B. Reynolds, T. J. Lansing, and J. T. Parsons. 1988. Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95. Oncogene Res. 3:343–355.
   PubMedGoogle Scholar
• Pyper, J. M., and J. B. Bolen. 1990. Identification of a novel c-src expressed in human brain. Mol. Cell. Biol. 10:2035–2040.
   PubMedGoogle Scholar
• Reichman, C., and H. Hanafusa. Submitted for publication.
   Google Scholar
• Sadowski, I., J. C. Stone, and T. Pawson. 1986. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol. Cell. Biol. 6:4396–4408.
   PubMed Web of Science ®Google Scholar
• Scharf, S. J. 1990. Cloning with PCR, p. 84–91. In M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White (ed.), PCR protocols. A guide to methods and applications. Academic Press, Inc., San Diego.
   Google Scholar
• Sekiguchi, M., T. Oota, K. Sakakibara, N. Inui, and G. Fujii. 1979. Establishment and characterization of a human neuroblastoma cell line in tissue culture. Jpn. J. Exp. Med. 49:67–84.
   PubMedGoogle Scholar
• Skolnik, E. Y., B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83–90.
   PubMed Web of Science ®Google Scholar
• Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40.
   PubMed Web of Science ®Google Scholar
• Stahl, M. L., C. R. Ferenz, K. L. Kelleher, R. W. Kriz, and J. L. Knopf. 1988. Sequence similarity of phospholipase C with the non-catalytic region of src. Nature (London) 332:269–272.
   PubMed Web of Science ®Google Scholar
• Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113–130.
   PubMed Web of Science ®Google Scholar
• Suh, P.-G., S. H. Ryu, K. H. Moon, H. W. Suh, and S. G. Rhee. 1988. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Proc. Natl. Acad. Sci. USA 85:5419–5423.
   PubMed Web of Science ®Google Scholar
• Takebe, Y., M. Seiki, J. Fujisawa, P. Hoy, K. Yokota, K. Arai, M. Yoshida, and N. Arai. 1988. SRa promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466–472.
   PubMed Web of Science ®Google Scholar
• Trahey, M., G. Wong, R. Halenbeck, B. Rubinfeld, G. A. Martin, M. Landner, C. M. Long, W. J. Crosier, K. Watt, K. Koths, and F. McCormick. 1988. Molecular cloning of two types of GAP complementary DNA from human placenta. Science 242:1697–1700.
   PubMed Web of Science ®Google Scholar
• Tsuchie, H., C. H. W. Chang, M. Yoshida, and P. K. Vogt. 1989. A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene. Oncogene 4:1281–1284.
   PubMedGoogle Scholar
• Vogel, U. S., R. A. F. Dixon, M. D. Schaber, R. E. Diehl, M. S. Marshall, E. M. Scolnick, I. S. Sigal, and J. B. Gibbs. 1988. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (London) 335:90–93.
   PubMed Web of Science ®Google Scholar
• Yonemoto, W., A. J. Filson, A. E. Queral-Lustig, J. Y. Wang, and J. S. Brugge. 1987. Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor. Mol. Cell. Biol. 7:905–913.
   PubMedGoogle Scholar