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Molecular and Cellular Biology Volume 12, 1992 - Issue 8
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DNA Dynamics and Chromosome Structure

Effects of Mutation Position on Frequency of Marker Rescue by Homologous Recombination

Lin Jiang1 Departments of Immunology, University of Toronto, Toronto, Ontario, CanadaM5S 1A8
,
Alison Connor1 Departments of Immunology, University of Toronto, Toronto, Ontario, CanadaM5S 1A8
&
Marc J. Shulman1 Departments of Immunology, University of Toronto, Toronto, Ontario, CanadaM5S 1A8;2 Medical Genetics, University of Toronto, Toronto, Ontario, CanadaM5S 1A8
Pages 3609-3613 | Received 10 Mar 1992, Accepted 20 May 1992, Published online: 01 Apr 2023

REFERENCES

  • Baker, M. D., N. Pennell, L. Bosnoyan, and M. J. Shulman. 1988. Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. Proc. Natl. Acad. Sci. USA 85:6432–6436.
  • Bauman, B., M. J. Potash, and G. Kohler. 1985. Consequences of frameshift mutation at the immunoglobulin heavy chain locus of the mouse. EMBO J. 4:351–359.
  • Berinstein, N., N. Pennell, C. A. Ottaway, and M. J. Shulman. 1992. Gene replacement with one-sided homologous recombination. Mol. Cell. Biol. 12:360–367.
  • Hasty, P., J. Rivera-Perez, and A. Bradley. 1992. The role and fate of DNA ends for homologous recombination in embryonic stem cells. Mol. Cell. Biol. 12:2464–2474.
  • Kang, Y., and M. J. Shulman. 1991. Effects of vector cutting on its recombination with the chromosomal immunoglobulin gene in hybridoma cells. Somatic Cell Mol. Genet. 17:525–536.
  • Shulman, M. J., L. Nissen, and C. Collins. 1990. Homologous recombination in hybridoma cells: dependence on time and fragment length. Mol. Cell. Biol. 10:4466–4472.
  • Smith, A. J. H., and B. Kalogerakis. 1990. Replacement recombination events targeted at immunoglobulin heavy chain DNA sequences in mouse myeloma cells. J. Mol. Biol. 213:415–435.
  • Thomas, K., and M. R. Cappechi. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503–512.

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